Aagaard-Tillery K, Spong CY, Thom E. Pharmacogenomics of maternal tobacco use: metabolic gene polymorphisms and risk of adverse pregnancy outcomes. Obstet Gynecol 2010; 115:568-77.
Aamodt AH, Stovner LJ, Thorstensen K, Lydersen S, White LR, Aasly JO. Prevalence of haemochromatosis gene mutations in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2007; 78:315-7.
Aarnoudse AJ, Dieleman JP, Visser LE et al. Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration. Pharmacogenet Genomics 2008; 18:299-305.
Aarnoutse RE, Kleinnijenhuis J, Koopmans PP et al. Effect of low-dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers. Clin Pharmacol Ther 2005; 78:664-74.
Abad S, Moachon L, Blanche P, Bavoux F, Sicard D, Salmon-Céron D. Possible interaction between gliclazide, fluconazole and sulfamethoxazole resulting in severe hypoglycaemia. Br J Clin Pharmacol 2001; 52:456-7.
Abadie-Viollon C, Martin H, Blanchard N et al. Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions. Toxicol In Vitro 2010; 24:346-56.
Abass K, Reponen P, Mattila S, Pelkonen O. Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved. Chem Biol Interact 2010; 185:163-73.
Abass K, Reponen P, Mattila S, Pelkonen O. Metabolism of α-thujone in human hepatic preparations in vitro. Xenobiotica 2011; 41:101-11.
Abass K, Reponen P, Turpeinen M, Jalonen J, Pelkonen O. Characterization of diuron N-demethylation by mammalian hepatic microsomes and cDNA-expressed human cytochrome P450 enzymes. Drug Metab Dispos 2007; 35:1634-41.
Abass K, Turpeinen M, Pelkonen O. An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes. J Environ Sci Health B 2009; 44:553-63.
Abate C, Niso M, Contino M et al. 1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity. ChemMedChem 2011; 6:73-80.
Abaut AY, Chevanne F, Le Corre P. Influence of efflux transporters on liver, bile and brain disposition of amitriptyline in mice. Int J Pharm 2009; 378:80-5.
Abbas N, Lücking CB, Ricard S et al. A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson’s Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson’s Disease. Hum Mol Genet 1999; 8:567-74.
Abbas R, Chow CP, Browder NJ et al. In vitro metabolism and interaction of cilostazol with human hepatic cytochrome P450 isoforms. Hum Exp Toxicol 2000; 19:178-84.
Abbasi M, Lavasanifar A, Berthiaume LG, Weinfeld M, Uludağ H. Cationic polymer-mediated small interfering RNA delivery for P-glycoprotein down-regulation in tumor cells. Cancer 2010; 116:5544-54.
Abbasi M, Lavasanifar A, Uludaˇ H. Recent attempts at RNAi-mediated P-glycoprotein downregulation for reversal of multidrug resistance in cancer. Med Res Rev 2011. doi:10. 1002/med. 20244.
Abbott GW, Sesti F, Splawski I et al. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 1999; 97:175-87.
AbdAlla S, Lother H, Langer A, el Faramawy Y, Quitterer U. Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis. Cell 2004; 119:343-54.
AbdAlla S, Lother H, Quitterer U. AT (1)-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration. Nature 2000; 407:94-8.
Abdel Halim M, Al-Otaibi T, Gheith O et al. Toxic tacrolimus blood levels with rifampin administration in a renal transplant recipient. Ann Transplant 2010; 15:57-60.
Abdelmalik N, Ruhé HG, Barwari K et al. Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism. Thromb Haemost 2008; 6:2168-74.
Abdelmegeed MA, Moon KH, Chen C, Gonzalez FJ, Song BJ. Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity. Biochem Pharmacol 2010; 79:57-66.
Abdelmegeed MA, Yoo SH, Henderson LE, Gonzalez FJ, Woodcroft KJ, Song BJ. PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver. J Nutr 2011; 141:603-10.
Abdel-Rahman MH, Pilarski R, Massengill JB, Christopher BN, Noss R, Davidorf FH. Melanoma candidate genes CDKN2A/p16/INK4A, p14ARF, and CDK4 sequencing in patients with uveal melanoma with relative high-risk for hereditary cancer predisposition. Melanoma Res 2011; 21:175-9.
Abdel-Rahman SM, Gotschall RR, Kauffman RE, Leeder JS, Kearns GL. Investigation of terbinafine as a CYP2D6 inhibitor in vivo. Clin Pharmacol Ther 1999; 65:465-72.
Abdel-Rahman SM, Jacobs RF, Massarella J et al. Single-dose pharmacokinetics of intravenous itraconazole and hydroxypropyl-beta-cyclodextrin in infants, children, and adolescents. Antimicrob Agents Chemother 2007; 51:2668-73.
Abderrahmani A, Steinmann M, Plaisance V et al. The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1). Molec Cell Biol 2001; 21:7256-627.
Abdollahi MR, Gaunt TR, Syddall HE et al. Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits. J Med Genet 2005; 42:396-401.
Abdollahi MR, Lewis RM, Gaunt TR et al. Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. Hum Mutat 2007; 28:365-73.
Abdul MI, Jiang X, Williams KM et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin Pharmacol 2010; 69:508-15.
Abduljalil K, Frank D, Gaedigk A et al. Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan. Clin Pharmacol Ther 2010; 88:643-51.
Abduljalil K, Kinzig M, Bulitta J et al. Modeling the autoinhibition of clarithromycin metabolism during repeated oral administration. Antimicrob Agents Chemother 2009; 53:2892-901.
Abdull Razis AF, Bagatta M, de Nicola GR, Iori R, Ioannides C. Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables. Toxicology 2010; 277:74-85.
Abdull Razis AF, Bagatta M, de Nicola GR, Iori R, Ioannides C. Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin. Lung Cancer 2011; 71:298-305.
Abdull Razis AF, Iori R, Ioannides C. The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer 2011; 128:2775-82.
Abdullah C, Wang X, Becker D. Expression analysis and molecular targeting of cyclin-dependent kinases in advanced melanoma. Cell Cycle 2011; 10:997-88.
Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. Blood 1997; 90:4271-7.
Abe F, Ueyama J, Kimata A et al. Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats. Life Sci 2008; 83:229-35.
Abe T, Kakyo M, Tokui T et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem 1999; 274:17159-63.
Abe Y, Namba H, Zheng Y, Nawa H. In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neurons. Neuroscience 2009; 161:95-110.
Abel MH, Huhtaniemi I, Pakarinen P, Kumar TR, Charlton HM. Age-related uterine and ovarian hypertrophy in FSH receptor knockout and FSHbeta subunit knockout mice. Reproduction 2003; 125:165-73.
Abel S, Back DJ, Vourvahis M. Maraviroc: pharmacokinetics and drug interactions. Antivir Ther 2009; 14:607-18.
Abel S, Beaumont KC, Crespi CL et al. Potential role for P-glycoprotein in the non-proportional pharmacokinetics of UK-343,664 in man. Xenobiotica 2001; 31:665-76.
Abel S, Jenkins TM, Whitlock LA, Ridgway CE, Muirhead GJ. Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 2008; 65 Suppl 1:38-46.
Abel S, Russell D, Taylor-Worth RJ, Ridgway CE, Muirhead GJ. Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 2008; 65 Suppl 1:27-37.
Abel S, Russell D, Whitlock LA, Ridgway CE, Muirhead GJ. Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/levonorgestrel in healthy volunteers. Br J Clin Pharmacol 2008; 65 Suppl 1:19-26.
Abel S, van der Ryst E, Rosario MC et al. Assessment of the pharmacokinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers. Br J Clin Pharmacol 2008; 65 Suppl 1:5-18.
Abelö A, Andersson TB, Antonsson M, Naudot AK, Skånberg I, Weidolf L. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metab Dispos 2000; 28:966-72.
Abelö A, Andersson TB, Bredberg U, Skånberg I, Weidolf L. Stereoselective metabolism by human liver CYP enzymes of a substituted benzimidazole. Drug Metab Dispos 2000; 28:58-64.
Abellán R, Mansego ML, Martínez-Hervás S et al. Association of selected ABC gene family single nucleotide polymorphisms with postprandial lipoproteins: results from the population-based Hortega study. Atherosclerosis 2010; 211:203-9.
Abicht A, Lochmüller H. Congenital myasthenic syndromes. In: Pagon RA, Bird TC, Dolan CR, Stephens K (Eds). GeneReviews. University of Washington, Seattle, 1993-2003. Available from: http://www. ncbi. nlm. nih. gov/books/NBK1168/
Aboraia AS, Makowski B, Bahja A et al. Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones. Eur J Med Chem 2010; 45:4427-34.
Abou-Donia MB, Dechkovskaia AM, Goldstein LB, Abdel-Rahman A, Bullman SL, Khan WA. Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity. Pharmacol Biochem Behav 2004; 77:253-62.
Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, McLendon RE, Schiffman SS. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. J Toxicol Environ Health A 2008; 71:1415-29.
Aboutabl ME, Zordoky BN, El-Kadi AO. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Br J Pharmacol 2009; 158:1808-19.
Aboutabl ME, Zordoky BN, Hammock BD, El-Kadi AO. Inhibition of soluble epoxide hydrolase confers cardioprotection and prevents cardiac cytochrome P450 induction by benzo(a)pyrene. J Cardiovasc Pharmacol 2011; 57:273-81.
Abraham I, Jain S, Wu CP et al. Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells. Biochem Pharmacol 2010; 80:1497-506.
Abraham JE, Maranian MJ, Driver KE et al. CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen. Breast Cancer Res 2010; 12:64.
Abraham JE, Maranian MJ, Driver KE et al. CYP2D6 gene variants and their association with breast cancer susceptibility. Cancer Epidemiol Biomarkers Prev 2011; 20:1255-8.
Abrahamsson T. The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat. Br J Pharmacol 1986; 87:657-64.
Abrams AJ, Farooq A, Wang G. S-Nitrosylation of ApoE in Alzheimer’s disease. Biochemistry 2011; 50:3405-7.
Abramson DH, Ellsworth RM, Zimmerman LE. Monocular cancer in retinoblastoma survivors. Trans. Am. Acad. Ophthal. Otolaryng 1976; 81:454-7.
Abramsson A, Landgren S, Zetterberg M et al. No association of LOXL1 gene polymorphisms with Alzheimer’s disease. Neuromolecular Med 2011; 13:160-6.
Abrhale T, Brodie A, Sabnis G et al. GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells. BMC Cancer 2011; 11:231.
Abu-Amero KK, Al-Boudari OM, Mohamed GH, Dzimiri N. The Glu27 genotypes of the beta2-adrenergic receptor are predictors for severe coronary artery disease. BMC Med Genet 2006; 7:31.
Abu-Amero KK, Al-Boudari OM, Mousa A et al. The mitochondrial DNA variant 16189T>C is associated with coronary artery disease and myocardial infarction in Saudi Arabs. Genet Test Mol Biomarkers 2010; 14:43-7.
Abu-Duhier FM, Goodeve AC, Wilson GA, Care RS, Peake IR, Reilly JT. Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia. Br J Haematol 2001; 113:983-8.
Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G, Wakil SJ. The subcellular localization of acetyl-CoA carboxylase 2. Proc Nat Acad Sci USA 2000; 97:1444-9.
Abu-Elheiga L, Matzuk MM, Kordari P et al. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. Proc Nat Acad Sci USA 2005; 102:12011-6.
Abu-Qare AW, Abou-Donia MB. Combined exposure to DEET (N,N-diethyl-m-toluamide) and permethrin: pharmacokinetics and toxicological effects. J Toxicol Environ Health B Crit Rev 2003; 6:41-53.
Abushahin F, Goldman KN, Barbieri E, Milad M, Rademaker A, Bulun SE. Aromatase inhibition for refractory endometriosis-related chronic pelvic pain. Fertil Steril 2011; 96:939-42.
Aceves Avila FJ, Esquivel Nava GA, Gallegos Arreola MP, Gómez Meda B, Zúñiga González G, Ramos-Remus C. Cyclophosphamide boluses induce micronuclei expression in buccal mucosa cells of patients with systemic lupus erythematosus independent of cytochrome P450 2D6 status. J Rheumatol 2004; 31:1335-9.
Acuña-Alonzo V, Flores-Dorantes T, Kruit JK et al. A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans. Hum Mol Genet 2010; 19:2877-85.
Achira M, Suzuki H, Ito K, Sugiyama Y. Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P4503A4. AAPS PharmSci 1999; 1:18.
Achour B, Barber J, Rostami-Hodjegan A. Cytochrome P450 Pig Liver Pie: Determination of individual cytochrome P450 isoenzyme contents in microsomes from two pig livers using LC MS. Drug Metab Dispos 2011; 39:2130-4.
Ada AO, C Kunak S, Hancer F et al. CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients. Neoplasma 2010; 57:512-21.
Adachi T, Nakagawa H, Chung I et al. Nrf2-dependent and-independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress. J Exp Ther Oncol 2007; 6:335-48.
Adachi T, Nakagawa H, Hagiya Y, Yasuoka T, Ishikawa T. Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells. Mol Pharm 2009; 6:1678-88.
Adamo KB, Dent R, Langefeld CD et al. Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response. Obesity 2007; 15:1068-75.
Adamopoulos S, Kolokathis F, Gkouziouta A et al. Cytokine gene polymorphisms are associated with markers of disease severity and prognosis in patients with idiopathic dilated cardiomyopathy. Cytokine 2011; 54:68-73.
Adams CM, Hu CW, Jeng AY et al. The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase. Bioorg Med Chem Lett 2010; 20:4324-7.
Adams LS, Zhang Y, Seeram NP, Heber D, Chen S. Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev Res 2010; 3:108-13.
Adams M, Pieniaszek HJ Jr, Gammaitoni AR, Ahdieh H. Oxymorphone extended release does not affect CYP2C9 or CYP3A4 metabolic pathways. J Clin Pharmacol 2005; 45:337-45.
Adams P, Falek A, Arnold J. Hungtington disease in Georgia: age at onset. Am J Hum Genet 1988; 43:695-794.
Adams VR, Leggas M. Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors. Clin Ther 2007; 29:1338-53.
Adamson ED. Two proto-oncogenes that play dual roles in embryonal cell growth and differentiation. Int J Dev Biol 1993; 37:111-6.
Adamson MM, Hutchinson JB, Shelton A, Wagner AD, Taylor JL. Reduced hippocampal activity during encoding in cognitively normal adults carrying the APOE ε4 allele. Neuropsychologia 2011; 49:2448-55.
Addante F, Sancarlo D, Copetti M et al. Effect of obesity, serum lipoproteins, and apolipoprotein e genotypes on mortality in hospitalized elderly patients. Rejuvenation Res 2011; 14:111-8.
Adedoyin A, Arns PA, Richards WO, Wilkinson GR, Branch RA. Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6. Clin Pharmacol Ther 1998; 64:8-17.
Adhikari AS, Agarwal N, Wood BM et al. CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res 2010; 70:4602-12.
Adinolfi A, Hopkinson DA. Blue sepharose chromatography of human alcohol dehydrogenase: evidence for interlocus and interallelic differences in affinity characteristics. Ann Hum Genet 1978; 41:399-407.
