General References


Jaakkola T, Backman JT, Neuvonen M, Neuvonen PJ. Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone. Clin Pharmacol Ther 2005; 77:404-14.

Jaakkola T, Laitila J, Neuvonen PJ, Backman JT. Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol 2006; 99:44-51.

Jaakola VP, Griffith MT, Hanson MA et al. The 2. 6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 2008; 322:1211-7.

Jaanson P, Marandi T, Kiivet RA et al. Maintenance therapy with zuclopenthixol decanoate: associations between plasma concentrations, neurological side effects and CYP2D6 genotype. Psychopharmacology 2002; 162:67-73.

Jablonska O, Shi Z, Valdez KE, Ting AY, Petroff BK. Temporal and anatomical sensitivities to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin leading to premature acyclicity with age in rats. Int J Androl 2010; 33:405-12.

Jackman KA, Miller AA, Drummond GR, Sobey CG. Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke. Brain Res 2009; 1286:215-20.

Jackman KM, Frye CB, Hunger SP. Flavopiridol displays preclinical activity in acute lymphoblastic leukemia. Pediatr Blood Cancer 2008; 50:772-8.

Jackson CM, Lipworth BJ. Beta2-adrenergic receptor genotype and survival after acute coronary syndrome. JAMA 2006; 295:757.

Jackson JP, Ferguson SS, Moore R, Negishi M, Goldstein JA. The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29. Mol Pharmacol 2004; 65:1397-404.

Jackson JP, Kabirov KK, Kapetanovic IM, Lyubimov A. In vitro assessment of P450 induction potential of novel chemopreventive agents SR13668, 9-cis-UAB30, and pentamethychromanol in primary cultures of human hepatocytes. Chem Biol Interact 2009; 179:263-72.

Jackson-Fisher AJ, Bellinger G, Ramabhadran R, Morris JK, Lee KF, Stern DF. ErbB2 is required for ductal morphogenesis of the mammary gland. Proc Natl Acad Sci USA 2004; 101:17138-43.

Jacob RM, Johnstone EC, Neville MJ et al. Identification of CYP2B6 sequence variants by use of multiplex PCR with allele-specific genotyping. Clin Chem 2004; 50:1372-7.

Jacobs A, Emmert D, Wieschrath S, Hrycyna CA, Wiese M. Recombinant synthesis of human ABCG2 expressed in the yeast Saccharomyces cerevisiae: an experimental methodological study. Protein J 2011; 30:201-11.

Jacobs S, Doering LC. Astrocytes prevent abnormal neuronal development in the fragile x mouse. J Neurosci 2010; 30:4508-14.

Jacobsen W, Christians U, Benet LZ. In vitro evaluation of the disposition of A novel cysteine protease inhibitor. Drug Metab Dispos 2000; 28:1343-51.

Jacobsen W, Kirchner G, Hallensleben K et al. Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos 1999; 27:173-9.

Jacobsen W, Kuhn B, Soldner A et al. Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin. Drug Metab Dispos 2000; 28:1369-78.

Jacobson PA, Green K, Birnbaum A, Remmel RP. Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA. Cancer Chemother Pharmacol 2002; 49:461-7.

Jacobson PA, Schladt D, Oetting WS et al. Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation. Transplantation 2011; 91:309-16.

Jacobson SG, Cideciyan AV, Bennett J, Kingsley RM, Sheffield VC, Stone EM. Novel mutation in the TIMP3 gene causes Sorsby fundus dystrophy. Arch Ophthalmol 2002; 120:376-9.

Jacolot S, Yang Y, Paitry P, Férec C, Mura C. Iron metabolism in macrophages from HFE hemochromatosis patients. Mol Genet Metab 2010; 101:258-67.

Jáchymová M, Horký K, Bultas J et al. Association of the Glu298Asp polymorphism in the endothelial nitric oxide synthase gene with essential hypertension resistant to conventional therapy. Biochem Biophys Res Commun 2001; 284:426-30.

Jada SR, Xiaochen S, Yan LY et al. Pharmacogenetics of SLCO1B1: haplotypes, htSNPs and hepatic expression in three distinct Asian populations. Eur J Clin Pharmacol 2007; 6:555-63.

Jafar T, Prasad N, Agarwal V et al. MDR-1 gene polymorphisms in steroid-responsive versus steroid-resistant nephrotic syndrome in children. Nephrol Dial Transplant 2011. doi:10. 1093/ndt/gfr150.

Jaffe CA, Turgeon DK, Lown K, Demott-Friberg R, Watkins PB. Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans. Am J Physiol Endocrinol Metab 2002; 283:1008-15.

Jaffe EK, Stith L. ALAD porphyria is a conformational disease. Am J Hum Genet 2007; 80:329-37.

Jaga K, Dharmani C. Methyl parathion: an organophosphate insecticide not quite forgotten. Rev Environ Health 2006; 21:57-67.

Jaganathan SK. Can flavonoids from honey alter multidrug resistance? Med Hypotheses 2011; 76:535-7.

Jäger W, Correia MA, Bornheim LM et al. Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism. Drug Metab Dispos 1999; 27:1505-11.

Jäger W, Gehring E, Hagenauer B, Aust S, Senderowicz A, Thalhammer T. Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: role of multidrug resistance protein 2 (Mrp2). Life Sci 2003; 73:2841-54.

Jägestedt M, von Bahr C. Combination of serotonergic agents resulted in severe adverse effects. Lakartidningen 2004; 101:1618-9.

Jagoda EM, Lang L, McCullough K et al. [(76) Br]BMK-152, a nonpeptide analogue, with high affinity and low nonspecific binding for the corticotropin-releasing factor type 1 receptor. Synapse 2011; 65:910-8.

Jahnel J, Fickert P, Langner C et al. Impact of experimental colitis on hepatobiliary transporter expression and bile duct injury in mice. Liver Int 2009; 29:1316-25.

Jaikang C, Chaiyasut C, Narongchai P, Niwatananun K, Narongchai S, Kusirisin W. Inhibitory effects of caffeic acid ester analogues on free radicals and human liver microsome CYP1A2 activities. Med Chem 2011; 7:99-105.

Jain L, Abraham S, Shord SS. The interactions of anti-cancer drugs approved in the last decade in the United States with membrane transporters. Anticancer Agents Med Chem 2010; 10:601-16.

Jain R, Agarwal S, Mandava NK, Sheng Y, Mitra AK. Interaction of dipeptide prodrugs of saquinavir with multidrug resistance protein-2 (MRP-2): evasion of MRP-2 mediated efflux. Int J Pharm 2008; 362:44-51.

Jain RB, Wang RY. Association of caffeine consumption and smoking status with the serum concentrations of polychlorinated biphenyls, dioxins, and furans in the general U. S. population: NHANES 2003-2004. J Toxicol Environ Health A 2011; 74:1225-39.

Jain S, Li Y, Patil S, Kumar A. A single-nucleotide polymorphism in human angiotensinogen gene is associated with essential hypertension and affects glucocorticoid induced promoter activity. J Mol Med 2005; 83:121-31.

Jain S, Shah M, Li Y, Vinukonda G, Sehgal PB, Kumar A. Upregulation of human angiotensinogen (AGT) gene transcription by interferon-gamma: involvement of the STAT1-binding motif in the AGT promoter. Biochim Biophys Acta 2006; 1759:340-7.

Jaisue S, Gerber JP, Davey AK. Pharmacokinetics of fexofenadine following LPS administration to rats. Xenobiotica 2010; 40:743-50.

Jaiswal AK, Gonzalez FJ, Nebert DW. Human P(1)-450 gene sequence and correlation of mRNA with genetic differences in benzo(a)pyrene metabolism. Nucleic Acids Res 1985; 13:4503-20.

Jaiswal AK, Nebert DW. Two RFLPs associated with the human P(1)450 gene linked to the MPI locus on chromosome 15 (HGM8 D15S8). Nucleic Acids Res 1986; 14:4376.

Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ. Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3-prime nontranslated region, and localization of gene to chromosome 15. J Exp Path 1987; 3:1-17.

Jakate AS, Roy P, Patel A et al. Effect of azole antifungals ketoconazole and fluconazole on the pharmacokinetics of dexloxiglumide. Br J Clin Pharmacol 2005; 60:498-507.

Jakobsson T, Venteclef N, Toresson G et al. GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus. Mol Cell 2009; 34:510-8.

Jaksch M, Hofmann S, Kleinle S et al. A systematic mutation screen of 10 nuclear and 25 mitochondrial candidate genes in 21 patients with cytochrome c oxidase (COX) deficiency shows tRNA(Ser)(UCN) mutations in a subgroup with syndromal encephalopathy. J Med Genet 1998; 35:895-900.

Jaksch M, Lochmuller H, Schmitt F, Volpel B, Obermaier-Kusser B, Horvath R. A mutation in mt tRNALeu(UUR) causing a neuropsychiatric syndrome with depression and cataract. Neurology 2001; 57:1930-1.

Jakubikova J, Adamia S, Kost-Alimova M et al. Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications. Blood 2011; 117:4409-19.

Jakubowska A, Gronwald J, Menkiszak et al. Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk. J Med Genet 2007; 44:408-11.

