General References

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

G

Gabriely I, Yang XM, Cases JA, Ma XH, Rossetti L, Barzilai N. Hyperglycemia modulates angiotensinogen gene expression. Am J Physiol Regul Integr Comp Physiol 2001; 281:795-802.

Gade-Andavolu R, Comings DE, MacMurray J et al. Association of CCR5 delta32 deletion with early death in multiple sclerosis. Genet Med 2004; 6:126-31.

Gadeyne C, van der Heyden S, Gasthuys F, Croubels S, Schauvliege S, Polis I. The influence of modulation of P-glycoprotein and/or Cytochrome P450 3A on the pharmacokinetics and pharmacodynamics of orally administered in dogs. J Vet Pharmacol Ther 2011; 34:417-23.

Gadhe CG, Madhavan T, Kothandan G, Cho SJ. In silico quantitative structure-activity relationship studies on P-gp modulators of tetrahydroisoquinoline-ethyl-phenylamine series. BMC Struct Biol 2011; 11:5.

Gaedigk A, Baker DW, Totah RA et al. Variability of CYP2J2 expression in human fetal tissues. J Pharmacol Exp Ther 2006; 319:523-32.

Gaedigk A, Bhathena A, Ndjountché L et al. Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans. Pharmacogenomics J 2005; 5:173-82.

Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, Meyer UA. Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am J Hum Genet 1991; 48:943-50.

Gaedigk A, Bradford LD, Alander SW, Leeder JS. CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status. Drug Metab Dispos 2006; 34:563-9.

Gaedigk A, Bradford LD, Marcucci KA, Leeder JS. Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. Clin Pharmacol Ther 2002; 72:76-89.

Gaedigk A, Coetsee C. The CYP2D6 gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements. Eur J Clin Pharmacol 2008; 64:465-75.

Gaedigk A, Eklund JD, Pearce RE et al. Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype. Clin Pharmacol Ther 2007; 81:817-20.

Gaedigk A, Frank D, Fuhr U. Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual. Eur J Clin Pharmacol 2009; 65:97-100.

Gaedigk A, Gotschall RR, Forbes NS, Simon SD, Kearns GL, Leeder JS. Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenetics 1999; 9:669-82.

Gaedigk A, Isidoro-García M, Pearce RE et al. Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. Eur J Clin Pharmacol 2010; 66:859-64.

Gaedigk A, Ndjountché L, Gaedigk R, Leeder JS, Bradford LD. Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects. Clin Pharmacol Ther 2003; 73:575-6.

Gaedigk A, Ndjountché L, Leeder JS, Bradford LD. Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjects. Clin Pharmacol Ther 2005; 77:228-30.

Gaedigk A, Ryder DL, Bradford LD, Leeder JS. CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism. Clin Chem 2003; 49:1008-11.

Gage BF, Eby C, Johnson JA et al. Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin. Clin Pharmacol Ther 2008; 84:326-31.

Gagné JF, Montminy V, Belanger P, Journault K, Gaucher G, Guillemette C. Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Mol Pharmacol 2002; 62:608-17.

Gagnon J, Mauriège P, Roy S et al. The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts. J Clin Invest 1996; 98:2086-93.

Gagnon JF, Bernard O, Villeneuve L, Têtu B, Guillemette C. Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer. Clin Cancer Res 2006; 12:1850-8.

Gahan LJ, Pauchet Y, Vogel H, Heckel DG. An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac toxin. PLoS Genet 2010. doi:10. 1371/journal. pgen. 1001248.

Gaillard I, Clauser E, Corvol P. Structure of human angiotensinogen gene. DNA 1989; 8:87-99.

Gait JE. Hemolytic reactions to nitrofurantoin in patients with glucose-6-phosphate dehydrogenase deficiency: theory and practice. DICP 1990; 24:1210-3.

Gajiwala KS, Wu JC, Christensen J et al. KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients. Proc Natl Acad Sci USA 2009; 106:1542-7.

Galani A, Kitsiou-Tzeli S, Sofokleous C, Kanavakis E, Kalpini-Mavrou A. Androgen insensitivity syndrome: clinical features and molecular defects. Hormones 2008; 7:217-29.

Galata Z, Moschonis G, Makridakis M et al. Plasma proteomic analysis in obese and overweight prepubertal children. Eur J Clin Invest 2011. doi:10. 1111/j. 1365-2362. 2011. 02536. x.

Galbally M, Lewis AJ, Lum J, Buist A. Serotonin discontinuation syndrome following in utero exposure to antidepressant medication: prospective controlled study. Aust N Z J Psychiatry 2009; 43:846-54.

Galbiatti AL, Ruiz MT, Chicote-Biselli PM et al. 5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer. Braz J Med Biol Res 2010; 43:445-50.

Gale RE, Green C, Allen C et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008; 111:2776-84.

Gale SE, Frolov A, Han X et al. A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation. J Biol Chem 2006; 281:11082-9.

Gałecki P, Florkowski A, Bieńkiewicz M, Szemraj J. Functional polymorphism of cyclooxygenase-2 gene (G-765C) in depressive patients. Neuropsychobiology 2010; 62:116-20.

Galetin A, Brown C, Hallifax D, Ito K, Houston JB. Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates. Drug Metab Dispos 2004; 32:1411-20.

Galetin A, Burt H, Gibbons L, Houston JB. Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition. Drug Metab Dispos 2006; 34:166-75.

Galetin A, Clarke SE, Houston JB. Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. Drug Metab Dispos 2002; 30:1512-22.

Galetin A, Clarke SE, Houston JB. Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine. Drug Metab Dispos 2003; 31:1108-16.

Galetin A, Gertz M, Houston JB. Potential role of intestinal first-pass metabolism in the prediction of drug-drug interactions. Expert Opin Drug Metab Toxicol 2008; 4:909-22.

Galetin A, Hinton LK, Burt H, Obach RS, Houston JB. Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs. Curr Drug Metab 2007; 8:685-93.

Galetin A, Houston JB. Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: impact on prediction of first-pass metabolism. J Pharmacol Exp Ther 2006; 318:1220-9.

Galetin A, Ito K, Hallifax D, Houston JB. CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions. J Pharmacol Exp Ther 2005; 314:180-90.

Gälman C, Bonde Y, Matasconi M, Angelin B, Rudling M. Dramatically increased intestinal absorption of cholesterol following hypophysectomy is normalized by thyroid hormone. Gastroenterology 2008; 134:1127-36.

Galteau MM, Shamsa F. Urinary 6beta-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals. Eur J Clin Pharmacol 2003; 59:713-33.

Galvani AP, Novembre J. The evolutionary history of the CCR5-Delta32 HIV-resistance mutation. Microbes Infect 2005; 7:302-9.

Gallagher CJ, Keene KL, Mychaleckyj JC et al. Investigation of the estrogen receptor-alpha gene with type 2 diabetes and/or nephropathy in African-American and European-American populations. Diabetes 2007; 56:675-84.

Gallagher EP, Kunze KL, Stapleton PL, Eaton DL. The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicol Appl Pharmacol 1996; 141:595-606.

Gallagher EP, Wienkers LC, Stapleton PL, Kunze KL, Eaton DL. Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1. Cancer Res 1994; 54:101-8.

Gallemann D, Wimmer E, Hoefer CC et al. In vitro characterization of sarizotan metabolism: hepatic clearance, identification and characterization of metabolites, drug metabolizing enzymes identification and evaluation of cytochrome P450 inhibition. Drug Metab Dispos 2010; 38:905-16.

Galletti F, Iacone R, Ragone E et al. Lack of association between polymorphism in the beta2-adrenergic receptor gene, hypertension, and obesity in the Olivetti heart study. Am J Hypertens 2004; 17:718-20.

Gallus GN, Dotti MT, Mignarri A et al. Four novel CYP27A1 mutations in seven Italian patients with CTX. Eur J Neurol 2010; 17:1259-62.

Galluzzi JR, Cupples LA, Otvos JD, Wilson PW, Schaefer EJ, Ordovas JM. Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in the Framingham Offspring Study. Atherosclerosis 2001; 159:417-24.

Gambetti P, Parchi P. Insomnia in prion diseases: sporadic and familial. N Engl J Med 1999; 340:1675-7.

Gambetti P, Petersen R, Monari L, Tabaton M, Autilio-Gambetti L. Fatal familial insomnia and the widening spectrum of prion diseases. Brit Med Bull 1993; 49:980-94.

Gambetti P, Petersen RB, Parchi P et al. Inherited prion diseases. In: Prusiner SB (Ed). Prion biology and diseases. Cold Spring Harbor Laboratory Press, New York, 1999:509-83.

Gambier N, Batt AM, Marie B, Pfister M, Siest G, Visvikis-Siest S. Association of CYP2A6*1B genetic variant with the amount of smoking in French adults from the Stanislas cohort. Pharmacogenomics J 2005; 5:271-5.

Gambier N, Marteau JB, Batt AM et al. Interaction between CYP1A1 T3801C and AHR G1661A polymorphisms according to smoking status on blood pressure in the Stanislas cohort. J Hypertens 2006; 24:2199-205.

Gambillara E, Laffitte E, Widmer N et al. Severe pustular eruption associated with imatinib and voriconazole in a patient with chronic myeloid leukemia. Dermatology 2005; 211:363-5.

Gamble JT, Nakatsu K, Marks GS. Comparison of the formation of N-alkylprotoporphyrin IX after interaction of porphyrinogenic xenobiotics with single cDNA-expressed human P450 enzymes in microsomes prepared from baculovirus-infected insect cells and human lymphoblastoid cell lines. Drug Metab Dispos 2003; 31:202-5.

Gamblin TC, Chen F, Zambrano A et al. Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer’s disease. Proc Natl Acad Sci USA 2003; 100:10032-7.

Gamelin L, Capitain O, Morel A et al. Predictive factors of oxaliplatin neurotoxicity: the involvement of the oxalate outcome pathway. Clin Cancer Res 2007; 13:6359-68.

Gamerdinger M, Clement AB, Behl C. Cholesterol-like effects of selective cyclooxygenase inhibitors and fibrates on cellular membranes and amyloid-beta production. Mol Pharmacol 2007; 72:141-51.

Gamliel A, Teicher C, Hartmann T, Beyreuther K, Stein R. Overexpression of wild-type presenilin 2 or its familial Alzheimer’s disease-associated mutant does not induce or increase susceptibility to apoptosis in different cell lines. Neuroscience 2003; 117:19-28.

Gamliel-Lazarovich A, Gantman A, Coleman R, Jeng AY, Kaplan M, Keidar S. FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice. J Hypertens 2010; 28:1900-7.

Gan GG, Phipps ME, Lee MM et al. Contribution of VKORC1 and CYP2C9 polymorphisms in the interethnic variability of warfarin dose in Malaysian populations. Ann Hematol 2011; 90:635-41.

Gan HK, Kaye AH, Luwor RB. The EGFRvIII variant in glioblastoma multiforme. J Clin Neurosci 2009; 16:748-54.

Gan HT, Tham M, Hariharan S, Ramasamy S, Yu YH, Ahmed S. Identification of ApoE as an autocrine/paracrine factor that stimulates neural stem cell survival via MAPK/ERK signaling pathway. J Neurochem 2011; 117:565-78.

Gan J, Liu-Kreyche P, Humphreys WG. In vitro assessment of cytochrome P450 inhibition and induction potential of tanespimycin and its major metabolite, 17-amino-17-demethoxygeldanamycin. Cancer Chemother Pharmacol 2011. doi:10. 1007/s00280-011-1672-2.

Gan J, Qu Q, He B, Shyu WC, Rodrigues AD, He K. Troglitazone thiol adduct formation in human liver microsomes: enzyme kinetics and reaction phenotyping. Drug Metab Lett 2008; 2:184-9.

Gan L, Ye S, Chu A et al. Identification of cathepsin B as a mediator of neuronal death induced by Aβ-activated microglial cells using a functional genomics approach. J Biol Chem 2004; 279:5565-72.

Gan LS, Moseley MA, Khosla B et al. CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells. Drug Metab Dispos 1996; 24:344-9.

Gan SH, Ismail R, Wan Adnan WA, Zulmi W, Kumaraswamy N, Larmie ET. Relationship between Type A and B personality and debrisoquine hydroxylation capacity. Br J Clin Pharmacol 2004; 57:785-9.

Gan SH, Ismail R, Wan Adnan WA, Zulmi W. Impact of CYP2D6 genetic polymorphism on tramadol pharmacokinetics and pharmacodynamics. Mol Diagn Ther 2007; 11:171-81.

Gandara DR, Kawaguchi T, Crowley J et al. Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics. J Clin Oncol 2009; 27:3540-6.

Gandrille S, Jude B, Alhenc-Gelas M, Millaire A, Aiach M. Compound heterozygosity in a family with protein C deficiency illustrating the complexity of the underlying molecular mechanism. Thromb Haemost 1993; 70:747-52.

Ganesan S, Sahu R, Walker LA, Tekwani BL. Cytochrome P450-dependent toxicity of dapsone in human erythrocytes. J Appl Toxicol 2010; 30:271-5.

Ganesan S, Tekwani BL, Sahu R, Tripathi LM, Walker LA. Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes. Toxicol Appl Pharmacol 2009; 241:14-22.

Ganfornina MD, Do Carmo S, Lora JM et al. Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress. Aging Cell 2008; 7:506-15.

Ganguly A, Basu S, Banerjee K et al. Redox active copper chelate overcomes multidrug resistance in T-lymphoblastic leukemia cell by triggering apoptosis. Mol Biosyst 2011; 7:1701-12.

Ganguly A, Basu S, Chakraborty P et al. Targeting mitochondrial cell death pathway to overcome drug resistance with a newly developed iron chelate. PLoS One 2010. doi:10. 1371/journal. pone. 0011253.

Ganor Y, Goldberg-Stern H, Amrom D et al. Autoimmune epilepsy: some epilepsy patients harbor autoantibodies to glutamate receptors and dsDNA on both sides of the blood-brain barrier, which may kill neurons and decrease in brain fluids after hemispherotomy. Clin Dev Immunol 2004; 11:241-52.

Ganta S, Devalapally H, Amiji M. Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation. J Pharm Sci 2010; 99:4630-41.

Gantenbein M, Attolini L, Bruguerolle B et al. Oxidative metabolism of bupivacaine into pipecolylxylidine in humans is mainly catalyzed by CYP3A. Drug Metab Dispos 2000; 28:383-5.

Gantla S, Bakker CT, Deocharan B et al. Splice-site mutations: a novel genetic mechanism of Crigler-Najjar syndrome type 1. Am J Hum Genet 1998; 62:585-92.

Gantois I, Fang K, Jiang L et al. Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior. Proc Natl Acad Sci USA 2007; 104:4182-7.

Ganzer S, Artl S, Schoder V et al. CSF-tau, CSF-Abeta1-42, APOE-genotype and clinical parameters in the diagnosis of Alzheimer’s disease: combination of CSF-tau and MMSE yields highest sensitivity and specificity. J Neural Transm 2003; 110:1149-60.

Ganzera M, Schneider P, Stuppner H. Inhibitory effects of the essential oil of chamomile (Matricaria recutita L. ) and its major constituents on human cytochrome P450 enzymes. Life Sci 2006; 78:856-61.

Gao A, Liang H, Wang X et al. Reversal effects of two new milbemycin compounds on multidrug resistance in MCF-7/adr cells in vitro. Eur J Pharmacol 2011; 659:108-13.

Gao A, Wang X, Xiang W, Liang H, Gao J, Yan Y. Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin. J Pharm Pharmacol 2010; 62:393-9.

Gao F, Fang Q, Zhang R et al. Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population. Endocr J 2009; 56:487-94.

Gao F, Johnson DL, Ekins S et al. Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2, CYP2C9, CYP2C19, CYP2D6, rCYP2D6, and CYP3A4 in vitro using a single point IC(50). J Biomol Screen 2002; 7:373-82.

Gao LB, Zhou B, Zhang L et al. R497K polymorphism in epidermal growth factor receptor gene is associated with the risk of acute coronary syndrome. BMC Med Genet 2008; 9:74.

Gao N, Nester RA, Sarkar MA. 4-Hydroxy estradiol but not 2-hydroxy estradiol induces expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor A through phosphatidylinositol 3-kinase/Akt/FRAP pathway in OVCAR-3 and A2780-CP70 human ovarian carcinoma cells. Toxicol Appl Pharmacol 2004; 196:124-35.

Gao N, Qiao HL, Jia LJ, Tian X, Zhang YW. Relationships between specific serum IgE, IgG, IFN-gamma level and IFN-gamma, IFNR1 polymorphisms in patients with penicillin allergy. Eur J Clin Pharmacol 2008; 64:971-7.

Gao N, Qu X, Yan J, Huang Q, Yuan HY, Ouyang DS. L-FABP T94A decreased fatty acid uptake and altered hepatic triglyceride and cholesterol accumulation in Chang liver cells stably transfected with L-FABP. Mol Cell Biochem 2010; 345:207-14.

Gao P, Wei JM, Li PY et al. Screening of deoxyribozyme with high reversal efficiency against multidrug resistance in breast carcinoma cells. J Cell Mol Med 2011; 15:2130-8.

Gao Q, Niti M, Feng L, Yap KB, Ng TP. Omega-3 polyunsaturated fatty acid supplements and cognitive decline: Singapore Longitudinal Aging Studies. J Nutr Health Aging 2011; 15:32-5.

Gao S, Kinzig KP, Aja S et al. Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Nat Acad Sci USA 2007; 104:17358-63.

Gao SP, Mark KG, Leslie K et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 2007; 117:3846-56.

Gao W. Androgen receptor as a therapeutic target. Adv Drug Deliv Rev 2010; 62:1277-84.

Gao W, Wu Z, Bohl CE, Yang J, Miller DD, Dalton JT. Characterization of the in vitro metabolism of selective androgen receptor modulator using human, rat, and dog liver enzyme preparations. Drug Metab Dispos 2006; 34:243-53.

Gao X, Bashirova A, Iversen AK et al. AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis. Nat Med 2005; 11:1290-2.

Gao X, Nelson GW, Karacki P et al. Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS. N Engl J Med 2001; 344:1668-75.

Gao X, O’Brien TR, Welzel TM et al. HLA-B alleles associate consistently with HIV heterosexual transmission, viral load, and progression to AIDS, but not susceptibility to infection. AIDS 2010; 24:1835-40.

Gao Y, Liu D, Wang H, Zhu J, Chen C. Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects on in vitro and in vivo drug-drug interactions. Xenobiotica 2010; 40:467-75.

Gao Y, Zhang LR, Fu Q. CYP3A4*1G polymorphism is associated with lipid-lowering efficacy of atorvastatin but not of simvastatin. Eur J Clin Pharmacol 2008; 64:877-82.

Gao YD, Olson SH, Balkovec JM et al. Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach. Xenobiotica 2007; 37:124-38.

Gapska P, Scott RJ, Serrano-Fernandez P et al. Vitamin D receptor variants and the malignant melanoma risk: a population-based study. Cancer Epidemiol 2009; 33:103-7.

Garai K, Baban B, Frieden C. Dissociation of apolipoprotein E oligomers to monomer is required for high-affinity binding to phospholipid vesicles. Biochemistry 2011; 50:2550-8.

