General References


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Zhai S, Sausville EA, Senderowicz AM et al. Clinical pharmacology and pharmacogenetics of flavopiridol 1-h i. v. infusion in patients with refractory neoplasms. Anticancer Drugs 2003; 14:125-35.

Zhai Y, Zhou G, Deng G et al. Estrogen receptor alpha polymorphisms associated with susceptibility to hepatocellular carcinoma in hepatitis B virus carriers. Gastroenterology 2006; 130:2001-9.

Zhan P, Wang J, Zhang Y et al. CYP2E1 Rsa I/Pst I polymorphism is associated with lung cancer risk among Asians. Lung Cancer 2010; 69:19-25.

Zhan Y, Brown C, Maynard E et al. Ets-1 is a critical regulator of Ang II-medicated vascular inflammation and remodeling. J Clin Invest 2005; 115:2508-16.

Zhan ZJ, Bian HL, Wang JW, Shan WG. Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities. Bioorg Med Chem Lett 2010; 20:1532-4.

Zhang A, London R, Schulz FM et al. Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma. Stem Cells Dev 2010; 19:1277-84.

Zhang A, Park SK, Wright RO et al. HFE H63D polymorphism as a modifier of the effect of cumulative lead exposure on pulse pressure: the Normative Aging Study. Environ Health Perspect 2010; 118:1261-6.

Zhang A, Zheng C, Hou M et al. Deletion of the telomerase reverse transcriptase gene and haploinsufficiency of telomere maintenance in Cri du chat syndrome. Am J Hum Genet 2003; 72:940-8.

Zhang B, Beeghly-Fadiel A, Long J, Zheng W. Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Lancet Oncol 2011; 12:477-88.

Zhang B, Higuchi M, Yoshiyama Y et al. Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. J Neurosci 2004; 24:4657-67.

Zhang B, Shozu M, Okada M et al. Insulin-like growth factor I enhances the expression of aromatase P450 by inhibiting autophagy. Endocrinology 2010; 151:4949-58.

Zhang B, Tanaka H, Shono N et al. The I allele of the angiotensin-converting enzyme gene is associated with an increased percentage of slow-twitch type I fibers in human skeletal muscle. Clin Genet 2003; 63:139-44.

Zhang C, Browne A, Child D, Tanzi RE. Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Biol Chem 2010; 285:28472-80.

Zhang C, Kwan P, Zuo Z, Baum L. In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein. Life Sci 2010; 86:899-905.

Zhang C, Li Z, Shao Y et al. Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in chinese han population. J Mol Neurosci 2011; 43:406-11.

Zhang C, Lopez-Ridaura R, Rimm EB, Rifai N, Hunter DJ, Hu FB. Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men. Am J Clin Nutr 2005; 81:1429-35.

Zhang C, Wang Y, Chen H, Gu C, Fang X. SLC11A1 gene polymorphisms are not associated to somatic cell score and milk yield in Chinese Holstein. Vet Immunol Immunopathol 2009; 127:389-92.

Zhang C, Wong S, Delarosa EM et al. Inhibitory properties of trapping agents: glutathione, potassium cyanide, and methoxylamine, against major human cytochrome p450 isoforms. Drug Metab Lett 2009; 3:125-9.

Zhang C, Xie B, Fang Y et al. Influence of maternal MTHFR A1298C polymorphism on the risk in offspring of schizophrenia. Brain Res 2010; 1320:130-4.

Zhang C, Zuo Z, Kwan P, Baum L. In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein. Epilepsia 2011; 52:1894-904.

Zhang D, Fan D. New insights into the mechanisms of gastric cancer multidrug resistance and future perspectives. Future Oncol 2010; 6:527-37.

Zhang D, Ly VT, Lago M et al. CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3’-tert-butyl-3’-N-tert-butyloxycarbonyl-4-deacetyl-3’-dephenyl-3’-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183). Drug Metab Dispos 2009; 37:710-8.

Zhang D, Wang X, Yang M, Wang G, Liu H. Effects of CYP2C19 polymorphism on the pharmacokinetics of lansoprazole and its main metabolites in healthy Chinese subjects. Xenobiotica 2011; 41:511-7.

Zhang DS, Lin GF, Ma QW, Shen JH. Nonassociation of aryl hydrocarbon receptor genotypes with susceptibility to bladder cancer in Shanghai population. Acta Pharmacol Sin 2002; 23:188-92.

Zhang FF, Zheng YF, Zhu HJ, Shen XY, Zhu XQ. Effects of kaempferol and quercetin on cytochrome 450 activities in primarily cultured rat hepatocytes. Zhejiang Da Xue Xue Bao Yi Xue Ban 2006; 35:18-22.

Zhang FR, Huang W, Chen SM et al. Genomewide association study of leprosy. N Engl J Med 2009; 361:2609-18.

Zhang G, Wang H, Wang F et al. Gene polymorphisms of the renin-angiotensin-aldosterone system and angiotensin II type 1-receptor activating antibodies in renal rejection. Tohoku J Exp Med 2007; 213:203-14.

Zhang GS, Liu DS, Dai CW, Li RJ. Antitumor effects of celecoxib on K562 leukemia cells are mediated by cell-cycle arrest, caspase-3 activation, and downregulation of Cox-2 expression and are synergistic with hydroxyurea or imatinib. Am J Hematol 2006; 81:242-55.

Zhang GX, Wang BJ, Ouyang JZ et al. Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism. Hypertens Res 2010; 33:478-84.

Zhang H, Cui D, Wang B et al. Pharmacokinetic drug interactions involving 17alpha-ethinylestradiol: a new look at an old drug. Clin Pharmacokinet 2007; 46:133-57.

Zhang H, Jia WP, Hu C et al. The effect of single nucleotide polymorphism SNP + 45 of the adiponectin gene on the rosiglitazone maleate response in patients with type 2 diabetes. Zhonghua Yi Xue Za Zhi 2007; 87:2390-3.

Zhang H, Li M, Han Y et al. Down-regulation of miR-27a might reverse multidrug resistance of esophageal squamous cell carcinoma. Dig Dis Sci 2010; 55:2545-51.

Zhang H, Li YM, Zhang H, Jin X. DPYD*5 gene mutation contributes to the reduced DPYD enzyme activity and chemotherapeutic toxicity of 5-FU: results from genotyping study on 75 gastric carcinoma and colon carcinoma patients. Med Oncol 2007; 24:251-8.

Zhang H, Liu X, Kuang H, Yi R, Xing H. Association of sulfonylurea receptor 1 genotype with therapeutic response to gliclazide in type 2 diabetes. Diabetes Res Clin Pract 2007; 77:58-61.

Zhang H, Shi Z, Liu Y, Wei Y, Dai J. Lipid homeostasis and oxidative stress in the liver of male rats exposed to perfluorododecanoic acid. Toxicol Appl Pharmacol 2008; 227:16-25.

Zhang H, Shibata T, Krawczyk T et al. Facile detection of proteins on a solid-phase membrane by direct binding of dextran-based luminol-biotin chemiluminescent polymer. Talanta 2009; 79:700-5.

Zhang H, Shu H, Jiang W. Expression of PTEN, p53 and P-glycoprotein in non-small cell lung cancer and their predictive values. Zhongguo Fei Ai Za Zhi 2009; 12:1213-6.

Zhang H, Sridar C, Kenaan C, Amunugama H, Ballou DP, Hollenberg PF. Polymorphic variants of cytochrome P450 2B6 (CYP2B6. 4 – CYP2B6. 9) exhibit altered rates of metabolism for bupropion and efavirenz: A charge-reversal mutation in the K139E variant (CYP2B6. 8) impairs formation of a functional P450-reductase complex. J Pharmacol Exp Ther 2011; 338:803-9.

Zhang H, Wong CW, Coville PF, Wanwimolruk S. Effect of the grapefruit flavonoid naringin on pharmacokinetics of quinine in rats. Drug Metabol Drug Interact 2000; 17:351-63.