Jalava KM, Olkkola KT, Neuvonen PJ. Itraconazole greatly increases plasma concentrations and effects of felodipine. Clin Pharmacol Ther 1997; 61:410-5.

Jalba MS, Rhoads GG, Demissie K. Association of codon 16 and codon 27 beta 2-adrenergic receptor gene polymorphisms with obesity: a meta-analysis. Obesity 2008; 16:2096-106.

Jambroszyk M, Tipold A, Potschka H. Add-on treatment with verapamil in pharmacoresistant canine epilepsy. Epilepsia 2011; 52:284-91.

James C, Kapoor RR, Ismail D, Hussain K. The genetic basis of congenital hyperinsulinism. J Med Genet 2009; 46:289-99.

James HM, Gillis D, Hissaria P et al. Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis. J Rheumatol 2008; 4:562-71.

James JM, Gewolb C, Bautch VL. Neurovascular development uses VEGF-A signaling to regulate blood vessel ingression into the neural tube. Development 2009; 136:833-41.

James MO, Sacco JC, Faux LR. Effects of food natural products on the biotransformation of PCBs. Environ Toxicol Pharmacol 2008; 25:211-7.

Jamshidi Y, Moreton M, McKeown DA et al. Tribal ethnicity and CYP2B6 genetics in Ugandan and Zimbabwean populations in the UK: implications for efavirenz dosing in HIV infection. J Antimicrob Chemother 2010; 65:2614-9.

Jan MW, ZumBrunnen TL, Kazmi YR et al. Pharmacokinetics of fluvoxamine in relation to CYP2C19 phenotype and genotype. Drug Metabol Drug Interact 2002; 19:1-11.

Jana N, Zemskov E, Wang G, Nukima N. Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome release. Hum Molec Genet 2001; 10:1049-59.

Janardan SK, Lown KS, Schmiedlin-Ren P, Thummel KE, Watkins PB. Selective expression of CYP3A5 and not CYP3A4 in human blood. Pharmacogenetics 1996; 6:379-85.

Jancová P, Anzenbacherová E, Papousková B et al. Silybin is metabolized by cytochrome P450 2C8 in vitro. Drug Metab Dispos 2007; 35:2035-9.

Jancová P, Siller M, Anzenbacherová E, Křen V, Anzenbacher P, Simánek V. Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases. Xenobiotica 2011; 41:743-51.

Jang GR, Benet LZ. Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use. J Pharmacokinet Biopharm 1997; 25:647-72.

Jang GR, Benet LZ. Antiprogestin-mediated inactivation of cytochrome P450 3A4. Pharmacology 1998; 56:150-7.

Jang GR, Benet LZ. Cytochrome P4503A4-mediated N-demethylation of the antiprogestins lilopristone and onapristone. Drug Metab Dispos 1997; 25:1119-22.

Jang GR, Harris RZ. Drug interactions involving ethanol and alcoholic beverages. Expert Opin Drug Metab Toxicol 2007; 3:719-31.

Jang GR, Wrighton SA, Benet LZ. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. Biochem Pharmacol 1996; 52:753-61.

Jang HH, Kim DH, Ahn T, Yun CH. Functional and conformational modulation of human cytochrome P450 1B1 by anionic phospholipids. Arch Biochem Biophys 2010; 493:143-50.

Janha RE, Sisay-Joof F, Hamid-Adiamoh M et al. Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians. Pharmacogenomics 2009; 10:1423-31.

Jani AJ, Rathnam S, Mehta AA. Phenotyping of cytochrome P450 3A enzyme in Gujarat population. Drug Metab Lett 2008; 2:5-10.

Jani M, Makai I, Kis E et al. Ivermectin interacts with human ABCG2. J Pharm Sci 2011; 100:94-7.

Janicki PK. Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Med Sci Monit 2005; 11:322-8.

Janik-Papis K, Zaras M, Krzyzanowska A et al. Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a Polish population. Exp Mol Pathol 2009; 87:234-8.

Janjetovic Z, Tuckey RC, Nguyen MN, Thorpe EM Jr, Slominski AT. 20,23-dihydroxyvitamin D3, novel P450scc product, stimulates differentiation and inhibits proliferation and NF-kappaB activity in human keratinocytes. J Cell Physiol 2010; 223:36-48.

Janke D, Mehralivand S, Strand D et al. 6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4. Hum Mutat 2008; 29:659-69.

Jankowski JL, Fadale DJ, Anderson J et al. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vitro: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 2004; 13:159-70.

Jankowsky JL, Slunt HH, Gonzales V, Jenkins NA, Copeland NG, Borchelt DR. APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1. Neurobiol Aging 2004; 25:885-92.

Janmohamed A, Dolphin CT, Phillips IR, Shephard EA. Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450. Biochem Pharmacol 2001; 62:777-86.

Jann MW, Shirley KL, Small GW. Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. Clin Pharmacokinet 2002; 41:719-39.

Janneh O, Bray PG, Jones E et al. Concentration-dependent effects and intracellular accumulation of HIV protease inhibitors in cultured CD4 T cells and primary human lymphocytes. J Antimicrob Chemother 2010; 65:906-16.

Janneh O, Owen A, Bray PG, Back DJ, Pirmohamed M. The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes. Br J Pharmacol 2010; 159:484-93.

Jannetto PJ, Bratanow NC. Utilization of pharmacogenomics and therapeutic drug monitoring for opioid pain management. Pharmacogenomics 2009; 10:1157-67.

Jansen G, van der Heijden J, Oerlemans R et al. Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis. Arthritis Rheum 2004; 50:2130-9.

Jansen J, Friesema EC, Milici C, Visser TJ. Thyroid hormone transporters in health and disease. Thyroid 2005; 15:757-68.

Jansen MP, Sieuwerts AM, Look MP et al. HOXB13-to-IL17BR expression ratio is related with tumor aggressiveness and response to tamoxifen of recurrent breast cancer: a retrospective study. J Clin Oncol 2007; 25:662-8.

Janssen HL, Meinardi JR, Vleggaar FP et al. Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: results of a case-control study. Blood 2000; 96:2364-8.

Jansson I, Stoilov I, Sarfarazi M, Schenkman JB. Effect of two mutations of human CYP1B1, G61E and R469W, on stability and endogenous steroid substrate metabolism. Pharmacogenetics 2001; 11:793-801.

Jaquenoud Sirot E, Knezevic B, Morena GP et al. ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine. J Clin Psychopharmacol 2009; 29:319-26.

Jardin F, Picquenot JM, Parmentier F et al. Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value. Br J Haematol 2009; 146:607-18.

Jaremko M, Justenhoven C, Schroth W et al. Polymorphism of the DNA repair enzyme XRCC1 is associated with treatment prediction in anthracycline and cyclophosphamide/methotrexate/5-fluorouracil-based chemotherapy of patients with primary invasive breast cancer. Pharmacogenet Genomics 2007; 17:529-38.

Járomi L, Csöngei V, Polgár N et al. Functional variants of glucokinase regulatory protein and apolipoprotein A5 genes in ischemic stroke. J Mol Neurosci 2010; 41:121-8.

Jaruchotikamol A, Jarukamjorn K, Sirisangtrakul W, Sakuma T, Kawasaki Y, Nemoto N. Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes. Toxicol Appl Pharmacol 2007; 224:156-62.

Jarvik GP, Tsai NT, McKinstry LA et al. Vitamin C and E intake is associated with increased paraoxonase activity. Arterioscler Thromb Vasc Biol 2002; 22:1329-33.

Jarvis B, Coukell AJ. Mexiletine. A review of its therapeutic use in painful diabetic neuropathy. Drugs 1998; 56:691-707.

Jasińska M, Owczarek J, Orszulak-Michalak D. Influence of simvastatin at high dose and nifedipine on hemodynamic parameters in rabbits. Pharmacol Rep 2006; 58:48-59.

Jasińska M, Owczarek J, Orszulak-Michalak D. The influence of simvastatin at high dose and diltiazem on myocardium in rabbits, the biochemical study. Acta Pol Pharm 2006; 63:386-90.

Jaspers NG, Raams A, Silengo MC et al. First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure. Am J Hum Genet 2007; 80:457-66.

Jaszewska E, Kosmider A, Kiss AK, Naruszewicz M. Oenothera paradoxa defatted seeds extract containing pentagalloylglucose and procyanidins potentiates the cytotoxicity of vincristine. J Physiol Pharmacol 2010; 61:637-43.

Jáuregui I, Ferrer M, Montoro J et al. Antihistamines in the treatment of chronic urticaria. Investig Allergol Clin Immunol 2007; 17 Suppl 2:41-52.

Javitt NB. Oxysterols: functional significance in fetal development and the maintenance of normal retinal function. Curr Opin Lipidol 2007; 18:283-8.

Jawahar S, Moody C, Chan M, Finberg R, Geha R, Chatila T. Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II). Clin Exp Immunol 1996; 103:408-13.

Jayakanthan M, Chandrasekar S, Muthukumaran J, Mathur PP. Analysis of CYP3A4-HIV-1 protease drugs interactions by computational methods for Highly Active Antiretroviral Therapy in HIV/AIDS. J Mol Graph Model 2010; 28:455-63.

Jayasooriya AP, Mathai ML, Walker LL et al. Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance. Proc Natl Acad Sci USA 2008; 105:6531-6.

