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Lee CK, Choi JS. Effects of silibinin, inhibitor of CYP3A4 and P-glycoprotein in vitro, on the pharmacokinetics of paclitaxel after oral and intravenous administration in rats. Pharmacology 2010; 85:350-6.

Lee CK, Ki SH, Choi JS. Effects of oral curcumin on the pharmacokinetics of intravenous and oral etoposide in rats: possible role of intestinal CYP3A and P-gp inhibition by curcumin. Biopharm Drug Dispos 2011; 32:245-251.

Lee CR, Bottone FG Jr, Krahn JM et al. Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). Pharmacogenet Genomics 2007; 17:145-60.

Lee CR, Imig JD, Edin ML et al. Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. FASEB J 2010; 24:3770-81.

Lee CR, North KE, Bray MS, Couper DJ, Heiss G, Zeldin DC. CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study. Pharmacogenet Genomics 2007; 17:349-58.

Lee CR, North KE, Bray MS, Couper DJ, Heiss G, Zeldin DC. Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. Clin Pharmacol Ther 2008; 83:52-60.

Lee CR, Pieper JA, Frye RF, Hinderliter AL, Blaisdell JA, Goldstein JA. Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypes. Eur J Clin Pharmacol 2003; 58:791-4.

Lee CR, Pieper JA, Hinderliter AL, Blaisdell JA, Goldstein JA. Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C91 heterozygotes. Clin Pharmacol Ther 2002; 72:562-71.

Lee CR, Pieper JA, Hinderliter AL, Blaisdell JA, Goldstein JA. Losartan and E3174 pharmacokinetics in cytochrome P450 2C9*1/*1, *1/*2, and *1/*3 individuals. Pharmacotherapy 2003; 23:720-5.

Lee CY, Lai TY, Wu YM et al. Gene expression of P-glycoprotein and cytochrome P450 3A4 in peripheral blood mononuclear cells and correlation with expression in liver. Transplant Proc 2010; 42:834-6.

Lee CH. Reversing agents for ATP-binding cassette drug transporters. Methods Mol Biol 2010; 596:325-40.

Lee CH, Lee KY, Choe KH et al. Effects of oxidative DNA damage induced by polycyclic aromatic hydrocarbons and genetic polymorphism of the paraoxonase-1 (PON1) gene on lung cancer. J Prev Med Public Health 2005; 38:345-50.

Lee CH, Wu DC, Wu IC et al. Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis. Int J Cancer 2009; 125:1134-42.

Lee DJ, Kim KM, Kim BT, Kim KN, Joo NS. ApoE polymorphism may determine low-density lipoprotein cholesterol level in association with obesity and metabolic syndrome in postmenopausal Korean women. Yonsei Med J 2011; 52:429-34.

Lee DK, Bates CE, Lipworth BJ. Acute systemic effects of inhaled salbutamol in asthmatic subjects expressing common homozygous beta2-adrenoceptor haplotypes at positions 16 and 27. Br J Clin Pharmacol 2004; 57:100-4.

Lee DK, Currie GP, Hall IP, Lima JJ, Lipworth BJ. The arginine-16 beta2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterol. Br J Clin Pharmacol 2004; 57:68-75.

Lee DY, Jung YS, Kim YC, Kim SY, Lee MG. Faster clearance of omeprazole in mutant Nagase analbuminemic rats: possible roles of increased protein expression of hepatic CYP1A2 and lower plasma protein binding. Biopharm Drug Dispos 2009; 30:107-16.

Lee E, Kim TH, Choi JS et al. Evaluation of liver and thyroid toxicity in Sprague-Dawley rats after exposure to polybrominated diphenyl ether BDE-209. J Toxicol Sci 2010; 35:535-45.

Lee E, Ryan S, Birmingham B et al. Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment. Clin Pharmacol Ther 2005; 78:330-41.

Lee EB, Kim JY, Zhao J, Park MH, Song YW. Haplotype association of IL-8 gene with Behcet’s disease. Tissue Antigens 2007; 69:128-32.

Lee EJ, Oh B, Lee JY, Kimm K, Park JM, Baek KH. Association study between single nucleotide polymorphisms in the VEGF gene and polycystic ovary syndrome. Fertil Steril 2008; 89:1751-9.

Lee G, Makhanova N, Caron K et al. Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice. Endocrinology 2005; 146:2650-6.

Lee G, Thangevel R, Sharma VM et al. Phosphorylation of tau by fyn: implications for Alzheimer’s disease. J Neurosci 2004; 24:2304-12.

Lee HC, Chang TY, Yeung CY et al. Genetic variation in the vascular endothelial growth factor gene is associated with biliary atresia. J Clin Gastroenterol 2010; 44:135-9.

Lee HI, Kim MS, Lee KM et al. Anti-visceral obesity and antioxidant effects of powdered sea buckthorn (Hippophae rhamnoides L. ) leaf tea in diet-induced obese mice. Food Chem Toxicol 2011; 49:2370-6.

Lee HJ, Cha JH, Ham BJ et al. Association between a G-protein beta 3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. Pharmacogenomics J 2004; 4:29-33.