Garattini E, Fratelli M, Terao M. Mammalian aldehyde oxidases: genetics, evolution and biochemistry. Cell Mol Life Sci 2008; 65:1019-48.

Garbett K, Gal-Chis R, Gaszner G, Lewis DA, Mirnics K. Transcriptome alterations in the prefrontal cortex of subjects with schizophrenia who committed suicide. Neuropsychopharmacol Hung 2008; 10:9-14.

Garcés C, Benavente M, Ortega H et al. Influence of birth weight on the apo E genetic determinants of plasma lipid levels in children. Pediat Res 2002; 52:873-8.

Garcia EA, Newhouse S, Caulfield MJ, Munroe PB. Genes and hypertension. Curr Pharm Des 2003; 9:1679-89.

Garcia M, Rager J, Wang Q et al. Cryopreserved human hepatocytes as alternative in vitro model for cytochrome p450 induction studies. In Vitro Cell Dev Biol Anim 2003; 39:283-7.

Garcia SM, Curioni OA, de Carvalho MB, Gattás GJ. Polymorphisms in alcohol metabolizing genes and the risk of head and neck cancer in a Brazilian population. Alcohol Alcohol 2010; 45:6-12.

Garcia-Barceló M, Chow LY, Lam KL, Chiu HF, Wing YK, Waye MM. Occurrence of CYP2D6 gene duplication in Hong Kong Chinese. Clin Chem 2000; 46:1411-3.

García-Casado Z, Guerrero-Zotano A, Llombart-Cussac A et al. A polymorphism at the 3’-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole. BMC Cancer 2010; 10:36.

Garcia-Garcia AB, Blesa S, Martinez-Hervas S et al. Semiquantitative multiplex PCR: a useful tool for large rearrangement screening and characterization. Hum Mutat 2006; 27:822-8.

García-Martín E, Ayuso P, Martínez C, Blanca M, Agúndez JA. Histamine pharmacogenomics. Pharmacogenomics 2009; 10:867-83.

García-Martín E, Martínez C, Alonso-Navarro H et al. Dopamine receptor D3 (DRD3) genotype and allelic variants and risk for essential tremor. Mov Disord 2009; 24:1910-5.

García-Martín E, Martínez C, Pizarro RM et al. CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity. Clin Pharmacol Ther 2002; 71:196-204.

García-Martín E, Martínez C, Tabarés B, Frías J, Agúndez JA. Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms. Clin Pharmacol Ther 2004; 76:119-27.

García-Martín E, Pizarro RM, Martínez C et al. Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8. Pharmacogenomics 2006; 7:575-85.

García-Suástegui WA, Huerta-Chagoya A, Carrasco-Colín KL et al. Seasonal variations in the levels of PAH-DNA adducts in young adults living in Mexico City. Mutagenesis 2011; 26:385-91.

Gardemann A, Fink M, Stricker J et al. ACE I/D gene polymorphism: presence of the ACE D allele increases the risk of coronary artery disease in younger individuals. Atherosclerosis 1998; 139:153-9.

Gardemann A, Stricker J, Humme J et al. Angiotensinogen T174M and M235T gene polymorphisms are associated with the extent of coronary atherosclerosis. Atherosclerosis 1999; 145:309-14.

Gardiner K, Du Y. A-to-I editing of the 5HT2C receptor and behaviour. Brief Funct Genomic Proteomic 2006; 5:37-42.

Gardiner SJ, Begg EJ. Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacol Rev 2006; 58:521-90.

Gardner ER, Burger H, van Schaik RH et al. Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib. Clin Pharmacol Ther 2006; 80:192-201.

Gardner ER, Kelly M, Springman E et al. Antiangiogenic and antitumor activity of LP-261, a novel oral tubulin binding agent, alone and in combination with bevacizumab. Invest New Drugs 2010. doi:10. 1007/s10637-010-9520-5.

Gardner-Stephen DA, Mackenzie PI. Liver-enriched transcription factors and their role in regulating UDP glucuronosyltransferase gene expression. Curr Drug Metab 2008; 9:439-52.

Garenc C, Aubert S, Laroche J et al. Gene polymorphisms in the Quebec population: a risk to develop hypertriglyceridemia. Biochem Biophys Res Commun 2006; 344:588-96.

Garenc C, Pérusse L, Chagnon YC et al. Effects of beta2-adrenergic receptor gene variants on adiposity: the HERITAGE Family Study. Obes Res 2003; 11:612-8.

Gareri P, de Fazio P, Gallelli L et al. Venlafaxine-propafenone interaction resulting in hallucinations and psicomotor agitation. Ann Pharmacother 2008; 42:434-8.

Garey KW, Peloquin CA, Godo PG, Nafziger AN, Amsden GW. Lack of effect of zafirlukast on the pharmacokinetics of azithromycin, clarithromycin, and 14-hydroxyclarithromycin in healthy volunteers. Antimicrob Agents Chemother 1999; 43:1152-5.

Garfield AS, Heisler LK. Pharmacological targeting of the serotonergic system for the treatment of obesity. J Physiol 2009; 587:49-60.

Garg A, Agarwal AK. Lipodystrophies: disorders of adipose tissue biology. Biochim Biophys Acta 2009; 1791:507-13.

Garg SK, Kumar N, Bhargava VK, Prabhakar SK. Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. Clin Pharmacol Ther 1998; 64:286-8.

Garlepp MJ, Tabarias H, van Bockxmeer FM, Zilko PJ, Laing B, Mastaglia FL. Apolipoprotein E epsilon 4 in inclusion body myositis. Ann Neurol 1995; 38:957-9.

Garmy-Susini B, Jin H, Zhu Y, Sung RJ, Hwang R, Varner J. Integrin alpha-4-beta-1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation. J Clin Invest 2005; 115:1542-51.

Garnero P, Munoz F, Borel O, Sornay-Rendu E, Delmas PD. Vitamin D receptor gene polymorphisms are associated with the risk of fractures in postmenopausal women, independently of bone mineral density. J Clin Endocr Metab 2005; 90:4829-35.

Garnett WR. Clinical implications of drug interactions with coxibs. Pharmacotherapy 2001; 21:1223-32.

Garnier A, Bendall JK, Fuchs S et al. Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice. Circulation 2004; 110:1819-25.

Garnock-Jones KP, Keating GM. Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents. Paediatr Drugs 2009; 11:203-26.

Garriock HA, Tanowitz M, Kraft JB et al. Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder. Am J Psychiatry 2010; 167:565-73.

Garrison JL, Kunkel EJ, Hedge RS, Taunton J. A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum. Nature 2005; 436:285-9.

Garrity-Park MM, Loftus EV Jr, Bryant SC, Sandborn WJ, Smyrk TC. Tumor necrosis factor-alpha polymorphisms in ulcerative colitis-associated colorectal cancer. Am J Gastroenterol 2008; 103:407-15.

Garry PJ, Baumgartner RN, Brodie SG et al. Estrogen replacement therapy, serum lipids, and polymorphism of the apolipoprotein E gene. Clin Chem 1999; 45:1214-23.

Garsa AA, McLeod HL, Marsh S. CYP3A4 and CYP3A5 genotyping by Pyrosequencing. BMC Med Genet 2005; 6:19.

Gasche Y, Daali Y, Fathi M et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Engl J Med 2004; 351:2827-31.

Gashaw I, Kirchheiner J, Goldammer M et al. Cytochrome p450 3A4 messenger ribonucleic acid induction by rifampin in human peripheral blood mononuclear cells: correlation with alprazolam pharmacokinetics. Clin Pharmacol Ther 2003; 74:448-57.

Gasnier C, Benachour N, Clair E et al. Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines. J Occup Med Toxicol 2010; 5:29.

Gasnier C, Laurant C, Decroix-Laporte C et al. Defined plant extracts can protect human cells against combined xenobiotic effects. J Occup Med Toxicol 2011; 6:3.

Gaspari T, Hongbin Liu, Welungoda I et al. A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model. Diab Vasc Dis Res 2011; 8:117-24.

Gasparini L, Ongini E, Wenk G. Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer’s disease: old and new mechanisms of action. J Neurochem 2004; 91:521-36.

Gasperino J. Gender is a risk factor for lung cancer. Med Hypotheses 2011; 76:328-31.

Gass RJ, Gal J, Fogle PW, Detmar-Hanna D, Gerber JG. Neither dapsone hydroxylation nor cortisol 6beta-hydroxylation detects the inhibition of CYP3A4 by HIV-1 protease inhibitors. Eur J Clin Pharmacol 1998; 54:741-7.

Gassler N, Herr I, Schneider A et al. Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomas. J Pathol 2005; 207:295-300.

Gassó P, Mas S, Alvarez S et al. Xenobiotic metabolizing and transporter genes: gene-gene interactions in schizophrenia and related disorders. Pharmacogenomics 2010; 11:1725-31.

Gassó P, Mas S, Bernardo M, Álvarez S, Parellada E, Lafuente A. A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms. Pharmacogenomics J 2009; 9:404-10.

Gatanaga H, Hayashida T, Tsuchiya K et al. Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 *6 and *26. Clin Infect Dis 2007; 45:1230-7.

Gatanaga H, Oka S. Successful genotype-tailored treatment with small-dose efavirenz. AIDS 2009; 23:433-4.

Gatanaga H, Yazaki H, Tanuma J et al. HLA-Cw8 primarily associated with hypersensitivity to nevirapine. AIDS 2007; 21:264-5.

Gates MA, Tworoger SS, Terry KL et al. Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev 2008; 17:2436-44.

Gätke MR, Bundgaard JR, Viby-Mogensen J. Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia. Pharmacogenet Genomics 2007; 17:995-9.

Gattermann N, Retzlaff S, Wang YL et al. Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia. Blood 1997; 90:4961-72.

Gattermann N, Wulfert M, Junge B, Germing U, Haas R, Hofhaus G. Ineffective hematopoiesis linked with a mitochondrial tRNA mutation (G3242A) in a patient with myelodysplastic syndrome. Blood 2004; 103:1499-502.

Gaudet MM, Chanock S, Dunning A et al. HSD17B1 genetic variants and hormone receptor-defined breast cancer. Cancer Epidemiol Biomarkers Prev 2008; 17:2766-72.

Gaudet MM, Chanock S, Lissowska J et al. Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women. Pharmacogenet Genomics 2006; 16:547-53.

Gaudineau C, Auclair K. Inhibition of human P450 enzymes by nicotinic acid and nicotinamide. Biochem Biophys Res Commun 2004; 317:950-6.

Gaudineau C, Beckerman R, Welbourn S, Auclair K. Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract. Biochem Biophys Res Commun 2004; 318:1072-8.

Gaussin V, Tomlinson JE, Depre C et al. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy Circulation 2003; 108:2926-33.

Gaustadnes M, Wilcken B, Oliveriusova J et al. The molecular basis of cystathionine beta-synthase deficiency in Australian patients: genotype-phenotype correlations and response to treatment. Hum Mutat 2002; 20:117-26.

Gauthier L, Charrin B, Borrell-Pages M et al. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 2004; 118:127-38.

Gavalas NG, Akhtar S, Gawkrodger DJ, Watson PF, Weetman AP, Kemp EH. Analysis of allelic variants in the catalase gene in patients with the skin depigmenting disorder vitiligo. Biochem Biophys Res Commun 2006; 345:1586-91.

Gavras I, Gavras H. Role of alpha2-adrenergic receptors in hypertension. Am J Hypertens 2001; 14:171-7.

Gavrilova SI, Kolykhalov IV, Fedorova YB et al. Potential of preventive treatment of Alzheimer’s disease: results of a three-year prospective open comparative trial of the efficacy and safety of courses of treatment with cerebrolysin and cavinton in elderly patients with mild cognitive impairment syndrome. Neurosci Behav Physiol 2011; 41:391-8.

Gawrońska-Szklarz B, Siuda A, Kurzawski M, Bielicki D, Marlicz W, Droździk M. Effects of CYP2C19, MDR1, and interleukin 1-B gene variants on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxicillin, and metronidazole. Eur J Clin Pharmacol 2010; 66:681-7.

Gawrońska-Szklarz B, Wrześniewska J, Starzyńska T et al. Effect of CYP2C19 and MDR1 polymorphisms on cure rate in patients with acid-related disorders with Helicobacter pylori infection. Eur J Clin Pharmacol 2005; 61:375-9.

Gawronska-Szklarz B, Zarzycki M, Musial HD, Pudlo A, Loniewski I, Drozdzik M. Lidocaine pharmacokinetics in postmenopausal women on hormone therapy. Menopause 2006; 13:793-8.

Gay SC, Shah MB, Talakad JC et al. Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2. 0-A resolution. Mol Pharmacol 2010; 77:529-38.

Gayathri SB, Radha V, Vimaleswaran KS, Mohan V. Association of the PPARGC1A gene polymorphism with diabetic nephropathy in an Asian Indian population (CURES-41). Metab Syndr Relat Disord 2010; 8:119-26.

Gaysina D, Cohen-Woods S, Chow PC et al. Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS). Am J Med Genet B Neuropsychiatr Genet 2009; 150:836-44.

Gaysina D, Pierce M, Richards M, Hotopf M, Kuh D, Hardy R. Association between adolescent emotional problems and metabolic syndrome: The modifying effect of C-reactive protein gene (CRP) polymorphisms. Brain Behav Immun 2011; 25:750-8.

Gayther SA, Song H, Ramus SJ et al. Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. Cancer Res 2007; 67:3027-35.

Gazdar AF. Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 2009; 28 Suppl 1:24-31.

Gazi IF, Apostolou FA, Liberopoulos EN et al. Leptospirosis is associated with markedly increased triglycerides and small dense low-density lipoprotein and decreased high-density lipoprotein. Lipids 2011; 46:953-60.

Gazouli M, Mantzaris G, Kotsinas A et al. Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population. World J Gastroenterol 2005; 11:681-5.

Gazzin S, Berengeno AL, Strazielle N et al. Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat. PLoS One 2011. doi:10. 1371/journal. pone. 0016165.

Ge D, Gooljar SB, Kyriakou T et al. Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile. Obesity 2008; 16:492-6.

Ge D, Huang J, He J et al. beta2-Adrenergic receptor gene variations associated with stage-2 hypertension in northern Han Chinese. Ann Hum Genet 2005; 69:36-44.

Gebeyehu E, Engidawork E, Bijnsdorp A, Aminy A, Diczfalusy U, Aklillu E. Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians. Pharmacogenomics J 2011; 11:130-7.

Gebril OH, Kirby J, Savva G, Brayne C, Ince PG. HFE H63D, C282Y and AGTR1 A1166C polymorphisms and brain white matter lesions in the aging brain. J Neurogenet 2011; 25:7-14.

Geese WJ, Achanzar W, Rubin C et al. Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists. Pharmacogenet Genomics 2008; 18:903-10.

Gefitinib: new preparation. Non small-cell lung cancer: stricter assessment needed. Prescrire Int 2004; 13:168-70.

Geick A, Eichelbaum M, Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 2001; 276:14581-7.

Geiger EV, Doehring A, Kirchhof A, Lötsch J. Functional variants of the human 5-lipoxygenase gene and their genetic diagnosis. Prostaglandins Leukot Essent Fatty Acids 2009; 80:255-62.

Geisel J, Kivistö KT, Griese EU, Eichelbaum M. The efficacy of simvastatin is not influenced by CYP2D6 polymorphism. Clin Pharmacol Ther 2002; 72:595-6.

Geisen C, Luxembourg B, Watzka M et al. Prediction of phenprocoumon maintenance dose and phenprocoumon plasma concentration by genetic and non-genetic parameters. Eur J Clin Pharmacol 2011; 67:371-81.

Geisler T, Zürn C, Paterok M et al. Statins do not adversely affect post-interventional residual platelet aggregation and outcomes in patients undergoing coronary stenting treated by dual antiplatelet therapy. Eur Heart J 2008; 29:1635-43.

Geldenhuys WJ, van der Schyf CJ. Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer’s disease. Curr Top Med Chem 2008; 8:1035-48.

Geldenhuys WJ, van der Schyf CJ. The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer’s disease. Expert Rev Neurother 2009; 9:1073-85.

Gelder CM, Lambkin R, Hart KW et al. Associations between human leukocyte antigens and nonresponsiveness to influenza vaccine. J Infect Dis 2002; 185:114-7.

Gelineau-van Waes J, Maddox JR, Smith LM et al. Microarray analysis of E9. 5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex. BMC Genomics 2008; 9:156.

Gélisse P, Hillaire-Buys D, Halaili E et al. Carbamazepine and clarithromycin: a clinically relevant drug interaction. Rev Neurol 2007; 163:1096-9.

Gellera C, Meoni C, Castellotti B et al. Errors in Huntington disease diagnostic test caused by trinucleotide deletion in the IT15 gene. Am J Hum Genet 1996; 59:475-7.

Gellner K, Eiselt R, Hustert E et al. Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. Pharmacogenetics 2001; 11:111-21.

Gemmati D, Ongaro A, Tognazzo S et al. Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin’s lymphoma patients: association with toxicity and survival. Haematologica 2007; 92:478-85.

Generaux GT, Bonomo FM, Johnson M, Mahar Doan KM. Impact of SLCO1B1 (OATP1B1) and ABCG2 (BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins. Xenobiotica 2011; 41:639-51.

Geneviève D, Proulle V, Isidor B et al. Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome). Nat Genet 2008; 40:284-6.

Genin E, Hannequin D, Wallon D et al. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry 2011; 16:903-7.

Gennari L, Merlotti D, Nuti R. Aromatase activity and bone loss. Adv Clin Chem 2011; 54:129-64.

Gennuso F, Fernetti C, Tirolo C et al. Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1). Proc Nat Acad Sci USA 2004; 101:2470-5.

Genoud N, Behrens A, Miele G et al. Disruption of Doppel prevents neurodegeneration in mice with extentive Prnp deletions. Proc Nat Acad Sci USA 2004; 101:4198-203.

Genovese S, Epifano F, Curini M, Menger D, Zembruski NC, Weiss J. In vitro effects of natural prenyloxycinnamic acids on human cytochrome P450 isozyme activity and expression. Phytomedicine 2011; 18:586-91.

Genschel J, Haas R, Propsting MJ, Schmidt HHJ. Apolipoprotein A-I induced amyloidosis. FEBS Lett 1998; 430:145-9.

Genser D. Food and drug interaction: consequences for the nutrition/health status. Ann Nutr Metab 2008; 52 Suppl 1:29-32.

Gentile DM, Tomlinson ES, Maggs JL, Park BK, Back DJ. Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation. J Pharmacol Exp Ther 1996; 277:105-12.

Gentile DM, Verhoeven CH, Shimada T, Back DJ. The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel. J Pharmacol Exp Ther 1998; 287:975-82.

Gentile G, Borro M, Lala N, Missori S, Simmaco M, Martelletti P. Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine. J Headache Pain 2010; 11:431-5.

Gentile G, Missori S, Borro M, Sebastianelli A, Simmaco M, Martelletti P. Frequencies of genetic polymorphisms related to triptans metabolism in chronic migraine. J Headache Pain 2010; 11:151-6.