Zhang H, Wu X, Wang H, Mikheev AM, Mao Q, Unadkat JD. Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: mechanisms, tissue specificity, and time course. Mol Pharmacol 2008; 74:714-23.

Zhang H, Yang Z, Shen Y, Tong L. Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. Science 2003; 299:2064-7.

Zhang H, Zhang D, Li W et al. Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys. Drug Metab Dispos 2007; 35:795-805.

Zhang HL, Mao XJ, Zhang XM et al. APOE ε3 attenuates experimental autoimmune neuritis by modulating T cell, macrophage and Schwann cell functions. Exp Neurol 2011; 230:197-206.

Zhang HY, Tang XC. Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease. Trends Pharmacol Sci 2006; 27:619-25.

Zhang J, Chen J, Xu Q, Shen Y. Does the presenilin 2 gene predispose to schizophrenia? Schizophr Res 2009; 109:121-9.

Zhang J, Deng J, Zhang C et al. Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population. Clin Chim Acta 2010; 411:878-81.

Zhang J, Ha PT, Lou Y, Hoogmartens J, van Schepdael A. Kinetic study of cytochrome P450 3A4 activity on warfarin by capillary electrophoresis with fluorescence detection. J Chromatogr A 2005; 1082:235-9.

Zhang J, He XH, Xie XY, Hu X, He C. The potential for serum p53 to predict the response to chemotherapy of patients with gastric cancer. J Int Med Res 2010; 38:423-31.

Zhang J, Huang W, Qatanani M, Evans RM, Moore DD. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem 2004; 279:49517-22.

Zhang J, Kuehl P, Green ED et al. The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. Pharmacogenetics 2001; 11:555-72.

Zhang J, Liu Q, Chen Q et al. Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis. FASEB J 2006; 20:1212-4.

Zhang J, Lou Y, Hoogmartens J, van Schepdael A. Screening of drug metabolism by CE. Electrophoresis 2006; 27:4827-35.

Zhang J, Thi Thanh Ha P, Lou Y, Hoogmartens J, van Schepdael A. Kinetic study of CYP3A4 activity on verapamil by capillary electrophoresis. J Pharm Biomed Anal 2005; 39:612-7.

Zhang J, Tian Q, Chan SY, Duan W, Zhou S. Insights into oxazaphosphorine resistance and possible approaches to its circumvention. Drug Resist Updat 2005; 8:271-97.

Zhang J, Tian Q, Zhu YZ, Xu AL, Zhou SF. Reversal of resistance to oxazaphosphorines. Curr Cancer Drug Targets 2006; 6:385-407.

Zhang J, Tran Q, Lattard V, Cashman JR. Deleterious mutations in the flavin-containing monooxygenase 3 (FMO3) gene causing trimethylaminuria. Pharmacogenetics 2003; 13:495-500.

Zhang J, Yin L, Liang G, Liu R, Fan K, Pu Y. Detection of CYP2E1, a genetic biomarker of susceptibility to benzene metabolism toxicity in immortal human lymphocytes derived from the Han Chinese Population. Biomed Environ Sci 2011; 24:300-9.

Zhang J, Zhang D, McQuade JS, Behbehani M, Tsien JZ, Xu M. c-fos regulates neuronal excitability and survival. Nat Genet 2002; 30:416-20.

Zhang J, Zhou F, Wu X et al. 20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: a case for herb-drug interactions. Drug Metab Dispos 2010; 38:2179-87.

Zhang JG, Dehal SS, Ho T et al. Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos 2006; 34:734-7.

Zhang JG, Ho T, Callendrello AL, Crespi CL, Stresser DM. A multi-endpoint evaluation of cytochrome P450 1A2, 2B6 and 3A4 induction response in human hepatocyte cultures after treatment with β-naphthoflavone, phenobarbital and rifampicin. Drug Metab Lett 2010; 4:185-94.

Zhang JP, Lencz T, Malhotra AK. D2 receptor genetic variation and clinical response to antipsychotic drug treatment: A Meta-Analysis. Am J Psychiatry 2010; 167:763-72.

Zhang JP, Malhotra AK. Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction. Expert Opin Drug Metab Toxicol 2011; 7:9-37.

Zhang JW, Ge GB, Liu Y et al. Taxane’s substituents at C3’ affect its regioselective metabolism: different in vitro metabolism of cephalomannine and paclitaxel. Drug Metab Dispos 2008; 36:418-26.

Zhang JW, Liu Y, Cheng J et al. Inhibition of human liver cytochrome P450 by star fruit juice. J Pharm Pharm Sci 2007; 10:496-503.

Zhang JW, Liu Y, Li W, Hao DC, Yang L. Inhibitory effect of medroxyprogesterone acetate on human liver cytochrome P450 enzymes. Eur J Clin Pharmacol 2006; 62:497-502.

Zhang JW, Liu Y, Zhao JY et al. Metabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetate. Drug Metab Dispos 2008; 36:2292-8.

Zhang JY, Mi YJ, Chen SP et al. Euphorbia factor L1 reverses ABCB1-mediated multidrug resistance involving interaction with ABCB1 independent of ABCB1 downregualtion. J Cell Biochem 2011; 112:1076-83.

Zhang K, Yang C, Xu Y et al. Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population. J Neural Transm 2010; 117:393-401.

Zhang L, Ding H, Yan J et al. Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population. Pharmacogenet Genomics 2008; 18:45-51.

Zhang L, Fitzloff JF, Engel LC, Cook CS. Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide. Xenobiotica 2001; 31:73-83.

Zhang L, Geng Y, Xiao N et al. High dietary n-6/n-3 PUFA ratio promotes HDL cholesterol level, but does not suppress atherogenesis in apolipoprotein E-null mice 1. J Atheroscler Thromb 2009; 16:463-71.

Zhang L, Huang X, Meng Z et al. Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Mol Endocrinol 2009; 23:137-45.

Zhang L, Liu SY, Chen Q, Shi QY, Zou H, Wu L. Association between polymorphisms of CYP17 and CYP3A4 genes and intrahepatic cholestasis of pregnancy in Chengdu. Sichuan Da Xue Xue Bao Yi Xue Ban 2006; 37:551-3, 582.

Zhang L, Mei Q, Li QS, Hu YM, Xu JM. The effect of cytochrome P2C19 and interleukin-1 polymorphisms on H. pylori eradication rate of 1-week triple therapy with omeprazole or rabeprazole, amoxycillin and clarithromycin in Chinese people. J Clin Pharm Ther 2010; 35:713-22.

Zhang L, Rothman N, Wang Y et al. Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene. Carcinogenesis 1998; 19:1955-61.

Zhang L, Weddle DL, Thomas P et al. Low levels of expression of cytochromes P-450 in normal and cancerous fetal pancreatic tissues of hamsters treated with NNK and/or ethanol. Toxicol Sci 2000; 56:313-23.

Zhang L, Yan Y, Zhu D et al. Nutlin-1 strengthened anti-proliferation and differentiation-inducing activity of ATRA in ATRA-treated p-glycoprotein deregulated human myelocytic leukemia cells. Invest New Drugs 2010. doi:10. 1007/s10637-010-9512-5.

Zhang L, Yang S, He YJ et al. Fluorouracil selectively enriches stem-like leukemic cells in a leukemic cell line. Int J Biol Sci 2010; 6:419-27.

Zhang LF, Hu X, Wang P, Zhang L. Metabolism of osthol in isolated hepatocytes of rat. Yao Xue Xue Bao 2009; 44:1131-5.

Zhang M, Ardlie K, Wacholder S, Welch R, Chanock S, O’Brien TR. Genetic variations in CC chemokine receptors and hypertension. Am J Hypertens 2006; 19:67-72.

Zhang M, Moore GA, Barclay ML, Begg EJ. Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2009; 877:3025-30.

Zhang N, Kang TG, Yin HB. Optimal extraction of polysaccharide from Dioscorea nipponica by central composite design and response surface methodology. Zhong Yao Cai 2011; 34:123-6.