Jayson GC, Crowther D, Prendiville J et al. A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24 hour intravenous infusion. Br J Cancer 1995; 72:461-8.

Jazdzewski K, Bednarczuk T, Stepnowska M et al. beta-2-adrenergic receptor gene polymorphism confers susceptibility to Graves disease. Int J Mol Med 2007; 19:181-6.

Jazi R, Lalonde R, Qian S, Strazielle C. Regional brain evaluation of acetylcholinesterase activity in PS1/A246E transgenic mice. Neurosci Res 2009; 63:106-14.

Jeanneteau F, Funalot B, Jankovic J et al. A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. Proc Natl Acad Sci USA 2006; 103:10753-8.

Jeannot E, Poussin K, Chiche L et al. Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma. Cancer Res 2007; 67:2611-6.

Jedlitschky G, Vogelgesang S, Kroemer HK. MDR1-P-glycoprotein (ABCB1)-mediated disposition of amyloid-β peptides: implications for the pathogenesis and therapy of Alzheimer’s disease. Clin Pharmacol Ther 2010; 88:441-3.

Jefferson BK, Foster JH, McCarthy JJ et al. Aspirin resistance and a single gene. Am J Cardiol 2005; 95:805-8.

Jefferson JW, Pradko JF, Muir KT. Bupropion for major depressive disorder: Pharmacokinetic and formulation considerations. Clin Ther 2005; 27:1685-95.

Jeganathan S, Sanderson L, Dogruel M, Rodgers J, Croft S, Thomas SA. The distribution of nifurtimox across the healthy and trypanosome-infected murine blood-brain and blood-cerebrospinal fluid barriers. J Pharmacol Exp Ther 2011; 336:506-15.

Jemnitz K, Heredi-Szabo K, Janossy J, Ioja E, Vereczkey L, Krajcsi P. ABCC2/Abcc2: a multispecific transporter with dominant excretory functions. Drug Metab Rev 2010; 42:402-36.

Jendroska K, Hoffman O, Schelosky L, Lees AJ, Poewe W, Daniel SE. Absence of disease related prion protein in neurodegenerative disorders presenting with Parkinson’s syndrome. J Neurol Neurosurg Psychiat 1994; 57:1249-51.

Jendzelovský R, Mikes J, Koval’ J et al. Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. Photochem Photobiol Sci 2009; 8:1716-23.

Jenkins EC, Sanz MM, Ray JH, Stark-Houck SL, Brown WT. Distribution of diploidy, polyploidy, and endoreduplication in fra(X) positive and negative lymphocytes, amniocytes, and chorionic villi. Am J Med Genet 1991; 38:434-6.

Jenkins J, Williams D, Deng Y, Collins DA, Kitchen VS. Eltrombopag, an oral thrombopoietin receptor agonist, has no impact on the pharmacokinetic profile of probe drugs for cytochrome P450 isoenzymes CYP3A4, CYP1A2, CYP2C9 and CYP2C19 in healthy men: a cocktail analysis. Eur J Clin Pharmacol 2010; 66:67-76.

Jenner P. Genetic susceptibility and the occurrence of Parkinson’s disease. Parkinsonism Relat Disord 1999; 5:173-7.

Jennings BL, Sahan-Firat S, Estes AM et al. Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology. Hypertension 2010; 56:667-74.

Jensen BF, Vind C, Padkjaer SB, Brockhoff PB, Refsgaard HH. In silico prediction of cytochrome P450 2D6 and 3A4 inhibition using Gaussian kernel weighted k-nearest neighbor and extended connectivity fingerprints, including structural fragment analysis of inhibitors versus noninhibitors. J Med Chem 2007; 50:501-11.

Jensen KG, Dalgaard L. In vitro metabolism of the M1-muscarinic agonist 5-(2-ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine by human hepatic cytochromes P-450 determined at pH 7. 4 and 8. 5. Drug Metab Dispos 1999; 27:125-32.

Jensen LE, Wall AM, Cook M et al. A common ABCC2 promoter polymorphism is not a determinant of the risk of spina bifida. Birth Defects Res A Clin Mol Teratol 2004; 70:396-9.

Jensen RB, Vielwerth S, Larsen T, Greisen G, Leffers H, Juul A. The presence of the d3-growth hormone receptor polymorphism is negatively associated with fetal growth but positively associated with postnatal growth in healthy subjects. J Clin Endocrinol Metab 2007; 92:2758-63.

Jentsch JD, Trantham-Davidson H, Jairl C, Tinsley M, Cannon TD, Lavin A. Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice. Neuropsychopharmacology 2009; 34:2601-8.

Jeon HM, Sohn YW, Oh SY et al. ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9*-mediated suppression of SOX2. Cancer Res 2011; 71:3410-21.

Jeon S, Kim KH, Yun CH et al. An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells. Exp Mol Med 2008; 40:254-60.

Jeon YH, Bae SA, Lee YJ et al. Evaluation of the reversal of multidrug resistance by MDR1 ribonucleic acid interference in a human colon cancer model using a renilla luciferase reporter gene and coelenterazine. Mol Imaging 2010; 9:343-50.

Jeong ES, Won YS, Kim HC, Cho MH, Choi YK. IL-10 plays an important role in the anti-inflammatory properties against C. kutscheri infection in mice. J Microbiol Biotechnol 2009; 19:424-30.

Jeong HW, Cui W, Yang Y et al. SALL4, a stem cell factor, affects the side population by regulation of the ATP-binding cassette drug transport genes. PLoS One 2011. doi:10. 1371/journal. pone. 0018372.

Jeong JH, Jung YK, Kim HJ et al. The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues. Mol Cell Biol 2010; 30:2365-75.

Jeong YH, Kim IS, Park Y et al. Carriage of cytochrome 2C19 polymorphism is associated with risk of high post-treatment platelet reactivity on high maintenance-dose clopidogrel of 150 mg/day: results of the ACCEL-DOUBLE (Accelerated Platelet Inhibition by a Double Dose of Clopidogrel According to Gene Polymorphism) study. JACC Cardiovasc Interv 2010; 3:731-41.

Jeppesen U, Gram LF, Vistisen K, Loft S, Poulsen HE, Brøsen K. Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. Eur J Clin Pharmacol 1996; 51:73-8.

Jerevall PL, Brommesson S, Strand C et al. Exploring the two-gene ratio in breast cancer-independent roles for HOXB13 and IL17BR in prediction of clinical outcome. Breast Cancer Res Treat 2008; 107:225-34.

Jerling M. Clinical pharmacokinetics of ranolazine. Clin Pharmacokinet 2006; 45:469-91.

Jerling M, Bertilsson L, Sjöqvist F. The use of therapeutic drug monitoring data to document kinetic drug interactions: an example with amitriptyline and nortriptyline. Ther Drug Monit 1994; 16:1-12.

Jerling M, Dahl ML, Aberg-Wistedt A et al. The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol. Clin Pharmacol Ther 1996; 59:423-8.

Jerling M, Huan BL, Leung K, Chu N, Abdallah H, Hussein Z. Studies to investigate the pharmacokinetic interactions between ranolazine and ketoconazole, diltiazem, or simvastatin during combined administration in healthy subjects. J Clin Pharmacol 2005; 45:422-33.

Jerling M, Lindström L, Bondesson U, Bertilsson L. Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: evidence from a therapeutic drug monitoring service. Ther Drug Monit 1994; 16:368-74.

Jerling M, Merlé Y, Mentré F, Mallet A. Population pharmacokinetics of nortriptyline during monotherapy and during concomitant treatment with drugs that inhibit CYP2D6-an evaluation with the nonparametric maximum likelihood method. Br J Clin Pharmacol 1994; 38:453-62.

Jernström H, Bågeman E, Rose C, Jönsson PE, Ingvar C. CYP2C8 and CYP2C9 polymorphisms in relation to tumour characteristics and early breast cancer related events among 652 breast cancer patients. Br J Cancer 2009; 101:1817-23.

Jernström H, Chu W, Vesprini D et al. Genetic factors related to racial variation in plasma levels of insulin-like growth factor-1: implications for premenopausal breast cancer risk. Mol Genet Metab 2001; 72:144-54.

Jesien-Lewandowicz E, Jesionek-Kupnicka D, Zawlik I et al. High incidence of MGMT promoter methylation in primary glioblastomas without correlation with TP53 gene mutations. Cancer Genet Cytogenet 2009; 188:77-82.

Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low dose thiazides on the Renin Angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens 2008; 2:106-15.

Jetter A, Fätkenheuer G, Frank D et al. Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients? Antivir Ther 2010; 15:975-83.

Jetter A, Kinzig-Schippers M, Skott A et al. Cytochrome P450 2C9 phenotyping using low-dose tolbutamide. Eur J Clin Pharmacol 2004; 60:165-71.

Jetter A, Kinzig-Schippers M, Walchner-Bonjean M et al. Effects of grapefruit juice on the pharmacokinetics of sildenafil. Clin Pharmacol Ther 2002; 71:21-9.

Jeu L, Piacenti FJ, Lyakhovetskiy AG, Fung HB. Voriconazole. Clin Ther 2003; 25:1321-81.