Gentile S, Martin N, Scappini E, Williams J, Erxleben C, Armstrong DL. The human ERG1 channel polymorphism, K897T, creates a phosphorylation site that inhibits channel activity. Proc Natl Acad Sci USA 2008; 105:14704-8.

Gentilini D, Somigliana E, Vigano P, Vignali M, Busacca M, Di Blasio AM. The vascular endothelial growth factor +405G>C polymorphism in endometriosis. Hum Reprod 2008; 1:211-5.

Genualdo V, Spalenza V, Perucatti A et al. Fluorescence in situ hybridization mapping of six loci containing genes involved in the dioxin metabolism of domestic bovids. J Appl Genet 2011; 52:229-32.

Genvigir FD, Hirata MH, Hirata RD. ABCA1 expression and statins: inhibitory effect in peripheral blood mononuclear cells. Pharmacogenomics 2009; 10:997-1005.

Genvigir FD, Rodrigues AC, Cerda A et al. Effects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cells. Pharmacogenomics 2010; 11:1235-46.

Genvigir FD, Rodrigues AC, Cerda A, Hirata MH, Curi R, Hirata RD. ABCA1 and ABCG1 expressions are regulated by statins and ezetimibe in Caco-2 cells. Drug Metabol Drug Interact 2011; 26:33-6.

Genvigir FD, Soares SA, Hirata MH et al. Effects of ABCA1 SNPs, including the C-105T novel variant, on serum lipids of Brazilian individuals. Clin Chim Acta 2008; 389:79-86.

George J, Dharanipragada K, Krishnamachari S, Chandrasekaran A, Sam SS, Sunder E. A single-nucleotide polymorphism in the MDR1 gene as a predictor of response to neoadjuvant chemotherapy in breast cancer. Clin Breast Cancer 2009; 9:161-5.

George J, Goodwin B, Liddle C, Tapner M, Farrell GC. Time-dependent expression of cytochrome P450 genes in primary cultures of well-differentiated human hepatocytes. J Lab Clin Med 1997; 129:638-48.

George J, Liddle C, Murray M, Byth K, Farrell GC. Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis. Biochem Pharmacol 1995; 49:873-81.

George S, Kasimis BS, Cogswell J et al. Phase I study of flavopiridol in combination with Paclitaxel and Carboplatin in patients with non-small-cell lung cancer. Clin Lung Cancer 2008; 9:160-5.

Geraudie P, Hinfray N, Gerbron M, Porcher JM, Brion F, Minier C. Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): Seasonal variations and impact of environmental contaminants. Aquat Toxicol 2011; 105:378-384.

Gerbal-Chaloin S, Pascussi JM, Pichard-Garcia L et al. Induction of CYP2C genes in human hepatocytes in primary culture. Drug Metab Dispos 2001; 29:242-51.

Gerbal-Chaloin S, Pichard-Garcia L, Fabre JM et al. Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide. Cell Signal 2006; 18:740-50.

Gerber JG, Rhodes RJ, Gal J. Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19. Chirality 2004; 16:36-44.

Gerber JG, Rosenkranz SL, Fichtenbaum CJ et al. Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 Study. J Acquir Immune Defic Syndr 2005; 39:307-12.

Gerdes LU, Gerdes C, Kervinen K et al. The apolipoprotein epsilon4 allele determines prognosis and the effect onprognosis of simvastatin in survivors of myocardial infarction: a substudy of the Scandinavian simvastatin survival study. Circulation 2000; 101:1366-71.

Gerger A, Hofmann G, Langsenlehner U et al. Integrin alpha-2 and beta-3 gene polymorphisms and colorectal cancer risk. Int J Colorectal Dis 2009; 24:159-63.

Gerhard T, Gong Y, Beitelshees AL et al. Alpha-adducin polymorphism associated with increased risk of adverse cardiovascular outcomes: results from GENEtic Substudy of the International VErapamil SR-trandolapril STudy (INVEST-GENES). Am Heart J 2008; 156:397-404.

Gerhardsson L, Lundh T, Minthon L, Londos E. Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer’s disease. Dement Geriatr Cogn Disord 2008; 25:508-15.

Gerk PM, Li W, Megaraj V, Vore M. Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate. J Pharmacol Exp Ther 2007; 320:893-9.

German P, Parikh S, Lawrence J et al. Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers. J Acquir Immune Defic Syndr 2009; 51:424-9.

Gerónimo-Pardo M, Cuartero-del-Pozo AB, Jiménez-Vizuete JM, Cortiñas-Sáez M, Peyró-García R. Clarithromycin-nifedipine interaction as possible cause of vasodilatory shock. Ann Pharmacother 2005; 39:538-42.

Gerr F, Frumkin H, Hodgins P. Hemolytic anemia following succimer administration in a glucose-6-phosphate dehydrogenase deficient patient. J Toxicol Clin Toxicol 1994; 32:569-75.

Gerretsen P, Pollock BG. Pharmacogenetics and the serotonin transporter in late-life depression. Expert Opin Drug Metab Toxicol 2008; 4:1465-78.

Gerritsen G, Rensen PC, Kypreos KE, Zannis VI, Havekes LM, Willems van Dijk K. ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression. J Lipid Res 2005; 46:1466-73.

Gerstenberg G, Aoshima T, Fukasawa T et al. Effects of the CYP 2D6 genotype and cigarette smoking on the steady-state plasma concentrations of fluvoxamine and its major metabolite fluvoxamino acid in Japanese depressed patients. Ther Drug Monit 2003; 25:463-8.

Gerstenblith MR, Goldstein AM, Fargnoli MC, Peris K, Landi MT. Comprehensive evaluation of allele frequency differences of MC1R variants across populations. Hum Mutat 2007; 28:495-505.

Gerstmann J, Straussler E, Scheinker I. Ueber eine eigenartige hereditaer-familiaere Erkrankung des Zentralnervensystems. Z Ges Neurol Psychiat 1936; 154:736-62.

Gervais F, Singajara R, Xanthoudakis S et al. Recruitment and activation of caspase-8 by the huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nat Cell Biol 2002; 4:95-105.

Gervais FG, Xu D, Robertson GS et al. Involvement of caspases in proteolytic claevage of Alzheimer’s amyloid-beta precursor protein and amyloidogenic A-beta peptide formation. Cell 1999; 97:395-406.

Gervasini G, García-Martín E, Ladero JM et al. Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients. BMC Cancer 2007; 7:118.

Gervasini G, Martínez C, Benítez J, Agúndez JA. Effect of neurotransmitters on NADPH-cytochrome P450 reductase in vitro activity. Drug Metab Lett 2007; 1:172-5.

Gervasini G, Vizcaino S, Carrillo JA, Caballero MJ, Benitez J. The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine: a pilot study. Br J Clin Pharmacol 2006; 62:177-86.

Gervasini G, Vizcaino S, Gasiba C, Carrillo JA, Benítez J. Differences in CYP3A5*3 genotype distribution and combinations with other polymorphisms between Spaniards and Other Caucasian populations. Ther Drug Monit 2005; 27:819-21.

Gerzenshtein L, Patel SM, Scarsi KK, Postelnick MJ, Flaherty JP. Breakthrough Candida infections in patients receiving voriconazole. Ann Pharmacother 2005; 39:1342-5.

Getachew Y, James L, Lee WM, Thiele DL, Miller BC. Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice. Biochem Pharmacol 2010; 79:1363-71.

Getz GS, Wool GD, Reardon CA. HDL apolipoprotein-related peptides in the treatment of atherosclerosis and other inflammatory disorders. Curr Pharm Des 2010; 16:3173-84.

Gewiese-Rabsch J, Drucker C, Malchow S, Scheller J, Rose-John S. Role of IL-6 trans-signaling in CCl4 induced liver damage. Biochim Biophys Acta 2010; 1802:1054-61.

Gex-Fabry M, Eap CB, Oneda B et al. CYP2D6 and ABCB1 genetic variability: influence on paroxetine plasma level and therapeutic response. Ther Drug Monit 2008; 30:474-82.

Ghaemmaghami S, Ahn M, Lessard P et al. Continuous quinacrine treatment results in the formation of drug-resistant prions. PLoS Pathog 2009. doi:10. 1371/journal. ppat. 1000673.

Ghahramani P, Ellis SW, Lennard MS, Ramsay LE, Tucker GT. Cytochromes P450 mediating the N-demethylation of amitriptyline. Br J Clin Pharmacol 1997; 43:137-44.

Ghai S, Monga R, Mohanty TK, Chauhan MS, Singh D. Tissue-specific promoter methylation coincides with Cyp19 gene expression in buffalo (Bubalus bubalis) placenta of different stages of gestation. Gen Comp Endocrinol 2010; 169:182-9.

Ghali JK, Koren MJ, Taylor JR et al. Efficacy and safety of oral conivaptan: a V1A/V2 vasopressin receptor antagonist, assessed in a randomized, placebo-controlled trial in patients with euvolemic or hypervolemic hyponatremia. J Clin Endocrinol Metab 2006; 91:2145-52.

Ghanem CI, Arias A, Novak A et al. Acetaminophen-induced stimulation of MDR1 expression and activity in rat intestine and in LS 174T human intestinal cell line. Biochem Pharmacol 2011; 81:244-50.

Ghanem CI, Ruiz ML, Villanueva SS et al. Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose. Biochem Pharmacol 2009; 77:1621-8.

Ghassabian S, Chetty M, Tattam BN et al. A high-throughput assay using liquid chromatography-tandem mass spectrometry for simultaneous in vivo phenotyping of 5 major cytochrome p450 enzymes in patients. Ther Drug Monit 2009; 31:239-46.

Ghebranious N, Mukesh B, Giampietro PF et al. A pilot study of gene/gene and gene/environment interactions in Alzheimer disease. Clin Med Res 2011; 9:17-25.

Ghebremedhin E, Schultz C, Thal DR et al. Gendet and age modify the association between APOE and AD-related neuropathology. Neurology 2001; 56:1696-701.

Ghelani AM, Samanta A, Jones AC, Mastana SS. Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom. Rheumatol Int 2011; 31:1355-61.

Ghilardi G, Biondi ML, Battaglioli L, Zambon A, Guagnellini E, Scorza R. Genetic risk factor characterizes abdominal aortic aneurysm from arterial occlusive disease in human beings: CCR5 Delta 32 deletion. J Vasc Surg 2004; 40:995-1000.

Ghirmai S, Azar MR, Cashman JR. Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation. Bioorg Med Chem 2009; 17:6671-81.

Ghobadi C, Gregory A, Crewe HK, Rostami-Hodjegan A, Lennard MS. CYP2D6 is primarily responsible for the metabolism of clomiphene. Drug Metab Pharmacokinet 2008; 23:101-5.

Ghodke Y, Joshi K, Patwardhan B. Traditional medicine to modern pharmacogenomics: Ayurveda Prakriti type and CYP2C19 gene polymorphism associated with the metabolic variability. Evid Based Complement Alternat Med 2009. doi:10. 1093/ecam/nep206.

Ghorbanihaghjo A, Veisi P, Argani H et al. Prevention of DNA damage in renal transplantation by losartan and enalapril: the role of renin-angiotensin system polymorphisms. Clin Exp Nephrol 2008; 12:65-73.

Ghosal A, Chowdhury SK, Gupta S et al. Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 351125, a CCR5 antagonist. Xenobiotica 2005; 35:405-17.

Ghosal A, Chowdhury SK, Tong W et al. Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar). Drug Metab Dispos 2006; 34:628-35.

Ghosal A, Gupta S, Ramanathan R et al. Metabolism of loratadine and further characterization of its in vitro metabolites. Drug Metab Lett 2009; 3:162-70.

Ghosal A, Hapangama N, Yuan Y et al. Rapid determination of enzyme activities of recombinant human cytochromes P450, human liver microsomes and hepatocytes. Biopharm Drug Dispos 2003; 24:375-84.

Ghosal A, Lu X, Penner N et al. Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist. Drug Metab Dispos 2011; 39:30-8.

Ghosal A, Ramanathan R, Yuan Y et al. Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist. Drug Metab Dispos 2007; 35:2186-95.

Ghosal A, Satoh H, Thomas PE, Bush E, Moore D. Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450. Drug Metab Dispos 1996; 24:940-7.

Ghosal A, Yuan Y, Hapangama N et al. Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine. Biopharm Drug Dispos 2004; 25:243-52.

Ghose R, Omoluabi O, Gandhi A et al. Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters. Life Sci 2011; 89:57-64.

Ghosh A, Hellewell JS. A review of the efficacy and tolerability of agomelatine in the treatment of major depression. Expert Opin Investig Drugs 2007; 16:1999-2004.

Ghosh AK, Bilcer G, Hong L, Koelsch G, Tang J. Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality. Curr Alzheimer Res 2007; 4:418-22.

Ghosh AK, Gemma S, Tang J. beta-Secretase as a therapeutic target for Alzheimer’s disease. Neurotherapeutics 2008; 5:399-408.

Ghosh C, Gonzalez-Martinez J, Hossain M et al. Pattern of P450 expression at the human blood-brain barrier: Roles of epileptic condition and laminar flow. Epilepsia 2010; 51:1408-17.

Ghosh D, Jiang W, Lo J, Egbuta C. Higher order organization of human placental aromatase. Steroids 2011; 76:753-8.

Ghosh J, Joshi G, Pradhan S, Mittal B. Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine. J Neurol 2010; 257:898-904.

Ghosh K, Shankarkumar U, Shetty S, Mohanty D. Chronic synovitis and HLA B27 in patients with severe haemophilia. Lancet 2003; 361:933-4.

Ghosh M, Wang H, Ai Y et al. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. J Exp Med 2007; 204:2053-61.

Ghotbi R, Gomez A, Milani L et al. Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers. Pharmacogenomics J 2009; 9:208-17.

Ghotbi R, Mannheimer B, Aklillu E et al. Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure-an impact similar to male gender or smoking in schizophrenic patients. Eur J Clin Pharmacol 2010; 66:465-74.

Giacobini E. Cholinesterases and cholinesterase inhibitors. Martin Dunitz, London, 2000.

Giacobini E. Cholinesterases in human brain: the effect of cholinesterase inhibitors on Alzheimer’s disease and related disorders. In Giacobini E, Pepeu G (Eds). The Brain Cholinergic System in Health and Disease. Oxon: Healthcare 2006; 235-64.

Giantin M, Carletti M, Capolongo F et al. Effect of breed upon cytochromes P450 and phase II enzyme expression in cattle liver. Drug Metab Dispos 2008; 36:885-93.

Giantin M, Lopparelli RM, Zancanella V et al. Effects of illicit dexamethasone upon hepatic drug metabolizing enzymes and related transcription factors mRNAs and their potential use as biomarkers in cattle. J Agric Food Chem 2010; 58:1342-9.

Giao PT, de Vries PJ. Pharmacokinetic interactions of antimalarial agents. Clin Pharmacokinet 2001; 40:343-73.

Giasson BI, Forman MS, Higuchi M et al. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 2003; 300:636-40.

Gibbons AS, Udawela M, Jeon WJ, Seo MS, Brooks L, Dean B. The neurobiology of APOE in schizophrenia and mood disorders. Front Biosci 2011; 16:962-79.

Gibbs MA, Baillie MT, Shen DD, Kunze KL, Thummel KE. Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells. Pharm Res 2000; 17:299-305.

Gibbs MA, Thummel KE, Shen DD, Kunze KL. Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression. Drug Metab Dispos 1999; 27:180-7.

Gibson AW, Edberg JC, Wu J, Westendorp RG, Huizinga TW, Kimberly RP. Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus. J Immunol 2001; 166:3915-22.

Gibson GG, el-Sankary W, Plant NJ. Receptor-dependent regulation of the CYP3A4 gene. Toxicology 2002; 181-182:199-202.

Gibson GG, Plant NJ, Swales KE, Ayrton A, El-Sankary W. Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. Xenobiotica 2002; 32:165-206.

Giegling I, Moreno-de-Luca D, Calati R et al. Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits. Neuropsychobiology 2009; 59:23-7.

Giera S, Bansal R, Ortiz-Toro TM, Taub DG, Zoeller RT. Individual polychlorinated biphenyl (PCB) congenersp produce tissue- and gene-specific effects on thyroid hormone signaling during development. Endocrinology 2011; 152:2909-19.

Giessmann T, May K, Modess C et al. Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans. Clin Pharmacol Ther 2004; 76:192-200.

Giessmann T, Modess C, Hecker U et al. CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects. Clin Pharmacol Ther 2004; 75:213-22.

Gietl A, Giegling I, Hartmann AM et al. ABCG1 gene variants in suicidal behavior and aggression-related traits. Eur Neuropsychopharmacol 2007; 17:410-6.

Gigante PR, Kotchetkov IS, Kellner CP et al. Polymorphisms in complement component 3 (C3F) and complement factor H (Y402H) increase the risk of postoperative neurocognitive dysfunction following carotid endarterectomy. J Neurol Neurosurg Psychiatry 2011; 82:247-53.

Gil Berglund E, Johannsson G, Beck O, Bengtsson BA, Rane A. Growth hormone replacement therapy induces codeine clearance. Eur J Clin Invest 2002; 32:507-12.

Gil JP. Amodiaquine pharmacogenetics. Pharmacogenomics 2008; 9:1385-90.

Gilardi F, Mitro N, Godio C et al. The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol. Pharmacol Ther 2007; 116:449-72.

Gilardi F, Viviani B, Galmozzi A et al. Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling. Neuroscience 2009; 164:530-40.

Gilbert AM, Bursavich MG, Lombardi S et al. N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorg Med Chem Lett 2008; 18:6454-7.

Gilbert JA, Salavaggione OE, Ji Y et al. Gemcitabine pharmacogenomics: cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomics. Clin Cancer Res 2006; 12:1794-803.

Gilbert SM, Benson MC, McKiernan JM. Linkage disequilibrium between the androgen receptor gene CAG and GGC repeats in the African-American population. Curr Urol Rep 2002; 3:189-93.

Gildea JJ, Wang X, Jose PA, Felder RA. Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor. Hypertension 2008; 51:360-6.

Gilep AA, Guryev OL, Usanov SA, Estabrook RW. An enzymatically active chimeric protein containing the hydrophilic form of NADPH-cytochrome P450 reductase fused to the membrane-binding domain of cytochrome b5. Biochem Biophys Res Commun 2001; 284:937-41.

Gilep AA, Guryev OL, Usanov SA, Estabrook RW. Apo-cytochrome b5 as an indicator of changes in heme accessability: preliminary studies with cytochrome P450 3A4. J Inorg Biochem 2001; 87:237-44.

Gilep AA, Guryev OL, Usanov SA, Estabrook RW. Reconstitution of the enzymatic activities of cytochrome P450s using recombinant flavocytochromes containing rat cytochrome b(5) fused to NADPH-cytochrome P450 reductase with various membrane-binding segments. Arch Biochem Biophys 2001; 390:215-21.

Gilmer TM, Cable L, Alligood K et al. Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib. Cancer Res 2008; 68:571-9.

Gilot D, Le Meur N, Giudicelli F et al. RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity. PLoS One 2011. doi:10. 1371/journal. pone. 0018261.