Zhang N, Shi YH, Hao CF et al. Association of +45G15G(T/G) and +276(G/T) polymorphisms in the ADIPOQ gene with polycystic ovary syndrome among Han Chinese women. Eur J Endocrinol 2008; 158:255-60.

Zhang PY, Wong IL, Yan CS et al. Design and syntheses of permethyl ningalin B analogues: potent multidrug resistance (MDR) reversal agents of cancer cells. J Med Chem 2010; 53:5108-20.

Zhang QX, Melnikov Z, Feierman DE. Characterization of the acetaminophen-induced degradation of cytochrome P450-3A4 and the proteolytic pathway. Basic Clin Pharmacol Toxicol 2004; 94:191-200.

Zhang QY, Dunbar D, Kaminsky L. Human cytochrome P-450 metabolism of retinals to retinoic acids. Drug Metab Dispos 2000; 28:292-7.

Zhang QY, Dunbar D, Ostrowska A, Zeisloft S, Yang J, Kaminsky LS. Characterization of human small intestinal cytochromes P-450. Drug Metab Dispos 1999; 27:804-9.

Zhang QY, Gu J, Su T et al. Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6. Biochem Biophys Res Commun 2005; 338:318-24.

Zhang QY, Kaminsky LS, Dunbar D, Zhang J, Ding X. Role of small intestinal cytochromes p450 in the bioavailability of oral nifedipine. Drug Metab Dispos 2007; 35:1617-23.

Zhang R, Liu C, Wang N, Mi S. Determination of cytochrome P450 3A4 activity with testosterone probe using high performance liquid chromatography. Se Pu 2008; 26:80-3.

Zhang R, Sun J, Ma L et al. Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line. Toxicol Appl Pharmacol 2011; 252:18-27.

Zhang S, Song N, Li Q, Fan H, Liu C. Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats. J Chromatogr B Analyt Technol Biomed Life Sci 2008; 871:78-89.

Zhang T, Yong SL, Drinko JK et al. LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte apoptosis, cardiac fibrosis and contractile dysfunction in mice. Int J Cardiol 2011; 147:239-45.

Zhang T, Zhu Y, Gunaratna C. Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 780:371-9.

Zhang W, Chan RJ, Chen H et al. Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. J Biol Chem 2009; 284:22353-63.

Zhang W, Chang YZ, Kan QC et al. Association of human micro-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients. Anaesthesia 2010; 65:130-5.

Zhang W, Chang YZ, Kan QC et al. CYP3A4*1G genetic polymorphism influences CYP3A activity and response to fentanyl in Chinese gynecologic patients. Eur J Clin Pharmacol 2010; 66:61-6.

Zhang W, Deng S, Chen XP et al. Pharmacokinetics of rosuvastatin when coadministered with rifampicin in healthy males: a randomized, single-blind, placebo-controlled, crossover study. Clin Ther 2008; 30:1283-9.

Zhang W, Duan S, Kistner EO et al. Evaluation of genetic variation contributing to differences in gene expression between populations. Am J Hum Genet 2008; 82:631-40.

Zhang W, Gordon M, Schultheis AM et al. FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. J Clin Oncol 2007; 25:3712-8.

Zhang W, Han F, Guo P et al. Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS-a high throughput approach to evaluate drug-drug interactions. J Chromatogr B Analyt Technol Biomed Life Sci 2010; 878:1169-77.

Zhang W, Kilicarslan T, Tyndale RF, Sellers EM. Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro. Drug Metab Dispos 2001; 29:897-902.

Zhang W, Konopleva M, Shi YX et al. Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia. J Natl Cancer Inst 2008; 100:184-98.

Zhang W, Li J, Allen SM et al. Silencing the breast cancer resistance protein expression and function in caco-2 cells using lentiviral vector-based short hairpin RNA. Drug Metab Dispos 2009; 37:737-44.

Zhang W, Lim LY. Effects of spice constituents on P-glycoprotein-mediated transport and CYP3A4-mediated metabolism in vitro. Drug Metab Dispos 2008; 36:1283-90.

Zhang W, Lu D, Dong W et al. Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice. FEBS J 2011; 278:1484-92.

Zhang W, Purchio A, Chen K, Burns SM, Contag CH, Contag PR. In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors. Biochem Pharmacol 2003; 65:1889-96.

Zhang W, Purchio AF, Coffee R, West DB. Differential regulation of the human CYP3A4 promoter in transgenic mice and rats. Drug Metab Dispos 2004; 32:163-7.

Zhang W, Purchio AF, Chen K et al. A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene. Drug Metab Dispos 2003; 31:1054-64.

Zhang W, Ramamoorthy Y, Kilicarslan T, Nolte H, Tyndale RF, Sellers EM. Inhibition of cytochromes P450 by antifungal imidazole derivatives. Drug Metab Dispos 2002; 30:314-8.

Zhang W, Ramamoorthy Y, Tyndale RF, Sellers EM. Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro. Drug Metab Dispos 2003; 31:768-72.

Zhang W, Shannon WD, Duncan J, Scheffer GL, Scheper RJ, McLeod HL. Expression of drug pathway proteins is independent of tumour type. J Pathol 2006; 209:213-9.

Zhang W, Yu BN, He YJ et al. Role of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese males. Clin Chim Acta 2006; 373:99-103.

Zhang WV, D’Esposito F, Edwards RJ, Ramzan I, Murray M. Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes. Drug Metab Dispos 2008; 36:2547-55.

Zhang WW, Zhang XJ, Liu HX et al. Cdk1 is required for the self-renewal of mouse embryonic stem cells. J Cell Biochem 2011; 112:942-8.

Zhang WX, Chen B, Jin Z et al. Influence of uridine diphosphate (UDP)-glucuronosyltransferases and ABCC2 genetic polymorphisms on the pharmacokinetics of mycophenolic acid and its metabolites in Chinese renal transplant recipients. Xenobiotica 2008; 38:1422-36.

Zhang WY, Tu YB, Haining RL, Yu AM. Expression and functional analysis of CYP2D6. 24, CYP2D6. 26, CYP2D6. 27, and CYP2D7 isozymes. Drug Metab Dispos 2009; 37:1-4.

Zhang X, Chang H, Wiseman S et al. Bisphenol A disrupts steroidogenesis in human H295R cells. Toxicol Sci 2011; 121:320-7.

Zhang X, Jones DR, Hall SD. Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition. Drug Metab Dispos 2009; 37:150-60.

Zhang X, Lalezari JP, Badley AD et al. Assessment of drug-drug interaction potential of enfuvirtide in human immunodeficiency virus type 1-infected patients. Clin Pharmacol Ther 2004; 75:558-68.

Zhang X, Li D, Duan S et al. Analysis of the association between Apolipoprotein D and schizophrenia. Neuropsychobiology 2006; 54:40-4.

Zhang X, Li L, Ding X, Kaminsky LS. Identification of cytochrome p450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose. Drug Metab Dispos 2011; 39:1433-9.

Zhang X, Liu P, Zhang B, Wang A, Yang M. Role of STAT3 decoy oligodeoxynucleotides on cell invasion and chemosensitivity in human epithelial ovarian cancer cells. Cancer Genet Cytogenet 2010; 197:46-53.

Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J. Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature 2007; 450:741-4.

Zhang X, Qiu F, Jiang J, Gao C, Tan Y. Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein. Xenobiotica 2011; 41:290-6.

Zhang X, Quinney SK, Gorski JC, Jones DR, Hall SD. Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite. Drug Metab Dispos 2009; 37:1587-97.

Zhang X, Soong R, Wang K et al. Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression. Biochem Cell Biol 2007; 85:337-46.

Zhang X, Wang Q, Neil B, Chen X. Effect of lycopene on androgen receptor and prostate-specific antigen velocity. Chin Med J 2010; 123:2231-6.

Zhang X, Wu X, Li J et al. MDR1 (multidrug resistence 1) can regulate GCS (glucosylceramide synthase) in breast cancer cells. J Surg Oncol 2011; 104:466-71.

