General References


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Xie HJ, Lundgren S, Broberg U, Finnström N, Rane A, Hassan M. Effect of cyclophosphamide on gene expression of cytochromes p450 and beta-actin in the HL-60 cell line. Eur J Pharmacol 2002; 449:197-205.

Xie J, Wu T, Xu K, Huang IK, Cleaver O, Huang CL. Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol 2009; 175:1315-27.

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Xie Y, Liu J, Liu Y, Klaassen CD, Waalkes MP. Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice. Mol Cell Biochem 2004; 255:11-8.

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Xie Z, Dong Y, Maeda U et al. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci 2007; 27:1247-54.

Xin HW, Wu XC, Li Q, Yu AR, Zhong MY, Liu YY. The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. Methods Find Exp Clin Pharmacol 2006; 28:25-9.

Xin X, Luan X, Xiao J et al. Association study of four activity SNPs of CYP3A4 with the precocious puberty in Chinese girls. Neurosci Lett 2005; 381:284-8.

Xing D, Scangas G, Nitta M et al. A role for BRCA1 in uterine leiomyosarcoma. Cancer Res 2009; 69:8231-5.

Xing PP, Wu WH, Du P, Han FM, Chen Y. Effects of brucine combined with glycyrrhetinic acid or liquiritin on rat hepatic cytochrome P450 activities in vivo. Yao Xue Xue Bao 2011; 46:573-80.

Xing Q, Gao R, Li H et al. Polymorphisms of the ABCB1 gene are associated with the therapeutic response to risperidone in Chinese schizophrenia patients. Pharmacogenomics 2006; 7:987-93.

Xing Q, Qian X, Li H et al. The relationship between the therapeutic response to risperidone and the dopamine D2 receptor polymorphism in Chinese schizophrenia patients. Int J Neuropsychopharmacol 2007; 10:631-7.

Xing Y, Cohen A, Rothblat G et al. Aldosterone production in human adrenocortical cells is stimulated by high-density lipoprotein 2 (HDL2) through increased expression of aldosterone synthase (CYP11B2). Endocrinology 2011; 152:751-63.

Xing YY, Yu JT, Yan WJ et al. NEDD9 is genetically associated with Alzheimer’s disease in a Han Chinese population. Brain Res 2011; 1369:230-4.

Xiong H, Callaghan D, Jones A et al. ABCG2 is upregulated in Alzheimer’s brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Abeta(1-40) peptides. J Neurosci 2009; 29:5463-75.

Xiong H, Carr RA, Locke CS et al. Dual effects of rifampin on the pharmacokinetics of atrasentan. J Clin Pharmacol 2007; 47:423-9.

Xiong J, Taniguchi M, Kashiwada Y, Sekiya M, Yamagishi T, Takaishi Y. Papyriferic acid derivatives as reversal agents of multidrug resistance in cancer cells. Bioorg Med Chem 2010; 18:2964-75.

Xiong WJ, Jin H, Li SJ, Jin JC, Ji BN, Yu C. Evaluating human liver reserve function by measuring serum concentrations of phenacetin and its metabolites. J Dig Dis 2010; 11:358-63.

Xiong Y, Wang M, Fang K et al. A systematic genetic polymorphism analysis of the CYP2C9 gene in four different geographical Han populations in mainland China. Genomics 2011; 97:277-81.

Xita N, Chatzikyriakidou A, Stavrou I, Zois Ch, Georgiou I, Tsatsoulis A. The (TTTA)n polymorphism of aromatase (CYP19) gene is associated with age at menarche. Hum Reprod 2010; 25:3129-33.

Xu B, Goulding EH, Zang K et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 2003; 6:736-42.

Xu B, Song X, Yip NC et al. Simultaneous detection of MDR1 and WT1 gene expression to predict the prognosis of adult acute lymphoblastic leukemia. Hematology 2010; 15:74-80.

Xu BQ, Ishii M, Ding LR, Fischer NE, Inaba T. Interaction of serum proteins with CYP isoforms in human liver microsomes: inhibitory effects of human and bovine albumin, alpha-globulins, alpha-1-acid glycoproteins and gamma-globulins on CYP2C19 and CYP2D6. Life Sci 2003; 72:1953-62.

Xu C, Chen JA, Qiu Z et al. Ovotoxicity and PPAR-mediated aromatase downregulation in female Sprague-Dawley rats following combined oral exposure to benzo[a]pyrene and di-(2-ethylhexyl) phthalate. Toxicol Lett 2010; 199:323-32.

Xu C, Rao YS, Xu B et al. An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles. Biochem Biophys Res Commun 2002; 290:318-24.

Xu C, Schachar R, Tannock R et al. Linkage study of the alpha2A adrenergic receptor in attention-deficit hyperactivity disorder families. Am J Med Genet 2001; 105:159-62.