Gill HJ, Tingle MD, Park BK. N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity. Br J Clin Pharmacol 1995; 40:531-8.

Gill RM, Lee TH, Utter GH et al. The TNF (-308A) polymorphism is associated with microchimerism in transfused trauma patients. Blood 2008; 111:3880-3.

Gillespie JR, Ulici V, Dupuis H et al. Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression. Endocrinology 2011; 152:1755-66.

Gillies GE, McArthur S. Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines. Pharmacol Rev 2010; 62:155-98.

Gillman PK. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol 2007; 151:737-48.

Gillum JG, Israel DS, Polk RE. Pharmacokinetic drug interactions with antimicrobial agents. Clin Pharmacokinet 1993; 25:450-82.

Ginguené C, Champier J, Maallem S et al. P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) localize in the microvessels forming the blood-tumor barrier in ependymomas. Brain Pathol 2010; 20:926-35.

Ginosar Y, Davidson EM, Meroz Y, Blotnick S, Shacham M, Caraco Y. Mu-opioid receptor (A118G) single-nucleotide polymorphism affects alfentanil requirements for extracorporeal shock wave lithotripsy: a pharmacokinetic-pharmacodynamic study. Br J Anaesth 2009; 103:420-7.

Giordano C, Pichiorri F, Blakely EL et al. Isolated distal myopathy of the upper limbs associated with mitochondrial DNA depletion and polymerase gamma mutations. Arch Neurol 2010; 67:1144-6.

Giordano C, Powell H, Leopizzi M et al. Fatal congenital myopathy and gastrointestinal pseudo-obstruction due to POLG1 mutations. Neurology 2009; 72:1103-5.

Giovannetti E, Erdem L, Olcay E, Leon LG, Peters GJ. Influence of polymorphisms on EGFR targeted therapy in non-small-cell lung cancer. Front Biosci 2011; 16:116-30.

Giovannetti E, Mey V, Nannizzi S, Pasqualetti G, del Tacca M, Danesi R. Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer. Mol Cancer Ther 2006; 5:1387-95.

Giovannucci E, Stampfer MJ, Krithivas K et al. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci U S A 1997; 94:3320-3.

Girard H, Court MH, Bernard O et al. Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver. Pharmacogenetics 2004; 14:501-15.

Girard H, Levesque E, Bellemare J, Journault K, Caillier B, Guillemette C. Genetic diversity at the UGT1 locus is amplified by a novel 3-prime alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity. Pharmacogenet Genomics 2007; 17:1077-89.

Girard H, Villeneuve L, Court MH et al. The novel UGT1A9 intronic I399 polymorphism appears as a predictor of 7-ethyl-10-hydroxycamptothecin glucuronidation levels in the liver. Drug Metab Dispos 2006; 34:1220-8.

Girardin F, Pechère-Bertschi A. Antihypertensive therapy and drug-drug interactions. Rev Med Suisse 2005; 1:2099-100, 2102-4.

Giraud C, Manceau S, Treluyer JM. ABC transporters in human lymphocytes: expression, activity and role, modulating factors and consequences for antiretroviral therapies. Expert Opin Drug Metab Toxicol 2010; 6:571-89.

Giraud C, Tran A, Rey E, Vincent J, Tréluyer JM, Pons G. In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab Dispos 2004; 32:1279-86.

Giraud C, Treluyer JM, Rey E et al. In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism. Drug Metab Dispos 2006; 34:608-11.

Giraud M, Vandiedonck C, Garchon HJ. Genetic factors in autoimmune myasthenia gravis. Ann N Y Acad Sci 2008; 1132:180-92.

Girelli D, Russo C, Ferraresi P et al. Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease. N Engl J Med 2000; 343:774-80.

Girennavar B, Jayaprakasha GK, Jadegoud Y, Nagana Gowda GA, Patil BS. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorg Med Chem 2007; 15:3684-91.

Girennavar B, Jayaprakasha GK, Patil BS. Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins. J Food Sci 2007; 72:417-21.

Girennavar B, Poulose SM, Jayaprakasha GK, Bhat NG, Patil BS. Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes. Bioorg Med Chem 2006; 14:2606-12.

Girish C, Manikandan S. Aprepitant: a substance P antagonist for chemotherapy induced nausea and vomiting. Indian J Cancer 2007; 44:25-30.

Girolami F, Spalenza V, Carletti M et al. Gene expression and inducibility of the aryl hydrocarbon receptor-dependent pathway in cultured bovine blood lymphocytes. Toxicol Lett 2011; 206:204-9.

Gisbert JP, Gomollón F, Cara C et al. Thiopurine methyltransferase activity in Spain: a study of 14,545 patients. Dig Dis Sci 2007; 5:1262-9.

Giubergia V, Gravina LP, Castaños C, Chertkoff L, Grenoville M. Influence of beta2-adrenoceptor polymorphisms on the response to chronic use of albuterol in asthmatic children. Pediatr Pulmonol 2008; 43:421-5.

Giuffre’ I. Molecular analysis of Italian patients with congenital glaucoma. Ophthalmic Genet 2011. doi:10. 3109/13816810. 2011. 596891.

Giusti B, Gori AM, Marcucci R et al. Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients. Pharmacogenet Genomics 2007; 17:1057-64.

Giusti B, Gori AM, Marcucci R, Abbate R. Relation of CYP2C19 loss-of-function polymorphism to the occurrence of stent thrombosis. Expert Opin Drug Metab Toxicol 2010; 6:393-407.

Giusti B, Saracini C, Bolli P et al. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. J Med Genet 2008; 45:721-30.

Givan S, Sprague G. The ankyrin-repeat containing protein Akr1p is required for the endocytosis of yeast pheromone receptors. Molec Biol Cell 1997; 8:1317-27.

Giwercman A, Rylander L, Rignell-Hydbom A et al. Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. Pharmacogenet Genomics 2007; 17:391-401.

Gizatullin R, Zaboli G, Jönsson EG, Asberg M, Leopardi R. Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression. Biol Psychiatry 2006; 59:295-300.

Gizer IR, Ficks C, Waldman ID. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 2009; 126:51-90.

Gjerde J, Hauglid M, Breilid H et al. Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Ann Oncol 2008; 19:56-61.

Gjesing AP, Andersen G, Albrechtsen A et al. Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects. Diabet Med 2007; 24:392-7.

Gjesing AP, Andersen G, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O. Association of the beta3-adrenergic receptor Trp64Arg polymorphism with common metabolic traits: studies of 7605 middle-aged white people. Mol Genet Metab 2008; 94:90-7.

Gjesing AP, Sparsø T, Borch-Johnsen K et al. No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes. PLoS One 2009. doi:10. 1371/journal. pone. 0007206.

Gladding P, Webster M, Zeng I et al. The pharmacogenetics and pharmacodynamics of clopidogrel response: an analysis from the PRINC (Plavix Response in Coronary Intervention) trial. JACC Cardiovasc Interv 2008; 1:620-7.

Glaeser H, Bailey DG, Dresser GK et al. Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther 2007; 81:362-70.

Glaeser H, Drescher S, Eichelbaum M, Fromm MF. Influence of rifampicin on the expression and function of human intestinal cytochrome P450 enzymes. Br J Clin Pharmacol 2005; 59:199-206.

Glaeser H, Drescher S, Hofmann U et al. Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans. Clin Pharmacol Ther 2004; 76:230-8.

Glaeser H, Drescher S, van der Kuip H et al. Shed human enterocytes as a tool for the study of expression and function of intestinal drug-metabolizing enzymes and transporters. Clin Pharmacol Ther 2002; 71:131-40.

Glaser B. Familial Hyperinsulinism (FHI). In: Pagon RA, Bird TC, Dolan CR, Stephens K (Eds). GeneReviews. University of Washington, Seattle, 1993-2003. Available from: http://www. ncbi. nlm. nih. gov/books/NBK1375/

Glasgow SC, Yu J, Carvalho LP, Shannon WD, Fleshman JW, McLeod HL. Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. Br J Cancer 2005; 92:259-64.

Glatt H. Sulfotransferases in the bioactivation of xenobiotics. Chem Biol Interact 2000; 129:141-70.

Glatt SJ, Bousman C, Wang RS et al. Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis. Drug Alcohol Depend 2007; 90:159-65.

Gleeson MP, Davis AM, Chohan KK et al. Generation of in-silico cytochrome P450 1A2, 2C9, 2C19, 2D6, and 3A4 inhibition QSAR models. J Comput Aided Mol Des 2007; 21:559-73.

Gleiter CH, Mörike KE. Clinical pharmacokinetics of candesartan. Clin Pharmacokinet 2002; 41:7-17.

Glenner GG, Wong CW. Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984; 120:885-90.

Glessner JT, Wang K, Cai G et al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 2009; 459:569-73.

Glimelius B, Garmo H, Berglund A et al. Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. Pharmacogenomics J 2011; 11:61-71.

Glöckner F, Meske V, Lütjohann D, Ohm TG. Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice. J Neuropathol Exp Neurol 2011; 70:292-301.

Glockner F, Ohn TG. Hippocampal apolipoprotein D level depends on Braak stage and APOE genotype. Neuroscience 2003; 122:103-10.

Gloria-Bottini F, Magrini A, Cozzoli E, Bergamaschi A, Bottini E. ADA genetic polymorphism and the effect of smoking on neonatal bilirubinemia and developmental parameters. Early Hum Dev 2008; 84:739-43.

Gloria-Bottini F, Ronchetti F, Ammendola L, Bottini N. Adenosine deaminase polymorphism and the relationship of total immunoglobulin E with skin prick test: a study on school children. Allergy Asthma Proc 2006; 27:115-8.

Glossop JR, Dawes PT, Nixon NB, Mattey DL. Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis. Arthritis Res Ther 2005; 7:1227-34.

Glover DD, McRobie DJ, Tracy TS. Effects of gestational and overt diabetes on placental cytochromes P450 and glutathione S-transferase. Prim Care Update Ob Gyns 1998; 5:189.

Glowacka D, Loesch C, Johnson KT et al. The T393C polymorphism of the Galphas gene (GNAS1) is associated with the course of Graves’ disease. Horm Metab Res 2009; 41:430-5.

Główka F, Karaźniewicz-Łada M, Grześkowiak E, Rogozinska D, Romanowski W. Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis. Eur J Drug Metab Pharmacokinet 2011; 36:167-73.

Gloyn AL, Diatloff-Zito C, Edghill EL et al. KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features. Eur J Hum Genet 2006; 14:824-30.

Gloyn AL, Hashim Y, Ashcroft SJ et al. Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6. 2 with Type 2 diabetes mellitus (UKPDS 53). Diabet Med 2001; 18:206-12.

Gloyn AL, Weedon MN, Owen KR et al. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6. 2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 2003; 52:568-72.

Gluba A, Banach M, Mikhailidis DP, Rysz J. Genetic determinants of cardiovascular disease: the renin-angiotensin-aldosterone system, paraoxonases, endothelin-1, nitric oxide synthase and adrenergic receptors. In Vivo 2009; 23:797-812.

Glück S, Gorouhi F. Clinical and economic benefits of aromatase inhibitor therapy in early-stage breast cancer. Am J Health Syst Pharm 2011; 68:1699-706.

Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK, Levy RH. Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. Clin Pharmacokinet 1997; 33:214-24.

Glukhov AV, Flagg TP, Fedorov VV, Efimov IR, Nichols CG. Differential K(ATP) channel pharmacology in intact mouse heart. J Mol Cell Cardiol 2010; 48:152-60.

Glynn SA, Boersma BJ, Howe TM et al. A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide. Clin Cancer Res 2009; 15:4165-73.

Gnerre C, Blättler S, Kaufmann MR, Looser R, Meyer UA. Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. Pharmacogenetics 2004; 14:635-45.

Gnewuch C, Liebisch G, Langmann T et al. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. World J Gastroenterol 2009; 15:3134-41.

Gnoth MJ, Buetehorn U, Muenster U, Schwarz T, Sandmann S. In vitro and in vivo P-glycoprotein transport characteristics of rivaroxaban. J Pharmacol Exp Ther 2011; 338:372-80.

Gnoth MJ, Sandmann S, Engel K, Radtke M. In vitro to in vivo comparison of the substrate characteristics of sorafenib tosylate toward P-glycoprotein. Drug Metab Dispos 2010; 38:1341-6.

Goard CA, Mather RG, Vinepal B et al. Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents. Int J Cancer 2010; 127:2936-48.

Goate A, Chartier-Harlin M-C, Mullan M et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature 1991; 349:704-6.

Gobbi S, Zimmer C, Belluti F et al. Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem 2010; 53:5347-51.

Goda K, Bacsó Z, Szabó G. Multidrug resistance through the spectacle of P-glycoprotein. Curr Cancer Drug Targets 2009; 9:281-97.

Goda R, Nagai D, Akiyama Y et al. Detection of a new N-oxidized metabolite of flutamide, N-[4-nitro-3-(trifluoromethyl)phenyl]hydroxylamine, in human liver microsomes and urine of prostate cancer patients. Drug Metab Dispos 2006; 34:828-35.

Godard-Codding CA, Clark R, Fossi MC et al. Pacific Ocean-wide profile of CYP1A1 expression, stable carbon and nitrogen isotope ratios, and organic contaminant burden in sperm whale skin biopsies. Environ Health Perspect 2011; 119:337-43.

Godawska-Matysik A, Kieć-Kononowicz K. Biotransformation of praziquantel by human cytochrome p450 3A4 (CYP 3A4). Acta Pol Pharm 2006; 63:381-5.

Godbillon J, Richard J, Gerardin A, Meinertz T, Kasper W, Jähnchen E. Pharmacokinetics of the enantiomers of acenocoumarol in man. Br J Clin Pharmacol 1981; 12:621-9.

Godin C, Auclair A, Ferland M, Hebert SS, Carreau M, Levesque G. Presenilin-1 is indirectly implicated in Notch1 cleavage. Neuroreport 2003; 14:1613-6.

Godin N, Liu F, Lau GJ et al. Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice. Kidney Int 2010; 77:1086-97.

Godlewska BR, Olajossy-Hilkesberger L, Ciwoniuk M et al. Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene. Pharmacogenomics J 2009; 9:234-41.

Godoy W, Albano RM, Moraes EG et al. CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism. Carcinogenesis 2002; 23:611-6.

Gödtel-Armbrust U, Metzger A, Kroll U, Kelber O, Wojnowski L. Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John’s wort. Naunyn Schmiedebergs Arch Pharmacol 2007; 375:377-82.

Goecke TW, Ekici AB, Niesler B et al. Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. Acta Obstet Gynecol Scand 2010; 89:7-14.

Goedde HW, Agarwal DP, Fritze G et al. Distribution of ADH-2 and ALDH2 genotypes in different populations. Hum Genet 1992; 88:344-6.

Goedert M, Crowther RA, Spillantini MG. Tau mutations cause frontotemporal dementias. Neuron 1998; 21:955-8.

Goedert M, Spillantini MG, Crowther RA et al. Tau gene mutation in familial progressive subcortical gliosis. Nat Medicine 1999; 5:454-7.

Goedert M, Spillantini MG, Potier MC, Ulrich J, Crowther RA. Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J 1989; 8:393-9.

Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer’s disease: identification as the microtubule-associated protein tau. Proc Nat Acad Sci USA 1988; 85:4051-5.

Goekkurt E, Hoehn S, Wolschke C et al. Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)-novel predictors for response and survival in gastric cancer patients. Br J Cancer 2006; 94:281-6.

Goekkurt E, Stoehlmacher J, Stueber C et al. Pharmacogenetic analysis of liver toxicity after busulfan/cyclophosphamide-based allogeneic hematopoietic stem cell transplantation. Anticancer Res 2007; 27:4377-80.

Goel S, Cohen M, Cömezoglu SN et al. The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development. Clin Cancer Res 2008; 14:2701-9.

Goel VK, Ibrahim N, Jiang G et al. Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice. Oncogene 2009; 28:2289-98.

Goetz AK, Dix DJ. Toxicogenomic effects common to triazole antifungals and conserved between rats and humans. Toxicol Appl Pharmacol 2009; 238:80-9.

Goetz MP, Rae JM, Suman VJ et al. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 2005; 23:9312-8.

Goetz MP, Schaid DJ, Wickerham DL et al. Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: Results from the NSABP P-1 and P-2 clinical trials. Clin Cancer Res 2011. doi:10. 1158/1078-0432. CCR-11-0860.

Goetz MP, Suman VJ, Couch FJ et al. Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance. Clin Cancer Res 2008; 14:5864-8.

Goetz MP, Suman VJ, Ingle JN et al. A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. Clin Cancer Res 2006; 12:2080-7.

Goh BC, Lee SC, Wang LZ et al. Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies. J Clin Oncol 2002; 20:3683-90.

Goh BC, Reddy NJ, Dandamudi UB et al. An evaluation of the drug interaction potential of pazopanib, an oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, using a modified Cooperstown 5+1 cocktail in patients with advanced solid tumors. Clin Pharmacol Ther 2010; 88:652-9.

Gohin M, Bodinier P, Fostier A, Bobe J, Chesnel F. Aromatase expression in Xenopus oocytes: a three cell-type model for the ovarian estradiol synthesis. J Mol Endocrinol 2011; 47:241-50.

Gökalp O, Gunes A, Cam H et al. Mild hypoglycaemic attacks induced by sulphonylureas related to CYP2C9, CYP2C19 and CYP2C8 polymorphisms in routine clinical setting. Eur J Clin Pharmacol 2011. doi:10. 1007/s00228-011-1078-4.

Gökbuget N, Hoelzer D. Treatment of adult acute lymphoblastic leukemia. Semin Hematol 2009; 46:64-75.

Gołab-Janowska M, Honczarenko K, Gawrońska-Szklarz B, Potemkowski A. CYP2D6 gene polymorphism as a probable risk factor for Alzheimer’s disease and Parkinson’s disease with dementia. Neurol Neurochir Pol 2007; 41:113-21.

Gold LS, de Roos AJ, Brown EE et al. Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma. Cancer Epidemiol 2009; 33:276-80.

Goldberg RJ. Antidepressant use in the elderly. Current status of nefazodone, venlafaxine and moclobemide. Drugs Aging 1997; 11:119-31.

Goldberg RM, Niedzwiecki D, Bertagnolli M, Blackstock AW, Tepper JE, Mayer RJ. Cancer and leukemia group B gastrointestinal cancer committee. Clin Cancer Res 2006; 12:3589-95.

Goldberg Y, Nicholson D, Rasper D et al. Cleavage of huntingtin by apopain, a propoptotic cysteine protease, is modulated by the polyglutamine tract. Nat Genet 1996; 13:442-9.

Goldenberg MM. Safety and efficacy of sildenafil citrate in the treatment of male erectile dysfunction. Clin Ther 1998; 20:1033-48.

Goldenstein BL, Nelson BW, Xu K et al. Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity. Mol Pharmacol 2009; 75:1222-30.

Goldfarb LG, Brown P, Haltia M et al. Creutzfeldt-Jakob disease cosegregates with the codon 178-asn PRNP mutation in families of European origin. Ann Neurol 1992; 31:274-81.

Goldfarb LG, Brown P, McCombie WR et al. Transmissible familial Creatzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene. Proc Nat Acad Sci USA 1991; 88:10926-30.