Lee HJ, Kang SG. Genetics of tardive dyskinesia. Int Rev Neurobiol 2011; 98:231-64.

Lee HJ, Lee SY, Choi JE et al. G protein beta3 subunit, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms in Koreans with irritable bowel syndrome. Neurogastroenterol Motil 2010; 22:758-63.

Lee HK, Lewis LD, Tsongalis GJ et al. Negative urine opioid screening caused by rifampin-mediated induction of oxycodone hepatic metabolism. Clin Chim Acta 2006; 367:196-200.

Lee HS, Jin C, Park J, Kim DH. Modulation of cytochrome P450 activities by 7,8-benzoflavone and its metabolites. Biochem Mol Biol Int 1994; 34:483-91.

Lee HS, Park EJ, Ji HY et al. Identification of cytochrome P450 enzymes responsible for N -dealkylation of a new oral erectogenic, mirodenafil. Xenobiotica 2008; 38:21-33.

Lee HS, Song J, Kim TM et al. Effects of a preparation of combined glutathione-enriched yeast and rice embryo/soybean extracts on ethanol hangover. J Med Food 2009; 12:1359-67.

Lee HW, Kim DW, Phapale PB et al. In vitro inhibitory effects of Wen-pi-tang-Hab-Wu-ling-san on human cytochrome P450 isoforms. J Clin Pharm Ther 2011; 36:496-503.

Lee HW, Lim MS, Lee J et al. Frequency of CYP2C9 variant alleles, including CYP2C9*13 in a Korean population and effect on glimepiride pharmacokinetics. J Clin Pharm Ther 2011. doi:10. 1111/j. 1365-2710. 2010. 01238. x.

Lee IS, Kim SY, Jang HW et al. Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism. J Korean Med Sci 2010; 25:1379-83.

Lee IW, Kuo PH, Su MT, Kuan LC, Hsu CC, Kuo PL. Quantitative trait analysis suggests polymorphisms of estrogen-related genes regulate human sperm concentrations and motility. Hum Reprod 2011; 26:1585-96.

Lee J, Chen L, Snieder H et al. Heritability of obesity-related phenotypes and association with adiponectin gene polymorphisms in the Chinese national twin registry. Ann Hum Genet 2010; 74:146-54.

Lee J, Jo YS, Sung YH et al. Telomerase deficiency affects normal brain functions in mice. Neurochem Res 2010; 35:211-8.

Lee J, Kim HJ, Moon JA et al. Transgenic overexpression of p23 induces spontaneous hydronephrosis in mice. Int J Exp Pathol 2011; 92:251-9.

Lee J, Park EH, Couture G, Harvey I, Garneau P, Pelletier J. An upstream open reading frame impedes translation of the huntingtin gene. Nucleic Acids Res 2002; 30:5110-9.

Lee JB, Lee KA, Lee KY. Cytochrome P450 2C19 polymorphism is associated with reduced clopidogrel response in cerebrovascular disease. Yonsei Med J 2011; 52:734-8.

Lee JE, Bae SY, Kim JY et al. Aldosterone synthase gene (CYP11B2) polymorphism in Korean End-Stage renal disease patients on hemodialysis. Electrolyte Blood Press 2009; 7:67-72.

Lee JH, Cho YK, Jung YS, Kim YC, Lee MG. Time-dependent effects of Klebsiella pneumoniae endotoxin on the telithromycin pharmacokinetics in rats; restoration of the parameters in 96-hour KPLPS rats to the control levels. Pulm Pharmacol Ther 2008; 21:860-5.

Lee JH, Shin YJ, Kim HJ, Oh JH, Jang YP, Lee YJ. Danshen extract does not alter pharmacokinetics of docetaxel and clopidogrel, reflecting its negligible potential in P-glycoprotein-and cytochrome P4503A-mediated herb-drug interactions. Int J Pharm 2011; 410:68-74.

Lee JJ, Jo SA, Park JH et al. Choline acetyltransferase 2384G>A polymorphism and the risk of Alzheimer disease. Alzheimer Dis Assoc Disord 2011. doi:10. 1097/WAD. 0b013e31821cbcaf.

Lee JK, Abe K, Bridges AS et al. Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver. Drug Metab Dispos 2009; 37:1916-21.

Lee JS, Chu IS, Mikaelyan A et al. Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat Genet 2004; 36:1306-11.

Lee JS, Suh KT, Eun IS. Polymorphism in interleukin-6 gene is associated with bone mineral density in patients with adolescent idiopathic scoliosis. J Bone Joint Surg Br 2010; 92:1118-22.

Lee JT, Kroemer HK, Silberstein DJ et al. The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone. N Engl J Med 1990; 322:1764-8.

Lee JY, Duke RK, Tran VH, Hook JM, Duke CC. Hyperforin and its analogues inhibit CYP3A4 enzyme activity. Phytochemistry 2006; 67:2550-60.

Lee JY, Hong HR, Kang HS. Ethnicity differences in plasma apoC-III levels between African American and Caucasian youths. World J Pediatr 2011; 7:136-42.