Zhang X, Zhang QY, Liu D et al. Expression of cytochrome p450 and other biotransformation genes in fetal and adult human nasal mucosa. Drug Metab Dispos 2005; 33:1423-8.

Zhang XJ, Huang W, Yang S et al. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet 2009; 41:205-10.

Zhang XY, Tan YL, Zhou DF et al. Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population. J Clin Psychopharmacol 2007; 27:246-51.

Zhang Y, Bao YL, Yang MT et al. Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells. Int J Biochem Cell Biol 2010; 42:1964-72.

Zhang Y, Chen CJ, Yang QL, Cheng LQ, Wang H, Huang LZ. Effect of interfering hepatocyte nuclear factor-1 alfa in HepG2 on the expressions of apoM, apoA-I and the correlative key enzyme of cholesterol metabolism. Zhonghua Gan Zang Bing Za Zhi 2011; 19:121-6.

Zhang Y, El-Sikhry H, Chaudhary KR et al. Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol 2009; 297:37-46.

Zhang Y, Emmanuel N, Kamboj G et al. PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t(X; 21)(p22; q22). Genes Chromosomes Cancer 2004; 40:365-70.

Zhang Y, Gaikwad NW, Olson K, Zahid M, Cavalieri EL, Rogan EG. Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Metabolism 2007; 56:887-94.

Zhang Y, Guo X, Lin ET, Benet LZ. Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor. Drug Metab Dispos 1998; 26:360-6.

Zhang Y, Guo X, Lin ET, Benet LZ. In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes. Pharmacology 1999; 58:147-59.

Zhang Y, Klaassen CD. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J Lipid Res 2010; 51:3230-42.

Zhang Y, Klein K, Sugathan A et al. Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease. PLoS One 2011. doi:10. 1371/journal. pone. 0023506.

Zhang Y, Laterra J, Pomper MG. Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp. Neoplasia 2009; 11:96-101.

Zhang Y, Li H, Wang H et al. Syl611, a novel semisynthetic taxane derivative, reverses multidrug resistance by p-glycoprotein inhibition and facilitating inward transmembrane action. Cancer Chemother Pharmacol 2010; 66:851-9.

Zhang Y, Li M, Yao Q, Chen C. Roles and mechanisms of copper transporting ATPases in cancer pathogenesis. Med Sci Monit 2009; 15:1-5.

Zhang Y, Lin H. Quantum tunneling in testosterone 6beta-hydroxylation by cytochrome P450: reaction dynamics calculations employing multiconfiguration molecular-mechanical potential energy surfaces. J Phys Chem A 2009; 113:11501-8.

Zhang Y, Liu J. Transgenic alfalfa plants co-expressing glutathione S-transferase (GST) and human CYP2E1 show enhanced resistance to mixed contaminates of heavy metals and organic pollutants. J Hazard Mater 2011; 189:357-62.

Zhang Y, Luo Z, Ma L, Xu Q, Yang Q, Si L. Resveratrol prevents the impairment of advanced glycosylation end products (AGE) on macrophage lipid homeostasis by suppressing the receptor for AGE via peroxisome proliferator-activated receptor gamma activation. Int J Mol Med 2010; 25:729-34.

Zhang Y, McGillicuddy FC, Hinkle CC et al. Adipocyte modulation of high-density lipoprotein cholesterol. Circulation 2010; 121:1347-55.

Zhang Y, Si D, Chen X et al. Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics of gliclazide MR in Chinese subjects. Br J Clin Pharmacol 2007; 64:67-74.

Zhang Y, Wang H, Wei L et al. Transcriptional modulation of BCRP gene to reverse multidrug resistance by toremifene in breast adenocarcinoma cells. Breast Cancer Res Treat 2010; 123:679-89.

Zhang Y, Zanotti I, Reilly MP et al. Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo. Circulation 2003; 108:661-3.

Zhang Y, Zhao T, Li W, Vore M. The 5’-untranslated region of multidrug resistance associated protein 2 (MRP2; ABCC2) regulates downstream open reading frame expression through translational regulation. Mol Pharmacol 2010; 77:237-46.

Zhang Y, Zhong D, Si D, Guo Y, Chen X, Zhou H. Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype. Br J Clin Pharmacol 2005; 59:14-7.

Zhang YY, Liu Y, Zhang JW et al. Characterization of human cytochrome P450 isoforms involved in the metabolism of 7-epi-paclitaxel. Xenobiotica 2009; 39:283-92.

Zhang YY, Xie KM, Yang GQ et al. The effect of glucosylceramide synthase on P-glycoprotein function in K562/AO2 leukemia drug-resistance cell line. Int J Hematol 2011; 93:361-7.

Zhang Z, Deng X, Ren X et al. Expression of mutant p53 and of the multidrug resistant proteins P-glycoprotein and glutathione S-transferase-pi correlated in colorectal adenocarcinoma. Scand J Gastroenterol 2010; 45:925-34.

Zhang Z, Hartmann H, Minh Do V et al. Destabilization of beta-catenin bby mutations in presenilin-1 potentiates neuronal apoptosis. Nature 1998; 395:698-702.

Zhang Z, Li Y, Shou M et al. Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4. Xenobiotica 2004; 34:473-86.

Zhang Z, Li Y, Stearns RA, Ortiz de Montellano PR, Baillie TA, Tang W. Cytochrome P450 3A4-mediated oxidative conversion of a cyano to an amide group in the metabolism of pinacidil. Biochemistry 2002; 41:2712-8.

Zhang ZJ, Zhang XB, Hou G, Yao H, Reynolds GP. Interaction between polymorphisms of the dopamine D3 receptor and manganese superoxide dismutase genes in susceptibility to tardive dyskinesia. Psychiatr Genet 2003; 13:187-92.

Zhang ZY, Chen M, Chen J, Padval MV, Kansra VV. Biotransformation and in vitro assessment of metabolism-associated drug-drug interaction for CRx-102, a novel combination drug candidate. J Pharm Biomed Anal 2009; 50:200-9.

Zhang ZY, King BM, Mollova NN, Wong YN. In vitro interactions between a potential muscle relaxant E2101 and human cytochromes P450. Drug Metab Dispos 2002; 30:805-13.

Zhang ZY, King BM, Pelletier RD, Wong YN. Delineation of the interactions between the chemotherapeutic agent eribulin mesylate (E7389) and human CYP3A4. Cancer Chemother Pharmacol 2008; 62:707-16.

Zhang ZY, Wong YN. Enzyme kinetics for clinically relevant CYP inhibition. Curr Drug Metab 2005; 6:241-57.

Zhao AY, Wang XD, Chen GH, Lu LZ. Low-level expression of cholesterol 7 α-hydroxylase is associated with the formation of goose fatty liver. Poult Sci 2011; 90:1045-9.

Zhao F, Loke C, Rankin SC et al. Novel CYP2C9 genetic variants in Asian subjects and their influence on maintenance warfarin dose. Clin Pharmacol Ther 2004; 76:210-9.

Zhao F, Wang J, Yang Y et al. Effect of CYP2C19 genetic polymorphisms on the efficacy of proton pump inhibitor-based triple therapy for Helicobacter pylori eradication: a meta-analysis. Helicobacter 2008; 13:532-41.

Zhao G, Allis JW. Kinetics of bromodichloromethane metabolism by cytochrome P450 isoenzymes in human liver microsomes. Chem Biol Interact 2002; 140:155-68.

Zhao H, Yao Y, Wang Z, Lin F, Sun Y, Chen P. Therapeutic effect of pirarubicin-based chemotherapy for osteosarcoma patients with lung metastasis. J Chemother 2010; 22:119-24.

Zhao J, Leemann T, Dayer P. In vitro oxidation of oxicam NSAIDS by a human liver cytochrome P450. Life Sci 1992; 51:575-81.

Zhao L, Jin X, Xu Y et al. Functional study of the novel multidrug resistance gene HA117 and its comparison to multidrug resistance gene 1. J Exp Clin Cancer Res 2010; 29:98.