Goldgaber D, Goldfarb LG, Brown P et al. Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Straussler-Scheinker’s syndrome. Exp Neurol 1989; 106:204-6.

Goldman FD, Ballas ZK, Schutte BC et al. Defective expression of p56lck in an infant with severe combined immunodeficiency. J Clin Invest 1998; 102:421-9.

Goldschmidt N, Azaz-Livshits T, Gotsman, Nir-Paz R, Ben-Yehuda A, Muszkat M. Compound cardiac toxicity of oral erythromycin and verapamil. Ann Pharmacother 2001; 35:1396-9.

Goldstein AM. Familial melanoma, pancreatic cancer and germline CDKN2A mutations. Hum Mutat 2004; 23:630.

Goldstein AM, Chidambaram A, Halpern A et al. Rarity of CDK4 germline mutations in familial melanoma. Melanoma Res 2002; 12:51-5.

Goldstein FC, Ashley AV, Gearing M et al. Apolipoprotein E and age onset of Alzheimer’s disease in African American patients. Neurology 2001; 57:1923-5.

Goldstein JA, Blaisdell JA, Limdi NA. A potentially deleterious new CYP2C9 polymorphism identified in an African American patient with major hemorrhage on warfarin therapy. Blood Cells Mol Dis 2009; 42:155-8.

Goldstone JV, McArthur AG, Kubota A et al. Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish. BMC Genomics 2010; 11:643.

Goldwasser J, Cohen PY, Yang E, Balaguer P, Yarmush ML, Nahmias Y. Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha. PLoS One 2010. doi:10. 1371/journal. pone. 0012399.

Goldwater DR, Dougherty C, Schumacher M, Villano SA. Effect of ketoconazole on the pharmacokinetics of maribavir in healthy adults. Antimicrob Agents Chemother 2008; 52:1794-8.

Goler-Baron V, Assaraf YG. Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistance. PLoS One 2011. doi:10. 1371/journal. pone. 0016007.

Golovleva I, Biasotto M, Verpy E et al. Novel variants of human IFN-alpha detected in tumor cell lines and biopsy specimens. J Interferon Cytokine Res 1997; 17:637-45.

Golledge J, Biros E, Warrington N et al. A population-based study of polymorphisms in genes related to sex hormones and abdominal aortic aneurysm. Eur J Hum Genet 2011; 19:363-6.

Gomaa MS, Simons C, Brancale A. Homology model of 1alpha,25-dihydroxyvitamin D3 24-hydroxylase cytochrome P450 24A1 (CYP24A1): active site architecture and ligand binding. J Steroid Biochem Mol Biol 2007; 104:53-60.

Gomaa MS, Yee SW, Milbourne CE, Barbera MC, Simons C, Brancale A. Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding. J Enzyme Inhib Med Chem 2006; 21:361-9.

Gomes KB, Fernandes AP, Ferreira ACS et al. Mutations in the seipin and AGPAT2 genes clustering in consanguineous families with Berardinelli-Seip congenital lipodystrophy from two separate geographical regions of Brazil. J Clin Endocr Metab 2004; 89:357-61.

Gomes KB, Pardini VC, Ferreira AC, Fernandes AP. Phenotypic heterogeneity in biochemical parameters correlates with mutations in AGPAT2 or Seipin genes among Berardinelli-Seip congenital lipodystrophy patients. J Inherit Metab Dis 2005; 28:1123-31.

Gomes LG, Huang N, Agrawal V, Mendonça BB, Bachega TA, Miller WL. Extraadrenal 21-hydroxylation by CYP2C19 and CYP3A4: effect on 21-hydroxylase deficiency. J Clin Endocrinol Metab 2009; 94:89-95.

Gomez CF, Constantine L, Moen M, Vaz A, Wang W, Huggett DB. Ibuprofen metabolism in the liver and gill of rainbow trout, Oncorhynchus mykiss. Bull Environ Contam Toxicol 2011; 86:247-51.

Gómez de Barreda E, Pérez M, Gómez Ramos P et al. Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis 2010; 37:622-9.

Gómez-Lechón MJ, Donato T, Jover R et al. Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2. Eur J Biochem 2001; 268:1448-59.

Gómez-Reino JJ, Pablos JL, Carreira PE et al. Association of rheumatoid arthritis with a functional chemokine receptor, CCR5. Arthritis Rheum 1999; 42:989-92.

Gomez-Rubio P, Meza-Montenegro MM, Cantu-Soto E, Klimecki WT. Genetic association between intronic variants in AS3MT and arsenic methylation efficiency is focused on a large linkage disequilibrium cluster in chromosome 10. J Appl Toxicol 2010; 30:260-70.

Gomez-Sanchez JC, Delgado-Esteban M, Rodriguez-Hernandez I et al. The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke. J Exp Med 2011; 208:429-37.

Gomis R. Repaglinide as monotherapy in type 2 diabetes. Exp Clin Endocrinol Diabetes 1999; 107 Suppl 4:133-5.

Gong H, Guo P, Zhai Y et al. Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor. Mol Endocrinol 2007; 21:1781-90.

Gong H, Jarzynka MJ, Cole TJ et al. Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase. Cancer Res 2008; 68:7386-93.

Gong IY, Tirona RG, Schwarz UI et al. Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy. Blood 2011; 118:3163-71.

Gong P, Cederbaum AI, Nieto N. Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway. J Biol Chem 2003; 278:29693-700.

Gong QH, Cho JW, Huang T et al. Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics 2001; 11:357-68.

Gong R, Liu Z, Li L. Epistatic effect of plasminogen activator inhibitor 1 and beta-fibrinogen genes on risk of glomerular microthrombosis in lupus nephritis: interaction with environmental/clinical factors. Arthritis Rheum 2007; 56:1608-17.

Gong X, Schwartz PH, Linskey ME, Bota DA. Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy. Neurology 2011; 76:1126-34.

Gongadze N, Kezeli T, Antelava N. Prolong QT interval and “torsades de pointes” associated with different group of drugs. Georgian Med News 2007; 12:45-9.

Gonias SL, Lysiak JJ, Umans L, van Leuven F, Webb DJ, Wen J. Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis: a possible mechanism for the endotoxin insensitivity of the alpha-2-macroglobulin gene knock-out mouse. J Biol Chem 1996; 271:24982-88.

Gonsorcikova L, Vaxillaire M, Pruhova S et al. Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations. Pediatr Diabetes 2011; 12:266-9.

Gontero P, Sargent JM, Hopster DJ et al. Ex vivo chemosensitivity to mitomycin C in bladder cancer and its relationship with P-glycoprotein and apoptotic factors. Anticancer Res 2002; 22:4073-80.

González A, Alvarez-García V, Martínez-Campa C, Alonso-González C, Cos S. Melatonin promotes differentiation of 3T3-L1 fibroblasts. J Pineal Res 2011. doi:10. 1111/j. 1600-079X. 2011. 00911. x.

González Della Valle A, Khakharia S, Glueck CJ et al. VKORC1 variant genotypes influence warfarin response in patients undergoing total joint arthroplasty: a pilot study. Clin Orthop Relat Res 2009; 467:1773-80.

Gonzalez FJ. Role of gene knockout and transgenic mice in the study of xenobiotic metabolism. Drug Metab Rev 2003; 35:319-35.

Gonzalez FJ. Cytochrome P450 humanised mice. Hum Genomics 2004; 1:300-6.

Gonzalez FJ. CYP3A4 and pregnane X receptor humanized mice. J Biochem Mol Toxicol 2007; 21:158-62.

González HM, Romero EM, Chavez Tde J, Peregrina AA, Quezada V, Hoyo-Vadillo C. Phenotype of CYP2C19 and CYP3A4 by determination of omeprazole and its two main metabolites in plasma using liquid chromatography with liquid-liquid extraction. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 780:459-65.

González HM, Romero EM, Peregrina AA et al. CYP2C19- and CYP3A4-dependent omeprazole metabolism in West Mexicans. J Clin Pharmacol 2003; 43:1211-5.

González I, Peñas-Lledó EM, Pérez B, Dorado P, Álvarez M, Llerena A. Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers. Pharmacogenomics 2008; 9:833-40.

Gonzalez MC, Marteau C, Franchi J, Migliore-Samour D. Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation. Br J Dermatol 2001; 145:749-57.

González P, Alvarez R, Batalla A et al. Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction. Genes Immun 2001; 2:191-5.

González R, Collado JA, Nell S et al. Cytoprotective properties of alpha-tocopherol are related to gene regulation in cultured D-galactosamine-treated human hepatocytes. Free Radic Biol Med 2007; 43:1439-52.

González R, Cruz A, Ferrín G et al. Cytoprotective properties of rifampicin are related to the regulation of detoxification system and bile acid transporter expression during hepatocellular injury induced by hydrophobic bile acids. J Hepatobiliary Pancreat Sci 2011; 18:740-50.

González R, Cruz A, Ferrín G et al. Nitric oxide mimics transcriptional and post-translational regulation during α-Tocopherol cytoprotection against glycochenodeoxycholate-induced cell death in hepatocytes. J Hepatol 2011; 55:133-44.

González Sánchez JL, Proenza AM, Martínez Larrad MT et al. The glutamine 27 glutamic acid polymorphism of the beta2-adrenoceptor gene is associated with abdominal obesity and greater risk of impaired glucose tolerance in men but not in women: a population-based study in Spain. Clin Endocrinol 2003; 59:476-81.

Gonzalez-Covarrubias V, Ghosh D, Lakhman SS, Pendyala L, Blanco JG. A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity. Drug Metab Dispos 2007; 35:973-80.

Gonzalez-Covarrubias V, Zhang J, Kalabus JL, Relling MV, Blanco JG. Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors. Drug Metab Dispos 2009; 37:400-7.

Gonzalez-Gay MA, Garcia-Porrua C, Hajeer AH. Influence of human leukocyte antigen-DRB1 on the susceptibility and severity of rheumatoid arthritis. Semin Arthritis Rheum 2002; 31:355-60.

Gonzalez-Haba E, García MI, Cortejoso L et al. ABCB1 gene polymorphisms are associated with adverse reactions in fluoropyrimidine-treated colorectal cancer patients. Pharmacogenomics 2010; 11:1715-23.

Gonzalez-Herrera L, Martín Cerda-Flores R, Luna-Rivero M et al. Paraoxonase 1 polymorphisms and haplotypes and the risk for having offspring affected with spina bifida in Southeast Mexico. Birth Defects Res A Clin Mol Teratol 2010; 88:987-94.

González-Lobato L, Real R, Prieto JG, Álvarez AI, Merino G. Differential inhibition of murine Bcrp1/Abcg2 and human BCRP/ABCG2 by the mycotoxin fumitremorgin C. Eur J Pharmacol 2010; 644:41-8.

González-Navajas JM, Fine S, Law J et al. TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J Clin Invest 2010; 120:570-81.

González-Tejera G, Gaedigk A, Corey S. Genetic variants of the drug-metabolizing enzyme CYP2D6 in Puerto Rican psychiatry patients: a preliminary report and potential implications for breast cancer patients. P R Health Sci J 2010; 29:299-304.

González-Zuloeta Ladd AM, Arias Vásquez A, Siemes C et al. Differential roles of Angiotensinogen and Angiotensin Receptor type 1 polymorphisms in breast cancer risk. Breast Cancer Res Treat 2007; 101:299-304.

Goodarzi MO, Guo X, Taylor KD et al. Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans. Genet Med 2003; 5:322-7.

Goode BL, Chau M, Denis PE, Feinstein SC. Structural and functional differences between 3-repeat and 4-repeat tau isoforms: implications for normal tau function and the onset of neurodegenerative disease. J Biol Chem 2000; 275:38182-9.

Goode EL, Fridley BL, Vierkant RA et al. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. Cancer Epidemiol Biomarkers Prev 2009; 18:935-44.

Goode EL, Potter JD, Bigler J, Ulrich CM. Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev 2004; 13:157-62.

Goode EL, White KL, Vierkant RA et al. Xenobiotic-metabolizing gene polymorphisms and ovarian cancer risk. Mol Carcinog 2011; 50:397-402.

Goodman CS, Coulam CB, Jeyendran RS, Acosta VA, Roussev R. Which thrombophilic gene mutations are risk factors for recurrent pregnancy loss? Am J Reprod Immunol 2006; 56:230-6.

Goodman JE, Bowman ED, Chanock SJ, Alberg AJ, Harris CC. Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. Carcinogenesis 2004; 25:2467-72.

Goodman T, Ferro A, Sharma P. Pharmacogenetics of aspirin resistance: a comprehensive systematic review. Br J Clin Pharmacol 2008; 66:222-32.

Goodwin B, Hodgson E, D’Costa DJ, Robertson GR, Liddle C. Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Mol Pharmacol 2002; 62:359-65.

Goodwin B, Hodgson E, Liddle C. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol 1999; 56:1329-39.

Gopalan G, Gilbert DJ, Copeland NG, Jenkins NA, Donovan PJ. Chromosome localization of two new mammalian kinases related to yeast and fly chromosome segregation-regulators. Mammalian Genome 1998; 9:86-96.

Gordillo-Bastidas E, Panduro A, Gordillo-Bastidas D et al. Polymorphisms of alcohol metabolizing enzymes in indigenous Mexican population: unusual high frequency of CYP2E1*c2 allele. Alcohol Clin Exp Res 2010; 34:142-9.

Gordts PL, Reekmans S, Lauwers A, van Dongen A, Verbeek L, Roebroek AJ. Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis. Arterioscler Thromb Vasc Biol 2009; 29:1258-64.

Gore M, Sadosky A, Leslie D, Sheehan AH. Selecting an appropriate medication for treating neuropathic pain in patients with diabetes: a study using the U. K. and Germany Mediplus databases. Pain Pract 2008; 8:253-62.

Gorgels TG, Waarsing JH, de Wolf A, ten Brink JB, Loves WJ, Bergen AA. Dietary magnesium, not calcium, prevents vascular calcification in a mouse model for pseudoxanthoma elasticum. J Mol Med 2010; 88:467-75.

Goris A, Williams-Gray CH, Clark GR et al. Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson’s disease. Ann Neurol 2007; 62:145-53.

Görnemann T, Jähnichen S, Schurad B et al. Pharmacological properties of a wide array of ergolines at functional alpha(1)-adrenoceptor subtypes. Naunyn Schmiedebergs Arch Pharmacol 2008; 376:321-30.

Gorre ME, Mohammed M, Ellwood K et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293:876-80.

Gorshkova IN, Atkinson D. Enhanced binding of apolipoprotein A-I variants associated with hypertriglyceridemia to triglyceride-rich particles. Biochemistry 2011; 50:2040-7.

Gorski JC, Hall SD, Jones DR, VandenBranden M, Wrighton SA. Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily. Biochem Pharmacol 1994; 47:1643-53.

Gorski JC, Huang SM, Pinto A et al. The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther 2004; 75:89-100.

Gorski JC, Jones DR, Hamman MA, Wrighton SA, Hall SD. Biotransformation of alprazolam by members of the human cytochrome P4503A subfamily. Xenobiotica 1999; 29:931-44.

Gorski JC, Jones DR, Wrighton SA, Hall SD. Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily. Biochem Pharmacol 1994; 48:173-82.

Gorski JC, Jones DR, Wrighton SA, Hall SD. Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone. Xenobiotica 1997; 27:243-56.

Goryachkina K, Burbello A, Boldueva S, Babak S, Bergman U, Bertilsson L. Inhibition of metoprolol metabolism and potentiation of its effects by paroxetine in routinely treated patients with acute myocardial infarction (AMI). Eur J Clin Pharmacol 2008; 64:275-82.

Goryachkina K, Burbello A, Boldueva S, Babak S, Bergman U, Bertilsson L. CYP2D6 is a major determinant of metoprolol disposition and effects in hospitalized Russian patients treated for acute myocardial infarction. Eur J Clin Pharmacol 2008; 64:1163-73.

Goss PE, Ingle JN, Alés-Martínez JE et al. Exemestane for breast-cancer prevention in postmenopausal women. N Engl J Med 2011; 364:2381-91.

Gossen D, de Suray JM, Vandenhende F, Onkelinx C, Gangji D. Influence of fluoxetine on olanzapine pharmacokinetics. AAPS PharmSci 2002; 4:11.

Gotardo MA, Hyssa JT, Carvalho RS et al. Modulation of expression and activity of cytochrome P450s and alteration of praziquantel kinetics during murine schistosomiasis. Mem Inst Oswaldo Cruz 2011; 106:212-9.

Góth L, Bigler NW. Catalase deficiency may complicate urate oxidase (rasburicase) therapy. Free Radic Res 2007; 41:953-5.

Góth L, Eaton JW. Hereditary catalase deficiencies and increased risk of diabetes. Lancet 2000; 356:1820-1.

Góth L, Rass P, Páy A. Catalase enzyme mutations and their association with diseases. Mol Diagn 2004; 8:141-9.

Goto A, Adachi Y, Inaba A, Nakajima H, Kobayashi H, Sakai K. Identification of human p450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its inhibitory effect on enzyme activity. Biol Pharm Bull 2004; 27:684-90.

Goto A, Ueda K, Inaba A, Nakajima H, Kobayashi H, Sakai K. Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants. Biol Pharm Bull 2005; 28:328-34.

Goto H, Takikawa H. Effect of genipin on cholestasis induced by estradiol-17beta-glucuronide and lithocholate-3-O-glucuornide in rats. Hepatol Res 2010; 40:524-9.

Goto M, Mabe H, Nishimura G, Katsumata N. Progressive osseous heteroplasia caused by a novel nonsense mutation in the GNAS1 gene. J Pediatr Endocrinol Metab 2010; 23:303-9.

Goto M, Masuda S, Kiuchi T et al. CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation. Pharmacogenetics 2004; 14:471-8.

Goto M, Masuda S, Saito H et al. C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation. Pharmacogenetics 2002; 12:451-7.

Goto S, Narita I, Saito N et al. A(-20)C polymorphism of the angiotensinogen gene and progression of IgA nephropathy. Kidney Int 2002; 62:980-5.

Goto S, Seo T, Murata T et al. Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese. Ther Drug Monit 2007; 29:118-21.

Goto Y, Hattori A, Ishii Y, Tsujimoto M. Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1. FEBS 2006; 580:1833-8.

Goto Y, Hattori A, Mizutani S, Tsujimoto M. Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A. J Biol Chem 2007; 282:37074-81.

Goto Y, Nonaka I, Horai S. A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature 1990; 348:651-3.

Goto Y, Ohashi K, Utoh R, Yamamoto M, Okano T. Hepatocyte transplantation through the hepatic vein: A new route of cell transplantation to the liver. Cell Transplant 2010. doi:10. 3727/096368910X547417.

Gotoh M, Tauchi T, Yoshizawa S et al. Successful prior treatment with dasatinib followed by stem cell transplantation in a patient with CML in blastic crisis with a BCR-ABL mutation. Int J Hematol 2010; 91:128-31.

Gotoh Y, Kawakami M, Matsumoto N, Okada Y. Permethrin emulsion ingestion: clinical manifestations and clearance of isomers. J Toxicol Clin Toxicol 1998; 36:57-61.