Adjei AA, Gaedigk A, Simon SD, Weinshilboum RM, Leeder JS. Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol 2008; 82:155-65.
Adjei AA, Thomae BA, Prondzinski JL, Eckloff BW, Wieben ED, Weinshilboum RM. Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: gene resequencing and functional genomics. Br J Pharmacol 2003; 139:1373-82.
Adkison KK, Shachoy-Clark A, Fang L et al. The effects of ritonavir and lopinavir/ritonavir on the pharmacokinetics of a novel CCR5 antagonist, aplaviroc, in healthy subjects. Br J Clin Pharmacol 2006; 62:336-44.
Adli M, Hollinde DL, Stamm T et al. Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism. Biol Psychiatry 2007; 62:1295-302.
Adorni MP, Favari E, Ronda N et al. Free cholesterol alters macrophage morphology and mobility by an ABCA1 dependent mechanism. Atherosclerosis 2011; 215:70-6.
Adrian K, Bernhard MK, Breitinger HG, Ogilvie A. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. Biochim Biophys Res Acta 2000; 1492:127-38.
Adrian K, Strouch MJ, Zeng Q et al. Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer. Cancer Res 2009; 69:9169-74.
Advani A, Johnson SJ, Nicol MR et al. Adult-onset hypogonadotropic hypogonadism caused by aberrant expression of aromatase in an adrenocortical adenocarcinoma. Endocr J 2010; 57:651-6.
Aerssens J, Raeymaekers P, Lilienfeld S, Geerts H, Konings F, Parys W. APOE genotype: no influence on galantamine treatment efficacy nor on rate of decline in Alzheimer’s disease. Dement Geriatr Cogn Disord 2001; 22:69-77.
Afrin LB, Afrin JB. Value of preemptive CYP2C19 genotyping in allogeneic stem cell transplant patients considered for pentamidine administration. Clin Transplant 2011; 25:271-5.
Afsar NA, Haenisch S, Mateen A et al. Genotype frequencies of selected drug metabolizing enzymes and ABC drug transporters among breast cancer patients on FAC chemotherapy. Basic Clin Pharmacol Toxicol 2010; 107:570-6.
Afshar M, Thormann W. Validated capillary electrophoresis assay for the simultaneous enantioselective determination of propafenone and its major metabolites in biological samples. Electrophoresis 2006; 27:1517-25.
Afshar M, Thormann W. Capillary electrophoretic investigation of the enantioselective metabolism of propafenone by human cytochrome P-450 SUPERSOMES: Evidence for atypical kinetics by CYP2D6 and CYP3A4. Electrophoresis 2006; 27:1526-36.
Aft R. Bisphosphonates in breast cancer: antitumor effects. Clin Adv Hematol Oncol 2011; 9:292-9.
Afzal AR, Kiechl S, Daryani YP et al. Common CCR5-del32 frameshift mutation associated with serum levels of inflammatory markers and cardiovascular disease risk in the Bruneck population. Stroke 2008; 39:1972-8.
Afzal S, Jensen SA, Vainer B et al. MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer. Ann Oncol 2009; 20:1660-6.
Afzelius L, Arnby CH, Broo A et al. State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications. Drug Metab Rev 2007; 39:61-86.
Agachan Cakmakoglu B, Attar R, Kahraman OT et al. Cyclooxygenase-2 gene and epithelial ovarian carcinoma risk. Mol Biol Rep 2011; 38:3481-6.
Agalliu I, Salinas CA, Hansten PD, Ostrander EA, Stanford JL. Statin use and risk of prostate cancer: results from a population-based epidemiologic study. Am J Epidemiol 2008; 168:250-60.
Agarwal AK, Arioglu E, de Almeida S et al. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Nat Genet 2002; 31:21-3.
Agarwal AK, Barnes RI, Garg A. Genetic basis of congenital generalized lipodystrophy. Int J Obes Relat Metab Disord 2004; 28:336-9.
Agarwal AK, Garg A. A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy. J Clin Endocr Metab 2002; 87:408-11.
Agarwal AK, Garg A. Genetic basis of lipodystrophies and management of metabolic complications. Annu Rev Med 2006; 57:297-311.
Agarwal AK, Simha V, Oral EA et al. Phenotypic and genetic heterogeneity in congenital generalized lipodystrophy. J Clin Endocrinol Metab 2003; 88:4840-7.
Agarwal DP, Goedde HW. Pharmacogenetics of alcohol metabolism and alcoholism. Pharmacogenetics 1992; 2:48-62.
Agarwal S, Boddu SH, Jain R, Samanta S, Pal D, Mitra AK. Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor. Int J Pharm 2008; 359:7-14.
Agarwal S, Holton KL, Lanza R. Efficient differentiation of functional hepatocytes from human embryonic stem cells. Stem Cells 2008; 26:1117-27.
Agarwal S, Sane R, Gallardo JL, Ohlfest JR, Elmquist WF. Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux. J Pharmacol Exp Ther 2010; 334:147-55.
Agarwal S, Sane R, Ohlfest JR, Elmquist WF. The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain. J Pharmacol Exp Ther 2011; 336:223-33.
Agarwal V, Kommaddi RP, Valli K et al. Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite. PLoS One 2008. doi:10. 1371/journal. pone. 0002337.
Agbonon A, Eklu-Gadegbeku K, Aklikokou K et al. In vitro inhibitory effect of West African medicinal and food plants on human cytochrome P450 3A subfamily. J Ethnopharmacol 2010; 128:390-4.
Aggarwal PK, Jain V, Jha V. Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy. Hypertens Res 2010; 33:473-7.
Aggarwal PK, Jain V, Srinivasan R, Jha V. Maternal EDN1 G5665T polymorphism influences circulating endothelin-1 levels and plays a role in determination of preeclampsia phenotype. J Hypertens 2009; 27:2044-50.
Aghajanova L, Giudice LC. Effect of bisphenol A on human endometrial stromal fibroblasts in vitro. Reprod Biomed Online 2011; 22:249-56.
Aghajanpour L, Mashayekhi F, Rajaei F. Intercellular adhesion molecule-1 (ICAM-1) gene polymorphism and endometriosis in northern Iran. Arch Gynecol Obstet 2011; 283:1035-9.
Agic A, Xu H, Altgassen C et al. Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers. Reprod Sci 2007; 14:486-97.
Aglony M, Martínez-Aguayo A, Carvajal CA et al. Frequency of familial hyperaldosteronism type 1 in a hypertensive pediatric population: clinical and biochemical presentation. Hypertension 2011; 57:1117-21.
Ago H, Kanaoka Y, Irikura D et al. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature 2007; 448:609-12.
Agomelatine: AGO 178, AGO178, S 20098. Drugs R D 2008; 9:177-83.
Agrawal AK, Hop CE, Pang J et al. In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes. J Pharm Biomed Anal 2005; 37:351-8.
Agrawal DK. Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug. Expert Opin Investig Drugs 2001; 10:547-60.
Agrawal K, Onami S, Mortimer JE, Pal SK. Cognitive changes associated with endocrine therapy for breast cancer. Maturitas 2010; 67:209-14.
Agudo J, Ayuso E, Jimenez V et al. IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice. Diabetologia 2008; 51:1862-72.
Aguilar-Salinas CA, Canizales-Quinteros S, Rojas-Martínez R et al. The non-synonymous Arg230Cys variant (R230C) of the ATP-binding cassette transporter A1 is associated with low HDL cholesterol concentrations in Mexican adults: A population based nation wide study. Atherosclerosis 2011; 216:146-50.
Aguilar-Salinas CA, Reyes-Rodríguez E, Ordóñez-Sánchez ML, Torres MA et al. Early-onset type 2 diabetes: metabolic and genetic characterization in the mexican population. J Clin Endocrinol Metab 2001; 86:220-6.
Aguilera DG, Tsimberidou AM. Dasatinib in chronic myeloid leukemia: a review. Ther Clin Risk Manag 2009; 5:281-9.
Agúndez JA. Cytochrome P450 gene polymorphism and cancer. Curr Drug Metab 2004; 5:211-24.
Agúndez JA, Ledesma MC, Ladero JM, Benítez J. Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population. Clin Pharmacol Ther 1995; 57:265-9.
Agúndez JA, Martínez C, Ledesma MC, Ladona MG, Ladero JM, Benítez J. Genetic basis for differences in debrisoquin polymorphism between a Spanish and other white populations. Clin Pharmacol Ther 1994; 55:412-7.
Agúndez JA, Martínez C, Pérez-Sala D, Carballo M, Torres MJ, García-Martín E. Pharmacogenomics in aspirin intolerance. Curr Drug Metab 2009; 10:998-1008.
Agúndez JA, Ramirez R, Hernandez M, Llerena A, Benítez J. Molecular heterogeneity at the CYP2D gene locus in Nicaraguans: impact of gene-flow from Europe. Pharmacogenetics 1997; 7:337-40.
Agúndez JA, Rodríguez I, Olivera M et al. CYP2D6, NAT2 and CYP2E1 genetic polymorphisms in nonagenarians. Age Ageing 1997; 26:147-51.
Agurs-Collins T, Fuemmeler BF. Dopamine polymorphisms and depressive symptoms predict foods intake. Results from a nationally representative sample. Appetite 2011; 57:339-48.
Agusa T, Iwata H, Fujihara J et al. Genetic polymorphisms in AS3MT and arsenic metabolism in residents of the Red River Delta, Vietnam. Toxicol Appl Pharmacol 2009; 236:131-41.
Aguzzi A, Brandner S. The genetics of prions-a contradiction in terms? Lancet 1999; 354:22-5.
Aguzzi A, Weissmann C. A suspicious signature. Nature 1996; 383:666-7.
Ahern TP, Christensen M, Cronin-Fenton DP et al. Functional polymorphisms in UDP-glucuronosyl transferases and recurrence in tamoxifen-treated breast cancer survivors. Cancer Epidemiol Biomarkers Prev 2011; 20:1937-43.
Ahern TP, Pedersen L, Cronin-Fenton DP, Sørensen HT, Lash TL. No increase in breast cancer recurrence with concurrent use of tamoxifen and some CYP2D6-inhibiting medications. Cancer Epidemiol Biomarkers Prev 2009; 18:2562-4.
Ahirwar DK, Kesarwani P, Singh R, Ghoshal UC, Mittal RD. Role of tumor necrosis factor-alpha (C-863A) polymorphism in pathogenesis of inflammatory bowel disease in Northern India. J Gastrointest Cancer 2011. doi:10. 1007/s12029-010-9238-9.
Ahles A, Engelhardt S. Polymorphisms determine beta-adrenoceptor conformation: implications for cardiovascular disease and therapy. Trends Pharmacol Sci 2009; 30:188-93.
Ahlstedt I, Engberg S, Smith J et al. Occurrence and pharmacological characterization of four human tachykinin NK2 receptor variants. Biochem Pharmacol 2008; 76:476-81.
Ahlström MM, Zamora I. Characterization of type II ligands in CYP2C9 and CYP3A4. J Med Chem 2008; 51:1755-63.
Ahluwalia TS, Ahuja M, Rai TS et al. ACE variants interact with the RAS pathway to confer risk and protection against type 2 diabetic nephropathy. DNA Cell Biol 2009; 28:141-50.
Ahmad A. Genetics of cerebral venous thrombosis. J Pak Med Assoc 2006; 56:488-90.
Ahmad A, Ali SM, Ahmad MU, Sheikh S, Ahmad I. Orally administered endoxifen is a new therapeutic agent for breast cancer. Breast Cancer Res Treat 2010; 122:579-84.
Ahmad A, Shahabuddin S, Sheikh S et al. Endoxifen, a new cornerstone of breast cancer therapy: demonstration of safety, tolerability, and systemic bioavailability in healthy human subjects. Clin Pharmacol Ther 2010; 88:814-7.
Ahmad I, Shukla S, Kumar A et al. Maneb and paraquat-induced modulation of toxicant responsive genes in the rat liver: comparison with polymorphonuclear leukocytes. Chem Biol Interact 2010; 188:566-79.
Ahmed RR, Holler CJ, Webb RL, Li F, Beckett TL, Murphy MP. BACE1 and BACE2 enzymatic activities in Alzheimer’s disease. J Neurochem 2010; 112:1045-53.
Ahn CY, Kim EJ, Kwon JW et al. Effects of cysteine on the pharmacokinetics of intravenous clarithromycin in rats with protein-calorie malnutrition. Life Sci 2003; 73:1783-94.
Ahn D, Ge Y, Stricklett PK et al. Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention. J Clin Invest 2004; 114:504-11.
Ahn HJ, Kim KB, Liu KH et al. In vitro metabolism and transport of the new dipeptidyl peptidase 4 inhibitors, KR66222 and KR66223. Xenobiotica 2011; 41:445-55.
Ahn J, Albanes D, Berndt SI et al. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. Carcinogenesis 2009; 30:769-76.
Ahn J, Gammon MD, Santella RM et al. Associations between breast cancer risk and the catalase genotype, fruit and vegetable consumption, and supplement use. Am J Epidemiol 2005; 162:943-52.
Ahn J, Gammon MD, Santella RM et al. Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer risk. Carcinogenesis 2006; 27:1876-82.
Ahn J, Nowell S, McCann SE et al. Associations between catalase phenotype and genotype: modification by epidemiologic factors. Cancer Epidemiol Biomarkers Prev 2006; 15:1217-22.
Ahn J, Yu K, Stolzenberg-Solomon R et al. Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 2010; 19:2739-45.
Ahn JH, Park WS, Jun MA et al. Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett 2008; 18:6525-9.
Ahn MR, Kim DK, Sheen YY. Trichostatin A, a histone deacetylase inhibitor stimulate CYP3A4 proximal promoter activity in Hepa-I cells. Arch Pharm Res 2004; 27:415-21.
Ahn S, Duke CB 3rd, Barrett CM et al. I-387, a novel antimitotic indole, displays a potent in vitro and in vivo antitumor activity with less neurotoxicity. Mol Cancer Ther 2010; 9:2859-68.
Ahn S, Hwang DJ, Barrett CM et al. A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer. Cancer Chemother Pharmacol 2011; 67:293-304.
Ahn S, Kearbey JD, Li CM, Duke CB 3rd, Miller DD, Dalton JT. Biotransformation of a novel antimitotic agent, I-387, by mouse, rat, dog, monkey, and human liver microsomes and in vivo pharmacokinetics in mice. Drug Metab Dispos 2011; 39:636-43.
Ahn SJ, Jeon YH, Lee YJ et al. Enhanced anti-tumor effects of combined MDR1 RNA interference and human sodium/iodide symporter (NIS) radioiodine gene therapy using an adenoviral system in a colon cancer model. Cancer Gene Ther 2010; 17:492-500.
Ahn T, Yun CH. High-level expression of human cytochrome P450 3A4 by co-expression with human molecular chaperone HDJ-1 (Hsp40). Arch Pharm Res 2004; 27:319-23.
Ahn T, Yun CH. Effects of epitope sequence tandem repeat and proline incorporation on polyclonal antibody production against cytochrome 1A2 and 3A4. BMB Rep 2009; 42:418-20.
Ahonen J, Olkkola KT, Neuvonen PJ. Effect of route of administration of fluconazole on the interaction between fluconazole and midazolam. Eur J Clin Pharmacol 1997; 51:415-9.