Jeun J, Kim S, Cho SY et al. Hypocholesterolemic effects of Lactobacillus plantarum KCTC3928 by increased bile acid excretion in C57BL/6 mice. Nutrition 2010; 26:321-30.

Jeunemaitre X, Soubrier F, Kotelevtsev YV et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992; 71:7-20.

Jeynes B, Provias J. An investigation into the role of P-glycoprotein in Alzheimer’s disease lesion pathogenesis. Neurosci Lett 2011; 487:389-93.

Ji A, Meyer JM, Cai L et al. Scavenger receptor SR-BI in macrophage lipid metabolism. Atherosclerosis 2011; 217:106-12.

Ji BS, Li M, He L. Interaction of CJZ3, a lomerizine derivative, with ATPase activity of human P-glycoprotein in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells. Pharmazie 2010; 65:515-9.

Ji F, Wang W, Xia ZL et al. Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers. Carcinogenesis 2010; 31:648-53.

Ji F, Zhu SM, Wang AH et al. Genetic susceptibility of DNA damage induced by vinyl chloride monomer exposure. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2010; 28:12-7.

Ji G, Gu A, Zhou Y et al. Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm. PLoS One 2010. doi:10. 1371/journal. pone. 0013145.

Ji G, Gu A, Zhu P et al. Joint effects of XRCC1 polymorphisms and polycyclic aromatic hydrocarbons exposure on sperm DNA damage and male infertility. Toxicol Sci 2010; 116:92-8.

Ji HY, Kim SY, Kim DK, Jeong JH, Lee HS. Effects of eupatilin and jaceosidin on cytochrome p450 enzyme activities in human liver microsomes. Molecules 2010; 15:6466-75.

Ji HY, Lee HW, Kim HH et al. Role of human cytochrome P450 3A4 in the metabolism of DA-8159, a new erectogenic. Xenobiotica 2004; 34:973-82.

Ji HY, Lee HW, Kim HH, Choi JK, Lee HS. Characterization of human liver cytochrome P450 enzymes involved in the metabolism of a new H+/K+-ATPase inhibitor KR-60436. Toxicol Lett 2005; 155:103-14.

Ji HY, Lee SS, Yoo SE et al. In vitro metabolism of a new neuroprotective agent, KR-31543 in the human liver microsomes: identification of human cytochrome P450. Arch Pharm Res 2004; 27:239-45.

Ji HY, Liu KH, Lee H et al. Corydaline inhibits multiple cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes. Molecules 2011; 16:6591-602.

Ji HY, Shim HJ, Yoo M, Park ES, Lee HS. Transport of a new erectogenic udenafil in Caco-2 cells. Arch Pharm Res 2007; 30:1168-73.

Ji K, Choi K, Lee S et al. Effects of sulfathiazole, oxytetracycline and chlortetracycline on steroidogenesis in the human adrenocarcinoma (H295R) cell line and freshwater fish Oryzias latipes. J Hazard Mater 2010; 182:494-502.

Ji K, Seo J, Liu X et al. Genotoxicity and endocrine-disruption potentials of sediment near an oil spill site: Two years after the Hebei spirit oil spill. Environ Sci Technol 2011; 45:7481-8.

Ji L, Pan S, Marti-Jaun J, Hänseler E, Rentsch K, Hersberger M. Single-step assays to analyze CYP2D6 gene polymorphisms in Asians: allele frequencies and a novel *14B allele in mainland Chinese. Clin Chem 2002; 48:983-8.

Ji LD, Zhang LN, Shen P et al. Association of angiotensinogen gene M235T and angiotensin-converting enzyme gene I/D polymorphisms with essential hypertension in Han Chinese population: a meta-analysis. J Hypertens 2010; 28:419-28.

Ji N, Yuan J, Liu J, Tian S. Developing multidrug-resistant cells and exploring correlation between BCRP/ABCG2 over-expression and DNA methyltransferase. Acta Biochim Biophys Sin 2010; 42:854-62.

Ji Q, Shi X, Lin R et al. Participation of lipid transport and fatty acid metabolism in valproate sodium-induced hepatotoxicity in HepG2 cells. Toxicol In Vitro 2010; 24:1086-91.

Ji W, Gong BQ. Hypolipidemic effects and mechanisms of Panax notoginseng on lipid profile in hyperlipidemic rats. J Ethnopharmacol 2007; 113:318-24.

Ji W, Guo L, Lian J, Gong B. Hypolipidaemic mechanisms of action of CM108 (a flavone derivative) in hyperlipidaemic rats. J Pharm Pharmacol 2008; 60:1207-12.

Ji X, Takahashi N, Branko A et al. An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population. Nagoya J Med Sci 2008; 70:11-7.

Ji X, Takahashi N, Saito S et al. Relationship between three serotonin receptor subtypes (HTR3A, HTR2A and HTR4) and treatment-resistant schizophrenia in the Japanese population. Neurosci Lett 2008; 435:95-8.

Ji Y, Biernacka J, Snyder K et al. Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response. Pharmacogenomics J 2010. doi:10. 1038/tpj. 2010. 69.

Ji Y, Ferracci G, Warley A et al. Beta-actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90. Proc Nat Acad Sci USA 2007; 104:8839-44.

Ji Y, Zhang AM, Jia X et al. Mitochondrial DNA haplogroups M7b1’2 and M8a affect clinical expression of leber hereditary optic neuropathy in Chinese families with the m. 11778G→a mutation. Am J Hum Genet 2008; 83:760-8.

Ji Z, Long H, Hu Y et al. Expression of MDR1, HIF-1α and MRP1 in sacral chordoma and chordoma cell line CM-319. J Exp Clin Cancer Res 2010; 29:158.

Ji ZS, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells. J Biol Chem 2002; 277:21821-8.

Jia H, Hingorani AD, Sharma P et al. Association of the G(s)alpha gene with essential hypertension and response to beta-blockade. Hypertension 1999; 34:8-14.

Jia H, Xu A, Yuan J, Gao X, Gao J. Experimental study on cytochrome P450 enzymes after receiving ferment powder caterpillar fungus. Zhongguo Zhong Yao Za Zhi 2009; 34:2079-82.

Jia WH, Pan QH, Qin HD et al. A case-control and a family-based association study revealing an association between CYP2E1 polymorphisms and nasopharyngeal carcinoma risk in Cantonese. Carcinogenesis 2009; 30:2031-6.

Jia Y, Li ZY, Zhang HG, Li HB, Liu Y, Li XH. Panax notoginseng saponins decrease cholesterol ester via up-regulating ATP-binding cassette transporter A1 in foam cells. J Ethnopharmacol 2010; 132:297-302.

Jiang CQ, Lam TH, Liu B et al. Interleukin-6 Receptor Gene Polymorphism Modulates Interleukin-6 Levels and the Metabolic Syndrome: GBCS-CVD. Obesity 2010; 18:1969-74.

Jiang D, Bai X, Zhang Q et al. Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling. Eur J Clin Pharmacol 2009; 65:1187-93.

Jiang DK, Yao L, Wang WZ et al. TP53 Arg72Pro polymorphism is associated with esophageal cancer risk: A meta-analysis. World J Gastroenterol 2011; 17:1227-33.

Jiang H, Shi J, Li Y. Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz. Molecules 2011; 16:3146-51.

Jiang H, Zhong F, Sun L, Feng W, Huang ZX, Tan X. Structural and functional insights into polymorphic enzymes of cytochrome P450 2C8. Amino Acids 2011; 40:1195-204.

Jiang J, Liang X, Zhou X et al. DNA repair gene X-ray repair cross complementing group 1 Arg194Trp polymorphism on the risk of lung cancer: a meta-analysis on 22 studies. J Thorac Oncol 2010; 5:1741-7.

Jiang J, Yang SJ, Wang JC et al. Sequential treatment of drug-resistant tumors with RGD-modified liposomes containing siRNA or doxorubicin. Eur J Pharm Biopharm 2010; 76:170-8.

Jiang JG, Chen CL, Card JW et al. Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors. Cancer Res 2005; 65:4707-15.

Jiang JG, Chen RJ, Xiao B et al. Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. Prostaglandins Other Lipid Mediat 2007; 82:162-74.

Jiang JG, Fu XN, Chen CL, Wang DW. Expression of cytochrome P450 arachidonic acid epoxygenase 2J2 in human tumor tissues and cell lines. Ai Zheng 2009; 28:93-6.

Jiang JG, Ning YG, Chen C et al. Cytochrome p450 epoxygenase promotes human cancer metastasis. Cancer Res 2007; 67:6665-74.

Jiang JG, Shen GF, Chen C, Fu XN, Wang DW. Effects of cytochrome P450 arachidonic acid epoxygenases on the proliferation of tumor cells. Ai Zheng 2009; 28:14-9.

Jiang JH, Jia WH, Qin HD, Liang H, Pan ZG, Zeng YX. Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue. Ai Zheng 2004; 23:672-7.

Jiang K, Li K, Qin F, Lu X, Li F. Assessment of a novel β2-adrenoceptor agonist, trantinterol, for interference with human liver cytochrome P450 enzymes activities. Toxicol In Vitro 2011; 25:1033-8.

Jiang M, Fernandez S, Jerome WG et al. Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy. Cell Death Differ 2010; 17:469-81.

