General References


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Qi L, Heredia JE, Altarejos JY et al. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 2006; 312:1763-6.

Qi L, Rifai N, Hu FB. Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women. Diabetes 2009; 58:275-8.

Qi L, Zhang C, van Dam RM, Hu FB. Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals. J Clin Endocrinol Metab 2007; 92:3618-25.

Qi SN, Song LJ, Chen Y, Jing YX. Reversal of mdr1-mediated multidrug resistance in human leukemia cells by a new spin-labeled derivative of podophyllotoxin. Pharmazie 2010; 65:117-21.

Qi Y, Niu W, Zhou W, Hou S, Qiu C. Correlation between angiotensinogen gene polymorphisms and essential hypertension in Chinese population. J Hum Hypertens 2008; 22:147-50.

Qian J, Zhang ZB, Wan JX et al. Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population. Carcinogenesis 2008; 29:2325-9.

Qian L, Zolfaghari R, Ross AC. Liver-specific cytochrome P450 CYP2C22 is a direct target of retinoic acid and a retinoic acid-metabolizing enzyme in rat liver. J Lipid Res 2010; 51:1781-92.

Qian M, Shi LF, Hu JH. Enzyme kinetics of ligustilide metabolism in rat liver microsomes. Yao Xue Xue Bao 2009; 44:395-400.

Qian MR, Chen J, Liu Y, Yu LS, Chen SQ, Zeng S. CYP2D6*1, CYP2D6*10 co-expressed with CYPOR in Bac-to-Bac expression system and activity determination. Yao Xue Xue Bao 2011; 46:207-12.

Qian N, Chen X, Han S et al. Circulating IL-1beta levels, polymorphisms of IL-1B, and risk of cervical cancer in Chinese women. J Cancer Res Clin Oncol 2010; 136:709-16.

Qian W, Homma M, Itagaki F et al. MDR1 gene polymorphism in Japanese patients with schizophrenia and mood disorders including depression. Biol Pharm Bull 2006; 29:2446-50.

Qian W, Shichi H. Acetaminophen produces cataract in DBA2 mice by Ah receptor-independent induction of CYP1A2. J Ocul Pharmacol Ther 2000; 16:337-44.

Qian X, Lu Z, Tan M, Liu H, Lu D. A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension. Eur J Hum Genet 2007; 15:1239-45.

Qiang F, Lee BJ, Ha I, Kang KW, Woo ER, Han HK. Effect of maceligan on the systemic exposure of paclitaxel: in vitro and in vivo evaluation. Eur J Pharm Sci 2010; 41:226-31.

Qiao B, Johnson NW, Chen X, Li R, Tao Q, Gao J. Disclosure of a stem cell phenotype in an oral squamous cell carcinoma cell line induced by BMP-4 via an epithelial-mesenchymal transition. Oncol Rep 2011; 26:455-61.

Qiao H, Tong Y, Han H et al. A novel therapeutic regimen for hepatic fibrosis using the combination of mesenchymal stem cells and baicalin. Pharmazie 2011; 66:37-43.

Qiao HL, Wen Q, Gao N, Tian X, Jia LJ. Association of IL-10 level and IL-10 promoter SNPs with specific antibodies in penicillin-allergic patients. Eur J Clin Pharmacol 2007; 63:263-9.

Qiao HL, Yang J, Zhang YW. Relationships between specific serum IgE, cytokines and polymorphisms in the IL-4, IL-4Ralpha in patients with penicillins allergy. Allergy 2005; 60:1053-9.

Qiao Y, Liu R, Bai H et al. Association between cholesterol 7alpha-hydroxylase -204A/C gene polymorphism and endogenous hypertriglyceridemia in Chinese. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007; 24:432-6.

Qin F, Lennon-Edwards S, Lancel S et al. Cardiac-specific overexpression of catalase identifies hydrogen peroxide-dependent and -independent phases of myocardial remodeling and prevents the progression to overt heart failure in G(alpha)q-overexpressing transgenic mice. Circ Heart Fail 2010; 3:306-13.

Qin N, D’Andrea MR, Lubin ML, Shafaee N, Codd EE, Correa AM. Molecular cloning and functional expression of the human sodium channel beta-1B subunit, a novel splicing variant of the beta-1 subunit. Europ J Biochem 2003; 270:4762-70.

Qin Q, Chen XP, Yang ZS, Xiao YH, Min H, Li YJ. Neferine increases STI571 chemosensitivity via inhibition of P-gp expression in STI571-resistant K562 cells. Leuk Lymphoma 2011; 52:694-700.

Qin S, Shen L, Zhang A et al. Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China. Genomics 2008; 92:152-8.

Qin W, Peng Y, Ksiezak-Reding H et al. Inhibition of cyclooxygenase as potential novel therapeutic strategy in N141I presenilin-2 familial Alzheimer’s disease. Mol Psychiatry 2006; 11:172-81.

Qin XL, Bi HC, Wang XD et al. Mechanistic understanding of the different effects of Wuzhi tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506). Int J Pharm 2010; 389:114-21.

Qin XP, Xie HG, Wang W et al. Effect of the gene dosage of CgammaP2C19 on diazepam metabolism in Chinese subjects. Clin Pharmacol Ther 1999; 66:642-6.

Qiu F, Zhang R, Sun J et al. Inhibitory effects of seven components of danshen extract on catalytic activity of cytochrome P450 enzyme in human liver microsomes. Drug Metab Dispos 2008; 36:1308-14.

Qiu H, Gabrielsen A, Agardh HE et al. Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Proc Nat Acad Sci USA 2006; 103:8161-6.