Ahonen J, Olkkola KT, Takala A, Neuvonen PJ. Interaction between fluconazole and midazolam in intensive care patients. Acta Anaesthesiol Scand 1999; 43:509-14.
Ahrén B, Winzell MS, Wierup N, Sundler F, Burkey B, Hughes TE. DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide. Regul Pept 2007; 143:97-103.
Ahsan A, Norboo T, Baig MA, Pasha MAQ. Simultaneous selection of the wild-type genotypes of the G894T and 4B/4A polymorphisms of NOS3 associate with high-altitude adaptation. Ann Hum Genet 2005; 69:260-67.
Ai D, Pang W, Li N et al. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci USA 2009; 106:564-9.
Aiba I, Yamasaki T, Shinki T et al. Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids 2006; 71:849-56.
Aiba T, Susa M, Fukumori S, Hashimoto Y. The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180. Drug Metab Pharmacokinet 2005; 20:268-74.
Aiba T, Takehara Y, Okuno M, Hashimoto Y. Poor correlation between intestinal and hepatic metabolic rates of CYP3A4 substrates in rats. Pharm Res 2003; 20:745-8.
Aichhorn W, Whitworth AB, Weiss EM, Marksteiner J. Second-generation antipsychotics: is there evidence for sex differences in pharmacokinetic and adverse effect profiles? Drug Saf 2006; 29:587-98.
Aigrain L, Pompon D, Moréra S, Truan G. Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase. EMBO Rep 2009; 10:742-7.
Aihara T, Suemasu K, Takei H et al. Effects of exemestane, anastrozole and tamoxifen on bone mineral density and bone turnover markers in postmenopausal early breast cancer patients: results of N-SAS BC 04, the TEAM Japan substudy. Oncology 2010; 79:376-81.
Ailhaud G, Fukamizu A, Massiera F, Negrel R, Saint-Marc P, Teboul M. Angiotensinogen, angiotensin II and adipose tissue development. Int J Obes Relat Metab Disord 2000; 24 Suppl 4:33-5.
Aisen PS, Schafer KA, Grundman M et al. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA 2003; 289:2819-26.
Aithal GP, Day CP, Kesteven PJ, Daly AK. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet 1999; 353:717-9.
Aithal GP, Day CP, Leathart JB, Daly AK. Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis. Pharmacogenetics 2000; 10:511-8.
Aitken AE, Lee CM, Morgan ET. Roles of nitric oxide in inflammatory downregulation of human cytochromes P450. Free Radic Biol Med 2008; 44:1161-8.
Aitken AE, Morgan ET. Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes. Drug Metab Dispos 2007; 35:1687-93.
Aiyer HS, Gupta RC. Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. Cancer Prev Res 2010; 3:727-37.
Ajdary S, Ghamilouie MM, Alimohammadian MH, Riazi-Rad F, Pakzad SR. Toll-like receptor 4 polymorphisms predispose to cutaneous leishmaniasis. Microbes Infect 2011; 13:226-31.
Akaba K, Kimura T, Sasaki A et al. Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: a common missense mutation among Japanese, Koreans and Chinese. Biochem Molec Biol Int 1998; 46:21-6.
Akaba K, Kimura T, Sasaki A et al. Neonatal hyperbilirubinemia and a common mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese. J Hum Genet 1999; 44:22-5.
Akamine Y, Miura M, Sunagawa S, Kagaya H, Yasui-Furukori N, Uno T. Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers. Xenobiotica 2010; 40:782-9.
Akao T, Sato K, Hanada M. Hepatic contribution to a marked increase in the plasma concentration of baicalin after oral administration of its aglycone, baicalein, in multidrug resistance-associated protein 2-deficient rat. Biol Pharm Bull 2009; 32:2079-82.
Akasaka H, Katsuya T, Saitoh S et al. Effects of angiotensin II type 1 receptor gene polymorphisms on insulin resistance in a Japanese general population: the Tanno-Sobetsu study. Hypertens Res 2006; 29:961-7.
Akasaka K, Kaburagi T, Yasuda S et al. Impact of functional ABCG2 polymorphisms on the adverse effects of gefitinib in Japanese patients with non-small-cell lung cancer. Cancer Chemother Pharmacol 2010; 66:691-8.
Akbas SH, Bilgen T, Keser I et al. The effect of MDR1 (ABCB1) polymorphism on the pharmacokinetic of tacrolimus in Turkish renal transplant recipients. Transplant Proc 2006; 38:1290-2.
Akgül S, Derman O, Alikaşifoğlu M, Aktaş D. CYP1A1 polymorphism in adolescents with polycystic ovary syndrome. Int J Gynaecol Obstet 2011; 112:8-10.
Akhavan S, de Cristofaro R, Peyvandi F, Lavoretano S, Landolfi R, Mannucci PM. Molecular and functional characterization of a natural homozygous Arg67His mutation in the prothrombin gene of a patient with a severe procoagulant defect contrasting with a mild hemorrhagic phenotype. Blood 2002; 100:1347-53.
Akhtar N, Ahad A, Khar RK et al. The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review. Expert Opin Ther Pat 2011; 21:561-76.
Akhtar TA, Orsomando G, Mehrshahi P et al. A central role for gamma-glutamyl hydrolases in plant folate homeostasis. Plant J 2010; 64:256-66.
Akhter MS, Biswas A, Ranjan R, Sharma A, Kumar S, Saxena R. The nitric oxide synthase 3 gene polymorphisms and their association with deep vein thrombosis in Asian Indian patients. Clin Chim Acta 2010; 411:649-52.
Akin C, Metcalfe DD. The biology of Kit in disease and the application of pharmacogenetics. J Allergy Clin Immunol 2004; 114:13-9.
Akin L, Kurtoglu S, Kendirci M, Akin MA, Hartmann MF, Wudy SA. Hook effect: a pitfall leading to misdiagnosis of hypoaldosteronism in an infant with pseudohypoaldosteronism. Horm Res Paediatr 2010; 74:72-5.
Akintoye SO, Kelly MH, Brillante B et al. Pegvisomant for the treatment of gsp-mediated growth hormone excess in patients with McCune-Albright syndrome. J Clin Endocrinol Metab 2006; 91:2960-6.
Akita H, Chiba H, Tsuchihashi K et al. Cholesteryl ester transfer protein gene: two common mutations and their effect on plasma high-density lipoprotein cholesterol content. J Clin Endocr Metab 1994; 79:1615-8.
Akiyama I, Tomiyama K, Sakaguchi M et al. Expression of CYP3A4 by an immortalized human hepatocyte line in a three-dimensional culture using a radial-flow bioreactor. Int J Mol Med 2004; 14:663-8.
Akiyama M, Shimizu H. An update on molecular aspects of the non-syndromic ichthyoses. Exp Dermatol 2008; 17:373-82.
Akk G, Steinbach JH. Galantamine activates muscle-type nicotinic acetylcholine receptors without binding to the acetylcholine-binding site. J Neurosci 2005; 25:1992-2001.
Akkız H, Bayram S, Bekar A, Akgöllü E, Ülger Y. Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma. Mol Cell Biochem 2011; 347:201-8.
Akli S, van Pelt CS, Bui T, Meijer L, Keyomarsi K. Cdk2 is required for breast cancer mediated by the low molecular weight isoform of cyclin E. Cancer Res 2011; 71:3377-86.
Aklillu E, Herrlin K, Gustafsson LL, Bertilsson L, Ingelman-Sundberg M. Evidence for environmental influence on CYP2D6-catalysed debrisoquine hydroxylation as demonstrated by phenotyping and genotyping of Ethiopians living in Ethiopia or in Sweden. Pharmacogenetics 2002; 12:375-83.
Aklillu E, Kalow W, Endrenyi L, Harper P, Miura J, Ozdemir V. CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine. Pharmacogenet Genomics 2007; 17:989-93.
Aklillu E, Persson I, Bertilsson L, Johansson I, Rodrigues F, Ingelman-Sundberg M. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther 1996; 278:441-6.
Aknin-Seifer IE, Touraine RL, Lejeune H et al. Is the CAG repeat of mitochondrial DNA polymerase gamma (POLG) associated with male infertility? A multi-centre French study. Hum Reprod 2005; 20:736-40.
Akomolafe A, Lunetta KL, Erlich PM et al. Genetic association between endothelial nitric oxide synthase and Alzheimer disease. Clin Genet 2006; 70:49-56.
Akram A, Schmeidler J, Katsel P, Hof PR, Haroutunian V. Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis? Mol Neurodegener 2010; 5:36.
Aksentijevich I, Masters SL, Ferguson PJ et al. An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med 2009; 360:2426-37.
Akuffo EL, Davis JB, Fox SM et al. The discovery and early validation of novel plasma biomarkers in mild-to-moderate Alzheimer’s disease patients responding to treatment with rosiglitazone. Biomarkers 2008; 13:618-36.
Akune T, Ohba S, Kamekura S et al. PPAR-gamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004; 113:846-55.
Akutsu T, Kobayashi K, Sakurada K, Ikegaya H, Furihata T, Chiba K. Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos 2007; 35:72-8.
Al Ahmad A, Taboada CB, Gassmann M, Ogunshola OO. Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult. J Cereb Blood Flow Metab 2011; 31:693-705.
Al Koudsi N, Ahluwalia JS, Lin SK, Sellers EM, Tyndale RF. A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo. Pharmacogenomics J 2009; 9:274-82.
Al Koudsi N, Tyndale RF. Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism. Xenobiotica 2010; 40:381-92.
Al-Abdulhadi SA, Al-Rabia MW. Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21. 3 and transmitted in family pedigrees with asthma and atopy. Ann Saudi Med 2010; 30:115-22.
Alakus H, Mönig SP, Warnecke-Eberz U et al. Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer. World J Gastroenterol 2009; 15:6061-7.
Alakus H, Warnecke-Eberz U, Bollschweiler E et al. GNAS1 T393C polymorphism is associated with histopathological response to neoadjuvant radiochemotherapy in esophageal cancer. Pharmacogenomics J 2009; 9:202-7.
Alam M, Caldwell B, Johnson R, Darlington D, Mains R, Eipper B. Novel proteins that interact with the COOH-terminal cystosolic routing determinants of an integral membrane peptide-processing enzyme. J Biol Chem 1996; 271:28636-40.
Alam M, Johnson R, Darlington D, Hand T, Mains R, Eipper B. Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptigylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme. J Biol Chem 1997; 272:12667-75.
Alamartine E, Berthoux P, Mariat C, Cambazard F, Berthoux F. Interleukin-10 promoter polymorphisms and susceptibility to skin squamous cell carcinoma after renal transplantation. J Invest Dermatol 2003; 120:99-103.
Alayli G, Cengiz K, Cantürk F, Durmuş D, Akyol Y, Menekşe EB. Acute myopathy in a patient with concomitant use of pravastatin and colchicine. Ann Pharmacother 2005; 39:1358-61.
Albalushi T, Horiuchi Y, Ishiguro H et al. Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population. Am J Med Genet B Neuropsychiatr Genet 2008; 147:392-6.
Albani D, Polito L, Signorini A, Forloni G. Neuroprotective properties of resveratrol in different neurodegenerative disorders. Biofactors 2010; 36:370-6.
Albani D, Tettamanti M, Batelli S et al. Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: evidence from the “Monzino 80-plus” prospective study. Age (Dordr) 2011. doi:10. 1007/s11357-011-9249-x.
Albano E. Alcohol, oxidative stress and free radical damage. Proc Nutr Soc 2006; 65:278-90.
Albasanz-Puig A, Murray J, Preusch M et al. Oncostatin M is expressed in atherosclerotic lesions: A role for Oncostatin M in the pathogenesis of atherosclerosis. Atherosclerosis 2011; 216:292-8.
Al-Bataineh MM, van der Merwe D, Schultz BD, Gehring R. Tumor necrosis factor alpha increases P-glycoprotein expression in a BME-UV in vitro model of mammary epithelial cells. Biopharm Drug Dispos 2010; 31:506-15.
Al-Belooshi T, John A, Tariq S, Al-Otaiba A, Raza H. Increased mitochondrial stress and modulation of mitochondrial respiratory enzyme activities in acetaminophen-induced toxicity in mouse macrophage cells. Food Chem Toxicol 2010; 48:2624-32.
Albers LJ, Reist C, Helmeste D, Vu R, Tang SW. Paroxetine shifts imipramine metabolism. Psychiatry Res 1996; 59:189-96.
Albers LJ, Reist C, Vu RL et al. Effect of venlafaxine on imipramine metabolism. Psychiatry Res 2000; 96:235-43.
Albert CM, MacRae CA, Chasman DI et al. Common variants in cardiac ion channel genes are associated with sudden cardiac death. Circ Arrhythm Electrophysiol 2010; 3:222-9.
Albert CM, Nam EG, Rimm EB et al. Cardiac sodium channel gene variants and sudden cardiac death in women. Circulation 2008; 117:16-23.
Albert MS, Basu S, Bassett SS et al. Genetic association of Alzheimer’s disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet 2003; 12:2765-76.
Albertí JJ, Sentellas S, Salvà M. In vitro liver metabolism of aclidinium bromide in preclinical animal species and humans: identification of the human enzymes involved in its oxidative metabolism. Biochem Pharmacol 2011; 81:761-76.
Alberts R, Lu L, Williams RW, Schughart K. Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures. Respir Res 2011; 12:61.
Albertsen H, Plaetke R, Ballard L et al. Genetic mapping of the BRCA1 region on chromosome 17q21. Am J Hum Genet 1994; 54:516-25.
Albin N, Johnson MR, Shahinian H, Wang K, Diasio RB. Initial characterization of the molecular defect in human dihydropyrimidine dehydrogenase deficiency. Proc Am Assoc Cancer Res 1995; 36:211.
Albrecht C, Elliott JI, Sardini A et al. Functional analysis of candidate ABC transporter proteins for sitosterol transport. Biochim Biophys Acta 2002; 1567:133-42.
Albrecht C, McVey JH, Elliott JI et al. A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome. Blood 2005; 106:542-9.
Albrecht EA, Dhanasekaran SM, Tomlins S. Immediate early inflammatory gene responses of human umbilical vein endothelial cells to hemorrhagic venom. Inflamm Res 2011; 60:213-7.
Albrecht W, Unger A, Nussler AK, Laufer S. In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase. Drug Metab Dispos 2008; 36:894-903.
Albuquerque EX, Pereira EF, Aracava Y et al. Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents. Proc Natl Acad Sci USA 2006; 103:13220-5.
Alcaro S, Arcone R, Vecchio I et al. Molecular modelling and enzymatic studies of acetylcholinesterase and butyrylcholinesterase recognition with paraquat and related compounds. SAR QSAR Environ Res 2007; 18:595-602.
Alcorn J, McNamara PJ. Ontogeny of hepatic and renal systemic clearance pathways in infants: part I. Clin Pharmacokinet 2002; 41:959-98.
Alcorn J, McNamara PJ. Ontogeny of hepatic and renal systemic clearance pathways in infants: part II. Clin Pharmacokinet 2002; 41:1077-94.
Al-Chalabi A, Dürr A, Wood NW et al. Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy. PLoS One 2009. doi:10. 1371/journal. pone. 0007114.