Jiang Q, Dibra F, Lee MD, Oldenburg R, Uitto J. Overexpression of fetuin-a counteracts ectopic mineralization in a mouse model of pseudoxanthoma elasticum (abcc6(-/-)). J Invest Dermatol 2010; 130:1288-96.

Jiang Q, Heneka M, Landreth GE. The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer’s disease: therapeutic implications. CNS Drugs 2008; 22:1-14.

Jiang Q, Li Q, Grand-Pierre AE, Schurgers LJ, Uitto J. Administration of vitamin K does not counteract the ectopic mineralization of connective tissues in Abcc6 (-/-) mice, a model for pseudoxanthoma elasticum. Cell Cycle 2011; 10:701-7.

Jiang R, Yamaori S, Takeda S, Yamamoto I, Watanabe K. Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes. Life Sci 2011; 89:165-70.

Jiang S, Zu Y, Zhang Y, Fu Y, Wang Z, Wang J. Transport of a hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel, by human intestinal epithelial Caco-2 cells. Planta Med 2010; 76:1592-5.

Jiang W, Cazacu S, Xiang C et al. FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway. Neoplasia 2008; 10:235-43.

Jiang W, Couroucli XI, Wang L, Barrios R, Moorthy B. Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo. Biochem Biophys Res Commun 2011; 407:79-85.

Jiang W, Wang L, Kondraganti SR et al. Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo. J Pharmacol Exp Ther 2010; 335:369-79.

Jiang W, Wang L, Zhang W, Coffee R, Fazili IS, Moorthy B. Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters. Biochem Biophys Res Commun 2009; 390:1419-24.

Jiang X, Sheng H, Li J et al. Association between renin-angiotensin system gene polymorphism and essential hypertension: a community-based study. J Hum Hypertens 2009; 23:176-81.

Jiang X, Sheng HH, Lin G et al. Effect of renin-angiotensin-aldosterone system gene polymorphisms on blood pressure response to antihypertensive treatment. Chin Med J 2007; 120:782-6.

Jiang XL, Shen HW, Yu AM. Pinoline may be used as a probe for CYP2D6 activity. Drug Metab Dispos 2009; 37:443-6.

Jiang Y, He X, Ortiz de Montellano PR. Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes. Biochemistry 2006; 45:533-42.

Jiang Y, Ortiz de Montellano PR. Cooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone. Chembiochem 2009; 10:650-3.

Jiang Y, Zhou L, Yan T, Shen Z, Shao Z, Lu J. Association of sulfotransferase SULT1A1 with breast cancer risk: a meta-analysis of case-control studies with subgroups of ethnic and menopausal statue. J Exp Clin Cancer Res 2010; 29:101.

Jiang YG, Wang YM, Liu TH, Liu J. Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B. World J Gastroenterol 2003; 9:2221-5.

Jiang YJ, Lu B, Tarling EJ et al. Regulation of ABCG1 expression in human keratinocytes and murine epidermis. J Lipid Res 2010; 51:3185-95.

Jiang Z, Akey JM, Shi J et al. A polymorphism in the promoter region of catalase is associated with blood pressure levels. Hum Genet 2001; 109:95-8.

Jiang Z, Dalton TP, Jin L et al. Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. Hum Mutat 2005; 25:196-206.

Jiang Z, Li C, Xu Y, Cai S. A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk. Int J Colorectal Dis 2010; 25:169-80.

Jiang Z, Wang Z, Xu Y, Wang B, Huang W, Cai S. Analysis of RGS2 expression and prognostic significance in stage II and III colorectal cancer. Biosci Rep 2010; 30:383-90.

Jiang Z, Zhou R, Xu C, Feng G, Zhou Y. Genetic variation of the ATP-binding cassette transporter A1 and susceptibility to coronary heart disease. Mol Genet Metab 2011; 103:81-8.

Jiao H, Liu C, Guo W, Peng L, Chen Y, Martin FL. Association of CYP1B1 polymorphisms with breast cancer: A case-control Study in the Han population in Ningxia Hui autonomous region, P. R. China. Biomark Insights 2010; 5:21-7.

Jiao R, Zhang Z, Yu H, Huang Y, Chen ZY. Hypocholesterolemic activity of grape seed proanthocyanidin is mediated by enhancement of bile acid excretion and up-regulation of CYP7A1. J Nutr Biochem 2010; 21:1134-9.

Jiao Y, Shi C, Edil BH et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science 2011; 331:1199-203.

Jiao YL, Zhang BC, You L et al. Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis. J Clin Immunol 2010; 30:840-4.

Jie Z, Hong K, Jianhong T, Biao C, Yongmei Z, Jingchuan L. Haplotype analysis of the CYP2J2 gene associated with myocardial infarction in a Chinese Han population. Cell Biochem Funct 2010; 28:435-9.

Jiko M, Yano I, Sato E et al. Pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine, and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers. Int J Clin Oncol 2007; 12:284-90.

Jimeno A, Hallur G, Chan A et al. Development of two novel benzoylphenylurea sulfur analogues and evidence that the microtubule-associated protein tau is predictive of their activity in pancreatic cancer. Mol Cancer Ther 2007; 6:1509-16.

Jin C, Miners JO, Lillywhite KJ, Mackenzie PI. Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. J Pharmacol Exp Ther 1993; 264:475-9.

Jin F, Xiong WJ, Jing JC, Feng Z, Qu LS, Shen XZ. Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review. J Cancer Res Clin Oncol 2011; 137:1095-104.

Jin G, Yoo SS, Cho S et al. Dual roles of a variable number of tandem repeat polymorphism in the TERT gene in lung cancer. Cancer Sci 2011; 102:144-9.

Jin H, Evangelou E, Ioannidis JP, Ralston SH. Polymorphisms in the 5’ flank of COL1A1 gene and osteoporosis: meta-analysis of published studies. Osteoporos Int 2011; 22:911-21.

Jin H, Meyer JM, Mudaliar S, Jeste DV. Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectin. Schizophr Res 2008; 100:70-85.

Jin H, Stewart TL, Hof RV, Reid DM, Aspden RM, Ralston S. A rare haplotype in the upstream regulatory region of COL1A1 is associated with reduced bone quality and hip fracture. J Bone Miner Res 2009; 24:448-54.

Jin H, van’t Hof RJ, Albagha OM, Ralston SH. Promoter and intron 1 polymorphisms of COL1A1 interact to regulate transcription and susceptibility to osteoporosis. Hum Mol Genet 2009; 18:2729-38.

Jin HS, Hong KW, Lim JE et al. Genetic variations in the sodium balance-regulating genes ENaC, NEDD4L, NDFIP2 and USP2 influence blood pressure and hypertension. Kidney Blood Press Res 2010; 33:15-23.

Jin J, Bi H, Hu J et al. Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats. Biopharm Drug Dispos 2010; 31:264-8.

Jin J, Sun L, Jiao W et al. SLC11A1 (Formerly NRAMP1) gene polymorphisms associated with pediatric tuberculosis in China. Clin Infect Dis 2009; 48:733-8.

Jin JL, Sun J, Ge HJ et al. Association between CYP19 gene SNP rs2414096 polymorphism and polycystic ovary syndrome in Chinese women. BMC Med Genet 2009; 10:139.

Jin JQ, Hu YY, Niu YM et al. CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-analysis. World J Gastroenterol 2011; 17:260-6.

Jin L, Li J, Nation RL, Nicolazzo JA. Impact of p-glycoprotein inhibition and lipopolysaccharide administration on blood-brain barrier transport of colistin in mice. Antimicrob Agents Chemother 2011; 55:502-7.

Jin M, Arya P, Patel K et al. Effect of alcohol on drug efflux protein and drug metabolic enzymes in U937 macrophages. Alcohol Clin Exp Res 2011; 35:132-9.

Jin M, Earla R, Shah A et al. A LC-MS/MS method for concurrent determination of nicotine metabolites and role of CYP2A6 in nicotine metabolism in U937 macrophages: implications in oxidative stress in HIV + smokers. J Neuroimmune Pharmacol 2011. doi:10. 1007/s11481-011-9283-6.

Jin M, Gock SB, Jannetto PJ, Jentzen JM, Wong SH. Pharmacogenomics as molecular autopsy for forensic toxicology: genotyping cytochrome P450 3A4*1B and 3A5*3 for 25 fentanyl cases. J Anal Toxicol 2005; 29:590-8.

Jin MJ, Han HK. Effect of piperine, a major component of black pepper, on the intestinal absorption of fexofenadine and its implication on food-drug interaction. J Food Sci 2010; 75:93-6.

Jin R, Koop DR, Raucy JL, Lasker JM. Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4. Arch Biochem Biophys 1998; 359:89-98.

Jin SK, Chung HJ, Chung MW et al. Influence of CYP2D6*10 on the pharmacokinetics of metoprolol in healthy Korean volunteers. J Clin Pharm Ther 2008; 33:567-73.

Jin W, Liu Y, Xu SG et al. UHRF1 inhibits MDR1 gene transcription and sensitizes breast cancer cells to anticancer drugs. Breast Cancer Res Treat 2010; 124:39-48.

Jin Y. Activities of aldo-keto reductase 1 enzymes on two inhaled corticosteroids: Implications for the pharmacological effects of inhaled corticosteroids. Chem Biol Interact 2011; 191:234-8.