Zhao L, Moos MPW, Grabner R et al. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med 2004; 10:966-73.

Zhao L-X, Zhou C-J, Tanaka A et al. Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2. Biochem J 2000; 350:865-72.

Zhao M, Li LP, Shen J, Jiang HD. Inhibitory and inductive effects of (-)- and (+)-tetrahydropalmatine on CYP450 in mice. Zhejiang Da Xue Xue Bao Yi Xue Ban 2011; 40:33-9.

Zhao Q, Gu D, Kelly TN et al. Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study. Am J Hypertens 2010; 23:606-13.

Zhao Q, Wang L, Yang W et al. Interactions among genetic variants from contractile pathway of vascular smooth muscle cell in essential hypertension susceptibility of Chinese Han population. Pharmacogenet Genomics 2008; 18:459-66.

Zhao Q, Zhang H, Li Y, Liu J, Hu X, Fan L. Anti-tumor effects of CIK combined with oxaliplatin in human oxaliplatin-resistant gastric cancer cells in vivo and in vitro. J Exp Clin Cancer Res 2010; 29:118.

Zhao T, He YQ, Wang J, Ding KM, Wang CH, Wang ZT. Inhibition of human cytochrome P450 enzymes 3A4 and 2D6 by β-Carboline alkaloids, harmine derivatives. Phytother Res 2011; 25:1671-7.

Zhao W, Elie V, Roussey G et al. Population pharmacokinetics and pharmacogenetics of tacrolimus in de novo pediatric kidney transplant recipients. Clin Pharmacol Ther 2009; 86:609-18.

Zhao W, Fakhoury M, Deschênes G et al. Population pharmacokinetics and pharmacogenetics of mycophenolic acid following administration of mycophenolate mofetil in de novo pediatric renal-transplant patients. J Clin Pharmacol 2010; 50:1280-91.

Zhao W, Fakhoury M, Jacqz-Aigrain E. Developmental pharmacogenetics of immunosuppressants in pediatric organ transplantation. Ther Drug Monit 2010; 32:688-99.

Zhao XJ, Ishizaki T. Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes. Br J Clin Pharmacol 1997; 44:505-11.

Zhao XJ, Jones DR, Wang YH, Grimm SW, Hall SD. Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites. Xenobiotica 2002; 32:863-78.

Zhao XJ, Kawashiro T, Ishizaki T. Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways. Drug Metab Dispos 1998; 26:188-91.

Zhao XJ, Koyama E, Ishizaki T. An in vitro study on the metabolism and possible drug interactions of rokitamycin, a macrolide antibiotic, using human liver microsomes. Drug Metab Dispos 1999; 27:776-85.

Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T. Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450. J Pharmacol Exp Ther 1996; 279:1327-34.

Zhao XP, Zhong J, Liu XQ, Wang GJ. CYP3A4 mediated in vitro metabolism of vinflunine in human liver microsomes. Acta Pharmacol Sin 2007; 28:118-24.

Zhao Y, Hellum BH, Liang A, Nilsen OG. The in vitro inhibition of human Cyp1A2, Cyp2D6 and Cyp3A4 by tetrahydropalmatine, neferine and berberine. Phytother Res 2011. doi:10. 1002/ptr. 3554.

Zhao Y, Liu J, Hong Q et al. Involvement of MyoD and PEA3 in regulation of transcription activity of MDR1 gene. Acta Biochim Biophys Sin 2010; 42:900-7.

Zhao Y, Zhai D, Chen X et al. Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats. Toxicology 2007; 230:145-50.

Zhao YX, Liang WQ, Wang Y, Liu DX. Cationic submicron emulsions overcome multidrug resistance in SGC7901/VCR cells. Pharmazie 2011; 66:130-5.

Zhao Z, He X, Bi Y et al. Induction of CYP4F3 by benzene metabolites in human white blood cells in vivo in human promyelocytic leukemic cell lines and ex vivo in human blood neutrophils. Drug Metab Dispos 2009; 37:282-91.

Zhao Z, Koeplinger KA, Waldon DJ. Stereoselective hydroxylation of nonpeptidic HIV protease inhibitors by CYP2D6. Chirality 1999; 11:731-9.

Zharikova OL, Fokina VM, Nanovskaya TN et al. Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide. Biochem Pharmacol 2009; 78:1483-90.

Zhe C, Li-Juan W, Ming Hui W, Yu J, Yu Jie S, Jun G. Mechanism governing reversal of multidrug resistance in human breast carcinoma cells by chelerythrine. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2011; 33:45-50.

Zheng B, Wiklund F, Gharizadeh B et al. Genetic polymorphism of chemokine receptors CCR2 and CCR5 in Swedish cervical cancer patients. Anticancer Res 2006; 26:3669-74.

Zheng C, Wang L, Li R et al. Gene delivery of cytochrome p450 epoxygenase ameliorates monocrotaline-induced pulmonary artery hypertension in rats. Am J Respir Cell Mol Biol 2010; 43:740-9.

Zheng H, Webber S, Zeevi A et al. The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients. Hum Immunol 2002; 63:765-70.

Zheng J, Chen B, Jiang B et al. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res 2010; 33:243-6.

Zheng J, Zhou HH. Effects of the flavonoids on cytochrome P-450 CYP1, 2E1, 3A4 and 19. Yao Xue Xue Bao 2007; 42:8-12.

Zheng L, Qing YP, Xu N et al. Pharmacokinetics and safety of bromotetrandrine (BrTet, W198) after single-dose intravenous administration in healthy Chinese volunteers. J Clin Pharm Ther 2010; 35:113-9.

Zheng L, Sharma R, Gaskin F, Fu SM, Ju ST. A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms. J Immunol 2007; 179:8035-41.

Zheng L, Yu C, Zhang Z, Yang C, Cai X. Expression of interferon regulatory factor 1, 3, and 7 in primary Sjögren syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107:661-8.

Zheng LS, Wang F, Li YH et al. Vandetanib (Zactima, ZD6474) antagonizes ABCC1-and ABCG2-mediated multidrug resistance by inhibition of their transport function. PLoS One 2009. doi:10. 1371/journal. pone. 0005172.

Zheng M, Wang J, Lubinski J et al. Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction. Xenobiotica 2009; 39:544-55.

Zheng N, Pang S, Oe T, Felix CA, Wehrli S, Blair IA. Characterization of an etoposide-glutathione conjugate derived from metabolic activation by human cytochrome p450. Curr Drug Metab 2006; 7:897-911.

Zheng N, Zou P, Wang S, Sun D. In vitro metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin in human liver microsomes. Drug Metab Dispos 2011; 39:627-35.

Zheng Q, Sha X, Liu J, Heath E, Lorusso P, Li J. Association of human cytochrome P450 1A1 (CYP1A1) and sulfotransferase 1A1 (SULT1A1) polymorphisms with differential metabolism and cytotoxicity of aminoflavone. Mol Cancer Ther 2010; 9:2803-13.

Zheng X, Cui D, Xu S, Brabant G, Derwahl M. Doxorubicin fails to eradicate cancer stem cells derived from anaplastic thyroid carcinoma cells: characterization of resistant cells. Int J Oncol 2010; 37:307-15.

Zheng Y, Wang JJ, Sun L, Li HL. Association between CYP1A1 polymorphism and colorectal cancer risk: a meta-analysis. Mol Biol Rep 2011. doi:10. 1007/s11033-011-1126-2.

Zheng Y, Yu B, Weecharangsan W et al. Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7alpha-APTADD to breast cancer cells. Int J Pharm 2010; 390:234-41.

Zheng Y, Zhou F, Wu X et al. 23-Hydroxybetulinic acid from Pulsatilla chinensis (Bunge) Regel synergizes the antitumor activities of doxorubicin in vitro and in vivo. J Ethnopharmacol 2010; 128:615-22.

Zhong B, Cai X, Yi X, Zhou A, Chen S, Su B. In vitro and in vivo effects of a cyclooxygenase-2 inhibitor nimesulide analog JCC76 in aromatase inhibitors-insensitive breast cancer cells. J Steroid Biochem Mol Biol 2011; 126:10-8.