Al-Chalabi A, Enayat ZE, Bakker MC et al. Association of apolipoprotein E e4 allele with bulbar-onset motor neuron disease. Lancet 1996; 347:159-60.
Al-Deeb ID, Arafat TA, Irshaid YM. The effect of licorice drink on the systemic exposure of verapamil in rabbits. Drug Metab Lett 2010; 4:173-9.
Alderman CP, Gebauer MG, Gilbert AL, Condon JT. Possible interaction of zopiclone and nefazodone. Ann Pharmacother 2001; 35:1378-80.
Alderman CP, Hundertmark JD, Soetratma TW. Interaction of serotonin re-uptake inhibitors with perhexiline. Aust N Z J Psychiatry 1997; 31:601-3.
Alderman J. Coadministration of sertraline with cisapride or pimozide: an open-label, nonrandomized examination of pharmacokinetics and corrected QT intervals in healthy adult volunteers. Clin Ther 2005; 27:1050-63.
Alderman J, Preskorn SH, Greenblatt DJ et al. Desipramine pharmacokinetics when coadministered with paroxetine or sertraline in extensive metabolizers. J Clin Psychopharmacol 1997; 17:284-91.
Al-Dosari M, Zhang G, Knapp JE, Liu D. Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver. Biochem Biophys Res Commun 2006; 339:673-8.
Aldrich MC, Selvin S, Hansen HM et al. CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification. Cancer Res 2009; 69:2340-8.
Alebouyeh M, Moussavi F, Haddad-Deylami H, Vossough P. Hydroxyurea in the treatment of major beta-thalassemia and importance of genetic screening. Ann Hematol 2004; 83:430-3.
Aleksa K, Matsell D, Krausz K, Gelboin H, Ito S, Koren G. Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity. Pediatr Nephrol 2005; 20:872-85.
Alenius M, Wadelius M, Dahl ML, Hartvig P, Lindström L, Hammarlund-Udenaes M. Gene polymorphism influencing treatment response in psychotic patients in a naturalistic setting. J Psychiatr Res 2008; 42:884-93.
Alexandrino-Silva C, Nadalini Mauá FH, de Andrade AG, de Toledo Ferraz Alves TC. Hypotension caused by therapeutic doses of venlafaxine: case report and proposed pathophysiological mechanisms. J Psychopharmacol 2008; 22:214-6.
Alexanian A, Rufanova VA, Miller B, Flasch A, Roman RJ, Sorokin A. Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth. Anticancer Res 2009; 29:3819-24.
Alexopoulos GS, Streim J, Carpenter D, Docherty JP; Expert Consensus Panel for Using Antipsychotic Drugs in Older Patients. Using antipsychotic agents in older patients. J Clin Psychiatry 2004; 65 Suppl 2:5-99.
Alexopoulos P, Richter-Schmidinger T, Horn M et al. Hippocampal volume differences between healthy young Apolipoprotein E ε2 and ε4 carriers. J Alzheimers Dis 2011; 26:207-10.
Alfakir M, Dawe N, Eyre R et al. The temporal and spatial expression patterns of ABCG2 in the developing human heart. Int J Cardiol 2010. doi:10. 1016/j. ijcard. 2010. 10. 025.
Alfalah M, Parkin ET, Jacob R et al. A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase. J Biol Chem 2001; 276:21105-9.
Alfaras I, Pérez M, Juan ME et al. Involvement of breast cancer resistance protein (BCRP1/ABCG2) in the bioavailability and tissue distribution of trans-resveratrol in knockout mice. J Agric Food Chem 2010; 58:4523-8.
Alfaro CL, Lam YW, Simpson J, Ereshefsky L. CYP2D6 status of extensive metabolizers after multiple-dose fluoxetine,fluvoxamine, paroxetine, or sertraline. J Clin Psychopharmacol 1999; 19:155-63.
Alfaro CL, Lam YW, Simpson J, Ereshefsky L. CYP2D6 inhibition by fluoxetine, paroxetine, sertraline, and venlafaxine in a crossover study: intraindividual variability and plasma concentration correlations. J Clin Pharmacol 2000; 40:58-66.
Alfirevic A, Mills T, Harrington P et al. Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics 2006; 16:287-96.
Alfirevic A, Vilar FJ, Alsbou M et al. TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole. Pharmacogenomics 2009; 10:531-40.
Al-Fulaij MA, Ren Y, Beinborn M, Kopin AS. Pharmacological analysis of human D1 and D2 dopamine receptor missense variants. J Mol Neurosci 2008; 34:211-23.
Algeciras-Schimnich A, O’Kane DJ, Snozek CL. Pharmacogenomics of tamoxifen and irinotecan therapies. Clin Lab Med 2008; 28:553-67.
Ali F, Raufi MA, Washington B, Ghali JK. Conivaptan: a dual vasopressin receptor v1a/v2 antagonist [corrected]. Cardiovasc Drug Rev 2007; 25:261-79.
Ali O, Wharton J, Gibbs JS, Howard L, Wilkins MR. Emerging therapies for pulmonary arterial hypertension. Expert Opin Investig Drugs 2007; 16:803-18.
Aliberti J, Serhan C, Sher A. Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection. J Exp Med 2002; 196:1253-62.
Aljamali MN, Margaritis P, Schlachterman A et al. Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality. J Clin Invest 2008; 118:1825-34.
Al-Jenoobi FI, Al-Thukair AA, Abbas FA et al. Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects. Drug Metab Lett 2010; 4:51-5.
Alkhatib G. The biology of CCR5 and CXCR4. Curr Opin HIV AIDS 2009; 4:96-103.
Al-Mahdi M, Al Mutair A, Al Balwi M, Hussain K. Successful transfer from insulin to oral sulfonylurea in a 3-year-old girl with a mutation in the KCNJ11 gene. Ann Saudi Med 2010; 30:162-4.
Almeida S, Zandoná MR, Franken N, Callegari-Jacques SM, Osório-Wender MC, Hutz MH. Estrogen-metabolizing gene polymorphisms and lipid levels in women with different hormonal status. Pharmacogenomics J 2005; 5:346-51.
Almkvist O, Jelic V, Amberla K, Hellstrom-Lindahl E, Meurling L, Norberg A. Responder characteristics to a single oral dose of cholinesterase inhibitor: a double-blind placebo-controlled study with tacrine in Alzheimer patients. Dement Geriatr Cogn Disord 2001; 12:22-32.
Alon US. Clinical practice: Fibroblast growth factor (FGF)23: a new hormone. Eur J Pediatr 2011; 170:545-54.
Alonen A, Finel M, Kostiainen R. The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Biochem Pharmacol 2008; 76:763-72.
Alonen A, Jansson J, Kallonen S et al. Enzyme-assisted synthesis and structure characterization of glucuronic acid conjugates of losartan, candesartan, and zolarsartan. Bioorg Chem 2008; 36:148-55.
Alonso, Grundke-Iqbal I, Iqbal K. Alzheimer’s disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubles. Nat Med 1996; 2:783-7.
Al-Otaiba A, John A, Al-Belooshi T, Raza H. Redox homeostasis and respiratory metabolism in camels (Camelus dromedaries): comparisons with domestic goats and laboratory rats and mice. J Comp Physiol B 2010; 180:1121-32.
Al-Salami H, Butt G, Tucker I, Mikov M. Influence of the semisynthetic bile acid MKC on the ileal permeation of gliclazide in vitro in healthy and diabetic rats treated with probiotics. Methods Find Exp Clin Pharmacol 2008; 30:107-13.
Al-Shurbaji A, Säwe J. The pharmacokinetics of ketobemidone are not affected by CYP2D6 or CYP2C19 phenotype. Eur J Clin Pharmacol 2002; 57:877-81.
Altare F, Durandy A, Lammas D et al. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 1998; 280:1432-5.
Altarescu G, Rachmilewitz D, Zevin S. Relationship between CYP2A6 genetic polymorphism, as a marker of nicotine metabolism, and ulcerative colitis. Isr Med Assoc J 2011; 13:87-90.
Althaus M, Groen Y, Wijers AA et al. Variants of the SLC6A3 (DAT1) polymorphism affect performance monitoring-related cortical evoked potentials that are associated with ADHD. Biol Psychol 2010; 85:19-32.
Althaus M, Retzow A, Castell JV et al. In vitro identification of the cytochrome P450 isoform responsible for the metabolism of alpha-dihydroergocryptine. Xenobiotica 2000; 30:1033-45.
Altinisik J, Balta ZB, Aydin G, Ulutin T, Buyru N. Investigation of glutathione S-transferase M1 and T1 deletions in lung cancer. Mol Biol Rep 2010; 37:263-7.
Altmäe S, Haller K, Peters M et al. Allelic estrogen receptor 1 (ESR1) gene variants predict the outcome of ovarian stimulation in in vitro fertilization. Mol Hum Reprod 2007; 13:521-6.
Altshuler D, Hirschhorn JN, Klannemark M et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000; 26:76-80.
Altstiel LD, Greenberg DA, Marin D, Lantz M, Mohs R. Apolipoprotein E genotype and cognition in the very old. Lancet 1997; 349:1451.
Álvarez V, González P, Corao AI et al. The Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene promoter is not associated with late onset Alzheimer disease. Alzheimer Dis Assoc Disord 2008; 22:177-80.
Alvarez V, López-Larrea C, Coto E. Mutational analysis of the CCR5 and CXCR4 genes (HIV-1 co-receptors) in resistance to HIV-1 infection and AIDS development among intravenous drug users. Hum Genet 1998; 102:483-6.
Álvarez XA, Cacabelos R, Sampedro C et al. Efficacy and safety of Cerebrolysin in moderate to moderately severe Alzheimer’s disease: results of a randomized, double-blind, controlled trial investigating three dosages of Cerebrolysin. Eur J Neurol 2011; 18:59-68.
Álvarez XA, Mouzo R, Pichel V et al. Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer’s disease patients. Effects on cognitive performance, brain bioelectrical activity, and cerebral perfusion. Methods Find Exp Clin Pharmacol 1999; 21:633-44.
Álvarez XA, Pichel V, Pérez P et al. Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamics. Methods Find Exp Clin Pharmacol 2000; 22:585-94.
Álvarez-Álvarez M, Galdos L, Fernández-Martínez M et al. 5-Hydroxytryptamine 6 receptor (5-HT(6)) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer’s disease in the Basque Country. Neurosci Lett 2003; 339:85-7.
Alvarez-Gonzalez I, Mojica R, Madrigal-Bujaidar E, Camacho-Carranza R, Escobar-García D, Espinosa-Aguirre JJ. The antigenotoxic effects of grapefruit juice on the damage induced by benzo(a)pyrene and evaluation of its interaction with hepatic and intestinal Cytochrome P450 (Cyp) 1a1. Food Chem Toxicol 2011; 49:807-11.
Alvarez-Guerra M, Bertholom N, Garay RP. Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat. Fundam Clin Pharmacol 1999; 13:50-8.
Álvarez-Lorenzo C, Rey-Rico A, Brea J, Loza MI, Concheiro A, Sosnik A. Inhibition of P-glycoprotein pumps by PEO-PPO amphiphiles: branched versus linear derivatives. Nanomedicine 2010; 5:1371-83.
Alves AJ, Eynon N, Oliveira J, Goldhammer E. RAAS and adrenergic genes in heart failure: Function, predisposition and survival implications. World J Cardiol 2010; 2:187-97.
Alves da Costa C, Dunys J, Brau F, Wilk S, Cappai R, Checler F. 6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation. J Biol Chem 2006; 281:9824-31.
Alves da Costa C, Mattson MP, Ancolio K, Checler F. The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart. J Biol Chem 2003; 278:12064-9.
Alves Dos Santos R, Teixeira AC, Mayorano MB, Carrara HH, Moreira de Andrade J, Takahashi CS. Variability in estrogen-metabolizing genes and their association with genomic instability in untreated breast cancer patients and healthy women. J Biomed Biotechnol 2011. doi:10. 1155/2011/571784.
Alves L, Hülsmeyer V, Jaggy A, Fischer A, Leeb T, Drögemüller M. Polymorphisms in the ABCB1 gene in phenobarbital responsive and resistant idiopathic epileptic Border Collies. J Vet Intern Med 2011; 25:484-9.
Alvi AJ, Austen B, Weston VJ et al. A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival. Blood 2005; 105:4484-91.
Alzheimer’s Disease Collaborative Group. The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nat Genet 1995; 11:219-22.
Allabi AC, Gala JL, Horsmans Y et al. Functional impact of CYP2C95, CYP2C96, CYP2C98, and CYP2C911 in vivo among black Africans. Clin Pharmacol Ther 2004; 76:113-8.
Allabi AC, Gala JL, Horsmans Y. CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. Pharmacogenet Genomics 2005; 15:779-86.
Allabi AC, Horsmans Y, Alvarez JC et al. Acenocoumarol sensitivity and pharmacokinetic characterization of CYP2C9 *5/*8,*8/*11,*9/*11 and VKORC1*2 in black African healthy Beninese subjects. Eur J Drug Metab Pharmacokinet 2011. doi:10. 1007/s13318-011-0056-7
Allam MF, Serrano del Castillo A, Fernández-Crehuet Navajas R. Smoking and Parkinson’s disease: explanatory hypothesis. Int J Neurosci 2002; 112:851-4.
Allan JM, Wild CP, Rollinson S et al. Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. Proc Natl Acad Sci USA 2001; 98:11592-7.
Allayee H, Baylin A, Hartiala J et al. Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction. Am J Clin Nutr 2008; 88:934-40.
Allayee H, de Bruin TWA, Dominguez KM et al. Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p. Hypertension 2001; 38:773-8.
Allcock RJN, Windsor L, Gut IG et al. High-density SNP genotyping defines 17 distinct haplotypes of the TNF block in the Caucasian population: implications for haplotype tagging. Hum Mutat 2004; 24:517-25.
Allegaert K, de Hoon J, Naulaers G, van de Velde M. Neonatal clinical pharmacology: recent observations of relevance for anaesthesiologists. Acta Anaesthesiol Belg 2008; 59:283-8.
Allegaert K, van den Anker JN, de Hoon JN et al. Covariates of tramadol disposition in the first months of life. Br J Anaesth 2008; 100:525-32.
Allegaert K, van den Anker JN, Debeer A et al. Maturational changes in the in vivo activity of CYP3A4 in the first months of life. Int J Clin Pharmacol Ther 2006; 44:303-8.
Allegaert K, van den Anker JN, Naulaers G, de Hoon J. Determinants of drug metabolism in early neonatal life. Curr Clin Pharmacol 2007; 2:23-9.
Allegaert K, van Schaik RH, Vermeersch S et al. Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants. Pediatr Res 2008; 63:674-9.
Allegaert K, Verbesselt R, Rayyan M, Debeer A, de Hoon J. Urinary metabolites to assess in vivo ontogeny of hepatic drug metabolism in early neonatal life. Methods Find Exp Clin Pharmacol 2007; 29:251-6.
Allen B, Ingram E, Takao M et al. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci 2002; 22:9340-51.
Allen NC, Bagade S, McQueen MB et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the Sz Gene database. Nat Genet 2008; 40:827-34.
Allikmets R, Gerrard B, Hutchinson A, Dean M. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. Hum Mol Genet 1996; 5:1649-55.