Qiu H, Mathäs M, Nestler S et al. The unique complexity of the CYP3A4 upstream region suggests a nongenetic explanation of its expression variability. Pharmacogenet Genomics 2010; 20:167-78.

Qiu H, Taudien S, Herlyn H et al. CYP3 phylogenomics: evidence for positive selection of CYP3A4 and CYP3A7. Pharmacogenet Genomics 2008; 18:53-66.

Qiu L, Zhang L, Zheng C, Wang R. Improving physicochemical properties and doxorubicin cytotoxicity of novel polymeric micelles by poly(ε-caprolactone) segments. J Pharm Sci 2011; 100:2430-42.

Qiu LX, Yao L, Mao C et al. Lack of association of CYP1A2-164 A/C polymorphism with breast cancer susceptibility: a meta-analysis involving 17,600 subjects. Breast Cancer Res Treat 2010; 122:521-5.

Qiu XY, Jiao Z, Zhang M et al. Association of MDR1, CYP3A4*18B, and CYP3A5*3 polymorphisms with cyclosporine pharmacokinetics in Chinese renal transplant recipients. Eur J Clin Pharmacol 2008; 64:1069-84.

Qu L, He B, Pan Y et al. Association between polymorphisms in RAPGEF1, TP53, NRF1 and type 2 diabetes in Chinese Han population. Diabetes Res Clin Pract 2011; 91:171-6.

Qu W, Bradbury JA, Tsao CC et al. Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain. J Biol Chem 2001; 276:25467-79.

Qu W, Cheng L, Dill AL et al. Nitric oxide donor, V-PROLI/NO, provides protection against arsenical induced toxicity in rat liver cells: Requirement for Cyp1a1. Chem Biol Interact 2011; 193:88-96.

Qu YQ, Fang ZZ, Yang L et al. Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol. Pharmazie 2011; 66:216-21.

Quan J, Piao L, Wang X, Li T, Yin X. Rossicaside B protects against carbon tetrachloride-induced hepatotoxicity in mice. Basic Clin Pharmacol Toxicol 2009; 105:380-6.

Quan J, Yin X, Xu H. Boschniakia rossica prevents the carbon tetrachloride-induced hepatotoxicity in rat. Exp Toxicol Pathol 2011; 63:53-9.

Quaye IK, Ekuban FA, Goka BQ et al. Haptoglobin 1-1 is associated with susceptibility to severe Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg 2000; 94:216-9.

Queiro R, Gonzalez S, López-Larrea C et al. HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis. Arthritis Res Ther 2006; 8:185.

Queiroz DM, Saraiva IE, Rocha GA et al. IL2-330G polymorphic allele is associated with decreased risk of Helicobacter pylori infection in adulthood. Microbes Infect 2009; 11:980-7.

Queiroz KC, Ruela-de-Sousa RR, Fuhler GM et al. Hedgehog signaling maintains chemoresistance in myeloid leukemic cells. Oncogene 2010; 29:6314-22.

Quick SK, Shields PG, Nie J et al. Effect modification by catalase genotype suggests a role for oxidative stress in the association of hormone replacement therapy with postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev 2008; 17:1082-7.

Quiney C, Billard C, Faussat AM, Salanoubat C, Kolb JP. Hyperforin inhibits P-gp and BCRP activities in chronic lymphocytic leukaemia cells and myeloid cells. Leuk Lymphoma 2007; 48:1587-99.

Quinn DI, Nemunaitis J, Fuloria J et al. Effect of the cytochrome P450 2C19 inhibitor omeprazole on the pharmacokinetics and safety profile of bortezomib in patients with advanced solid tumours, non-Hodgkin’s lymphoma or multiple myeloma. Clin Pharmacokinet 2009; 48:199-209.

Quinn JA, Jiang SX, Reardon DA et al. Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma. Cancer 2009; 115:2964-70.

Quinn JF, Raman R, Thomas RG et al. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA 2010; 304:1903-11.

Quinney SK, Galinsky RE, Jiyamapa-Serna VA et al. Hydroxyitraconazole, formed during intestinal first-pass metabolism of itraconazole, controls the time course of hepatic CYP3A inhibition and the bioavailability of itraconazole in rats. Drug Metab Dispos 2008; 36:1097-101.

Quintana FJ, Basso AS, Iglesias AH et al. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 2008; 453:65-71.

Quintieri L, Bortolozzo S, Stragliotto S et al. Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro. Drug Metab Pharmacokinet 2010; 25:466-76.

Quintieri L, Geroni C, Fantin M et al. Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes. Clin Cancer Res 2005; 11:1608-17.

Quintieri L, Palatini P, Moro S, Floreani M. Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin. Drug Metab Pharmacokinet 2011. doi:10. 2133/dmpk. DMPK-11-RG-048.

Quintieri L, Palatini P, Nassi A, Ruzza P, Floreani M. Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes. Biochem Pharmacol 2008; 75:1426-37.

Quinton ND, Lee AJ, Ross RJ, Eastell R, Blakemore AI. A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum Genet 2001; 108:233-6.

Quinton ND, Meechan DW, Brown K, Eastwood H, Blakemore AI. Single nucleotide polymorphisms in the leptin receptor gene: studies in anorexia nervosa. Psychiatr Genet 2004; 14:191-4.

Quiñones L, Lee K, Varela F N et al. Cancer pharmacogenetics: study of genetically determined variations on cancer susceptibility due to xenobiotic exposure. Rev Med Chil 2006; 134:499-515.