Jin Y, Desta Z, Stearns V et al. CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst 2005; 97:30-9.

Jin Y, Dietz HC, Montgomery RA et al. Glanzmann thrombasthenia. Cooperation between sequence variants in cis during splice site selection. J Clin Invest 1996; 98:1745-54.

Jin Y, Hayes DF, Li L et al. Estrogen receptor genotypes influence hot flash prevalence and composite score before and after tamoxifen therapy. J Clin Oncol 2008; 26:5849-54.

Jin Y, Pollock BG, Frank E et al. Effect of age, weight, and CYP2C19 genotype on escitalopram exposure. J Clin Pharmacol 2010; 50:62-72.

Jin Y, Zollinger M, Borell H, Zimmerlin A, Patten CJ. CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis. Drug Metab Dispos 2011; 39:191-8.

Jing L, Jin CM, Li SS et al. Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy. Mol Cell Biochem 2011. doi:10. 1007/s11010-011-1022-z.

Jing X, Liu X, Wen T et al. Combined effects of epileptic seizure and phenobarbital induced overexpression of P-glycoprotein in brain of chemically kindled rats. Br J Pharmacol 2010; 159:1511-22.

Jinnai N, Sakagami T, Sekigawa T et al. Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach. Hum Mol Genet 2004; 13:3203-17.

Jinnai T, Horiuchi H, Makiyama T et al. Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan. Circ J 2009; 73:1498-503.

Jinno H, Saeki M, Saito Y et al. Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients. J Pharmacol Exp Ther 2003; 306:688-93.

Jinno H, Saeki M, Tanaka-Kagawa T et al. Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10. Drug Metab Dispos 2003; 31:528-32.

Jinno H, Tanaka-Kagawa T, Hanioka N et al. Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver. Mol Pharmacol 2004; 65:496-502.

Jo DG, Kim MJ, Choi YH et al. Pro-apoptotic function of calsenilin/DREAM/KChIP3. FASEB J 2001; 15:586-91.

Jobe SO, Ramadoss J, Koch JM, Jiang Y, Zheng J, Magness RR. Estradiol-17beta and its cytochrome P450- and catechol-O-methyltransferase-derived metabolites stimulate proliferation in uterine artery endothelial cells: role of estrogen receptor-alpha versus estrogen receptor-beta. Hypertension 2010; 55:1005-11.

Joerger M, Bosch TM, Doodeman VD, Beijnen JH, Smits PH, Schellens JH. Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers. Eur J Clin Pharmacol 2006; 62:681-4.

Johansen A, Ek J, Mortensen HB, Pedersen O, Hansen T. Half of clinically defined maturity-onset diabetes of the young patients in Denmark do not have mutations in HNF4A, GCK, and TCF1. J Clin Endocrinol Metab 2005; 90:4607-14.

Johansen CT, Wang J, Lanktree MB et al. Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet 2010; 42:684-7.

Johansen CT, Wang J, Lanktree MB et al. An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia. Arterioscler Thromb Vasc Biol 2011; 31:1916-26.

Johansson A, Hampel H, Faltraco F et al. Increased frequency of a new polymorphism in the cell division cycle 2 (cdc2) gene in patients with Alzheimer’s disease and frontotemporal dementia. Neurosci Lett 2003; 340:69-73.

Johansson I, Lundqvist E, Bertilsson L, Dahl ML, Sjöqvist F, Ingelman-Sundberg M. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci USA 1993; 90:11825-9.

Johansson I, Oscarson M, Yue QY, Bertilsson L, Sjöqvist F, Ingelman-Sundberg M. Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol Pharmacol 1994; 46:452-9.

Johansson LE, Danielsson P, Norgren S, Marcus C, Ridderstråle M. Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity. Int J Pediatr Obes 2009; 4:119-25.

Johansson M, McKay JD, Wiklund F et al. Genetic variation in the SST gene and its receptors in relation to circulating levels of insulin-like growth factor-I, IGFBP3, and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2009; 18:1644-50.

Johansson S, Halleland H, Halmøy A et al. Genetic analyses of dopamine related genes in adult ADHD patients suggest an association with the DRD5-microsatellite repeat, but not with DRD4 or SLC6A3 VNTRs. Am J Med Genet B Neuropsychiatr Genet 2008; 147:1470-5.

Johansson S, Raeder H, Eide SA et al. Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians. Diabetes 2007; 56:3112-7.

Johnatty SE, Beesley J, Chen X et al. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility “hot-spot”. PLoS Genet 2010. doi:10. 1371/journal. pgen. 1001016.

Johns LE, Houlston RS. Glutathione S-transferase mu1 (GSTM1) status and bladder cancer risk: a meta-analysis. Mutagenesis 2000; 15:399-404.

Johnson AD, Gong Y, Wang D et al. Promoter polymorphisms in ACE (angiotensin I-converting enzyme) associated with clinical outcomes in hypertension. Clin Pharmacol Ther 2009; 85:36-44.

Johnson AD, Zhang Y, Papp AC et al. Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues. Pharmacogenet Genomics 2008; 18:781-91.

Johnson BM, Adams LM, Zhang K et al. Ketoconazole and rifampin significantly affect the pharmacokinetics, but not the safety or QTc interval, of casopitant, a neurokinin-1 receptor antagonist. J Clin Pharmacol 2010; 50:951-9.

Johnson BM, Song IH, Adkison KK et al. Evaluation of the drug interaction potential of aplaviroc, a novel human immunodeficiency virus entry inhibitor, using a modified cooperstown 5 + 1 cocktail. J Clin Pharmacol 2006; 46:577-87.

Johnson CN, Ahmed M, Miller ND. 5-HT6 receptor antagonists: prospects for the treatment of cognitive disorders including dementia. Curr Opin Drug Discov Devel 2008; 11:642-54.

Johnson DC, Corthals S, Ramos C et al. Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping. Blood 2008; 112:4924-34.

Johnson DC, Corthals SL, Walker BA et al. Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma. J Clin Oncol 2011; 29:797-804.

Johnson DR, Guo GL, Klaassen CD. Expression of rat Multidrug Resistance Protein 2 (Mrp2) in male and female rats during normal and pregnenolone-16alpha-carbonitrile (PCN)-induced postnatal ontogeny. Toxicology 2002; 178:209-19.

Johnson DR, Li CW, Chen LY, Ghosh JC, Chen JD. Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Mol Pharmacol 2006; 69:99-108.

Johnson DW, Berg JN, Baldwin MA et al. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet 1996; 13:189-95.

Johnson FM, Agrawal S, Burris H et al. Phase 1 pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors. Cancer 2010; 116:1582-91

Johnson GE, Quick EL, Parry EM, Parry JM. Metabolic influences for mutation induction curves after exposure to Sudan-1 and para red. Mutagenesis 2010; 25:327-33.

Johnson JA. Predictability of the effects of race or ethnicity on pharmacokinetics of drugs. Int J Clin Pharmacol Ther 2000; 38:53-60.

Johnson JA, Herring VL, Wolfe MS, Relling MV. CYP1A2 and CYP2D6 4-hydroxylate propranolol and both reactions exhibit racial differences. J Pharmacol Exp Ther 2000; 294:1099-105.

Johnson JA, Terra SG. Beta-adrenergic receptor polymorphisms: cardiovascular disease associations and pharmacogenetics. Pharm Res 2002; 19:1779-87.

Johnson JA, Zineh I, Puckett BJ, McGorray SP, Yarandi HN, Pauly DF. Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther 2003; 74:44-52.

Johnson JL, Devel L, Czarny B et al. A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice. Arterioscler Thromb Vasc Biol 2011; 31:528-35.

Johnson JN, Tester DJ, Perry J, Salisbury BA, Reed CR, Ackerman MJ. Prevalence of early-onset atrial fibrillation in congenital long QT syndrome. Heart Rhythm 2008; 5:704-9.

Johnson KW, Phebus LA, Cohen ML. Serotonin in migraine: theories, animal models and emerging therapies. Prog Drug Res 1998; 51:219-44.

Johnson L, Orchard PJ, Baker KS et al. Glutathione S-transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantation. J Clin Pharmacol 2008; 48:1052-62.

Johnson MR, Wang K, Diasio RB. Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype. Clin Cancer Res 2002; 8:768-74.

Johnson N, Bentley J, Wang LZ et al. Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells. Br J Cancer 2010; 102:342-50.

Johnson S. Gradual micronutrient accumulation and depletion in Alzheimer’s disease. Med Hypotheses 2001; 56:595-7.

Johnson TN, Kerbusch T, Jones B, Tucker GT, Rostami-Hodjegan A, Milligan PA. Assessing the efficiency of mixed effects modelling in quantifying metabolism based drug-drug interactions: using in vitro data as an aid to assess study power. Pharm Stat 2009; 8:186-202.

Johnson TN, Tanner MS, Taylor CJ, Tucker GT. Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis. Br J Clin Pharmacol 2001; 51:451-60.

Jokanović M. Medical treatment of acute poisoning with organophosphorus and carbamate pesticides. Toxicol Lett 2009; 190:107-15.

Jokinen MJ, Ahonen J, Neuvonen PJ, Olkkola KT. The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine. Anesth Analg 2000; 91:1207-12.