Allingham-Hawkins DJ, Babul-Hirji R, Chitayat D et al. Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study-preliminary data. Am J Med Genet 1999; 83:322-5.
Allis JW, Zhao G. Quantitative evaluation of bromodichloromethane metabolism by recombinant rat and human cytochrome P450s. Chem Biol Interact 2002; 140:137-53.
Allison JP, Krummel MF. The yin and yang of T cell costimulation. Science 1995; 270:932-3.
Allmyr M, Panagiotidis G, Sparve E, Diczfalusy U, Sandborgh-Englund G. Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones. Basic Clin Pharmacol Toxicol 2009; 105:339-44.
Allorge D, Harlow J, Boulet O et al. In-vitro analysis of the contribution of CYP2D6. 35 to ultra-rapid metabolism. Pharmacogenetics 2001; 11:739-41.
Allqvist A, Miura J, Bertilsson L, Mirghani RA. Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers. Eur J Clin Pharmacol 2007; 63:173-9.
Aman MG, Vinks AA, Remmerie B et al. Plasma pharmacokinetic characteristics of risperidone and their relationship to saliva concentrations in children with psychiatric or neurodevelopmental disorders. Clin Ther 2007; 29:1476-86.
Amant C, Bauters C, Bodart JC et al. D allele of the angiotensin I-converting enzyme is a major risk factor for restenosis after coronary stenting. Circulation 1997; 96:56-60.
Amant C, Hamon M, Bauters C et al. The angiotensin II type 1 receptor gene polymorphism is associated with coronary artery vasoconstriction. J Am Coll Cardiol 1997; 29:486-90.
Amar L, Azizi M, Menard J, Peyrard S, Watson C, Plouin PF. Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism. Hypertension 2010; 56:831-8.
Amar MJ, D’Souza W, Turner S et al. 5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice. J Pharmacol Exp Ther 2010; 334:634-41.
Ambrose C, Duyao M, Barnes G et al. Structure and expression of the Hungtington’s disease gene: evidence against simple inactivation due to an expansed CAG repeat. Somat Cell Molec Genet 1994; 20:27-38.
Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 1999; 39:361-98.
Amchin J, Ereshefsky L, Zarycranski W, Taylor K, Albano D, Klockowski PM. Effect of venlafaxine versus fluoxetine on metabolism of dextromethorphan, a CYP2D6 probe. J Clin Pharmacol 2001; 41:443-51.
Amchin J, Zarycranski W, Taylor KP, Albano D, Klockowski PM. Effect of venlafaxine on the pharmacokinetics of terfenadine. Psychopharmacol Bull 1998; 34:383-9.
Amchin J, Zarycranski W, Taylor KP, Albano D, Klockowski PM. Effect of venlafaxine on the pharmacokinetics of alprazolam. Psychopharmacol Bull 1998; 34:211-9.
Amchin J, Zarycranski W, Taylor KP, Albano D, Klockowski PM. Effect of venlafaxine on the pharmacokinetics of risperidone. J Clin Pharmacol 1999; 39:297-309.
Ames BD, Lee MY, Moody C, Zhang W, Tang Y, Tsai SC. Structural and biochemical characterization of ZhuI Aromatase/Cyclase from the R1128 polyketide pathway. Biochemistry 2011; 50:8392-406.
Ames PR, Margaglione M, Ciampa A et al. Increased warfarin consumption and residual fibrin turnover in thrombotic patients with primary antiphospholipid syndrome. Thromb Res 2011; 127:595-9.
Amet Y, Berthou F, Baird S, Dreano Y, Bail JP, Menez JF. Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. Biochem Pharmacol 1995; 50:1775-82.
Amin AS, Boink GJ, Atrafi F et al. Facilitatory and inhibitory effects of SCN5A mutations on atrial fibrillation in Brugada syndrome. Europace 2011; 13:968-75.
Amini-Shirazi N, Ghahremani MH, Ahmadkhaniha R et al. Influence of CYP2C9 polymorphism on metabolism of valproate and its hepatotoxin metabolite in Iranian patients. Toxicol Mech Methods 2010; 20:452-7.
Amir E, Seruga B, Niraula S, Carlsson L, Ocaña A. Toxicity of adjuvant endocrine therapy in postmenopausal breast cancer patients: A systematic review and meta-analysis. J Natl Cancer Inst 2011; 103:1299-309.
Amirian ES, Ittmann MM, Scheurer ME. Associations between arachidonic acid metabolism gene polymorphisms and prostate cancer risk. Prostate 2011; 71:1382-9.
Amirimani B, Ning B, Deitz AC, Weber BL, Kadlubar FF, Rebbeck TR. Increased transcriptional activity of the CYP3A4*1B promoter variant. Environ Mol Mutagen 2003; 42:299-305.
Amirzargar A, Shahram F, Nikoopour E et al. Proinflammatory cytokine gene polymorphisms in Behçet’s disease. Eur Cytokine Netw 2010; 21:292-6.
Amitay M, Shurki A. The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger. Proteins 2009; 77:370-7.
Ammon S, Marx C, Behrens C et al. Diclofenac does not interact with codeine metabolism in vivo: a study in healthy volunteers. BMC Clin Pharmacol 2002; 2:2.
Amoêdo ND, Castelo-Branco MT, Paschoal ME et al. Expression of ABC transporters, p53, Bax, Bcl-2 in an archival sample of non-small cell lung cancer bearing a deletion in the EGFR gene. Int J Mol Med 2009; 23:609-14.
Amoroso A, Pirulli D, Florian F et al. AGXT gene mutations and their influence on clinical heterogeneity of type 1 primary hyperoxaluria. J Am Soc Nephrol 2001; 12:2072-9.
Amouyel P, Vidal O, Launay JM, Laplanche JL. The apolipoprotein E alleles as major susceptibility factors for Creutzfeldt-Jakob disease. The French Research Group on Epidemiology of Human Spongiform Encephalopathies. Lancet 1994; 344:1315-8.
Ampasavate C, Sotanaphun U, Phattanawasin P, Piyapolrungroj N. Effects of Curcuma spp. on P-glycoprotein function. Phytomedicine 2010; 17:506-12.
Amstutz U, Farese S, Aebi S, Largiadèr CR. Hypermethylation of the DPYD promoter region is not a major predictor of severe toxicity in 5-fluorouracil based chemotherapy. J Exp Clin Cancer Res 2008; 27:54.
Amstutz U, Farese S, Aebi S, Largiadèr CR. Dihydropyrimidine dehydrogenase gene variation and severe 5-fluorouracil toxicity: a haplotype assessment. Pharmacogenomics 2009; 10:931-44.
An G, Gallegos J, Morris ME. The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux. Drug Metab Dispos 2011; 39:426-32.
An G, Morris ME. Effects of the isoflavonoid biochanin A on the transport of mitoxantrone in vitro and in vivo. Biopharm Drug Dispos 2010; 31:340-50.
An G, Wu F, Morris ME. 5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice. Pharm Res 2011; 28:1090-9.
An J, Yin L, Shang Y et al. The combined effects of BDE47 and BaP on oxidatively generated DNA damage in L02 cells and the possible molecular mechanism. Mutat Res 2011; 721:192-8.
An JH, Kim DS, Lee YH et al. Proteomic analysis of the protective effects of Platycodi Radix in liver of chronically alcoholic rats. J Med Food 2009; 12:1190-8.
An P, Vlahov D, Margolick JB et al. A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals. J Infect Dis 2003; 188:228-31.
An S, Jang YS, Park JS, Kwon BM, Paik YK, Jeong TS. Inhibition of acyl-coenzyme A: cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes. Exp Mol Med 2008; 40:407-17.
An Y, Ongkeko WM. ABCG2: the key to chemoresistance in cancer stem cells? Expert Opin Drug Metab Toxicol 2009; 5:1529-42.
An Y, Yao J, Wei JS et al. Establish a gemcitabine-resistant pancreatic cancer cell line SW1990/GZ and research the relationship between SW1990/GZ and pancreatic cancer stem cell. Zhonghua Wai Ke Za Zhi 2010; 48:999-1003.
Anagnostopoulou K, Kolovou G, Kostakou P, Mihas C, Mikhailidis D, Cokkinos DV. Pharmacogenetic study of cholesteryl ester transfer protein gene and simvastatin treatment in hypercholesterolaemic subjects. Expert Opin Pharmacother 2007; 8:2459-63.
Anakk S, Watanabe M, Ochsner SA, McKenna NJ, Finegold MJ, Moore DD. Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest 2011; 121:86-95.
Anania MC, Sensi M, Radaelli E et al. TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells. Oncogene 2011; 30:3011-23.
Ananth J, Parameswaran S, Gunatilake S, Burgoyne K, Sidhom T. Neuroleptic malignant syndrome and atypical antipsychotic drugs. J Clin Psychiatry 2004; 65:464-70.
Ananth S, Zhuang L, Gopal E et al. Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: a RPE specific phenomenon. Biochem Biophys Res Commun 2010; 394:75-80.
Anantharaman D, Samant TA, Sen S, Mahimkar MB. Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk. Oral Oncol 2011; 47:866-72.
Anapolsky A, Teng S, Dixit S, Piquette-Miller M. The role of pregnane X receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice. Drug Metab Dispos 2006; 34:405-9.
Anastasi E, Campese AF, Bellavia D et al. Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J Immunol 2003; 171:4504-11.
Ancrenaz V, Daali Y, Fontana P et al. Impact of genetic polymorphisms and drug-drug interactions on clopidogrel and prasugrel response variability. Curr Drug Metab 2010; 11:667-77.
Andersen V, Ernst A, Christensen J et al. The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study. BMC Med Genet 2010; 11:82.
Andersen V, Ostergaard M, Christensen J, Overvad K, Tjønneland A, Vogel U. Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. BMC Cancer 2009; 9:407.
Andersen V, Pedersen N, Larsen NE, Sonne J, Larsen S. Intestinal first pass metabolism of midazolam in liver cirrhosis -effect of grapefruit juice. Br J Clin Pharmacol 2002; 54:120-4.
Andersohn F, Schmedt N, Weinmann S, Willich SN, Garbe E. Priapism associated with antipsychotics: role of alpha1 adrenoceptor affinity. J Clin Psychopharmacol 2010; 30:68-71.
Anderson BM, Schnetz-Boutaud NC, Bartlett J et al. Examination of association of genes in the serotonin system to autism. Neurogenetics 2009; 10:209-16.
Anderson DH, Ozaki S, Nealon M et al. Local cellular sources of apolipoprotein E in the human and retinal pigmented epithelium: implications for the process of drusen formation. Am J Ophthal 2001; 131:767-81.
Anderson GD. A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother 1998; 32:554-63.
Anderson GD. Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach. Clin Pharmacokinet 2005; 44:989-1008.
Anderson GD. Using pharmacokinetics to predict the effects of pregnancy and maternal-infant transfer of drugs during lactation. Expert Opin Drug Metab Toxicol 2006; 2:947-60.
Anderson GD. Gender differences in pharmacological response. Int Rev Neurobiol 2008; 83:1-10.
Anderson GD. Developmental pharmacokinetics. Semin Pediatr Neurol 2010; 17:208-13.
Anderson GD, Rosito G, Mohustsy MA, Elmer GW. Drug interaction potential of soy extract and Panax ginseng. J Clin Pharmacol 2003; 43:643-8.
Anderson LE, Dring AM, Hamel LD, Stoner MA. Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR). Toxicol Lett 2011; 202:148-54.
Anderson PL, Lamba J, Aquilante CL, Schuetz E, Fletcher CV. Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study. J Acquir Immune Defic Syndr 2006; 42:441-9.
Anderson SF, Schlegel BP, Nakajima T, Wolpin ES, Parvin JD. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat Genet 1998; 19:254-6.
Andersson H, Garscha U, Brittebo E. Effects of PCB126 and 17β-oestradiol on endothelium-derived vasoactive factors in human endothelial cells. Toxicology 2011; 285:46-56.
Andersson P, McGuire J, Rubio C et al. A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proc Nat Acad Sci USA 2002; 99:9990-5.
Andersson T, Hassan-Alin M, Hasselgren G, Röhss K, Weidolf L. Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharmacokinet 2001; 40:411-26.
Andersson T, Hassan-Alin M, Hasselgren G, Röhss K. Drug interaction studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharmacokinet 2001; 40:523-37.
Andersson T, Miners JO, Veronese ME et al. Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism. Br J Clin Pharmacol 1993; 36:521-30.
Ando H, Tsuruoka S, Yanagihara H et al. Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin. Br J Clin Pharmacol 2005; 60:494-7.
Ando Y, Shimizu T, Nakamura K et al. Potent and non-specific inhibition of cytochrome P450 by JM216, a new oral platinum agent. Br J Cancer 1998; 78:1170-4.
Andorfer C, Kress Y, Espinoza M et al. Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 2003; 86:582-90.
Andrade LC, de Almeida MJ, Neves MA, Dinis TC, Sá e Melo ML. 6beta-Methyl-B-norandrostenedione. Acta Crystallogr C 2010; 66:185-6.
Andrade LC, Paixão JA, de Almeida MJ, Neves MA, Sá e Melo ML. 6-[(4-Fluorophenyl)(1H-imidazol-1-yl)methyl]-1,3-benzodioxol-5-ol and 6-[(4-methoxyphenyl)(1H-imidazol-1-yl)methyl]-1,3-benzodioxol-5-ol. Acta Crystallogr C 2010; 66:499-502.
Andrade RA, Evans RT, Hamill RJ, Zerai T, Giordano TP. Clinical evidence of interaction between itraconazole and nonnucleoside reverse transcriptase inhibitors in HIV-infected patients with disseminated histoplasmosis. Ann Pharmacother 2009; 43:908-13.
Andrade RJ, Agúndez JA, Lucena MI, Martínez C, Cueto R, García-Martín E. Pharmacogenomics in drug induced liver injury. Curr Drug Metab 2009; 10:956-70.
Andreadis A, Brown WM, Kosik KS. Structure and novel exons of the human tau gene. Biochemistry 1992; 31:10626-33.
Andreasen AH, Brøsen K, Damkier P. A comparative pharmacokinetic study in healthy volunteers of the effect of carbamazepine and oxcarbazepine on cyp3a4. Epilepsia 2007; 48:490-6.
Andreassen TN, Eftedal I, Klepstad P et al. Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study. Eur J Clin Pharmacol 2011. doi:10. 1007/s00228-011-1093-5.
Andreassi MG, Botto N, Maffei S. Factor V Leiden, prothrombin G20210A substitution and hormone therapy: indications for molecular screening. Clin Chem Lab Med 2006; 44:514-21.
Andrén L, Andreasson A, Eggertsen R. Interaction between a commercially available St. John’s wort product (Movina) and atorvastatin in patients with hypercholesterolemia. Eur J Clin Pharmacol 2007; 63:913-6.
Andreotti G, Boffetta P, Rosenberg PS et al. Variants in blood pressure genes and the risk of renal cell carcinoma. Carcinogenesis 2010; 31:614-20.
Andres MA, Feger U, Nath A, Munsaka S, Jiang CS, Chang L. APOE ε4 allele and CSF APOE on cognition in HIV-infected subjects. J Neuroimmune Pharmacol 2011; 6:389-98.