Zhong J, Yan Z, Liu D et al. Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome. J Lab Clin Med 2006; 147:91-5.

Zhong Q, Chen CF, Li S et al. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science 1999; 285:747-50.

Zhong S, Huang M, Yang X et al. Relationship of glutathione S-transferase genotypes with side-effects of pulsed cyclophosphamide therapy in patients with systemic lupus erythematosus. Br J Clin Pharmacol 2006; 62:457-72.

Zhong S, Sharp DS, Grove JS et al. Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels. J Clin Invest 1996; 97:2917-23.

Zhong S, Ye WP, Xu PP et al. Aromatase expression in leptin-pretreated human breast pre-adipocytes is enhanced by zeranol and suppressed by (-)-gossypol. Anticancer Res 2010; 30:5077-84.

Zhong SL, Liu Y, Yu XY et al. The influence of genetic polymorphisms and interacting drugs on initial response to warfarin in Chinese patients with heart valve replacement. Eur J Clin Pharmacol 2011; 67:581-90.

Zhong W, Yamagata HD, Taguchi K et al. Lymphocyte-specific protein tyrosine kinase is a novel risk gene for Alzheimer disease. J Neurol Sci 2005; 238:53-7.

Zhong XL, Yu JT, Hou GY et al. Common variant in GAB2 is associated with late-onset Alzheimer’s disease in Han Chinese. Clin Chim Acta 2011; 412:446-9.

Zhou C, Assem M, Tay JC et al. Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J Clin Invest 2006; 116:1703-12.

Zhou C, Nitschke AM, Xiong W et al. Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype. Breast Cancer Res 2008; 10:105.

Zhou C, Poulton EJ, Grün F et al. The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol Pharmacol 2007; 71:220-9.

Zhou C, Pridgen B, King N, Xu J, Breslow JL. Hyperglycemic Ins2AkitaLdlr-/- mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease. J Lipid Res 2011; 52:1483-93.

Zhou C, Tabb MM, Sadatrafiei A, Grün F, Blumberg B. Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. Drug Metab Dispos 2004; 32:1075-82.

Zhou D, Afzelius L, Grimm SW, Andersson TB, Zauhar RJ, Zamora I. Comparison of methods for the prediction of the metabolic sites for CYP3A4-mediated metabolic reactions. Drug Metab Dispos 2006; 34:976-83.

Zhou D, Andersson TB, Grimm SW. In vitro evaluation of potential drug-drug interactions with ticagrelor: cytochrome P450 reaction phenotyping, inhibition, induction, and differential kinetics. Drug Metab Dispos 2011; 39:703-10.

Zhou D, Linnenbach AJ, Liu R et al. Expression and characterization of dog cytochrome P450 2A13 and 2A25 in baculovirus-infected insect cells. Drug Metab Dispos 2010; 38:1015-8.

Zhou D, Zhang D, Liu Y et al. The E23K variation in the KCNJ11 gene is associated with type 2 diabetes in Chinese and East Asian population. J Hum Genet 2009; 54:433-5.

Zhou D, Zhang M, Ye X et al. In vitro metabolism of α7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite. Xenobiotica 2011; 41:232-42.

Zhou F, Xu H. Effect of emodin on P-gp expression in intrahepatic cholestatic rats. Zhongguo Zhong Yao Za Zhi 2010; 35:908-11.

Zhou G, Zhai Y, Cui Y et al. Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma. Hum Mutat 2007; 28:1091-7.

Zhou GB, Zhang J, Wang ZY, Chen SJ, Chen Z. Treatment of acute promyelocytic leukaemia with all-trans retinoic acid and arsenic trioxide: a paradigm of synergistic molecular targeting therapy. Philos Trans R Soc Lond B Biol Sci 2007; 362:959-71.

Zhou GW, Hu J, Li Q. CYP2E1 PstI/RsaI polymorphism and colorectal cancer risk: a meta-analysis. World J Gastroenterol 2010; 16:2949-53.

Zhou H, Gurley EC, Jarujaron S et al. HIV protease inhibitors activate the unfolded protein response and disrupt lipid metabolism in primary hepatocytes. Am J Physiol Gastrointest Liver Physiol 2006; 291:1071-80.

Zhou H, Jungbluth H, Sewry CA et al. Molecular mechanisms and phenotypic variation in RYR1-related congenital myopathies. Brain 2007; 130:2024-36.

Zhou J, Cai ZH, Zhu XS, Li L, Gao YF. Innate immune parameters and haemolymph protein expression profile to evaluate the immunotoxicity of tributyltin on abalone (Haliotis diversicolor supertexta). Dev Comp Immunol 2010; 34:1059-67.

Zhou J, Empey PE, Bies RR, Kochanek PM, Poloyac SM. Cardiac arrest and therapeutic hypothermia interaction with isoform-specific cytochrome P450 drug metabolism. Drug Metab Dispos 2011. doi:10. 1124/dmd. 111. 040642.

Zhou J, Liu M, Zhai Y, Xie W. The antiapoptotic role of pregnane X receptor in human colon cancer cells. Mol Endocrinol 2008; 22:868-80.

Zhou J, Lu Y, Gao XH et al. The growth hormone receptor gene is associated with mandibular height in a Chinese population. J Dent Res 2005; 84:1052-6.

Zhou J, Wang Y, Chen Z, Gao Y. Modulation of activities and mRNA expression of cytochrome P450 isoenzymes in rat liver by Sophora flaveacens and coadministration with Veratrum nigrum. Zhongguo Zhong Yao Za Zhi 2010; 35:1845-9.

Zhou JB, Yang JK. Meta-analysis of association of ACE2 G8790A polymorphism with Chinese Han essential hypertension. J Renin Angiotensin Aldosterone Syst 2009; 10:31-4.

Zhou JS, Xing W, Friend DS, Austen KF, Katz HR. Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis. J Exp Med 2007; 204:2797-802.

Zhou K, Donnelly L, Burch L et al. Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: a Go-DARTS study. Clin Pharmacol Ther 2010; 87:52-6.

Zhou L, Dey CR, Wert SE, DuVall MD, Frizzell RA, Whitsett JA. Correction of lethal intestinal defect in a mouse model of cystic fibrosis by human CFTR. Science 1994; 266:1705-8.

Zhou L, Erickson RR, Hardwick JP, Park SS, Wrighton SA, Holtzman JL. Catalysis of the cysteine conjugation and protein binding of acetaminophen by microsomes from a human lymphoblast line transfected with the cDNAs of various forms of human cytochrome P450. J Pharmacol Exp Ther 1997; 281:785-90.

Zhou L, Naraharisetti SB, Liu L et al. Contributions of human cytochrome P450 enzymes to glyburide metabolism. Biopharm Drug Dispos 2010; 31:228-42.

Zhou L, Yan T, Jiang Y et al. Prognostic and predictive value of TFF1 for adjuvant endocrine therapy in Chinese women with early ER positive breast cancer: comparing aromatase inhibitors with tamoxifen. Breast 2011; 20:15-20.

Zhou LX, Pihlstrom B, Hardwick JP, Park SS, Wrighton SA, Holtzman JL. Metabolism of phenytoin by the gingiva of normal humans: the possible role of reactive metabolites of phenytoin in the initiation of gingival hyperplasia. Clin Pharmacol Ther 1996; 60:191-8.

Zhou Q, Sparreboom A, Tan EH et al. Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer. Br J Clin Pharmacol 2005; 59:415-24.

Zhou Q, Yao TW, Yu YN, Zeng S. Stereoselective metabolism of propafenone by human liver CYP3A4 expressed in transgenic Chinese hamster CHL cells lines. Acta Pharmacol Sin 2001; 22:944-8.

Zhou Q, Yao TW, Zeng S. Chiral metabolism of propafenone in rat hepatic microsomes treated with two inducers. World J Gastroenterol 2001; 7:830-5.