Jokinen MJ, Olkkola KT, Ahonen J, Neuvonen PJ. Effect of rifampin and tobacco smoking on the pharmacokinetics of ropivacaine. Clin Pharmacol Ther 2001; 70:344-50.

Jokinen MJ, Ahonen J, Neuvonen PJ, Olkkola KT. Effect of clarithromycin and itraconazole on the pharmacokinetics of ropivacaine. Pharmacol Toxicol 2001; 88:187-91.

Jokinen MJ, Olkkola KT, Ahonen J, Neuvonen PJ. Effect of ciprofloxacin on the pharmacokinetics of ropivacaine. Eur J Clin Pharmacol 2003; 58:653-7.

Jonas DE, McLeod HL. Genetic and clinical factors relating to warfarin dosing. Trends Pharmacol Sci 2009; 30:375-86.

Jones A, Korpi ER, McKernan RM et al. Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression. J Neurosci 1997; 17:1350-62.

Jones AE, Brown KC, Werner RE et al. Variability in drug metabolizing enzyme activity in HIV-infected patients. Eur J Clin Pharmacol 2010; 66:475-85.

Jones D, Kamel-Reid S, Bahler D et al. Laboratory practice guidelines for detecting and reporting BCR-ABL drug resistance mutations in chronic myelogenous leukemia and acute lymphoblastic leukemia: a report of the Association for Molecular Pathology. J Mol Diagn 2009; 11:4-11.

Jones DA, Prior SL, Tang TS et al. Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus. Diabetes Res Clin Pract 2010; 90:196-201.

Jones DR, Ekins S, Li L, Hall SD. Computational approaches that predict metabolic intermediate complex formation with CYP3A4 (+b5). Drug Metab Dispos 2007; 35:1466-75.

Jones DR, Gorski JC, Haehner BD, O’Mara EM Jr, Hall SD. Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation. Clin Pharmacol Ther 1996; 60:374-84.

Jones DR, Gorski JC, Hamman MA, Mayhew BS, Rider S, Hall SD. Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation. J Pharmacol Exp Ther 1999; 290:1116-25.

Jones DR, Kim SY, Guderyon M, Yun CH, Moran JH, Miller GP. Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin. Chem Res Toxicol 2010; 23:939-45.

Jones EL, Ballard CG, Prasher VP et al. An intron 7 polymorphism in APP affects the age of onset of dementia in Down syndrome. Int J Alzheimers Dis 2010. doi:10. 4061/2011/929102.

Jones EL, Kalaria RN, Sharp SI, O’Brien JT, Francis PT, Ballard CG. Genetic associations of autopsy-confirmed vascular dementia subtypes. Dement Geriatr Cogn Disord 2011; 31:247-53.

Jones KD, Huang WH. Evaluation of toxicity of the pesticides, chlorpyrifos and arsenic, in the presence of compost humic substances in aqueous systems. J Hazard Mater 2003; 103:93-105.

Jones LK, O’Sullivan KM, Semple T et al. IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis. Nephrol Dial Transplant 2009; 24:3024-32.

Jones PB, Adams KW, Rozkalne A et al. Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain. PLoS One 2011. doi:10. 1371/journal. pone. 0014586.

Jones SN, Jones PG, Ibarguen H, Caskey CT, Craigen WJ. Induction of the Cyp1a-1 dioxin-responsive enhancer in transgenic mice. Nucleic Acids Res 1991; 19:6547-51.

Jones SR, Cyr DG. Regulation and characterization of the ATP-binding cassette transporter-B1 in the epididymis and epididymal spermatozoa of the rat. Toxicol Sci 2011; 119:369-79.

Jonker JW, Wagenaar E, van Eijl S, Schinkel AH. Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations. Mol Cell Biol 2003; 23:7902-8.

Jönsen A, Gunnarsson I, Gullstrand B et al. Association between SLE nephritis and polymorphic variants of the CRP and FcgammaRIIIa genes. Rheumatology 2007; 46:1417-21.

Jönsson E, Lannfelt L, Engvall B, Sedvall G. Lack of association between schizophrenia and the apolipoprotein E Є4 allele. Eur Arch Psychiatry Clin Neurosci 1996; 246:182-4.

Jönsson EG, Bah J, Melke J et al. Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers. BMC Psychiatry 2004; 4:4.

Joo H, Choi K, Rose RL, Hodgson E. Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos. J Biochem Mol Toxicol 2007; 21:76-80.

Joo Y, Kim HS, Woo RS et al. Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer’s disease models. Mol Pharmacol 2006; 69:76-84.

Joober R, Benkelfat C, Brisebois K et al. T102C polymorphism in the 5HT2A gene and schizophrenia: relation to phenotype and drug response variability. J Psychiatry Neurosci 1999; 24:141-6.

Joos AA, König F, Frank UG, Kaschka WP, Mörike KE, Ewald R. Dose-dependent pharmacokinetic interaction of clozapine and paroxetine in an extensive metabolizer. Pharmacopsychiatry 1997; 30:266-70.

Joost HG. The genetic basis of obesity and type 2 diabetes: lessons from the new zealand obese mouse, a polygenic model of the metabolic syndrome. Results Probl Cell Differ 2010; 52:1-11.

Jordan CG, Rashidi MR, Laljee H, Clarke SE, Brown JE, Beedham C. Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man. J Pharm Pharmacol 1999; 51:411-8.

Jorge AA, Arnhold IJ. Growth hormone receptor exon 3 isoforms and their implication in growth disorders and treatment. Horm Res 2009; 71 Suppl 2:55-63.

Jorge AA, Marchisotti FG, Montenegro LR et al. Growth hormone (GH) pharmacogenetics: influence of GH receptor exon 3 retention or deletion on first-year growth response and final height in patients with severe GH deficiency. J Clin Endocrinol Metab 2006; 91:1076-80.

Jorge LF, Eichelbaum M, Griese EU, Inaba T, Arias TD. Comparative evolutionary pharmacogenetics of CYP2D6 in Ngawbe and Embera Amerindians of Panama and Colombia: role of selection versus drift in world populations. Pharmacogenetics 1999; 9:217-28.

Jorge-Nebert LF, Eichelbaum M, Griese EU, Inaba T, Arias TD. Analysis of six SNPs of NAT2 in Ngawbe and Embera Amerindians of Panama and determination of the Embera acetylation phenotype using caffeine. Pharmacogenetics 2002; 12:39-48.

Jorge-Nebert LF, Jiang Z, Chakraborty R et al. Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations. Hum Mutat 2010; 31:27-40.

Jorgensen AL, Al-Zubiedi S, Zhang JE et al. Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study. Pharmacogenet Genomics 2009; 19:800-12.

Jorgensen TJ, Helzlsouer KJ, Clipp SC, Bolton JH, Crum RM, Visvanathan K. DNA repair gene variants associated with benign breast disease in high cancer risk women. Cancer Epidemiol Biomarkers Prev 2009; 18:346-50.

Jornil J, Jensen KG, Larsen F, Linnet K. Identification of cytochrome P450 isoforms involved in the metabolism of paroxetine and estimation of their importance for human paroxetine metabolism using a population-based simulator. Drug Metab Dispos 2010; 38:376-85.

Jose L, Binila C, Chandy SJ, Mathews JE, Mathews KP. Acenocoumarol and phenytoin toxicity in the presence of CYP2C9 mutation. J Assoc Physicians India 2008; 56:250-2.

Joseph S, Rusling JF, Lvov YM, Friedberg T, Fuhr U. An amperometric biosensor with human CYP3A4 as a novel drug screening tool. Biochem Pharmacol 2003; 65:1817-26.

Josephson F, Bertilsson L, Böttiger Y et al. CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels. Eur J Clin Pharmacol 2008; 64:775-81.

Joshi G, Pradhan S, Mittal B. Vascular gene polymorphisms (EDNRA -231 G>A and APOE HhaI) and risk for migraine. DNA Cell Biol 2011; 30:577-84.

Joshi M, Tyndale RF. Induction and recovery time course of rat brain CYP2E1 after nicotine treatment. Drug Metab Dispos 2006; 34:647-52.

Joshi M, Tyndale RF. Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine. Neuropharmacology 2006; 50:568-75.

Josien H, Bara T, Rajagopalan M et al. Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability. Bioorg Med Chem Lett 2009; 19:6032-7.

Jossé R, Aninat C, Glaise D et al. Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies. Drug Metab Dispos 2008; 36:1111-8.

Jounaïdi Y, Guzelian PS, Maurel P, Vilarem MJ. Sequence of the 5’-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7. Biochem Biophys Res Commun 1994; 205:1741-7.

Jounaïdi Y, Hecht JE, Waxman DJ. Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy. Cancer Res 1998; 58:4391-401.

Joung Y, Kim CH, Moon J et al. Association studies of -3081(A/T) polymorphism of norepinephrine transporter gene with attention deficit/hyperactivity disorder in Korean population. Am J Med Genet B Neuropsychiatr Genet 2010; 153:691-4.

Joutel A, Andreux F, Gaulis S et al. The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients. J Clin Invest 2000; 105:597-605.

Joutel A, Corpechot C, Ducros A et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 1996; 383:707-10.