Xu C, Wang Z, Fan M et al. Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer’s disease. Neuroreport 2010; 21:802-7.

Xu CM, Qian YL, Zhu LJ et al. Abnormal liver function associated with polymorphism of GSTT1, GSTM1 and CYP2E1 in workers exposed to N, N-dimethylformamide. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2009; 27:333-7.

Xu D, Chen M, Guo Y et al. Synergistic antifibrotic effect of verapamil and interferon-gamma in rats: partially based on enhanced verapamil oral bioavailability. Eur J Gastroenterol Hepatol 2010; 22:466-73.

Xu F, Falck JR, Ortiz de Montellano PR, Kroetz DL. Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes. J Pharmacol Exp Ther 2004; 308:887-95.

Xu FY, Queen G, Brandes L, Hatch GM. The phospholipidosis-lnducing potential of the chemopotentiating drug, N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE, tesmilifene) correlates with its stimulation of phosphatidylserine synthesis and exposure on the plasma membrane in MCF-7 breast cancer cells. Proc West Pharmacol Soc 2007; 50:61-3.

Xu H, He JH, Xiao ZD et al. Liver-enriched transcription factors regulate microRNA-122 that targets CUTL1 during liver development. Hepatology 2010; 52:1431-42.

Xu H, Kulkarni KH, Singh R et al. Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides. Mol Pharm 2009; 6:1703-15.

Xu H, Murray M, McLachlan AJ. Influence of genetic polymorphisms on the pharmacokinetics and pharmaco-dynamics of sulfonylurea drugs. Curr Drug Metab 2009; 10:643-58.

Xu H, Rajesan R, Harper P et al. Induction of cytochrome P450 1A by cow milk-based formula: a comparative study between human milk and formula. Br J Pharmacol 2005; 146:296-305.

Xu H, Tian W, Fu Y, Oyama TT, Anderson S, Cohen DM. Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene. Am J Physiol Renal Physiol 2007; 293:1865-76.

Xu HB, Li L, Liu GQ. Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells. Pharmazie 2009; 64:660-5.

Xu HB, Li L, Liu GQ. Reversal of multidrug resistance by guggulsterone in drug-resistant MCF-7 cell lines. Chemotherapy 2011; 57:62-70.

Xu HB, Liu YJ, Li L. Aromatase inhibitor versus tamoxifen in postmenopausal woman with advanced breast cancer: a literature-based meta-analysis. Clin Breast Cancer 2011; 11:246-51.

Xu HR, Chen WL, Li XN, Chu NN. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol 2010; 48:947-52.

Xu HW, Xu L, Hao JH, Qin CY, Liu H. Expression of P-glycoprotein and multidrug resistance-associated protein is associated with multidrug resistance in gastric cancer. J Int Med Res 2010; 38:34-42.

Xu J, He J, Castleberry AM, Balasubramanian S, Lau AG, Hall RA. Heterodimerization of alpha-2A- and beta-1-adrenergic receptors. J Biol Chem 2003; 278:10770-7.

Xu J, Xu X, Xue L et al. MTHFR c. 1793G>A polymorphism is associated with congenital cardiac disease in a Chinese population. Cardiol Young 2010; 20:318-26.

Xu JH, Deng WL, Fan ZZ. Effects of changwelqing on nuclear translocation of Y-box binding protein-1 and expregslon of P-glycoprotein in human colon cancer cell line with drug-resistance induced by vincristine. Zhongguo Zhong Xi Yi Jie He Za Zhi 2010; 30:743-7.

Xu K, Anderson TR, Neyer KM et al. Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence. Pharmacogenomics J 2007; 7:368-79.

Xu L, Chen Y, Pan Y, Skiles GL, Shou M. Prediction of human drug-drug interactions from time-dependent inactivation of CYP3A4 in primary hepatocytes using a population-based simulator. Drug Metab Dispos 2009; 37:2330-9.

Xu L, Desai MC. Pharmacokinetic enhancers for HIV drugs. Curr Opin Investig Drugs 2009; 10:775-86.

Xu L, Wang Y, Yamaguchi N, Pasek DA, Meissner G. Single channel properties of heterotetrameric mutant RyR1 ion channels linked to core myopathies. J Biol Chem 2008; 283:6321-9.

Xu M, He L. Convergent evidence shows a positive association of interleukin-1 gene complex locus with susceptibility to schizophrenia in the Caucasian population. Schizophr Res 2010; 120:131-42.

Xu M, Li S, Xing Q et al. Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study. Eur J Hum Genet 2010; 18:707-12.

Xu M, Sham P, Ye Z, Lindpaintner K, He L. A1166C genetic variation of the angiotensin II type I receptor gene and susceptibility to coronary heart disease: Collaborative of 53 studies with 20,435 cases and 23,674 controls. Atherosclerosis 2010; 213:191-9.