Andreutti-Zaugg C, Scott RJ, Iggo R. Inhibition of nonsense-mediated messenger RNA decay in clinical samples facilitates detection of human MSH2 mutations with an in vivo fusion protein assay and conventional techniques. Cancer Res 1997; 57:3288-93.
Andrew AS, Burgess JL, Meza MM et al. Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environ Health Perspect 2006; 114:1193-8.
Andrew S, Goldberg Y, Kremer B et al. Hungtington disease without CAG expansion: phenocopies or errors in assignment? Am J Hum Genet 1994; 54:852-63.
Andrews E, Damle BD, Fang A et al. Pharmacokinetics and tolerability of voriconazole and a combination oral contraceptive co-administered in healthy female subjects. Br J Clin Pharmacol 2008; 65:531-9.
Andrews E, Glue P, Fang J, Crownover P, Tressler R, Damle B. Assessment of the pharmacokinetics of co-administered maraviroc and raltegravir. Br J Clin Pharmacol 2010; 69:51-7.
Andrews J, Abd-Ellah MF, Randolph NL et al. Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells. Xenobiotica 2002; 32:937-47.
Andrews ZB, Horvath TL. Uncoupling protein-2 regulates lifespan in mice. Am J Physiol Endocrinol Metab 2009; 296:621-7.
Androutsopoulos VP, Papakyriakou A, Vourloumis D, Spandidos DA. Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg Med Chem 2011; 19:2842-9.
Andrulionyte L, Laukkanen O, Chiasson JL, Laakso M; STOP-NIDDM Study Group. Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial. J Mol Med 2006; 84:701-8.
Andrulionyte L, Peltola P, Chiasson JL, Laakso M; STOP-NIDDM Study Group. Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. Diabetes 2006; 55:2148-52.
Angelastro JM, Lamé MW. Overexpression of CD133 promotes drug resistance in C6 glioma cells. Mol Cancer Res 2010; 8:1105-15.
Angelini A, di Ilio C, Castellani ML, Conti P, Cuccurullo F. Modulation of multidrug resistance p-glycoprotein activity by flavonoids and honokiol in human doxorubicin- resistant sarcoma cells (MES-SA/DX-5): implications for natural sedatives as chemosensitizing agents in cancer therapy. J Biol Regul Homeost Agents 2010; 24:197-205.
Angelini S, Kumar R, Carbone F et al. Inherited susceptibility to bleomycin-induced micronuclei: correlating polymorphisms in GSTT1, GSTM1 and DNA repair genes with mutagen sensitivity. Mutat Res 2008; 638:90-7.
Anger GJ, Magomedova L, Piquette-Miller M. Impact of acute streptozotocin-induced diabetes on ABC transporter expression in rats. Chem Biodivers 2009; 6:1943-59.
Angiolillo DJ, Fernandez-Ortiz A, Bernardo E et al. 807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment. Blood Coagul Fibrinolysis 2004; 15:427-33.
Angiolillo DJ, Fernandez-Ortiz A, Bernardo E et al. Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease. Thromb Res 2005; 116:491-7.
Angiolillo DJ, Fernández-Ortiz A, Bernardo E et al. Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel. Arterioscler Thromb Vasc Biol 2006; 26:1895-900.
Angiolillo DJ, Gibson CM, Cheng S et al. Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies. Clin Pharmacol Ther 2011; 89:65-74.
Anglicheau D, Le Corre D, Lechaton S et al. Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy. Am J Transplant 2005; 5:595-603.
Anglicheau D, Legendre C, Beaune P, Thervet E. Cytochrome P450 3A polymorphisms and immunosuppressive drugs: an update. Pharmacogenomics 2007; 8:835-49.
Aninat C, Seguin P, Descheemaeker PN, Morel F, Malledant Y, Guillouzo A. Catecholamines induce an inflammatory response in human hepatocytes. Crit Care Med 2008; 36:848-54.
Anji A, Kumari M. Supplementing the liquid alcohol diet with chow enhances alcohol intake in C57 BL/6 mice. Drug Alcohol Depend 2008; 97:86-93.
Ankley GT, Cavallin JE, Durhan EJ et al. Temporal evaluation of effects of a model 3β-hydroxysteroid dehydrogenase inhibitor on endocrine function in the fathead minnow. Environ Toxicol Chem 2011; 30:2094-102.
Annaert W, de Strooper B. Presenilins: molecular switches between proteolysis and signal transduction. Trend Neurosci 1999; 22:439-43.
Annas A, Carlström K, Alván G, AL-Shurbaji A. The effect of ketoconazole and diltiazem on oestrogen metabolism in postmenopausal women after single dose oestradiol treatment. Br J Clin Pharmacol 2003; 56:334-6.
Anovazzi G, Kim YJ, Viana AC et al. Polymorphisms and haplotypes in the interleukin-4 gene are associated with chronic periodontitis in a Brazilian population. J Periodontol 2010; 81:392-402.
Ansari A, Arenas M, Greenfield S et al. Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease. Aliment Pharmacol Ther 2008; 28:973-83.
Ansari M, Lauzon-Joset JF, Vachon MF et al. Influence of GST gene polymorphisms on busulfan pharmacokinetics in children. Bone Marrow Transplant 2010; 45:261-7.
Ansari M, Sauty G, Labuda M et al. Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood 2009; 114:1383-6.
Ansari-Lari MA, Muzny DM, Lu J et al. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. Genome Res 1996; 6:314-26.
Anson BD, Ackerman MJ, Tester DJ et al. Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels. Am J Physiol Heart Circ Physiol 2004; 286:2434-41.
Antherieu S, Chesne C, Li R et al. Stable expression, activity and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug Metab Dispos 2010; 38:516-25.
Anthony IC, Norrby KE, Dingwall T et al. Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers. Brain 2010; 133:3685-98.
Anthony M, Berg MJ. Biologic and molecular mechanisms for sex differences in pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part I. J Womens Health Gend Based Med 2002; 11:601-15.
Anthony M, Romero K, Malone DC et al. Warfarin interactions with substances listed in drug information compendia and in the FDA-Approved label for warfarin sodium. Clin Pharmacol Ther 2009; 86:425-9.
Antia U. ‘Party pill’ drugs-BZP and TFMPP. N Z Med J 2009; 122:55-68.
Antia U, Tingle MD, Russell BR. Metabolic interactions with piperazine-based ‘party pill’ drugs. J Pharm Pharmacol 2009; 61:877-82.
Antila S, Honkanen T, Lehtonen L, Neuvonen PJ. The CYP3A4 inhibitor intraconazole does not affect the pharmacokinetics of a new calcium-sensitizing drug levosimendan. Int J Clin Pharmacol Ther 1998; 36:446-9.
Antolino Lobo I, Meulenbelt J, Nijmeijer SM, Scherpenisse P, van den Berg M, van Duursen MB. Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity. Drug Metab Dispos 2010; 38:1105-12.
Anton RF, Oroszi G, O’Malley S et al. An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry 2008; 65:135-44.
Antonić J, Grabnar I, Milčinski L et al. Influence of P-glycoprotein inhibition on secretion of ivermectin and doramectin by milk in lactating sheep. Vet Parasitol 2011; 179:159-66.
Antoniou A, Pharoah PDP, Narod S et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 2003; 72:1117-30.
Antoniou AC, Spurdle AB, Sinilnikova OM et al. Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet 2008; 82:937-48.
Antoniou T, Tseng AL. Interactions between antiretrovirals and antineoplastic drug therapy. Clin Pharmacokinet 2005; 44:111-45.
Antony S, Kohlhagen G, Agama K et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol 2005; 67:523-30.
Anttila AK, Rasanen L, Leinonen EV. Fluvoxamine augmentation increases serum mirtazapine concentrations three-to fourfold. Ann Pharmacother 2001; 35:1221-3.
Anttila S, Hukkanen J, Hakkola J et al. Expression and localization of CYP3A4 and CYP3A5 in human lung. Am J Respir Cell Mol Biol 1997; 16:242-9.
Anttila SA, Leinonen EV. A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev 2001; 7:249-64.
Antuna-Puente B, Boutet E, Vigouroux C et al. Higher adiponectin levels in patients with Berardinelli-Seip congenital lipodystrophy due to seipin as compared with 1-acylglycerol-3-phosphate-o-acyltransferase-2 deficiency. J Clin Endocrinol Metab 2010; 95:1463-8.
Antunes-Fernandes EC, Bovee TF, Daamen FE, Helsdingen RJ, van den Berg M, van Duursen MB. Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO(2)-PCBs. Toxicol Lett 2011; 206:158-65.
Antzelevitch C. Drug-induced spatial dispersion of repolarization. Cardiol J 2008; 15:100-21.
Anvari M, Khalilzadeh O, Esteghamati A et al. Graves’ disease and gene polymorphism of TNF-α, IL-2, IL-6, IL-12, and IFN-γ. Endocrine 2010; 37:344-8.
Anzenbacherová E, Bec N, Anzenbacher P et al. Flexibility and stability of the structure of cytochromes P450 3A4 and BM-3. Eur J Biochem 2000; 267:2916-20.
Aoki J, Ikeda K, Murayama O, Yoshihara E, Ogai Y, Iwahashi K. The association between personality, pain threshold and a single nucleotide polymorphism (rs3813034) in the 3’-untranslated region of the serotonin transporter gene (SLC6A4). J Clin Neurosci 2010; 17:574-8.
Aoki T, Hirota T, Tamari M et al. An association between asthma and TNF-308G/A polymorphism: meta-analysis. J Hum Genet 2006; 51:677-85.
Aomori T, Yamamoto K, Oguchi-Katayama A et al. Rapid single-nucleotide polymorphism detection of cytochrome P450 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2. Clin Chem 2009; 55:804-12.
Aono S, Adachi Y, Uyama E et al. Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert’s syndrome. Lancet 1995; 346:314-5.
Aono S, Yamada Y, Keino H et al. Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II. Biochem Biophys Res Commun 1993; 197:1239-44.
Aono S, Yamada Y, Keino H et al. A new type of defect in the gene for bilirubin uridine 5’-diphosphate-glucuronosyltransferase in a patient with Crigler-Najjar syndrome type I. Pediatr Res 1994; 35:629-32.
Aouali N, El Btaouri H, Dumontet C et al. Accumulation of lactosylceramide and overexpression of a PSC833-resistant P-glycoprotein in multidrug-resistant human sarcoma cells. Oncol Rep 2011; 25:1161-7.
Aoyagi T, Koshimizu TA, Tanoue A. Vasopressin regulation of blood pressure and volume: findings from V1a receptor-deficient mice. Kidney Int 2009; 76:1035-9.
Aoyagi Y, Nagata S, Kudo T et al. Peroxisome proliferator-activated receptor γ 2 mutation may cause a subset of ulcerative colitis. Pediatr Int 2010; 52:729-34.
Aoyama K, Yoshinari K, Kim HJ, Nagata K, Yamazoe Y. Simultaneous expression of plural forms of human cytochrome P450 at desired ratios in HepG2 cells: adenovirus-mediated tool for cytochrome P450 reconstitution. Drug Metab Pharmacokinet 2009; 24:209-17.
Aoyama T, Yamano S, Waxman DJ et al. Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J Biol Chem 1989; 264:10388-95.
Apáti A, Orbán TI, Varga N et al. High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells. Biochim Biophys Acta 2008; 1778:2700-9.
Apetoh L, Ghiringhelli F, Tesniere A et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 2007; 13:1050-9.
Apinan R, Tassaneeyakul W, Mahavorasirikul W et al. The influence of CYP2A6 polymorphisms and cadmium on nicotine metabolism in Thai population. Environ Toxicol Pharmacol 2009; 28:420-4.
Aplenc R, Glatfelter W, Han P et al. CYP3A genotypes and treatment response in paediatric acute lymphoblastic leukaemia. Br J Haematol 2003; 122:240-4.
Apostolov EO, Ray D, Savenka AV, Shah SV, Basnakian AG. Chronic uremia stimulates LDL carbamylation and atherosclerosis. J Am Soc Nephrol 2010; 21:1852-7.
Appel-Dingemanse S. Clinical pharmacokinetics of tegaserod, a serotonin 5-HT(4) receptor partial agonist with promotile activity. Clin Pharmacokinet 2002; 41:1021-42.
Apperley JF, Gardembas M, Melo JV et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N Engl J Med 2002; 347:481-7.
Appiah-Opong R, Commandeur JN, Axson C, Vermeulen NP. Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants. Food Chem Toxicol 2008; 46:3598-603.
Appiah-Opong R, Commandeur JN, van Vugt-Lussenburg B, Vermeulen NP. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 2007; 235:83-91.
Appiah-Opong R, de Esch I, Commandeur JN, Andarini M, Vermeulen NP. Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. Eur J Med Chem 2008; 43:1621-31.
Applebaum KM, Karagas MR, Hunter DJ et al. Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire. Environ Health Perspect 2007; 115:1231-6.
Apte U, Singh S, Zeng G et al. Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury. Am J Pathol 2009; 175:1056-65.
Aquilante CL, Yarandi HN, Cavallari LH et al. Beta-adrenergic receptor gene polymorphisms and hemodynamic response to dobutamine during dobutamine stress echocardiography. Pharmacogenomics J 2008; 8:408-15.
Aquino-Galvez A, Camarena A, Montaño M et al. Transporter associated with antigen processing (TAP) 1 gene polymorphisms in patients with hypersensitivity pneumonitis. Exp Mol Pathol 2008; 84:173-7.
Arab JP, Ramírez C, Muñoz P et al. Effects of Japanese herbal medicine Inchin-ko-to on endotoxin-induced cholestasis in the rat. Ann Hepatol 2009; 8:228-33.
Arab-Alameddine M, di Iulio J, Buclin T et al. Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals. Clin Pharmacol Ther 2009; 85:485-94.
Aragonès G, Guardiola M, Barreda M et al. Measurement of serum PON-3 concentration: method evaluation, reference values, and influence of genotypes in a population-based study. J Lipid Res 2011; 52:1055-61.
Arai H, Higuchi S, Muramatsu T, Iwarsubo T, Sasaki H, Trojanowski Q. Apolipoprotein E gene in diffuse Lewy body disease with or without co-existing Alzheimer’s disease. Lancet 1994; 344:1307.
Arai T, Kim HJ, Chiba H, Matsumoto A. Interaction of fenofibrate and fish oil in relation to lipid metabolism in mice. J Atheroscler Thromb 2009; 16:283-91.
Araki K, Yasui-Furukori N, Fukasawa T et al. Inhibition of the metabolism of etizolam by itraconazole in humans: evidence for the involvement of CYP3A4 in etizolam metabolism. Eur J Clin Pharmacol 2004; 60:427-30.
Araki N, Tsuruoka S, Wang N et al. Human CYP3A4-introduced HepG2 cells: in vitro screening system of new chemicals for the evaluation of CYP3A4-inhibiting activity. Xenobiotica 2008; 38:1355-64.
Araki S, Koya D, Makiishi T et al. APOE polymorphism and the progression of diabetic nephropathy in Japanese subjects with type 2 diabetes: results of a prospective observational follow-up study. Diabetes Care 2003; 26:2416-20.