Jovanović N, Božina N, Lovrić M, Medved V, Jakovljević M, Peleš AM. The role of CYP2D6 and ABCB1 pharmacogenetics in drug-naïve patients with first-episode schizophrenia treated with risperidone. Eur J Clin Pharmacol 2010; 66:1109-17.

Jover F, Cuadrado JM, Andreu L, Merino J. Reversible coma caused by risperidone-ritonavir interaction. Clin Neuropharmacol 2002; 25:251-3.

Jover R, Bort R, Gómez-Lechón MJ, Castell JV. Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting. Hepatology 2001; 33:668-75.

Jover R, Bort R, Gómez-Lechón MJ, Castell JV. Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved. FASEB J 2002; 16:1799-801.

Jover R, Bort R, Gómez-Lechón MJ, Castell JV. Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells. FEBS Lett 1998; 431:227-30.

Jover R, Hoffmann K, Meyer UA. Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesis. Biochem Biophys Res Commun 1996; 226:152-7.

Jover R, Moya M, Gómez-Lechón MJ. Transcriptional regulation of cytochrome p450 genes by the nuclear receptor hepatocyte nuclear factor 4-alpha. Curr Drug Metab 2009; 10:508-19

Joy MS, Boyette T, Hu Y et al. Effects of uridine diphosphate glucuronosyltransferase 2B7 and 1A7 pharmacogenomics and patient clinical parameters on steady-state mycophenolic acid pharmacokinetics in glomerulonephritis. Eur J Clin Pharmacol 2010; 66:1119-30.

Ju Z, Zhang H, Sun K et al. Alpha-adducin gene polymorphism is associated with essential hypertension in Chinese: a case-control and family-based study. J Hypertens 2003; 21:1861-8.

Juan ME, González-Pons E, Planas JM. Multidrug resistance proteins restrain the intestinal absorption of trans-resveratrol in rats. J Nutr 2010; 140:489-95.

Juang JM, de Las Fuentes L, Waggoner AD, Gu CC, Dávila-Román VG. Association and interaction of PPAR-complex gene variants with latent traits of left ventricular diastolic function. BMC Med Genet 2010; 11:65.

Judson RS, Salisbury BA, Reed CR, Ackerman MJ. Pharmacogenetic issues in thorough QT trials. Mol Diagn Ther 2006; 10:153-62.

Juhasz G, Dunham JS, McKie S et al. The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. Biol Psychiatry 2011; 69:762-71.

Juhel C, Tosini F, Steib M et al. Cholesterol-lowering effect of non-viscous soluble dietary fiber Nutriose6 in moderately hypercholesterolemic hamsters. Indian J Exp Biol 2011; 49:219-28.

Julia Z, Duchene E, Fournier N et al. Postprandial lipemia enhances the capacity of large HDL2 particles to mediate free cholesterol efflux via SR-BI and ABCG1 pathways in type IIB hyperlipidemia. J Lipid Res 2010; 51:3350-8.

Julsing MK, Vasilev NP, Schneidman-Duhovny D et al. Metabolic stereoselectivity of cytochrome P450 3A4 towards deoxypodophyllotoxin: In silico predictions and experimental validation. Eur J Med Chem 2008; 43:1171-9.

Jun JY, Ma Z, Segar L. Spontaneously diabetic Ins2+/Akita:ApoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis. Am J Physiol Endocrinol Metab 2011; 301:145-54.

Jun KR, Lee W, Jang MS et al. Tacrolimus concentrations in relation to CYP3A and ABCB1 polymorphisms among solid organ transplant recipients in Korea. Transplantation 2009; 87:1225-31.

Jun MA, Park WS, Kang SK et al. Synthesis and biological evaluation of pyrazoline analogues with beta-amino acyl group as dipeptidyl peptidase IV inhibitors. Eur J Med Chem 2008; 43:1889-902.

Jun S, Kohen R, Cain KC, Jarrett ME, Heitkemper MM. Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome. Neurogastroenterol Motil 2011; 23:233-9.

Jünemann AG, von Ahsen N, Reulbach U et al. C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma. Am J Ophthalmol 2005; 139:721-3.

Jung A, Huge A, Kuhlenbäumer G et al. Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura. J Neural Transm 2010; 117:1253-60.

Jung C, Kim RS, Lee SJ, Wang C, Jeng MH. HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4. Cancer Res 2004; 64:3046-51.

Jung C, Kim RS, Zhang HJ, Lee SJ, Jeng MH. HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling. Cancer Res 2004; 64:9185-92.

Jung CG, Horike H, Cha BY et al. Honokiol increases ABCA1 expression level by activating retinoid X receptor beta. Biol Pharm Bull 2010; 33:1105-11.

Jung CH, Rhee EJ, Kim SY et al. Associations between two single nucleotide polymorphisms of adiponectin gene and coronary artery diseases. Endocr J 2006; 53:671-7.

Jung HJ, Chung SY, Nam JW et al. Inhibition of P-glycoprotein-induced multidrug resistance by a clerodane-type diterpenoid from Sindora sumatrana. Chem Biodivers 2010; 7:2095-101.

Jung HY, Kang HE, Choi YH, Kim SH, Lee MG. Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels. Biopharm Drug Dispos 2009; 30:485-93.

Jung M, Triebel S, Anke T, Richling E, Erkel G. Influence of apple polyphenols on inflammatory gene expression. Mol Nutr Food Res 2009; 53:1263-80.

Jung MH, Park BL, Lee BC et al. Association of CHRM2 polymorphisms with severity of alcohol dependence. Genes Brain Behav 2011; 10:253-6.

Jung MY, Kang SW, Kim SK et al. The interleukin-1 family gene polymorphisms in Korean patients with rheumatoid arthritis. Scand J Rheumatol 2010; 39:190-6.

Jung SM, Kim KA, Cho HK et al. Cytochrome P450 3A inhibitor itraconazole affects plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients. Clin Pharmacol Ther 2005; 78:520-8.

Jung YO, Cho ML, Lee SY et al. Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)-alpha in a spontaneous arthritis animal model of interleukin (IL)-1 receptor antagonist-deficient mice. Immunol Lett 2009; 123:138-43.

Jungbluth H, Müller CR, Halliger-Keller B et al. Autosomal recessive inheritance of RYR1 mutations in a congenital myopathy with cores. Neurology 2002; 59:284-7.

Jungsuwadee P, Nithipongvanitch R, Chen Y et al. Mrp1 localization and function in cardiac mitochondria after doxorubicin. Mol Pharmacol 2009; 75:1117-26.

Junn E, Mouradian MM. Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine. Neurosci Lett 2002; 320:146-50.

Junnila S, Kokkola A, Karjalainen-Lindsberg ML, Puolakkainen P, Monni O. Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines. BMC Cancer 2010; 10:73.

Jürgens G, Christensen HR, Brøsen K, Sonne J, Loft S, Olsen NV. Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans. Clin Pharmacol Ther 2002; 71:214-20.

Jürgens G, Lange KH, Reuther LØ, Rasmussen BB, Brøsen K, Christensen HR. Effect of growth hormone on hepatic cytochrome P450 activity in healthy elderly men. Clin Pharmacol Ther 2002; 71:162-8.

Jurica J, Dostálek M, Konecný J, Glatz Z, Hadasová E, Tomandl J. HPLC determination of midazolam and its three hydroxy metabolites in perfusion medium and plasma from rats. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 852:571-7.

Jurima-Romet M, Casley WL, Leblanc CA, Nowakowska M. Evidence for the catalysis of dextromethorphan O-demethylation by a CYP2D6-like enzyme in pig liver. Toxicol In Vitro 2000; 14:253-63.

Jurima-Romet M, Crawford K, Cyr T, Inaba T. Terfenadine metabolism in human liver. In vitro inhibition by macrolide antibiotics and azole antifungals. Drug Metab Dispos 1994; 22:849-57.

Jurima-Romet M, Foster BC, Casley WL et al. CYP2D6-related oxidation polymorphism in a Canadian Inuit population. Can J Physiol Pharmacol 1997; 75:165-72.

Jurutka PW, Thompson PD, Whitfield GK et al. Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4. J Cell Biochem 2005; 94:917-43.

Jushchyshyn MI, Hutzler JM, Schrag ML, Wienkers LC. Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity. Arch Biochem Biophys 2005; 438:21-8.

Justesen US, Klitgaard NA, Brosen K, Pedersen C. Pharmacokinetic interaction between amprenavir and delavirdine after multiple-dose administration in healthy volunteers. Br J Clin Pharmacol 2003; 55:100-6.

Justesen US, Klitgaard NA, Brosen K, Pedersen C. Dose-dependent pharmacokinetics of delavirdine in combination with amprenavir in healthy volunteers. J Antimicrob Chemother 2004; 54:206-10.

Jutel M, Watanabe T, Klunker S et al. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Nature 2001; 413:420-5.

Juul K, Tybjaerg-Hansen A, Marklund S et al. Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study. Circulation 2004; 109:59-65.

Juyal RC, Das M, Punia S et al. Genetic susceptibility to Parkinson’s disease among South and North Indians: I. Role of polymorphisms in dopamine receptor and transporter genes and association of DRD4 120-bp duplication marker. Neurogenetics 2006; 7:223-9.