Gottardis MM, Saceda M, Garcia-Morales P et al. Regulation of retinoblastoma gene expression in hormone-dependent breast cancer. Endocrinology 1995; 136:5659-65.

Gottlieb B, Beitel LK, Wu JH, Trifiro M. The androgen receptor gene mutations database (ARDB): 2004 update. Hum Mutat 2004; 23:527-33.

Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology 2011; 32:50-7.

Götz J, Probst A, Spillantini MG et. Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J 1995; 14:1304-13.

Gotzkowsky SK, Dingemanse J, Lai A, Mottola D, Laliberte K. Lack of a pharmacokinetic interaction between oral treprostinil and bosentan in healthy adult volunteers. J Clin Pharmacol 2010; 50:829-34.

Gouas L, Nicaud V, Chaouch S et al. Confirmation of associations between ion channel gene SNPs and QTc interval duration in healthy subjects. Eur J Hum Genet 2007; 15:974-9.

Goudreau JL, Maraganore DM, Farrer MJ et al. Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson’s disease. Mov Disord 2002; 17:1305-11.

Gough AC, Miles JS, Spurr NK et al. Identification of the primary gene defect at the cytochrome P450 CYP2D locus. Nature 1990; 347:773-6.

Goulart AC, Rexrode KM, Cheng S et al. Association of genetic variants with the metabolic syndrome in 20,806 white women: The Women’s Health Genome Study. Am Heart J 2009; 158:257-62.

Goulas A, Fidani L, Kotsis A et al. An association study of a functional catalase gene polymorphism, -262C→T, and patients with Alzheimer’s disease. Neurosci Lett 2002; 330:210-3.

Goulding C, McManus R, Murphy A et al. The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. Gut 2005; 54:1157-61.

Goulding EH, Hewitt SC, Nakamura N, Hamilton K, Korach KS, Eddy EM. Ex3αERKO male infertility phenotype recapitulates the αERKO male phenotype. J Endocrinol 2010; 207:281-8.

Goulet JL, Snouwaert JN, Latour AM, Coffman TM, Koller BH. Altered inflammatory responses in leukotriene-deficient mice. Proc Natl Acad Sci USA 1994; 91:12852-6.

Gounden V, van Niekerk C, Snyman T, George JA. Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients. AIDS Res Ther 2010; 7:32.

Gounder MK, Nazar AS, Saleem A et al. Effects of drug efflux proteins and topoisomerase I mutations on the camptothecin analogue gimatecan. Invest New Drugs 2008; 26:205-13.

Gounder MM, Maki RG. Molecular basis for primary and secondary tyrosine kinase inhibitor resistance in gastrointestinal stromal tumor. Cancer Chemother Pharmacol 2011; 67 Suppl 1:25-43.

Gourh P, Agarwal SK, Divecha D et al. Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines. Arthritis Rheum 2009; 60:3794-806.

Gourh P, Agarwal SK, Martin E et al. Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations. J Autoimmun 2010; 34:155-62.

Gouveia CH, Christoffolete MA, Zaitune CR et al. Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation. Endocrinology 2005; 146:195-200.

Goverdhan SV, Howell MW, Mullins RF et al. Association of HLA class I and class II polymorphisms with age-related macular degeneration. Invest Ophthalmol Vis Sci 2005; 46:1726-34.

Goverdhan SV, Khakoo SI, Gaston H, Chen X, Lotery AJ. Age-related macular degeneration is associated with the HLA-Cw*0701 Genotype and the natural killer cell receptor AA haplotype. Invest Ophthalmol Vis Sci 2008; 49:5077-82.

Gozalo C, Gérard L, Loiseau P et al. Pharmacogenetics of toxicity, plasma trough concentration and treatment outcome with nevirapine-containing regimen in anti-retroviral-Naïve HIV-infected adults: an exploratory study of the TRIANON ANRS 081 Trial. Basic Clin Pharmacol Toxicol 2011. doi:10. 1111/j. 1742-7843. 2011. 00780. x.

Gra O, Mityaeva O, Berdichevets I et al. Microarray-based detection of CYP1A1, CYP2C9, CYP2C19, CYP2D6, GSTT1, GSTM1, MTHFR, MTRR, NQO1, NAT2, HLA-DQA1, and AB0 allele frequencies in native Russians. Genet Test Mol Biomarkers 2010; 14:329-42.

Gra OA, Kozhekbaeva ZhM, Litvinov VI. Analysis of genetic predisposition to pulmonary tuberculosis in native Russians. Genetika 2010; 46:262-71.

Grabe HJ, Schwahn C, Appel K et al. Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population. Am J Med Genet B Neuropsychiatr Genet 2010; 153:1483-93.

Graber-Maier A, Büter KB, Aeschlimann J et al. Effects of Curcuma extracts and curcuminoids on expression of P-glycoprotein and cytochrome P450 3A4 in the intestinal cell culture model LS180. Planta Med 2010; 76:1866-70.

Grace JM, Aguilar AJ, Trotman KM, Peggins JO, Brewer TG. Metabolism of beta-arteether to dihydroqinghaosu by human liver microsomes and recombinant cytochrome P450. Drug Metab Dispos 1998; 26:313-7.

Grace JM, Skanchy DJ, Aguilar AJ. Metabolism of artelinic acid to dihydroqinqhaosu by human liver cytochrome P4503A. Xenobiotica 1999; 29:703-17.

Gradhand U, Kim RB. Pharmacogenomics of MRP transporters (ABCC1-5) and BCRP (ABCG2). Drug Metab Rev 2008; 40:317-54.

Gradilone A, Pulcinelli FM, Lotti LV et al. Celecoxib induces MRP-4 in lung cancer cells: therapeutic implications. J Clin Oncol 2007; 25:4318-20.

Gradilone A, Pulcinelli FM, Lotti LV et al. Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets 2008; 8:414-20.

Gradman AH. Role of angiotensin II type 1 receptor antagonists in the treatment of hypertension in patients aged >or=65 years. Drugs Aging 2009; 26:751-67.

Graebert KS, Lemansky P, Kehle T, Herzog V. Localization and regulated release of Alzheimer amyloid precursor-like protein in thyrocytes. Lab Invest 1995; 72:513-23.

Graefe-Mody EU, Brand T, Ring A et al. Effect of linagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. Int J Clin Pharmacol Ther 2011; 49:300-10.

Graefe-Mody EU, Jungnik A, Ring A, Woerle HJ, Dugi KA. Evaluation of the pharmacokinetic interaction between the dipeptidyl peptidase-4 inhibitor linagliptin and pioglitazone in healthy volunteers. Int J Clin Pharmacol Ther 2010; 48:652-61.

Graefe-Mody U, Rose P, Ring A, Zander K, Iovino M, Woerle HJ. Assessment of the Pharmacokinetic Interaction between the novel DPP-4 inhibitor linagliptin and a sulfonylurea, glyburide, in healthy subjects. Drug Metab Pharmacokinet 2011; 26:123-9.

Graeser AC, Boesch-Saadatmandi C, Lippmann J et al. Nrf2-dependent gene expression is affected by the proatherogenic apoE4 genotype-studies in targeted gene replacement mice. J Mol Med 2011; 89:1027-35.

Graff DW, Williamson KM, Pieper JA et al. Effect of fluoxetine on carvedilol pharmacokinetics, CYP2D6 activity, and autonomic balance in heart failure patients. J Clin Pharmacol 2001; 41:97-106.

Graham DS, Graham RR, Manku H et al. Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nat Genet 2008; 40:83-9.

Graham DY, Javed SU, Keihanian S, Abudayyeh S, Opekun AR. Dual proton pump inhibitor plus amoxicillin as an empiric anti-H. pylori therapy: studies from the United States. J Gastroenterol 2010; 45:816-20.

Graham JM Jr, Anyane-Yeboa K, Raams A et al. Cerebro-oculo-facio-skeletal syndrome with a nucleotide excision-repair defect and a mutated XPD gene, with prenatal diagnosis in a triplet pregnancy. Am J Hum Genet 2001; 69:291-300.

Graham JS, Falk S, Samuel LM, Cendros JM, Evans TR. A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy. Cancer Chemother Pharmacol 2009; 63:945-52.

Grala TM, Kay JK, Walker CG et al. Expression analysis of key somatotropic axis and liporegulatory genes in ghrelin- and obestatin-infused dairy cows. Domest Anim Endocrinol 2010; 39:76-83.

Grallert H, Sedlmeier EM, Huth C et al. APOA5 variants and metabolic syndrome in Caucasians. J Lipid Res 2007; 48:2614-21.

Gram LF, Brøsen K. Moclobemide treatment causes a substantial rise in the sparteine metabolic ratio. Br J Clin Pharmacol 1993; 35:649-52.

Gram LF, Hansen MG, Sindrup SH et al. Citalopram: interaction studies with levomepromazine, imipramine, and lithium. Ther Drug Monit 1993; 15:18-24.

Grandone A, del Giudice EM, Cirillo G, Santarpia M, Coppola F, Perrone L. Prepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: two years’ treatment with anastrozole and genetic study. Horm Res Paediatr 2011; 75:374-9.

Grandy DK, Allen LJ, Zhang Y et al. Chromosomal localization of three human D5 dopamine receptor genes. Genomics 1992; 13:968-73.

Granfors MT, Wang JS, Kajosaari LI, Laitila J, Neuvonen PJ, Backman JT. Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro. Basic Clin Pharmacol Toxicol 2006; 98:79-85.

Grant AV, Araujo MI, Ponte EV et al. Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population. Genes Immun 2011; 12:46-50.

Grant CE, Gao M, DeGorter MK, Cole SP, Deeley RG. Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). Drug Metab Dispos 2008; 36:2571-81.

Grant CE, Kurz EU, Cole SPC, Deeley RG. Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA. Genomics 1997; 45:368-78.

Grant DJ, Maeda N. A base substitution in the promoter associated with the human haptoglobin 2-1 modified phenotype decreases transcriptional activity and responsiveness to interleukin-6 in human hepatoma cells. Am J Hum Genet 1993; 52:974-80.

Grant DM, Goodfellow GH, Sugamori K, Durette K. Pharmacogenetics of the human arylamine N-acetyltransferases. Pharmacology 2000; 61:204-11.

Grant S, Roberts JD. The use of cyclin-dependent kinase inhibitors alone or in combination with established cytotoxic drugs in cancer chemotherapy. Drug Resist Updat 2003; 6:15-26.

Granvil CP, Madan A, Sharkawi M, Parkinson A, Wainer IW. Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes. Drug Metab Dispos 1999; 27:533-41.

Granvil CP, Yu AM, Elizondo G et al. Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. Drug Metab Dispos 2003; 31:548-58.

Granzotto A, Zatta P. Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity. PLoS One 2011. doi:10. 1371/journal. pone. 0021565.

Grarup N, Andreasen CH, Andersen MK et al. The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects. J Clin Endocrinol Metab 2008; 93:2294-9.

Gras J, Llenas J. Effects of H1 antihistamines on animal models of QTc prolongation. Drug Saf 1999; 21 Suppl 1:39-44.

Grasbon-Frodl EM, Kösel S, Sprinzl M, von Eitzen U, Mehraein P, Graeber MB. Two novel point mutations of mitochondrial tRNA genes in histologically confirmed Parkinson disease. Neurogenetics 1999; 2:121-7.

Grasmäder K, Verwohlt PL, Kühn KU et al. Population pharmacokinetic analysis of mirtazapine. Eur J Clin Pharmacol 2004; 60:473-80.

Grasmäder K, Verwohlt PL, Rietschel M et al. Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting. Eur J Clin Pharmacol 2004; 60:329-36.

Grassi S, Tozzi A, Costa C et al. Neural 17β-estradiol facilitates long-term potentiation in the hippocampal CA1 region. Neuroscience 2011; 192:67-73.

Gratschev D, Löf C, Heikkilä J et al. Sphingosine kinase as a regulator of calcium entry through autocrine sphingosine 1-phosphate signaling in thyroid FRTL-5 cells. Endocrinology 2009; 150:5125-34.

Gratz S, Wu QK, El-Nezami H, Juvonen RO, Mykkänen H, Turner PC. Lactobacillus rhamnosus strain GG reduces aflatoxin B1 transport, metabolism, and toxicity in Caco-2 Cells. Appl Environ Microbiol 2007; 73:3958-64.

Grauer MT, Uhr M. P-glycoprotein reduces the ability of amitriptyline metabolites to cross the blood brain barrier in mice after a 10-day administration of amitriptyline. J Psychopharmacol 2004; 18:66-74.

Graves AB, Mortimer JA, Bowen JD et al. Head circumference and incident Alzheimer’s disease: modification by apolopoprotein E. Neurology 2001; 57:1453-60.

Gravlee CC, Non AL, Mulligan CJ. Genetic ancestry, social classification, and racial inequalities in blood pressure in Southeastern Puerto Rico. PLoS One 2009. doi:10. 1371/journal. pone. 0006821.

Gray VS. Syncopal episodes associated with cisapride and concurrent drugs. Ann Pharmacother 1998; 32:648-51.

Gray-McGuire C, Song Y, Morris NJ, Stein CM. Comparison of univariate and multivariate linkage analysis of traits related to hypertension. BMC Proc 2009; 3 Suppl 7:99.

Greaves LC, Preston SL, Tadrous PJ et al. Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission. Proc Natl Acad Sci USA 2006; 103:714-9.

Greb RR, Behre HM, Simoni M. Pharmacogenetics in ovarian stimulation – current concepts and future options. Reprod Biomed Online 2005; 11:589-600.

Greb RR, Grieshaber K, Gromoll J et al. A common single nucleotide polymorphism in exon 10 of the human follicle stimulating hormone receptor is a major determinant of length and hormonal dynamics of the menstrual cycle. J Clin Endocrinol Metab 2005; 90:4866-72.

Green EK, Harris JM, Lemmon H et al. Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD? Neurology 2002; 58:1566-8.

Gréen H, Falk IJ, Lotfi K et al. Association of ABCB1 polymorphisms with survival and in vitro cytotoxicty in de novo acute myeloid leukemia with normal karyotype. Pharmacogenomics J 2010, doi:10. 1038/tpj. 2010. 79.

Gréen H, Khan MS, Jakobsen-Falk I, Avall-Lundqvist E, Peterson C. Impact of CYP3A5*3 and CYP2C8-HapC on paclitaxel/carboplatin-induced myelosuppression in patients with ovarian cancer. J Pharm Sci 2011. doi:10. 1002/jps. 22680.

Gréen H, Skoglund K, Rommel F, Mirghani RA, Lotfi K. CYP3A activity influences imatinib response in patients with chronic myeloid leukemia: a pilot study on in vivo CYP3A activity. Eur J Clin Pharmacol 2010; 66:383-6.

Gréen H, Söderkvist P, Rosenberg P et al. Pharmacogenetic studies of paclitaxel in the treatment of ovarian cancer. Basic Clin Pharmacol Toxicol 2009; 104:130-7.

Green MD, Jiang X, King CD. Inhibition of human hepatic CYP isoforms by mGluR5 antagonists. Life Sci 2004; 75:947-53.

Green RF, Stoler JM. Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview. Am J Obstet Gynecol 2007; 197:12-25.

Green SA, Cole G, Jacinto M, Innis M, Liggett SB. A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J Biol Chem 1993; 268:23116-21.

Green SA, Rathz DA, Schuster AJ, Liggett SB. The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). Eur J Pharmacol 2001; 421:141-7.

Green SA, Turki J, Innis M, Liggett SB. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 1994; 33:9414-9.

Green VJ, Pirmohamed M, Kitteringham NR, Knapp MJ, Park BK. Glutathione S-transferase mu genotype (GSTM1*0) in Alzheimer’s patients with tacrine transaminitis. Br J Clin Pharmacol 1995; 39:411-5.

Greenbaum L, Strous RD, Kanyas K et al. Association of the RGS2 gene with extrapyramidal symptoms induced by treatment with antipsychotic medication. Pharmacogenet Genomics 2007; 17:519-28.

Greenberg DS, Toiber D, Berson A, Soreq H. Acetylcholinesterase variants in Alzheimer’s disease: from neuroprotection to programmed cell death. Neurodegener Dis 2010; 7:60-3.

Greenberg SM, Liao A, Nitsch RM et al. Genetic association of an alpha-2 macroglobulin (Val1000Ile) polymorphism and Alzheimer’s disease. Hum Mol Genet 1998; 7:1953-6.

Greenberg SM, Rebeck GW, Vonsattel JPG, Gomez-Isla T, Hyman BT. Apolipoprotein E epsilon-4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol 1995; 38:254-9.

Greenberg SM, Vonsattel JPG, Segal AZ et al. Association of apolipoprotein E epsilon-2 and vasculopathy in cerebral amyloid angiopathy. Neurology 1998; 50:961-5.

Greenblatt DJ. Clinical pharmacokinetics of oxazepam and lorazepam. Clin Pharmacokinet 1981; 6:89-105.

Greenblatt DJ, von Moltke LL, Giancarlo GM, Garteiz DA. Human cytochromes mediating gepirone biotransformation at low substrate concentrations. Biopharm Drug Dispos 2003; 24:87-94.

Greendale GA, Chu J, Ferrell R, Randolph JF Jr, Johnston JM, Sowers MR. The association of bone mineral density with estrogen receptor gene polymorphisms. Am J Med 2006; 119(9 Suppl 1):79-86.

Greene DA. Rosiglitazone: a new therapy for Type 2 diabetes. Expert Opin Investig Drugs 1999; 8:1709-1719.

Greene DS, Barbhaiya RH. Clinical pharmacokinetics of nefazodone. Clin Pharmacokinet 1997; 33:260-75.

Greene LM, Nathwani SM, Bright SA et al. The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance. J Pharmacol Exp Ther 2010; 335:302-13.

Greene S, Kaysen GA, Stevenson FT. Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are increased in hypoalbuminemia by post-transcriptional mechanisms. Kidney Int 1998; 53:67-75.

Greenland KJ, Sernia C. Oestrogenic regulation of brain angiotensinogen. J Neuroendocrinol 2004; 16:508-15.

Greer JP, Mosse CA. Natural killer-cell neoplasms. Curr Hematol Malig Rep 2009; 4:245-52.

Greer WL, Riddell DC, Gillan TL et al. The Nova Scotia (type D) form of Niemann-Pick disease is caused by a G3097→T transversion in NPC1. Am J Hum Genet 1998; 63:52-4.

Greger DL, Blum JW. Effects of dexamethasone on mRNA abundance of nuclear receptors and hepatic nuclear receptor target genes in neonatal calves. J Anim Physiol Anim Nutr 2007; 91:62-7.

Greger DL, Philipona C, Blum JW. Ontogeny of mRNA abundance of nuclear receptors and nuclear receptor target genes in young cattle. Domest Anim Endocrinol 2006; 31:76-87.

Gregersen PK, Amos CI, Lee AT et al. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet 2009; 41:820-3.

Gregg RE, Wetterau JR. The molecular basis of abetalipoproteinemia. Curr Opin Lipidol 1994; 5:81-6.

Gregoraszczuk E, Ptak A. Involvement of caspase-9 but not caspase-8 in the anti-apoptotic effects of estradiol and 4-OH-Estradiol in MCF-7 human breast cancer cells. Endocr Regul 2011; 45:3-8.