Arashiro R, Katsuren K, Fukuyama S, Ohta T. Effect of Trp64Arg mutation of the beta3-adrenergic receptor gene and C161T substitution of the peroxisome proliferator activated receptor gamma gene on obesity in Japanese children. Pediatr Int 2003; 45:135-41.
Araújo MA, Goulart LR, Cordeiro ER et al. Genotypic interactions of renin-angiotensin system genes in myocardial infarction. Int J Cardiol 2005; 103:27-32.
Araújo MA, Menezes BS, Lourenço C, Cordeiro ER, Gatti RR, Goulart LR. The A1166C polymorphism of the angiotensin II type-1 receptor in acute myocardial infarction. Arq Bras Cardiol 2004; 83:409-13; 404-8.
Araújo-Vilar D, Lattanzi G, González-Méndez B et al. Site-dependent differences in both prelamin A and adipogenic genes in subcutaneous adipose tissue of patients with type 2 familial partial lipodystrophy. J Med Genet 2009; 46:40-8.
Araya Z, Wikvall K. 6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes. Biochim Biophys Acta 1999; 1438:47-54.
Arayne MS, Sultana N, Bibi Z. Grape fruit juice-drug interactions. Pak J Pharm Sci 2005; 18:45-57.
Arbini AA, Mannucci M, Bauer KA. A Thr359Met mutation in factor VII of a patient with a hereditary deficiency causes defective secretion of the molecule. Blood 1996; 87:5085-94.
Arbini AA, Pollak ES, Bayleran JK, High KA, Bauer KA. Severe factor VII deficiency due to a mutation disrupting a hepatocyte nuclear factor 4 binding site in the factor VII promoter. Blood 1997; 89:176-82.
Arbus C, Benyamina A, Llorca PM et al. Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. Eur J Pharm Sci 2007; 32:357-66.
Arbustini E, Grasso M, Fasani R et al. Angiotensin converting enzyme gene deletion allele is independently and strongly associated with coronary atherosclerosis and myocardial infarction. Brit Heart J 1995; 74:584-91.
Arch DD, Bergeron M, Hathaway L, Kushner JP, Phillips JD, Franklin MR. Longitudinal study of a mouse model of familial porphyria cutanea tarda. Cell Mol Biol 2009; 55:46-54.
Ardies CM, Smith TJ, Kim S, Yang CS. Induction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) activation in rat lung microsomes by chronic ethanol consumption and repeated running exercise. Cancer Lett 1996; 103:209-18.
Arellano C, Philibert C, Vachoux C, Woodley J, Houin G. The metabolism of midazolam and comparison with other CYP enzyme substrates during intestinal absorption: in vitro studies with rat everted gut sacs. J Pharm Pharm Sci 2007; 10:26-36.
Arenaz I, Vicente J, Fanlo A et al. Haplotype structure and allele frequencies of CYP2B6 in Spaniards and Central Americans. Fundam Clin Pharmacol 2010; 24:247-53.
Arendash GW, Lewis J, Leighty RE et al. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer’s disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain Res 2004; 1012:29-41.
Arendt J, Rajaratnam SM. Melatonin and its agonists: an update. Br J Psychiatry 2008; 193:267-9.
Argani H, Ghorbanihaghjo A, Aghaeishahsavari M et al. Effects of losartan and enalapril on high-sensitivity C-reactive protein and total antioxidant in renal transplant recipients with Renin-Angiotensin system polymorphisms. Transplant Proc 2008; 40:16-21.
Argikar UA, Remmel RP. Variation in glucuronidation of lamotrigine in human liver microsomes. Xenobiotica 2009; 39:355-63.
Argikar UA, Remmel RP. Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos 2009; 37:229-36.
Argikar UA, Senekeo-Effenberger K, Larson EE, Tukey RH, Remmel RP. Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica 2009; 39:826-35.
Argov M, Bod T, Batra S, Margalit R. Novel steroid carbamates reverse multidrug-resistance in cancer therapy and show linkage among efficacy, loci of drug action and P-glycoprotein’s cellular localization. Eur J Pharm Sci 2010; 41:53-9.
Arias A, Villanueva SS, Ruiz ML et al. Regulation of expression and activity of rat intestinal multidrug resistance-associated protein 2 by cholestatic estrogens. Drug Metab Dispos 2009; 37:1277-85.
Arias B, Gutiérrez B, Pintor L, Gastó C, Fañanás L. Variability in the 5-HT(2A) receptor gene is associated with seasonal pattern in major depression. Mol Psychiatry 2001; 6:239-42.
Arias B, Serretti A, Mandelli L et al. Dysbindin gene (DTNBP1) in major depression: association with clinical response to selective serotonin reuptake inhibitors. Pharmacogenet Genomics 2009; 19:121-8.
Arikuma T, Yoshikawa S, Azuma R, Watanabe K, Matsumura K, Konagaya A. Drug interaction prediction using ontology-driven hypothetical assertion framework for pathway generation followed by numerical simulation. BMC Bioinformatics 2008; 9 Suppl 6:11.
Arima K, Kowalska A, Hasegawa M et al. Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene. Neurology 2000; 54:1787-95.
Arimoto R, Prasad MA, Gifford EM. Development of CYP3A4 inhibition models: comparisons of machine-learning techniques and molecular descriptors. J Biomol Screen 2005; 10:197-205.
Arinami T, Ishikawa M, Inoue A et al. Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin-2 gene (EDN2) to 1p34, and the endothelin-3 gene (EDN3) to 20q13. 2-q13. 3. Am J Hum Genet 1991; 48:990-6.
Ariyoshi N, Iga Y, Hirata K et al. Enhanced susceptibility of HLA-mediated ticlopidine-induced idiosyncratic hepatotoxicity by CYP2B6 polymorphism in Japanese. Drug Metab Pharmacokinet 2010; 25:298-306.
Ariyoshi N, Ohara M, Kaneko M et al. Gln172His replacement overcomes effects on the metabolism of cyclophosfamide and efavirenz caused by CYP2B6 variant with Arg262. Drug Metab Dispos 2011; 39:2045-8.
Ariyoshi N, Sawamura Y, Kamataki T. A novel single nucleotide polymorphism altering stability and activity of CYP2a6. Biochem Biophys Res Commun 2001; 281:810-4.
Ariyoshi N, Sekine H, Nakayama K, Saito K, Miyamoto A, Kamataki T. Identification of deletion-junction site of CYP2A6*4B allele lacking entire coding region of CYP2A6 in Japanese. Pharmacogenetics 2004; 14:701-5.
Ariyoshi N, Sekine H, Saito K, Kamataki T. Characterization of a genotype previously designated as CYP2A6 D-type: CYP2A6*4B, another entire gene deletion allele of the CYP2A6 gene in Japanese. Pharmacogenetics 2002; 12:501-4.
Ariyoshi N, Takahashi Y, Miyamoto M et al. Structural characterization of a new variant of the CYP2A6 gene (CYP2A6*1B) apparently diagnosed as heterozygotes of CYP2A6*1A and CYP2A6*4C. Pharmacogenetics 2000; 10:687-93.
Arkwright PD, McDermott MF, Houten SM et al. Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept. Clin Exp Immunol 2002; 130:484-8.
Arlander E, Ekström G, Alm C et al. Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: an interaction study with fluvoxamine and ketoconazole as in vivo inhibitors. Clin Pharmacol Ther 1998; 64:484-91.
Arman A, Yüksel B, Coker A, Sarioz O, Temiz F, Topaloglu AK. Novel growth hormone receptor gene mutation in a patient with Laron syndrome. J Pediatr Endocrinol Metab 2010; 23:407-14.
Armani A, Marzolla V, Rosano GM, Fabbri A, Caprio M. Phosphodiesterase type 5 (PDE5) in the adipocyte: a novel player in fat metabolism? Trends Endocrinol Metab 2011; 22:404-11.
Armanios M, Chen JL, Chang YP et al. Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc Natl Acad Sci USA 2005; 102:15960-4.
Armbruster D, Mueller A, Strobel A, Kirschbaum C, Lesch KP, Brocke B. Influence of functional tryptophan hydroxylase 2 gene variation and sex on the startle response in children, young adults, and older adults. Biol Psychol 2010; 83:214-21.
Armstrong AJ, Gebre AK, Parks JS, Hedrick CC. ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation. J Immunol 2010; 184:173-83.
Armstrong RA. Density and spatial pattern of β-amyloid (Aβ) deposits in corticobasal degeneration. Folia Neuropathol 2011; 49:14-20.
Armstrong SA, Mabon ME, Silverman LB et al. FLT3 mutations in childhood acute lymphoblastic leukemia. Blood 2004; 103:3544-6.
Armstrong SC, Wynn GH, Sandson NB. Pharmacokinetic drug interactions of synthetic opiate analgesics. Psychosomatics 2009; 50:169-76.
Arnaud MJ. Pharmacokinetics and metabolism of natural methylxanthines in animal and man. Handb Exp Pharmacol 2011:33-91.
Arnaud O, Boumendjel A, Gèze A et al. The acridone derivative MBLI-87 sensitizes breast cancer resistance protein-expressing xenografts to irinotecan. Eur J Cancer 2011; 47:640-8.
Arnaud O, Koubeissi A, Ettouati L et al. Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein. J Med Chem 2010; 53:6720-9.
Arnedo M, Taffé P, Sahli R et al. Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy. Pharmacogenet Genomics 2007; 17:755-64.
Arnett DK, Davis BR, Ford CE et al. Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study. Circulation 2005; 111:3374-83.
Arnold C, Konkel A, Fischer R, Schunck WH. Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids. Pharmacol Rep 2010; 62:536-47.
Arnold SE, Joo E, Martinoli MG et al. Apoliprotein E genotype in schizophrenia: Frequency, age and onset, and neurophathological features. Neuroreport 1997; 8:1523-6.
Arnoldi A, Crimella C, Tenderini E et al. Clinical phenotype variability in patients with hereditary spastic paraplegia type 5 associated with CYP7B1 mutations. Clin Genet 2011. doi:10. 1111/j. 1399-0004. 2011. 01624. x.
Arnoux JB, de Lonlay P, Ribeiro MJ et al. Congenital hyperinsulinism. Early Hum Dev 2010; 86:287-94.
Arold G, Donath F, Maurer A et al. No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John’s wort extract. Planta Med 2005; 71:331-7.
Aronin N, Chase K, Young C et al. CAG expansion affects the expression of mutant hungtingtin in Huntington’s disease brain. Neuron 1995; 15:1193-201.
Aron-Wisnewsky J, Julia Z, Poitou C et al. Effect of bariatric surgery-induced weight loss on SR-BI-, ABCG1-, and ABCA1-mediated cellular cholesterol efflux in obese women. J Clin Endocrinol Metab 2011; 96:1151-9.
Arora V, Cate ML, Ghosh C, Iversen PL. Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolism. Drug Metab Dispos 2002; 30:757-62.
Arora V, Iversen PL. Redirection of drug metabolism using antisense technology. Curr Opin Mol Ther 2001; 3:249-57.
Arosio B, Mastronardi L, Vergani C, Annoni G. Intereleukin-10 promoter polymorphism in mild cognitive impairment and in its clinical evolution. Int J Alzheimers Dis 2010. doi:10. 4061/2010/854527
Arráiz N, Bermúdez V, Rondon N et al. Novel mutations identification in exon 4 of LDLR gene in patients with moderate hypercholesterolemia in a Venezuelan population. Am J Ther 2010; 17:325-9.
Arranz MJ, Dawson E, Shaikh S et al. Cytochrome P4502D6 genotype does not determine response to clozapine. Br J Clin Pharmacol 1995; 39:417-20.
Arrington-Sanders R, Hutton N, Siberry GK. Ritonavir-fluticasone interaction causing Cushing syndrome in HIV-infected children and adolescents. Pediatr Infect Dis J 2006; 25:1044-8.
Arrizabalaga J, Rodriguez-Alcántara F, Castañer JL et al. Prevalence of HLA-B*5701 in HIV-infected patients in Spain (results of the EPI Study). HIV Clin Trials 2009; 10:48-51.
Arsenault J, Lehoux J, Lanthier L et al. A single-nucleotide polymorphism of alanine to threonine at position 163 of the human angiotensin II type 1 receptor impairs Losartan affinity. Pharmacogenet Genomics 2010; 20:377-88.
Arthur AT, Armati PJ, Bye C et al. Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission. BMC Med Genet 2008; 19:9:17.
Artico M, Riganò R, Buttari B et al. Protective role of parnaparin in reducing systemic inflammation and atherosclerotic plaque formation in ApoE-/- mice. Int J Mol Med 2011; 27:561-5.
Arukwe A. Modulation of brain steroidogenesis by affecting transcriptional changes of steroidogenic acute regulatory (StAR) protein and cholesterol side chain cleavage (P450scc) in juvenile Atlantic salmon (Salmo salar) is a novel aspect of nonylphenol toxicity. Environ Sci Technol 2005; 39:9791-8.
Arun Kumar AS, Chakradhara Rao US, Umamaheswaran G et al. Haplotype structures of common variants of CYP2C8, CYP2C9, and ADRB1 genes in a South Indian population. Genet Test Mol Biomarkers 2011; 15:407-13.
Asada T, Kariya T, Yamagata Z, Kinoshita T, Asaka A. ApoE epsilon-4 and cognitive decline in patients with Alzheimer’s disease. Neurology 1996; 47:603.
Asadullah K, Eskdale J, Wiese A, Gallagher G, Friedrich M, Sterry W. Interleukin-10 promoter polymorphism in psoriasis. J Invest Dermatol 2001; 116:975-8.
Asakawa C, Ogawa M, Kumata K et al. [(11)C]Sorafenib: Radiosynthesis and preliminary PET study of brain uptake in P-gp/Bcrp knockout mice. Bioorg Med Chem Lett 2011; 21:2220-3.
Asano K, Yamada-Yamasawa W, Kudoh H et al. Association between beta-adrenoceptor gene polymorphisms and relative response to beta 2-agonists and anticholinergic drugs in Japanese asthmatic patients. Respirology 2010; 15:849-54.
Asano T, Kushida H, Sadakane C et al. Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biol Pharm Bull 2001; 24:678-82.
Asano T, Takahashi KA, Fujioka M et al. Genetic analysis of steroid-induced osteonecrosis of the femoral head. J Orthop Sci 2003; 8:329-33.
Asano T, Takahashi KA, Fujioka M et al. ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation. Pharmacogenetics 2003; 13:675-82.
Asberg A. Interactions between cyclosporin and lipid-lowering drugs: implications for organ transplant recipients. Drugs 2003; 63:367-78.
Aschim EL, Nordenskjöld A, Giwercman A et al. Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene. J Clin Endocrinol Metab 2004; 89:5105-9.
Asghar A, Gorski JC, Haehner-Daniels B, Hall SD. Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin. Drug Metab Dispos 2002; 30:20-6.
Ashbee HR, Gilleece MH. Has the era of individualised medicine arrived for antifungals? A review of antifungal pharmacogenomics. Bone Marrow Transplant 2011. doi:10. 1038/bmt. 2011. 146.
Ashcroft FM. ATP-sensitive potassium channelopathies: focus on insulin secretion. J Clin Invest 2005; 115:2047-58.
Asher G, Tsvetkov P, Kahana C, Shaul Y. A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73. Genes Dev 2005; 19:316-21.