Zhou Q, Yu XM, Lin HB et al. Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese. Pharmacogenomics J 2009; 9:380-94.

Zhou Q, Zhang L, Zuniga MA, Tombes RM, Stewart JK. Mixed inhibition of P450 3A4 as a chemoprotective mechanism against aflatoxin B1-induced cytotoxicity with cis-terpenones. Chem Res Toxicol 2008; 21:732-8.

Zhou Q, Zheng Z, Xia B et al. Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. Pharm Res 2010; 27:1568-83.

Zhou Q, Zhou S, Chan E. Effect of omeprazole on the hydroxylation of warfarin enantiomers in human: in-vitro studies with liver microsomes and cDNA-expressed cytochrome P450 isozymes. Curr Drug Metab 2005; 6:399-411.

Zhou S, Chan E, Li X, Huang M. Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4. Ther Clin Risk Manag 2005; 1:3-13.

Zhou S, Chan E, Lim LY et al. Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4. Curr Drug Metab 2004; 5:415-42.

Zhou S, Chan E, Pan SQ, Huang M, Lee EJ. Pharmacokinetic interactions of drugs with St John’s wort. J Psychopharmacol 2004; 18:262-76.

Zhou S, Gao Y, Jiang W, Huang M, Xu A, Paxton JW. Interactions of herbs with cytochrome P450. Drug Metab Rev 2003; 35:35-98.

Zhou S, Koh HL, Gao Y, Gong ZY, Lee EJ. Herbal bioactivation: the good, the bad and the ugly. Life Sci 2004; 74:935-68.

Zhou S, Lim LY, Chowbay B. Herbal modulation of P-glycoprotein. Drug Metab Rev 2004; 36:57-104.

Zhou S, Paxton JW, Tingle MD, Kestell P. Identification of the human liver cytochrome P450 isoenzyme responsible for the 6-methylhydroxylation of the novel anticancer drug 5,6-dimethylxanthenone-4-acetic acid. Drug Metab Dispos 2000; 28:1449-56.

Zhou S, Yung Chan S, Cher Goh B et al. Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs. Clin Pharmacokinet 2005; 44:279-304.

Zhou SF. Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. Curr Drug Metab 2008; 9:310-22.

Zhou SF. Potential strategies for minimizing mechanism-based inhibition of cytochrome P450 3A4. Curr Pharm Des 2008; 14:990-1000.

Zhou SF, Chan E, Zhou ZW, Xue CC, Lai X, Duan W. Insights into the Structure, Function, and Regulation of Human Cytochrome P450 1A2. Curr Drug Metab 2009; 10:713-29.

Zhou SF, Di YM, Chan E et al. Clinical pharmacogenetics and potential application in personalized medicine. Curr Drug Metab 2008; 9:738-84.

Zhou SF, Lai X. An update on clinical drug interactions with the herbal antidepressant St. John’s wort. Curr Drug Metab 2008; 9:394-409.

Zhou SF, Liu JP, Chowbay B. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab Rev 2009; 41:89-295.

Zhou SF, Liu JP, Lai XS. Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development. Curr Med Chem 2009; 16:2661-805.

Zhou SF, Wang B, Yang LP, Liu JP. Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metab Rev 2010; 42:268-354.

Zhou SF, Wang LL, Di YM et al. Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development. Curr Med Chem 2008; 15:1981-2039.

Zhou SF, Xue CC, Yu XQ, Li C, Wang G. Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring. Ther Drug Monit 2007; 29:687-710.

Zhou SF, Xue CC, Yu XQ, Wang G. Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update. Curr Drug Metab 2007; 8:526-53.

Zhou SF, Zhou ZW, Yang LP, Cai JP. Substrates, inducers, inhibitors and structure-activity relationships of human cytochrome P450 2C9 and implications in drug development. Curr Med Chem 2009; 16:3480-675.

Zhou T, Shi Q, Bastow KF, Lee KH. Antitumor agents 286. Design, synthesis, and structure-activity relationships of 3’R,4’R-disubstituted-2’,2’-dimethyldihydropyrano[2,3-f]chromone (DSP) analogues as potent chemosensitizers to overcome multidrug resistance. J Med Chem 2010; 53:8700-8.

Zhou TB, Qin YH, Lei FY, Su LN, Zhao YJ, Huang WF. apoE expression in glomerulus and correlation with glomerulosclerosis induced by adriamycin in rats. Ren Fail 2011; 33:348-54.

Zhou TB, Qin YH, Lei FY, Su LN, Zhao YJ, Huang WF. All-trans retinoic acid regulates the expression of apolipoprotein E in rats with glomerulosclerosis induced by Adriamycin. Exp Mol Pathol 2011; 90:287-94.

Zhou X, Barber WH, Moore CK et al. Frequency distribution of cytochrome P450 3A4 gene polymorphism in ethnic populations and in transplant recipients. Res Commun Mol Pathol Pharmacol 2006; 119:89-104.

Zhou X, Han Y, Liu J, Gao L, Zhao J. Decreased protein and gene expression of hepatic cholesterol 7a-hydroxylase associated with dilated endoplasmic reticulum in chronic hypothyroid rats. Pathol Int 2009; 59:729-34.

Zhou X, Lee JE, Arnett FC et al. HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans. Arthritis Rheum 2009; 60:3807-14.

Zhou X, Zhuo X, Xie F et al. Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model. J Pharmacol Exp Ther 2010; 332:578-87.

Zhou XF, Cui J, DeStefano AL et al. Polymorphisms in the promoter region of catalase gene and essential hypertension. Dis Markers 2005; 21:3-7.

Zhou XP, Smith WM, Gimm O et al. Over-representation of PPARgamma sequence variants in sporadic cases of glioblastoma multiforme: preliminary evidence for common low penetrance modifiers for brain tumour risk in the general population. J Med Genet 2000; 37:410-4

Zhou XY, Sun JF, He YH et al. Correlation of the methylation status of CpG islands in the promoter region of 10 genes with the 5-Fu chemosensitivity in 3 breast cancer cell lines. Zhonghua Zhong Liu Za Zhi 2010; 32:328-33.

Zhou Y, Abidi P, Kim A et al. Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation. Arterioscler Thromb Vasc Biol 2007; 27:2198-205.

Zhou Y, Chang HH, Du J, Wang CY, Dong Z, Wang MH. Renal epoxyeicosatrienoic acid synthesis during pregnancy. Am J Physiol Renal Physiol 2005; 288:221-6.

Zhou Y, Ling XL. Establishment of a cisplatin-induced multidrug resistance cell line SK-Hep1/DDP. Chin J Cancer 2010; 29:167-71.

Zhou Y, Ling XL, Li SW, Li XQ, Yan B. Establishment of a human hepatoma multidrug resistant cell line in vitro. World J Gastroenterol 2010; 16:2291-7.

Zhou Y, Mohsenin A, Morschl E et al. Enhanced airway inflammation and remodeling in adenosine deaminase-deficient mice lacking the A2B adenosine receptor. J Immunol 2009; 182:8037-46.

Zhou Y, Su Y, Li B et al. Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho. Science 2003; 302:1215-7.

Zhou Y, Wu SL, Liu JQ, Liang WN, Liu GF. Possible association of ACE gene I/D polymorphism with blood pressure-lowering response to hydrochlorothiazide. Biomed Environ Sci 2007; 20:351-6.

Zhou YH, Hess KR, Raj VR et al. Establishment of prognostic models for astrocytic and oligodendroglial brain tumors with standardized quantification of marker gene expression and clinical variables. Biomark Insights 2010; 5:153-68.

Zhou Z, Vorperian VR, Gong Q, Zhang S, January CT. Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole. J Cardiovasc Electrophysiol 1999; 10:836-43.

Zhou Z, Zhu G, Hariri AR et al. Genetic variation in human NPY expression affects stress response and emotion. Nature 2008; 452:997-1001.

Zhou ZQ, Manguino D, Kewitt K et al. Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6-methylguanine-DNA methyltransferase. Proc Natl Acad Sci USA 2001; 98:12566-71.