Gregory PA, Gardner-Stephen DA, Rogers A, Michael MZ, Mackenzie PI. The caudal-related homeodomain protein Cdx2 and hepatocyte nuclear factor 1-alpha cooperatively regulate the UDP-glucuronosyltransferase 2B7 gene promoter. Pharmacogenet Genomics 2006; 16:527-36.

Gregory PA, Lewinsky RH, Gardner-Stephen DA, Mackenzie PI. Regulation of UDP glucuronosyltransferases in the gastrointestinal tract. Toxicol Appl Pharmacol 2004; 199:354-63.

Gregory RE, Ettinger DS. 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy. Drugs 1998; 55:173-89.

Grendys EC Jr, Blessing JA, Burger R, Hoffman J. A phase II evaluation of flavopiridol as second-line chemotherapy of endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 2005; 98:249-53.

Greuet J, Pichard L, Bonfils C, Domergue J, Maurel P. The fetal specific gene CYP3A7 is inducible by rifampicin in adult human hepatocytes in primary culture. Biochem Biophys Res Commun 1996; 225:689-94.

Greuet J, Pichard L, Ourlin JC et al. Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture. Hepatology 1997; 25:1166-75.

Gribble FM. Alpha2A-adrenergic receptors and type 2 diabetes. N Engl J Med 2010; 362:361-2.

Gribouval O, Gonzales M, Neuhaus T et al. Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Nat Genet 2005; 37:964-8.

Grieb P, Gordon-Krajcer W, Frontczak-Baniewicz M et al. 2-deoxyglucose induces beta-APP overexpression, tau hyperphosphorylation and expansion of the trans-part of the Golgi complex in rat cerebral cortex. Acta Neurobiol Exp 2004; 64:491-502.

Griese EU, Asante-Poku S, Ofori-Adjei D, Mikus G, Eichelbaum M. Analysis of the CYP2D6 gene mutations and their consequences for enzyme function in a West African population. Pharmacogenetics 1999; 9:715-23.

Griese EU, Zanger UM, Brudermanns U et al. Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population. Pharmacogenetics 1998; 8:15-26.

Griffith TN, Varela-Nallar L, Dinamarca MC, Inestrosa NC. Neurobiological effects of Hyperforin and its potential in Alzheimer’s disease therapy. Curr Med Chem 2010; 17:391-406.

Grigoriadis AE, Wang ZQ, Wagner EF. Fos and bone cell development: lessons from a nuclear oncogene. Trends Genet 1995; 11:436-41.

Grilo A, Sáez-Rosas MP, Santos-Morano J et al. Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough. Pharmacogenet Genomics 2011; 21:10-7.

Grillet N, Pattyn A, Contet C, Kieffer BL, Goridis C, Brunet JF. Generation and characterization of Rgs4 mutant mice. Mol Cell Biol 2005; 25:4221-8.

Grimm C, Polterauer S, Zeillinger R et al. Two multidrug-resistance (ABCB1) gene polymorphisms as prognostic parameters in women with ovarian cancer. Anticancer Res 2010; 30:3487-91.

Grimm SW, Richtand NM, Winter HR, Stams KR, Reele SB. Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics. Br J Clin Pharmacol 2006; 61:58-69.

Grimminger PP, Brabender J, Warnecke-Eberz U et al. XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer. J Surg Res 2010; 164:61-6.

Grinkova YV, Denisov IG, Waterman MR, Arase M, Kagawa N, Sligar SG. The ferrous-oxy complex of human aromatase. Biochem Biophys Res Commun 2008; 372:379-82.

Grinyó J, Vanrenterghem Y, Nashan B et al. Association of four DNA polymorphisms with acute rejection after kidney transplantation. Transpl Int 2008; 21:879-91.

Grisk O, Steinbach AC, Ciecholewski S et al. Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function. Pharmacogenet Genomics 2009; 19:276-88.

Grobe N, Zhang B, Fisinger U, Kutchan TM, Zenk MH, Guengerich FP. Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis. J Biol Chem 2009; 284:24425-31.

Grocott HP, White WD, Morris RW et al. Genetic polymorphisms and the risk of stroke after cardiac surgery. Stroke 2005; 36:1854-8.

Grodzovski I, Lichtenstein M, Galski H, Lorberboum-Galski H. IL-2-granzyme A chimeric protein overcomes multidrug resistance (MDR) through a caspase 3-independent apoptotic pathway. Int J Cancer 2011; 128:1966-80.

Gromadzka G, Członkowska A. Influence of IL-1RN intron 2 variable number of tandem repeats (VNTR) polymorphism on the age at onset of neuropsychiatric symptoms in Wilson’s disease. Int J Neurosci 2011; 121:8-15.

Gromoll J, Simoni M. Follicle-stimulating-hormone receptor and twinning. Lancet 2001; 357:230.

Gromotowicz A, Szemraj J, Stankiewicz A et al. Study of the mechanisms of aldosterone prothrombotic effect in rats. J Renin Angiotensin Aldosterone Syst 2011. doi:10. 1177/1470320310397405.

Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmacokinet 2004; 43:879-923.

Grönlund J, Saari T, Hagelberg N et al. Effect of telithromycin on the pharmacokinetics and pharmacodynamics of oral oxycodone. J Clin Pharmacol 2010; 50:101-8.

Grönlund J, Saari TI, Hagelberg N, Neuvonen PJ, Olkkola KT, Laine K. Miconazole oral gel increases exposure to oral oxycodone by inhibition of CYP2D6 and CYP3A4. Antimicrob Agents Chemother 2011; 55:1063-7.

Grönlund J, Saari TI, Hagelberg NM, Neuvonen PJ, Laine K, Olkkola KT. Effect of inhibition of cytochrome P450 enzymes 2D6 and 3A4 on the pharmacokinetics of intravenous oxycodone: a randomized, three-phase, crossover, placebo-controlled study. Clin Drug Investig 2011; 31:143-53.

Grönlund J, Saari TI, Hagelberg NM, Neuvonen PJ, Olkkola KT, Laine K. Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol 2010; 70:78-87.

Grønskov K, Poole RL, Hahnemann JM et al. Deletions and rearrangements of the H19/IGF2 enhancer region in patients with Silver-Russell syndrome and growth retardation. J Med Genet 2011; 48:308-11.

Gronwald J, Tung N, Foulkes WD et al. Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: an update. Int J Cancer 2006; 118:2281-4.

Gröschel B, Himmel N, Cinatl J et al. ddC- and 3TC-bis(SATE) monophosphate prodrugs overcome cellular resistance mechanisms to HIV-1 associated with cytidine kinase deficiency. Nucleosides Nucleotides 1999; 18:921-6.

Gross A, Ong TR, Grant R, Hoffmann T, Gregory DD, Sreerama L. Human aldehyde dehydrogenase-catalyzed oxidation of ethylene glycol ether aldehydes. Chem Biol Interact 2009; 178:56-63.

Gross AS, Goh YD, Addison RS, Shenfield GM. Influence of grapefruit juice on cisapride pharmacokinetics. Clin Pharmacol Ther 1999; 65:395-401.

Gross E, Busse B, Riemenschneider M et al. Strong association of a common dihydropyrimidine dehydrogenase gene polymorphism with fluoropyrimidine-related toxicity in cancer patients. PLoS One 2008. doi:10. 1371/journal. pone. 0004003.

Gross E, Ullrich T, Seck K et al. Detailed analysis of five mutations in dihydropyrimidine dehydrogenase detected in cancer patients with 5-fluorouracil-related side effects. Hum Mutat 2003; 22:498.

Grossman I. ADME pharmacogenetics: current practices and future outlook. Expert Opin Drug Metab Toxicol 2009; 5:449-62.

Grossman I, Avidan N, Singer C et al. Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers. Pharmacogenet Genomics 2007; 17:657-66.

Grossmann M, Dobrev D, Siffert W, Kirch W. Heterogeneity in hand veins responses to acetylcholine is not associated with polymorphisms in the G-protein beta3-subunit (C825T) and endothelial nitric oxide synthase (G894T) genes but with serum low density lipoprotein cholesterol. Pharmacogenetics 2001; 11:307-16.

Gross-Steinmeyer K, Stapleton PL, Tracy JH et al. Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols. Toxicol Sci 2009; 112:303-10.

Gross-Steinmeyer K, Stapleton PL, Tracy JH, Bammler TK, Strom SC, Eaton DL. Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. Toxicol Sci 2010; 116:422-32.

Grove J, Daly AK, Bassendine MF, Gilvarry E, Day CP. Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease. Gut 2000; 46:540-5.

Grover GS, Brayman TG, Voorman RL, Ware JA. Development of in vitro methods to predict induction of CYP1A2 and CYP3A4 in humans. Assay Drug Dev Technol 2007; 5:793-804.

Grover S, Gourie-Devi M, Baghel R et al. Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment. Pharmacogenomics 2010; 11:927-41.

Grover S, Talwar P, Gourie-Devi M et al. Genetic polymorphisms in sex hormone metabolizing genes and drug response in women with epilepsy. Pharmacogenomics 2010; 11:1525-34.

Growdon JH, Locascio JJ, Corkin S, Gomez-Ida T, Hyman BT. Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer’s disease. Neurology 1996; 47:444-8.

Grözinger M, Dragicevic A, Hiemke C, Shams M, Müller MJ, Härtter S. Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine. Pharmacopsychiatry 2003; 36:3-6.

Grözinger M, Härtter S, Hiemke C, Griese EU, Röschke J. Interaction of modafinil and clomipramine as comedication in a narcoleptic patient. Clin Neuropharmacol 1998; 21:127-9.

Grube M, Köck K, Oswald S et al. Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart. Clin Pharmacol Ther 2006; 80:607-20.

Gruber BM, Bubko I, Krzyszton-Russjan J, Anuszewska EL. Synergistic action of doxorubicin and sulindac in human cervix carcinoma cells-studies on possible mechanisms. Med Sci Monit 2010; 16:45-51.

Gruel Y, Pouplard C, Lasne D, Magdelaine-Beuzelin C, Charroing C, Watier H. The homozygous FcgammaRIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexes. Blood 2004; 104:2791-3.

Gruer PJ, Vega JM, Mercuri MF, Dobrinska MR, Tobert JA. Concomitant use of cytochrome P450 3A4 inhibitors and simvastatin. Am J Cardiol 1999; 84:811-5.

Grujic D, Salido EC, Shenoy BC et al. Hyperoxaluria is reduced and nephrocalcinosis prevented with an oxalate-degrading enzyme in mice with hyperoxaluria. Am J Nephrol 2009; 29:86-93.

Grulich-Henn J, Wagner V, Thon A et al. Entities and frequency of neonatal diabetes: data from the diabetes documentation and quality management system (DPV). Diabet Med 2010; 27:709-12.

Grün B, Krautter S, Riedel KD, Mikus G. Inhibition of the active principle of the weak opioid tilidine by the triazole antifungal voriconazole. Br J Clin Pharmacol 2009; 68:712-20.

Grundy CB, Melissari E, Lindo V, Scully MF, Kakkar VV, Cooper DN. Late-onset homozygous protein C deficiency. Lancet 1991; 338:575-6.

Grundy CB, Schulman S, Krawczak M, Kobosko J, Kakkar VV, Cooper DN. Protein C deficiency and thromboembolism: recurrent mutation at Arg 306 in the protein C gene. Hum Genet 1992; 88:586-8.

Grunenfelder J, Umbehr M, Plass A et al. Genetic polymorphisms of apolipoprotein E4 and tumor necrosis beta as predisposing for increased inflammatory cytokines after cardiopulmonary bypass. J Thorac Cardiovasc Surg 2004; 128:92-7.

Grupe A, Li Y, Rowland C et al. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Am J Hum Genet 2006; 78:78-88.

Gryfe R, Di Nicola N, Gallinger S, Redston M. Somatic instability of the APC I1307K allele in colorectal neoplasia. Cancer Res 1998; 58:4040-3.

Gschwantler-Kaulich D, Fink-Retter A, Czerwenka K et al. Differential expression pattern of estrogen receptors, aromatase, and sulfotransferase in breast cancer tissue and corresponding lymph node metastases. Tumour Biol 2011; 32:501-8.

Gsur A, Feik E, Madersbacher S. Genetic polymorphisms and prostate cancer risk. World J Urol 2004; 21:414-23.

Gu A, Ji G, Zhou Y et al. Polymorphisms of nucleotide-excision repair genes may contribute to sperm DNA fragmentation and male infertility. Reprod Biomed Online 2010; 21:602-9.

Gu A, Ji G, Zhu P et al. Nucleotide excision repair polymorphisms, polycyclic aromatic hydrocarbon exposure, and their effects on sperm deoxyribonucleic acid damage and male factor infertility. Fertil Steril 2010; 94:2620-5.

Gu B, Wang L, Zhang AP et al. Association between a polymorphism of the HTR3A gene and therapeutic response to risperidone treatment in drug-naive Chinese schizophrenia patients. Pharmacogenet Genomics 2008; 18:721-7.

Gu C, Collins R, Holsworth DD, Walker GS, Voorman RL. Metabolic aromatization of N-alkyl-1,2,3,4-tetrahydroquinoline substructures to quinolinium by human liver microsomes and horseradish peroxidase. Drug Metab Dispos 2006; 34:2044-55.

Gu CC, Chang YPC, Hunt SC et al. Haplotype association analysis of AGT variants with hypertension-related traits: the HyperGEN study. Hum Hered 2005; 60:164-76.

Gu D, Ge D, Snieder H et al. Association of alpha1A adrenergic receptor gene variants on chromosome 8p21 with human stage 2 hypertension. J Hypertens 2006; 24:1049-56.

Gu D, McNaughton L, Lemaster D et al. A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine. Chem Res Toxicol 2010; 23:788-801.

Gu D, Su S, Ge D et al. Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese. Hypertension 2006; 47:1147-54.

Gu DF, Hinks LJ, Morton NE, Day INM. The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit. Ann Hum Genet 2000; 64:383-90.

Gu F, Qureshi AA, Niu T et al. Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma. Melanoma Res 2008; 18:330-5.

Gu HF. Biomarkers of adiponectin: plasma protein variation and genomic DNA polymorphisms. Biomark Insights 2009; 4:123-33.

Gu J, Zhao H, Dinney CP et al. Nucleotide excision repair gene polymorphisms and recurrence after treatment for superficial bladder cancer. Clin Cancer Res 2005; 11:1408-15.

Gu M, Gash M, Mann V, Javoy-Agid F, Cooper J, Schapira AHV. Mitochondrial defect in Huntington’s disease caudate nucleous. Ann Neurol 1996; 39:385-9.

Gu X, Ke S, Liu D et al. Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents. J Biol Chem 2006; 281:17882-9.

Gu X, Qi P, Zhou F et al. An intronic polymorphism in the corticotropin-releasing hormone receptor 2 gene increases susceptibility to HBV-related hepatocellular carcinoma in Chinese population. Hum Genet 2010; 127:75-81.

Gu Y, Sanjo N, Chen F et al. The presinilin proteins are components of multiple membrane-bound complexes that have different biological activities. J Biol Chem 2004; 279:31329-36.

Gualtieri M, Ovrevik J, Mollerup S et al. Airborne urban particles (Milan winter-PM2. 5) cause mitotic arrest and cell death: Effects on DNA, mitochondria, AhR binding and spindle organization. Mutat Res 2011; 713:18-31.

Guan L, Chung HY, Su Y, Jiao R, Peng C, Chen ZY. Hypocholesterolemic activity of onion is mediated by enhancing excretion of fecal sterols in hamsters. Food Funct 2010; 1:84-9.

Guan MX, Yan Q, Li X et al. Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations. Am J Hum Genet 2006; 79:291-302.

Guan S, Wang B, Li W, Guan J, Fang X. Effects of berberine on expression of LOX-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDL. Am J Chin Med 2010; 38:1161-9.

Guan X, Zhao H, Niu J, Tang D, Ajani JA, Wei Q. The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer. BMC Gastroenterol 2009; 9:77.

Guan Y, Hao C, Cha DR et al. Thiazolidinediones expand body fluid volume through PPAR-gamma stimulation of ENaC-mediated renal salt absorption. Nat Med 2005; 11:861-6.

Guan ZZ, Wang YN, Xiao KQ, Hu PS, Liu JL. Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer’s disease. Neurochem Int 1999; 34:41-7.

Guangwei X, Rongzhu L, Wenrong X et al. Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats. Toxicology 2010; 267:140-6.

Guarisco JA, Hall JO, Coulombe RA Jr. Mechanisms of butylated hydroxytoluene chemoprevention of aflatoxicosis-inhibition of aflatoxin B1 metabolism. Toxicol Appl Pharmacol 2008; 227:339-46.

Guasti L, Paul A, Laufer E, King P. Localization of Sonic hedgehog secreting and receiving cells in the developing and adult rat adrenal cortex. Mol Cell Endocrinol 2011; 336:117-22.

Guay DR. Clinical pharmacokinetics of drugs used to treat urge incontinence. Clin Pharmacokinet 2003; 42:1243-85.

Guay DR. Rasagiline (TVP-1012): a new selective monoamine oxidase inhibitor for Parkinson’s disease. Am J Geriatr Pharmacother 2006; 4:330-46.

Guay DR. Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders. Am J Geriatr Pharmacother 2010; 8:331-73.

Gubbins PO, Gurley BJ, Williams DK et al. Examining sex-related differences in enteric itraconazole metabolism in healthy adults using grapefruit juice. Eur J Clin Pharmacol 2008; 64:293-301.

Gubbins PO, Melchert RB, McConnell SA, Franks AM, Penzak SR, Gurley BJ. Effect of interleukin 6 on the hepatic metabolism of itraconazole and its metabolite hydroxyitraconazole using primary human hepatocytes. Pharmacology 2003; 67:195-201.

Gubler MC, Antignac C. Renin-angiotensin system in kidney development: renal tubular dysgenesis. Kidney Int 2010; 77:400-6.

Gubler MC, Gribouval O, Morinière V, Pawtowski A, Antignac C. Mutations in renin-angiotensin system genes and kidney developmental anomalies. J Soc Biol 2009; 203:311-8.

Gucev Z, Tasic V, Jancevska A, Krstevska-Konstantinova M, Pop-Jordanova N. McCune-Albright syndrome (MAS): early and extensive bone fibrous dysplasia involvement and “mistaken identity” oophorectomy. J Pediatr Endocrinol Metab 2010; 23:837-42.

Gudbjartsson DF, Walters GB, Thorleifsson G et al. Many sequence variants affecting diversity of adult human height. Nat Genet 2008; 40:609-15.

Gudjónsson JE, Kárason A, Antonsdóttir AA et al. HLA-Cw6-positive and HLA-Cw6-negative patients with Psoriasis vulgaris have distinct clinical features. J Invest Dermatol 2002; 118:362-5.

Guedj M, Bourillon A, Combadières C et al. Variants of the MATP/SLC45A2 gene are protective for melanoma in the French population. Hum Mutat 2008; 29:1154-60.