Ashford JW. APOE genotype effects on Alzheimer’s disease onset and epidemiology. J Mol Neurosci 2004; 23:157-65.
Ashiru-Oredope DA, Patel N, Forbes B, Patel R, Basit AW. The effect of polyoxyethylene polymers on the transport of ranitidine in Caco-2 cell monolayers. Int J Pharm 2011; 409:164-8.
Ashkar S, Mesentsev A, Zhang WX, Mastyugin V, Dunn MW, Laniado-Schwartzman M. Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids. J Ocul Pharmacol Ther 2004; 20:65-74.
Ashley-Koch AE, Elliott L, Kail ME et al. Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. Blood 2008; 111:5721-6.
Ashraf J, Thompson EB. Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes. Mol Endocrinol 1993; 7:631-42.
Ashrafian H, Horowitz JD, Frenneaux MP. Perhexiline. Cardiovasc Drug Rev 2007; 25:76-97.
Ashton KA, Proietto A, Otton G et al. Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk. Cancer Epidemiol 2010; 34:328-37.
Asiedu C, Biggs J, Lilly M, Kraft AS. Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2. Cancer Res 1995; 55:3716-20.
Asimus S, Elsherbiny D, Hai TN et al. Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects. Fundam Clin Pharmacol 2007; 21:307-16.
Asleh R, Levy AP. In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease. Vasc Health Risk Manag 2005; 1:19-28.
Asp V, Ullerås E, Lindström V, Bergström U, Oskarsson A, Brandt I. Biphasic hormonal responses to the adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE in human cells. Toxicol Appl Pharmacol 2010; 242:281-9.
Assaraf YG. The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. Drug Resist Updat 2006; 9:227-46.
Asselta R, Peyvandi F. Factor V deficiency. Semin Thromb Hemost 2009; 35:382-9.
Assenat E, Gerbal-Chaloin S, Larrey D et al. Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology 2004; 40:951-60.
Aste N, Watanabe Y, Harada N, Saito N. Distribution and sex differences in aromatase-producing neurons in the brain of Japanese quail embryos. J Chem Neuroanat 2010; 39:272-88.
Atack JR. GABA(A) receptor subtype-selective efficacy: TPA023, an alpha2/alpha3 selective non-sedating anxiolytic and alpha5IA, an alpha5 selective cognition enhancer. CNS Neurosci Ther 2008; 14:25-35.
Atalay C, Demirkazik A, Gunduz U. Role of ABCB1 and ABCC1 gene induction on survival in locally advanced breast cancer. J Chemother 2008; 20:734-9.
Atanasova SY, von Ahsen N, Toncheva DI, Dimitrov TG, Oellerich M, Armstrong VW. Genetic polymorphisms of cytochrome P450 among patients with Balkan endemic nephropathy (BEN). Clin Biochem 2005; 38:223-8.
Ateeq B, Tomlins SA, Chinnaiyan AM. AGTR1 as a therapeutic target in ER-positive and ERBB2-negative breast cancer cases. Cell Cycle 2009; 8:3794-5.
Ateş NA, Tamer L, Ateş C et al. Glutathione S-transferase M1, T1, P1 genotypes and risk for development of colorectal cancer. Biochem Genet 2005; 43:149-63.
Ates O, Dalyan L, Hatemi G, Hamuryudan V, Topal-Sarikaya A. Genetic susceptibility to Behçet’s syndrome is associated with NRAMP1 (SLC11A1) polymorphism in Turkish patients. Rheumatol Int 2009; 29:787-91.
Ates O, Dalyan L, Müsellim B et al. NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis. Int J Immunogenet 2009; 36:15-29.
Ates O, Dolek B, Dalyan L, Musellim B, Ongen G, Topal-Sarikaya A. The association between BsmI variant of vitamin D receptor gene and susceptibility to tuberculosis. Mol Biol Rep 2011; 38:2633-6.
Athippozhy A, Huang L, Wooton-Kee CR et al. Differential gene expression in liver and small intestine from lactating rats compared to age-matched virgin controls detects increased mRNA of cholesterol biosynthetic genes. BMC Genomics 2011; 12:95.
Athyros VG, Papageorgiou AA, Hatzikonstandinou HA, Athyrou VV, Kontopoulos AG. Effect of atorvastatin versus simvastatin on lipid profile and plasma fibrinogen in patients with hypercholesterolaemia: A Pilot, Randomised, Double-Blind, Dose-Titrating Study. Clin Drug Investig 1998; 16:219-27.
Atkinson SH, Mwangi TW, Uyoga SM et al. The haptoglobin 2-2 genotype is associated with a reduced incidence of Plasmodium falciparum malaria in children on the coast of Kenya. Clin Infect Dis 2007; 44:802-9.
Atkinson SH, Rockett K, Sirugo G et al. Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype. PLoS Med 2006. doi:10. 1371/journal. pmed. 0030172.
Atshaves BP, McIntosh AL, Martin GG et al. Overexpression of sterol carrier protein-2 differentially alters hepatic cholesterol accumulation in cholesterol-fed mice. J Lipid Res 2009; 50:1429-47.
Attar-Herzberg D, Apel A, Gang N, Dvir D, Mayan H. The serotonin syndrome: initial misdiagnosis. Isr Med Assoc J 2009; 11:367-70.
Attie T, Pelet A, Edery P et al. Diversity of RET proto-oncogene mutations in familial and sporadic Hirschsprung disease. Hum Molec Genet 1995; 4:1381-6.
Au N, Rettie AE. Pharmacogenomics of 4-hydroxycoumarin anticoagulants. Drug Metab Rev 2008; 40:355-75.
Au WY, Lam CC, Chan EC, Kwong YL. Two novel factor VII gene mutations in a Chinese family with factor VII deficiency. Br J Haematol 2000; 111:143-5.
Aubert J, Begriche K, Knockaert L, Robin MA, Fromenty B. Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role. Clin Res Hepatol Gastroenterol 2011; 35:630-7.
Audero E, Coppi E, Mlinar B et al. Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Science 2008; 321:130-3.
Audí L, Carrascosa A, Esteban C et al. The exon 3-deleted/full-length growth hormone receptor polymorphism does not influence the effect of puberty or growth hormone therapy on glucose homeostasis in short non-growth hormone-deficient small-for-gestational-age children: results from a two-year controlled prospective study. J Clin Endocrinol Metab 2008; 93:2709-15.
Audi L, Fernández-Cancio M, Carrascosa A et al. Novel (60%) and recurrent (40%) androgen receptor gene mutations in a series of 59 patients with a 46,XY disorder of sex development. J Clin Endocrinol Metab 2010; 95:1876-88.
Auerbach SS, Dekeyser JG, Stoner MA, Omiecinski CJ. CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics. Drug Metab Dispos 2007; 35:428-39.
Auerbach SS, Stoner MA, Su S, Omiecinski CJ. Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3). Mol Pharmacol 2005; 68:1239-53.
Auerbach W, Hulbert M, Hilditch-Maguire P et al. The HD mutation causes progressive lethal neurogical disease in mice expressing reduced levels of huntingtin. Hum Molec Genet 2001; 10:2515-23.
Aulchenko YS, Ripatti S, Lindqvist I et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 2009; 41:47-55.
Ault BH, Schmidt BZ, Fowler NL et al. Human factor H deficiency. Mutations in framework cysteine residues and block in H protein secretion and intracellular catabolism. J Biol Chem 1997; 272:25168-75.
Auner V, Sehouli J, Oskay-Oezcelik G, Horvat R, Speiser P, Zeillinger R. ABC transporter gene expression in benign and malignant ovarian tissue. Gynecol Oncol 2010; 117:198-201.
Aung GL, O’Brien JG, Tien PG, Kawamoto LS. Increased aripiprazole concentrations in an HIV-positive male concurrently taking duloxetine, darunavir, and ritonavir. Ann Pharmacother 2010; 44:1850-4.
Aung HH, Lame MW, Gohil K et al. Comparative gene responses to collected ambient particles in vitro: endothelial responses. Physiol Genomics 2011; 43:917-29.
Aurade RM, Jayalakshmi SK, Sreeramulu K. Modulatory effects of natural curcuminoids on P-glycoprotein ATPase of insecticide-resistant pest Helicoverpa armigera (Lepidopetera: Noctüidae). J Membr Biol 2010; 236:271-8.
Aurade RM, Jayalakshmi SK, Sreeramulu K. P-glycoprotein ATPase from the resistant pest, Helicoverpa armigera: purification, characterization and effect of various insecticides on its transport function. Biochim Biophys Acta 2010; 1798:1135-43.
Aureli A, del Beato T, Sebastiani P et al. Attention-deficit hyperactivity disorder and intellectual disability: a study of association with brain-derived neurotrophic factor gene polymorphisms. Int J Immunopathol Pharmacol 2010; 23:873-80.
Aurich H, Sgodda M, Kaltwasser P et al. Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut 2009; 58:570-81.
Auro K, Alanne M, Kristiansson K et al. Combined effects of thrombosis pathway gene variants predict cardiovascular events. PLoS Genet 2007. doi:10. 1371/journal. pgen. 0030120.
Austin SA, Santhanam AV, Katusic ZS. Endothelial nitric oxide modulates expression and processing of amyloid precursor protein. Circ Res 2010; 107:1498-502.
Austinat M, Braeuninger S, Pesquero JB et al. Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema. Stroke 2009; 40:285-93.
Avdesh A, Wong P, Martins RN, Martin-Iverson MT. Memory function in a mouse genetic model of Alzheimer’s disease. J Alzheimers Dis 2011; 25:433-44.
Avenoso A, Spinà E, Campo G et al. Interaction between fluoxetine and haloperidol: pharmacokinetic and clinical implications. Pharmacol Res 1997; 35:335-9.
Avent KM, DeVoss JJ, Gillam EM. Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites. Chem Res Toxicol 2006; 19:914-20.
Aversa A, Caprio M, Antelmi A et al. Exposure to phosphodiesterase type 5 inhibitors stimulates aromatase expression in human adipocytes in vitro. J Sex Med 2011; 8:696-704.
Avizienyte E, Ward RA, Garner AP. Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations. Biochem J 2008; 415:197-206.
Avramovich Y, Amit T, Youdim MB. Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein. J Biol Chem 2002; 277:31466-73.
Avti PK, Vaiphei K, Pathak CM, Khanduja KL. Involvement of various molecular events in cellular injury induced by smokeless tobacco. Chem Res Toxicol 2010; 23:1163-74.
Awata T, Inoue K, Kurihara S et al. A common polymorphism in the 5’-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. Diabetes 2002; 51:1635-9.
Ayajiki K, Fujioka H, Toda N et al. Mediation of arachidonic acid metabolite(s) produced by endothelial cytochrome P-450 3A4 in monkey arterial relaxation. Hypertens Res 2003; 26:237-43.
Aycan Z, Onder A, Cetinkaya S. Eight-year follow-up of a girl with McCune-Albright syndrome. J Clin Res Pediatr Endocrinol 2011; 3:40-2.
Aydin M, Oktar S, Ozkan OV, Alçin E, Oztürk OH, Nacar A. Letrozole induces hepatotoxicity without causing oxidative stress: the protective effect of melatonin. Gynecol Endocrinol 2011; 27:209-15.
Aye IL, Waddell BJ, Mark PJ, Keelan JA. Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity. Biochim Biophys Acta 2010; 1801:1013-24.
Ayed-Boussema I, Pascussi JM, Maurel P, Bacha H, Hassen W. Zearalenone activates pregnane X receptor, constitutive androstane receptor and aryl hydrocarbon receptor and corresponding phase I target genes mRNA in primary cultures of human hepatocytes. Environ Toxicol Pharmacol 2011; 31:79-87.
Ayed-Boussema I, Pascussi JM, Zaied C, Maurel P, Bacha H, Hassen W. Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors. Drug Chem Toxicol 2011. doi:10. 3109/01480545. 2011. 589438.
Aylin Arici M, Kilinc E, Demir O, Ates M, Yesilyurt A, Gelal A. Interactions between verapamil and digoxin in Langendorff-perfused rat hearts: The role of inhibition of P-glycoprotein in the heart. Basic Clin Pharmacol Toxicol 2010. doi:10. 1111/j. 1742-7843. 2010. 00574. x.
Aymerich I, Duflot S, Fernández-Veledo S et al. The concentrative nucleoside transporter family (SLC28): new roles beyond salvage? Biochem Soc Trans 2005; 33:216-9.
Aynacioglu AS, Brockmöller J, Bauer S et al. Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin. Br J Clin Pharmacol 1999; 48:409-15.
Ayodo G, Price AL, Keinan A et al. Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants. Am J Hum Genet 2007; 81:234-42.
Ayoub N, Lucas C, Kaddoumi A. Genomics and pharmacogenomics of breast cancer: current knowledge and trends. Asian Pac J Cancer Prev 2011; 12:1127-40.
Azarpira N, Ashraf MJ, Khademi B, Darai M, Hakimzadeh A, Abedi E. Study the polymorphism of CYP3A5 and CYP3A4 loci in Iranian population with laryngeal squamous cell carcinoma. Mol Biol Rep 2011; 38:5443-8.
Azarpira N, Namazi S, Hendijani F, Banan M, Darai M. Investigation of allele and genotype frequencies of CYP2C9, CYP2C19 and VKORC1 in Iran. Pharmacol Rep 2010; 62:740-6.
Azcoitia I, Yague JG, García-Segura LM. Estradiol synthesis within the human brain. Neuroscience 2011; 191:139-47.
Azizi E, Massoud A, Amirzargar AA et al. Association of CTLA4 gene polymorphism in Iranian patients with ankylosing spondylitis. J Clin Immunol 2010; 30:268-71.
Azizi M, Hallouin MC, Jeunemaitre X, Guyene TT, Menard J. Influence of the M235T polymorphism of human angiotensinogen (AGT) on plasma AGT and renin concentrations after ethinylestradiol administration. J Clin Endocr Metab 2000; 85:4331-7.
Azizi Z, Noroozian M, Kaini-Moghaddam Z, Majlessi N. Association between NOS3 gene G894T polymorphism and late-onset Alzheimer disease in a sample from Iran. Alzheimer Dis Assoc Disord 2010; 24:204-8.
Azmanov DN, Dimitrova S, Florez L et al. LTBP2 and CYP1B1 mutations and associated ocular phenotypes in the Roma/Gypsy founder population. Eur J Hum Genet 2011; 19:326-33.
Azrak RG, Yu J, Pendyala L et al. Irinotecan pharmacokinetic and pharmacogenomic alterations induced by methylselenocysteine in human head and neck xenograft tumors. Mol Cancer Ther 2005; 4:843-54.
Azuma J, Hasunuma T, Kubo M et al. The relationship between clinical pharmacokinetics of aripiprazole and CYP2D6 genetic polymorphism: effects of CYP enzyme inhibition by coadministration of paroxetine or fluvoxamine. Eur J Clin Pharmacol 2011. doi:10. 1007/s00228-011-1094-4.
Azuma J, Nonen S. Chronic heart failure: beta-blockers and pharmacogenetics. Eur J Clin Pharmacol 2009; 65:3-17.
Azzato EM, Chen RA, Wacholder S, Chanock SJ, Klebanoff MA, Caporaso NE. Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations. Pharmacogenet Genomics 2010; 20:58-63.