Zhou ZX, Wang T, Jiang ZZ et al. Beneficial effects of colchicine on 17alpha-ethynylestradiol-induced cholestasis in rats. Arzneimittelforschung 2011; 61:173-9.

Zhou-Pan XR, Sérée E, Zhou XJ et al. Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions. Cancer Res 1993; 53:5121-6.

Zhu F, Wang Y, Zeng S, Fu X, Wang L, Cao J. Involvement of annexin A1 in multidrug resistance of K562/ADR cells identified by the proteomic study. OMICS 2009; 13:467-76.

Zhu G, Agusti A, Gulsvik A et al. CTLA4 gene polymorphisms are associated with chronic bronchitis. Eur Respir J 2009; 34:598-604.

Zhu HJ, Patrick KS, Yuan HJ et al. Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis. Am J Hum Genet 2008; 82:1241-8.

Zhu HJ, Wang JS, Markowitz JS et al. Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana. J Pharmacol Exp Ther 2006; 317:850-7.

Zhu HJ, Wang JS, Markowitz JS, Donovan JL, Gibson BB, DeVane CL. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology 2007; 32:757-64.

Zhu LR, Thomas PE, Lu G et al. CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody. Drug Metab Dispos 2006; 34:1672-6.

Zhu M, Kaul S, Nandy P, Grasela DM, Pfister M. Model-based approach to characterize efavirenz autoinduction and concurrent enzyme induction with carbamazepine. Antimicrob Agents Chemother 2009; 53:2346-53.

Zhu M, LE Moyec L, Starzec A, Stierle V, Marbeuf-Gueye C. Caveolin-1 and doxorubicin-induced P-glycoprotein modulate plasma cholesterol membrane accessibility in erythrolymphoblastic cell line. Anticancer Res 2010; 30:3451-8.

Zhu M, Zhao W, Jimenez H et al. Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos 2005; 33:500-7.

Zhu Q, Liao J, Xie L, Wang GJ, Liu XD. Mechanism-based inhibition of CYP1A2 by antofloxacin, an 8-NH2 derivative of levofloxacin in rats. Xenobiotica 2009; 39:293-301.

Zhu QS, Xing W, Qian B et al. Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia. Biochim Biophys Acta 2003; 1638:208-16.

Zhu R, Hu L, Li H, Su J, Cao Z, Zhang W. Novel natural inhibitors of CYP1A2 identified by in silico and in vitro screening. Int J Mol Sci 2011; 12:3250-62.

Zhu S, Meng QH. Association of angiotensin II type 1 receptor gene polymorphism with carotid atherosclerosis. Clin Chem Lab Med 2006; 44:282-4.

Zhu S, Nöthen MM, Uhlhaas S et al. Apolipoprotein E genotype distribution in schizophrenia. Psychiatr Genet 1996; 6:75-9.

Zhu W. CYP2D6: a key enzyme in morphine synthesis in animals. Med Sci Monit 2008; 14:15-8.

Zhu W, Cadet P, Baggerman G, Mantione KJ, Stefano GB. Human white blood cells synthesize morphine: CYP2D6 modulation. J Immunol 2005; 175:7357-62.

Zhu W, Mantione KJ, Shen L et al. Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: cyp2d6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling. Med Sci Monit 2005; 11:397-404.

Zhu W, Wang L, Zhang L et al. Isoflurane preconditioning neuroprotection in experimental focal stroke is androgen-dependent in male mice. Neuroscience 2010; 169:758-69.

Zhu X, Bouzekri N, Southam L et al. Linkage and association analysis of angiotensin I-converting enzyme (ACE)-gene polymorphisms with ACE concentration and blood pressure. Am J Hum Genet 2001; 68:1139-48.

Zhu X, Song J, Mar MH, Edwards LJ, Zeisel SH. Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline. Biochem J 2003; 370:987-93.

Zhu XX, Hu CP, Gu QH. CYP1A1 polymorphisms, lack of glutathione S-transferase M1 (GSTM1), cooking oil fumes and lung cancer risk in non-smoking women. Zhonghua Jie He He Hu Xi Za Zhi 2010; 33:817-22.

Zhu Y, D’Agostino J, Zhang QY. Role of intestinal cytochrome P450 in modulating the bioavailability of oral lovastatin: insights from studies on the intestinal epithelium-specific P450 reductase knockout mouse. Drug Metab Dispos 2011; 39:939-43.

Zhu Z, Puglisi J, Connors D et al. Use of cryopreserved transiently transfected cells in high-throughput pregnane X receptor transactivation assay. J Biomol Screen 2007; 12:248-54.

Zhu ZJ, Krasnykh O, Pan D et al. Structure-activity relationships of macrolides against Mycobacterium tuberculosis. Tuberculosis 2008; 88 Suppl 1:49-63.

Zhu ZY, Mu YQ, Fu XM, Li SM, Zhao FX. Association of CYP1B1 gene polymorphisms and the positive expression of estrogen alpha and estrogen beta with endometrial cancer risk. Eur J Gynaecol Oncol 2011; 32:188-91.

Zhuang XM, Wen YY, Li H et al. Metabolism of 3-cyanomethyl-4-methyl-DCK, a new anti-HIV candidate, in human intestinal microsomes. Yao Xue Xue Bao 2010; 45:1116-22.

Zhuang Z, Park WS, Pack S et al. Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas. Nat Genet 1998; 20:66-9.

Zhukareva V, Mann D, Pickering-Brown S et al. Sporadic Pick’s disease: a tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter. Ann Neurol 2002; 51:730-9.

Zhuo X, Gu J, Zhang QY, Spink DC, Kaminsky LS, Ding X. Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice. J Pharmacol Exp Ther 1999; 288:463-71.

Zhuo X, Zheng N, Felix CA, Blair IA. Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug Metab Dispos 2004; 32:993-1000.

Zi J, Liu D, Ma P et al. Effects of CYP2C9*3 and CYP2C9*13 on diclofenac metabolism and inhibition-based drug-drug interactions. Drug Metab Pharmacokinet 2010; 25:343-50.

Zielińska E, Zubowska M, Misiura K. Role of GSTM1, GSTP1, and GSTT1 gene polymorphism in ifosfamide metabolism affecting neurotoxicity and nephrotoxicity in children. J Pediatr Hematol Oncol 2005; 27:582-9.

Zienolddiny S, Campa D, Lind H et al. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. Carcinogenesis 2008; 29:1164-9.

Zientek M, Miller H, Smith D et al. Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds. J Pharmacol Toxicol Methods 2008; 58:206-14.

Zifa E, Theotokis P, Kaminari A et al. A novel G3337A mitochondrial ND1 mutation related to cardiomyopathy co-segregates with tRNALeu(CUN) A12308G and tRNAThr C15946T mutations. Mitochondrion 2008; 8:229-36.

Zill P, Baghai TC, Zwanzger P et al. Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment. Neuroreport 2000; 11:1893-7.

Zimmer C, Hafner M, Zender M, Ammann D, Hartmann RW, Vock CA. N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2). Bioorg Med Chem Lett 2011; 21:186-90.

Zimmermann C, Gutmann H, Drewe J. Thalidomide does not interact with P-glycoprotein. Cancer Chemother Pharmacol 2006; 57:599-606.

Zimmermann C, van Waterschoot RA, Harmsen S, Maier A, Gutmann H, Schinkel AH. PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide. Eur J Pharm Sci 2009; 36:565-71.

Zimmermann K, Wittman MD, Saulnier MG et al. Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors. Bioorg Med Chem Lett 2008; 18:4075-80.

Zimmermann T, Hoppe-Lotichius M, Körner A et al. The recipient CYP2D6 allele 4-associated poor metabolizer status correlates with an early fibrosis development after liver transplantation. Transpl Int 2011; 24:1059-67.

Zimniak P. Dubin-Johnson and Rotor syndromes: molecular basis and pathogenesis. Semin Liver Dis 1998; 13:248-60.

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