Gueguen Y, Ferrari L, Souidi M et al. Compared effect of immunosuppressive drugs cyclosporine A and rapamycin on cholesterol homeostasis key enzymes CYP27A1 and HMG-CoA reductase. Basic Clin Pharmacol Toxicol 2007; 100:392-7.

Guengerich FP, Distlerath LM, Reilly PEB et al. Human-liver cytochromes P-450 involved in polymorphisms of drug oxidation. Xenobiotica 1986; 16:367-78.

Guenova ML, Balatzenko GN, Nikolova VR, Spassov BV, Konstantinov SM. An anti-apoptotic pattern correlates with multidrug resistance in acute myeloid leukemia patients: a comparative study of active caspase-3, cleaved PARPs, Bcl-2, Survivin and MDR1 gene. Hematology 2010; 15:135-43.

Gueorguieva I, Jackson K, Wrighton SA, Sinha VP, Chien JY. Desipramine, substrate for CYP2D6 activity: population pharmacokinetic model and design elements of drug-drug interaction trials. Br J Clin Pharmacol 2010; 70:523-36.

Guérin S, Meyer L, Theodorou I et al. CCR5 delta32 deletion and response to highly active antiretroviral therapy in HIV-1-infected patients. AIDS 2000; 14:2788-90.

Guerreiro CS, Ferreira P, Tavares L et al. Fatty acids, IL6, and TNFalpha polymorphisms: an example of nutrigenetics in Crohn’s disease. Am J Gastroenterol 2009; 104:2241-9.

Guerrero R, Navarro P, Gallego E, Avila J, de Yebenes JG, Sanchez MP. Park2-null/tau transgenic mice reveal a functional relationship between parkin and tau. J Alzheimers Dis 2008; 13:161-72.

Guevara-Cruz M, Tovar AR, Larrieta E, Canizales-Quinteros S, Torres N. Increase in HDL-C concentration by a dietary portfolio with soy protein and soluble fiber is associated with the presence of the ABCA1R230C variant in hyperlipidemic Mexican subjects. Mol Genet Metab 2010; 101:268-72.

Guhathakurta S, Singh AS, Sinha S et al. Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes. Neurochem Int 2009; 55:754-9.

Gui J, Wang T, Trump D, Zimmer T, Lei M. Mutation-specific effects of polymorphism H558R in SCN5A-related sick sinus syndrome. J Cardiovasc Electrophysiol 2010; 21:564-73.

Guidelines for mutation analysis of BCR/ABL kinase domain: Interpreting TKI-Resistance Mutations in CML Patients. West Midlands Regional Genetics Laboratory. 2007.

Guido C, Perrotta I, Panza S et al. Human sperm physiology: estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) influence sperm metabolism and may be involved in the pathophysiology of varicocele-associated male infertility. J Cell Physiol 2011; 226:3403-12.

Guilhaumou R, Simon N, Quaranta S et al. Population pharmacokinetics and pharmacogenetics of vincristine in paediatric patients treated for solid tumour diseases. Cancer Chemother Pharmacol 2010. doi:10. 1007/s00280-010-1541-4.

Guillemette C, Ritter JK, Auyeung DJ, Kessler FK, Housman DE. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. Pharmacogenetics 2000; 10:629-44.

Guillén MI, Donato MT, Jover R et al. Oncostatin M down-regulates basal and induced cytochromes P450 in human hepatocytes. J Pharmacol Exp Ther 1998; 285:127-34.

Guimarães AP, Schmitz M, Polanczyk GV et al. Further evidence for the association between attention deficit/hyperactivity disorder and the serotonin receptor 1B gene. J Neural Transm 2009; 116:1675-80.

Guimarães AP, Zeni C, Polanczyk GV et al. Serotonin genes and attention deficit/hyperactivity disorder in a Brazilian sample: preferential transmission of the HTR2A 452His allele to affected boys. Am J Med Genet B Neuropsychiatr Genet 2007; 144:69-73.

Guitton J, Buronfosse T, Désage M, Lepape A, Brazier JL, Beaune P. Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil. Biochem Pharmacol 1997; 53:1613-9.

Guízar-Mendoza JM, Amador-Licona N, Flores-Martínez SE, López-Cardona MG, Ahuatzin-Trémary R, Sánchez-Corona J. Association analysis of the Gln223Arg polymorphism in the human leptin receptor gene, and traits related to obesity in Mexican adolescents. J Hum Hypertens 2005; 19:341-6.

Gulcebi MI, Ozkaynakcı A, Goren MZ, Aker RG, Ozkara C, Onat FY. The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy. Epilepsy Res 2011; 95:1-8.

Gulec S, Ozdol C, Rahimov U, Atmaca Y, Kumbasar D, Erol C. Myonecrosis after elective percutaneous coronary intervention: effect of clopidogrel-statin interaction. J Invasive Cardiol 2005; 17:589-93.

Gümüş-Akay G, Rüstemoğlu A, Karadağ A, Sunguroğlu A. Haplotype-based analysis of MDR1/ABCB1 gene polymorphisms in a Turkish population. DNA Cell Biol 2010; 29:83-90.

Gunderson MP, Veldhoen N, Skirrow RC et al. Effect of low dose exposure to the herbicide atrazine and its metabolite on cytochrome P450 aromatase and steroidogenic factor-1 mRNA levels in the brain of premetamorphic bullfrog tadpoles (Rana catesbeiana). Aquat Toxicol 2011; 102:31-8.

Gunes A, Melkersson KI, Scordo MG, Dahl ML. Association between HTR2C and HTR2A polymorphisms and metabolic abnormalities in patients treated with olanzapine or clozapine. J Clin Psychopharmacol 2009; 29:65-8.

Gunes A, Ozbey G, Vural EH et al. Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population. Pharmacogenomics 2009; 10:769-78.

Gunes A, Spina E, Dahl ML, Scordo MG. ABCB1 polymorphisms influence steady-state plasma levels of 9-Hydroxyrisperidone and risperidone active moiety. Ther Drug Monit 2008; 30:628-33.

Günesacar R, Opelz G, Erken E et al. VEGF 936 C/T gene polymorphism in renal transplant recipients: association of the T allele with good graft outcome. Hum Immunol 2008; 7:599-602.

Güngör K, Ozkur M, Cascorbi I et al. Beta 2-adrenergic receptor polymorphism and susceptibility to primary congenital and primary open angle glaucoma. Eur J Clin Pharmacol 2003; 59:527-31.

Gunjaca G, Boban M, Pehlić M et al. Predictive value of 8 genetic loci for serum uric acid concentration. Croat Med J 2010; 51:23-31.

Guns ES, Bullock PL, Reimer ML, Dixon R, Bally M, Mayer LD. Assessment of the involvement of CYP3A in the vitro metabolism of a new modulator of MDR in cancer chemotherapy, OC144-193, by human liver microsomes. Eur J Drug Metab Pharmacokinet 2001; 26:273-82.

Guo A, Marinaro W, Hu P, Sinko PJ. Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos 2002; 30:457-63.

Guo AY, Sun J, Riley BP, Thiselton DL, Kendler KS, Zhao Z. The dystrobrevin-binding protein 1 gene: features and networks. Mol Psychiatry 2009; 14:18-29.

Guo CJ, Li Y, Tian S, Wang X, Douglas SD, Ho WZ. Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor. J Investig Med 2002; 50:435-42.

Guo F, An T, Rein KS. The algal hepatoxoxin okadaic acid is a substrate for human cytochromes CYP3A4 and CYP3A5. Toxicon 2010; 55:325-32.

Guo H, Zou X, Xu H, Liu K. Effects of salvianolic A on rat liver microsomal cytochrome P450 system. Zhongguo Zhong Yao Za Zhi 2010; 35:348-51.

Guo J, Bei W, Hu Y et al. A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase and CYP7A1 in hyperlipidemic rats. J Ethnopharmacol 2011; 135:299-307.

Guo KK, Ren J. Cardiac overexpression of alcohol dehydrogenase (ADH) alleviates aging-associated cardiomyocyte contractile dysfunction: role of intracellular Ca2+ cycling proteins. Aging Cell 2006; 5:259-65.

Guo L, Liu Y, Bai Y, Sun Y, Xiao F, Guo Y. Gene expression profiling of drug-resistant small cell lung cancer cells by combining microRNA and cDNA expression analysis. Eur J Cancer 2010; 46:1692-702.

Guo LQ, Yamazoe Y. Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines. Acta Pharmacol Sin 2004; 25:129-36.

Guo S, Zhang X, Gan L, Zhu C, Gan Y. Effect of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) micelles on pharmacokinetics and intestinal toxicity of irinotecan hydrochloride: potential involvement of breast cancer resistance protein (ABCG2). J Pharm Pharmacol 2010; 62:973-84.

Guo T, Hajdu M, Agaram NP et al. Mechanisms of sunitinib resistance in gastrointestinal stromal tumors harboring KITAY502-3ins mutation: an in vitro mutagenesis screen for drug resistance. Clin Cancer Res 2009; 15:6862-70.

Guo T, Hobbs DW. Development of BACE1 inhibitors for Alzheimer’s disease. Curr Med Chem 2006; 13:1811-29.

Guo TW, Zhang FC, Yang MS et al. Positive association of the DIO2 (deiodinase type 2) gene with mental retardation in the iodine-deficient areas of China. J Med Genet 2004; 41:585-90.

Guo W, Dong Z, Guo Y et al. Polymorphisms of transforming growth factor-β1 associated with increased risk of gastric cardia adenocarcinoma in north China. Int J Immunogenet 2011; 38:215-24.

Guo WJ, Wang Q, Lanzi G et al. Gender-specific interactions between alcohol metabolism genes and severity of quantitative alcohol-related-traits in a Tibetan population. Neurosci Lett 2011; 495:22-5.

Guo X, Zeng Y, Deng H et al. Genetic polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the risk of nasopharyngeal carcinoma in a Han Chinese population of Southern China. BMC Res Notes 2010; 3:212.

Guo Y, Chen Y, Tan ZR, Klaassen CD, Zhou HH. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2011. doi:10. 1007/s00228-011-1108-2.

Guo Y, Köck K, Ritter CA et al. Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival. Clin Cancer Res 2009; 15:1762-9.

Guo Y, Li F, Ma XC, Cheng XG, Zhou HH, Klaassen CD. CYP2D plays a major role in berberine metabolism in liver of mice and humans. Xenobiotica 2011; 41:996-1005.

Guo Y, Traurig M, Ma L et al. CHRM3 gene variation is associated with decreased acute insulin secretion and increased risk for early-onset type 2 diabetes in Pima Indians. Diabetes 2006; 55:3625-9.

Guo Y, Wang Y, Si D, Fawcett PJ, Zhong D, Zhou H. Catalytic activities of human cytochrome P450 2C9*1, 2C9*3 and 2C9*13. Xenobiotica 2005; 35:853-61.

Guo Y, Zhang Y, Wang Y et al. Role of CYP2C9 and its variants (CYP2C9*3 and CYP2C9*13) in the metabolism of lornoxicam in humans. Drug Metab Dispos 2005; 33:749-53.

Guo Z, Inazu A, Yu W et al. Double deletions and missense mutations in the first nucleotide-binding fold of the ATP-binding cassette transporter A1 (ABCA1) gene in Japanese patients with Tangier disease. J Hum Genet 2002; 47:325-9.

Guo Z, Raeissi S, White RB, Stevens JC. Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes. Drug Metab Dispos 1997; 25:390-3.

Guo Z, Zhu J, Zhao L, Luo Q, Jin X. Expression and clinical significance of multidrug resistance proteins in brain tumors. J Exp Clin Cancer Res 2010; 29:122.

Guo ZD, Sun XC, Zhang JH. The role of apolipoprotein e in the pathological events following subarachnoid hemorrhage: a review. Acta Neurochir Suppl 2011; 110:5-7.

Guo ZS, Li C, Lin ZM et al. Association of IL-1 gene complex members with ankylosing spondylitis in Chinese Han population. Int J Immunogenet 2010; 37:33-7.

Gupta A, Dai Y, Vethanayagam RR et al. Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. Cancer Chemother Pharmacol 2006; 58:374-83.

Gupta A, Mugundu GM, Desai PB, Thummel KE, Unadkat JD. Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors. Drug Metab Dispos 2008; 36:1172-80.

Gupta A, Zhang Y, Unadkat JD, Mao Q. HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther 2004; 310:334-41.

Gupta D, Venkatesh M, Wang H et al. Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer. Clin Cancer Res 2008; 14:5332-40.

Gupta M, Chauhan C, Bhatnagar P et al. Genetic susceptibility to schizophrenia: role of dopaminergic pathway gene polymorphisms. Pharmacogenomics 2009; 10:277-91.

Gupta MK, Papay RS, Jurgens CW et al. alpha1-Adrenergic receptors regulate neurogenesis and gliogenesis. Mol Pharmacol 2009; 76:314-26.

Gupta RP, He YA, Patrick KS, Halpert JR, Bell NH. CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis. J Clin Endocrinol Metab 2005; 90:1210-9.

Gupta RP, Hollis BW, Patel SB, Patrick KS, Bell NH. CYP3A4 is a human microsomal vitamin D 25-hydroxylase. J Bone Miner Res 2004; 19:680-8.

Gupta RP, Patrick K, Bell NH. Mutational analysis of CYP27A1: assessment of 27-hydroxylation of cholesterol and 25-hydroxylation of vitamin D. Metabolism 2007; 56:1248-55.

Gupta S, Banfield C, Kantesaria B, Flannery B, Herron J. Pharmacokinetics/pharmacodynamics of desloratadine and fluoxetine in healthy volunteers. J Clin Pharmacol 2004; 44:1252-9.

Gupta SK, Kolz K, Cutler DL. Effects of multiple-dose pegylated interferon alfa-2b on the activity of drug-metabolizing enzymes in persons with chronic hepatitis C. Eur J Clin Pharmacol 2011; 67:591-9.

Gupta SV, Sass EJ, Davis ME et al. Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells. AAPS J 2011; 13:357-64.

Gupta VB, Laws SM, Villemagne VL et al. Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging. Neurology 2011; 76:1091-8.

Gupta-Rossi N, Six E, LeBail O et al. Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor. J Cell Biol 2004; 166:73-83.

Gurevich I, Tamir H, Arango V, Dwork AJ, Mann JJ, Schmauss C. Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron 2002; 34:349-56.

Gurley BJ, Gardner SF, Hubbard MA et al. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther 2002; 72:276-87.

Gurley BJ, Gardner SF, Hubbard MA et al. In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clin Pharmacol Ther 2004; 76:428-40.

Gurley BJ, Gardner SF, Hubbard MA et al. Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John’s wort, garlic oil, Panax ginseng and Ginkgo biloba. Drugs Aging 2005; 22:525-39.

Gurley BJ, Gardner SF, Hubbard MA et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther 2005; 77:415-26.

Gurley BJ, Swain A, Barone GW et al. Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans. Drug Metab Dispos 2007; 35:240-5.

Gurley BJ, Swain A, Hubbard MA et al. Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo. Clin Pharmacol Ther 2008; 83:61-9.

Gurtner GC, Davis V, Li H, McCoy MJ, Sharpe A, Cybulsky MI. Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes Dev 1995; 9:1-14.

Guryev OL, Gilep AA, Usanov SA, Estabrook RW. Interaction of apo-cytochrome b5 with cytochromes P4503A4 and P45017A: relevance of heme transfer reactions. Biochemistry 2001; 40:5018-31.

Gusella J, Gibbons K, Hobbs W et al. The G8 locus linked to Huntington’s disease. Am J Hum Genet 1984; 36:139.

Gusella J, McNeil S, Persichetti F et al. Huntington’s disease. Cold Spring Harbor Symp Quant Biol 1996; 61:615-26.

Gusella J, Tranzi R, Bader P et al. Deletion of Huntington’s disease linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome. Nature 1985; 318:75-8.

Gusella M, Frigo AC, Bolzonella C et al. Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer. Br J Cancer 2009; 100:1549-57.

Gusella M, Padrini R. G>C SNP of thymidylate synthase with respect to colorectal cancer. Pharmacogenomics 2007; 8:985-96.

Gusella M, Pasini F, Bolzonella C et al. Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours. Br J Clin Pharmacol 2011; 71:437-44.

Gustafson DL, Long ME, Bradshaw EL, Merz AL, Kerzic PJ. P450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing. Cancer Chemother Pharmacol 2005; 56:248-54.

Gustafson DL, Thamm DH. Pharmacokinetic modeling of doxorubicin pharmacokinetics in dogs deficient in ABCB1 drug transporters. J Vet Intern Med 2010; 24:579-86.

Gustafsson LL, Eriksson LS, Dahl ML, Eleborg L, Ericzon BG, Nyberg A. Cyclophosphamide-induced acute liver failure requiring transplantation in a patient with genetically deficient debrisoquine metabolism: a causal relationship? J Intern Med 1996; 240:311-4.

Gustavsson C, Parini P, Ostojic J et al. Cocoa butter and safflower oil elicit different effects on hepatic gene expression and lipid metabolism in rats. Lipids 2009; 44:1011-27.

Gut I, Ojima I, Vaclavikova R et al. Metabolism of new-generation taxanes in human, pig, minipig and rat liver microsomes. Xenobiotica 2006; 36:772-92.

Gutekunst C, Levey A, Hilman C et al. Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. Proc Nat Acad Sci USA 1995; 92:8710-4.

Guthrie SK, Hariharan M, Kumar AA, Bader G, Tandon R. The effect of paroxetine on thiothixene pharmacokinetics. J Clin Pharm Ther 1997; 22:221-6.

Gutiérrez B, Arranz MJ, Huezo-Diaz P et al. Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response. Schizophr Res 2002; 58:93-7.

Gutiérrez C, Vendrell J, Pastor R et al. Angiotensin I-converting enzyme and angiotensinogen gene polymorphisms in non-insulin-dependent diabetes mellitus. Lack of relationship with diabetic nephropathy and retinopathy in a Caucasian Mediterranean population. Metabolism 1997; 46:976-80.

Gutierrez GM, Kong E, Sabbagh Y et al. Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice. Proc Natl Acad Sci USA 2008; 105:18402-7.

Gutiérrez L, Quintana C, Patiño C et al. Iron speciation study in Hfe knockout mice tissues: magnetic and ultrastructural characterisation. Biochim Biophys Acta 2009; 1792:541-7.

Gutierrez MM, Rosenberg J, Abramowitz W. An evaluation of the potential for pharmacokinetic interaction between escitalopram and the cytochrome P450 3A4 inhibitor ritonavir. Clin Ther 2003; 25:1200-10.

Gutmann H, Poller B, Büter KB, Pfrunder A, Schaffner W, Drewe J. Hypericum perforatum: which constituents may induce intestinal MDR1 and CYP3A4 mRNA expression? Planta Med 2006; 72:685-90.

Gwak HS, Oh JH, Han HK. Effects of non-steroidal anti-inflammatory drugs on the pharmacokinetics and elimination of aciclovir in rats. J Pharm Pharmacol 2005; 57:393-8.

Gyamfi MA, Wan YJ. Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis. J Biol Chem 2009; 284:9321-30.

Gyémánt N, Engi H, Schelz Z et al. In vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosin. Br J Cancer 2010; 103:178-85.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z