Xu M, Zhou H, Gu Q, Li C. The expression of ATP-binding cassette transporters in hypertensive patients. Hypertens Res 2009; 32:455-61.

Xu M, Zhou H, Tan KC, Guo R, Shiu SW, Wong Y. ABCG1 mediated oxidized LDL-derived oxysterol efflux from macrophages. Biochem Biophys Res Commun 2009; 390:1349-54.

Xu M, Zhou H, Wang J, Li C, Yu Y. The expression of ATP-binding cassette transporter A1 in Chinese overweight and obese patients. Int J Obes 2009; 33:851-6.

Xu MQ, St Clair D, Feng GY et al. BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population. Pharmacogenet Genomics 2008; 18:449-57.

Xu MQ, Ye Z, Hu FB, He L. Quantitative assessment of the effect of angiotensinogen gene polymorphisms on the risk of coronary heart disease. Circulation 2007; 116:1356-66.

Xu P, Huecksteadt TP, Hoidal JR. Molecular cloning and characterization of the human xanthine dehydrogenase gene (XDH). Genomics 1996; 34:173-80.

Xu P, Zhu XL, Huecksteadt TP, Brothman AR, Hoidal JR. Assignment of human xanthine dehydrogenase gene to chromosome 2p22. Genomics 1994; 23:289-91.

Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y. Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer. J Biol Chem 2004; 279:25511-16.

Xu S, Linher-Melville K, Yang BB, Wu D, Li J. Micro-RNA378 (miR-378) regulates ovarian estradiol production by targeting aromatase. Endocrinology 2011; 152:3941-51.

Xu W, Xi B, Wu J et al. Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of beta-tubulin at Cys 12 and suppression of microtubule dynamics. Mol Cancer Ther 2009; 8:3318-30.

Xu W, Zhou Y, Hang X, Shen D. Current evidence on the relationship between CYP1B1 polymorphisms and lung cancer risk: a meta-analysis. Mol Biol Rep 2011. doi:10. 1007/s11033-011-1041-6.

Xu X, Fu J, Wang H, Zhang B, Wang X, Wang Y. Influence of P-glycoprotein on embryotoxicity of the antifouling biocides to sea urchin (Strongylocentrotus intermedius). Ecotoxicology 2011; 20:419-28.

Xu X, Kelsey KT, Wiencke JK, Wain JC, Christiani DC. Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility. Cancer Epidemiol Biomarkers Prev 1996; 5:687-92.

Xu X, Liu HY, Liu L, Xie L, Liu XD. The influence of a newly developed quinolone: antofloxacin, on CYP activity in rats. Eur J Drug Metab Pharmacokinet 2008; 33:1-7.

Xu X, Zhang XA, Wang DW. The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases. Adv Drug Deliv Rev 2011; 63:597-609.

Xu XL, Lee TC, Offor N et al. Tumor-associated retinal astrocytes promote retinoblastoma cell proliferation through production of IGFBP-5. Am J Pathol 2010; 177:424-35.

Xu Y, Carr LG, Bosron WF, Li TK, Edenberg HJ. Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics 1988; 2:209-14.

Xu Y, Ding H, Peng J et al. Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease. Pharmacogenet Genomics 2011; 21:489-94.

Xu Y, Hashizume T, Shuhart MC et al. Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol 2006; 69:56-65.

Xu Y, Iwanaga K, Zhou C, Cheesman MJ, Farin F, Thummel KE. Selective induction of intestinal CYP3A23 by 1alpha,25-dihydroxyvitamin D3 in rats. Biochem Pharmacol 2006; 72:385-92.

Xu Y, Shen Z, Shen J, Liu G, Li W, Tang Y. Computational insights into the different catalytic activities of CYP2A13 and CYP2A6 on NNK. J Mol Graph Model 2011; 30:1-9.

Xu Y, Sun Y, Yao L et al. Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment. Ann Oncol 2008; 19:1423-9.

Xuan C, Zhang BB, Li M, Deng KF, Yang T, Zhang XE. No association between APOE epsilon 4 allele and multiple sclerosis susceptibility: A meta-analysis from 5472 cases and 4727 controls. J Neurol Sci 2011; 308:110-6.

Xue L, Zgoda VG, Arison B, Almira Correia M. Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase. Arch Biochem Biophys 2003; 409:113-26.

Xue X, Qu XJ, Gao ZH et al. Riccardin D, a novel macrocyclic bisbibenzyl, induces apoptosis of human leukemia cells by targeting DNA topoisomerase II. Invest New Drugs 2010. doi:10. 1007/s10637-010-9554-8.

Xue YM, Zhou L, Luo R. Correlation between angiotensin II type 1 receptor gene polymorphism and type 2 diabetes mellitus complicated by hypertension. Di Yi Jun Yi Da Xue Xue Bao 2002; 22:444-6.