Lee K, Belinsky MG, Bell DW et al. Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. Cancer Res 1998; 58:2741-7.

Lee KH, Kim OY, Lim HH, Lee YJ, Jang Y, Lee JH. Contribution of APOA5-1131C allele to the increased susceptibility of diabetes mellitus in association with higher triglyceride in Korean women. Metabolism 2010; 59:1583-90.

Lee L, Robb LM, Lee M et al. Design, synthesis, and biological evaluations of 2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoline analogs of combretastatin-A4. J Med Chem 2010; 53:325-34.

Lee LS, Andrade AS, Flexner C. Interactions between natural health products and antiretroviral drugs: pharmacokinetic and pharmacodynamic effects. Clin Infect Dis 2006; 43:1052-9.

Lee MJ, Chen TF, Cheng TW, Chiu MJ. rs5848 variant of progranulin gene is a risk of Alzheimer’s disease in the Taiwanese population. Neurodegener Dis 2011; 8:216-20.

Lee MR, Kim YJ, Hwang DY et al. An in vitro bioassay for xenobiotics using the SXR-driven human CYP3A4/lacZ reporter gene. Int J Toxicol 2003; 22:207-13.

Lee MS. Role of genetic polymorphisms related to neurotransmitters and cytochrome P-450 enzymes in response to antidepressants. Drugs Today 2007; 43:569-81.

Lee MS, Park JY, Freake H, Kwun IS, Kim Y. Green tea catechin enhances cholesterol 7alpha-hydroxylase gene expression in HepG2 cells. Br J Nutr 2008; 99:1182-5.

Lee MT, Chen CH, Chou CH et al. Genetic determinants of warfarin dosing in the Han-Chinese population. Pharmacogenomics 2009; 10:1905-13.

Lee MY, Kumar RA, Sukumaran SM, Hogg MG, Clark DS, Dordick JS. Three-dimensional cellular microarray for high-throughput toxicology assays. Proc Natl Acad Sci USA 2008; 105:59-63.

Lee MY, Li H, Xiao Y, Zhou Z, Xu A, Vanhoutte PM. Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. Br J Pharmacol 2011; 162:1564-76.

Lee S, Das HK. Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity. Front Biosci 2010; 2:22-35.

Lee S, Kim BH, Nam WS et al. Effect of CYP2C19 polymorphism on the pharmacokinetics of voriconazole after single and multiple doses in healthy volunteers. J Clin Pharmacol 2011. doi:10. 1177/0091270010395510.

Lee SA, Hwang SH, Ahn SG, Lee HM, Jeong J, Lee HD. Effects of zoledronic acid on bone mineral density during aromatase inhibitor treatment of Korean postmenopausal breast cancer patients. Breast Cancer Res Treat 2011. doi:10. 1007/s10549-011-1728-3.

Lee SF, Shah S, Li H, Yu C, Han W, Yu G. Mamalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem 2002; 277:45013-9.

Lee SH, Ihm CG, Sohn SD et al. Polymorphisms in interleukin-1 beta and Interleukin-1 receptor antagonist genes are associated with kidney failure in Korean patients with type 2 diabetes mellitus. Am J Nephrol 2004; 24:410-4.

Lee SH, Kim HJ, Lee JS, Lee IS, Kang BY. Inhibition of topoisomerase I activity and efflux drug transporters’ expression by xanthohumol from hops. Arch Pharm Res 2007; 30:1435-9.

Lee SH, Lee KJ, Lee HJ, Ham BJ, Ryu SH, Lee MS. Association between the 5-HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder. Psychiatry Clin Neurosci 2005; 59:140-5.

Lee SH, Lee MS, Lee JH et al. MRP1 polymorphisms associated with citalopram response in patients with major depression. J Clin Psychopharmacol 2010; 30:116-25.

Lee SJ, Bell DA, Coulter SJ, Ghanayem B, Goldstein JA. Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype. J Pharmacol Exp Ther 2005; 313:302-9.

Lee S-J, Choi J-Y, Sung Y-M, Park H, Rhim H, Kang S. E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. FEBS Lett 2001; 503:61-4.

Lee SJ, Goldstein JA. Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests. Pharmacogenomics 2005; 6:357-71.

Lee SJ, Jusko WJ, Salaita CG et al. Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition. J Clin Pharmacol 2006; 46:515-26.

Lee SJ, Kim WY, Choi JY, Lee SS, Shin JG. Identification of CYP19A1 single-nucleotide polymorphisms and their haplotype distributions in a Korean population. J Hum Genet 2010; 55:189-93.

Lee SJ, Lee SS, Jeong HE et al. The CYP3A4*18 allele, the most frequent coding variant in asian populations, does not significantly affect the midazolam disposition in heterozygous individuals. Drug Metab Dispos 2007; 35:2095-101.

Lee SJ, Lee SS, Jung HJ et al. Discovery of novel functional variants and extensive evaluation of CYP2D6 geneticpolymorphisms in Koreans. Drug Metab Dispos 2009; 37:1464-70.

Lee SJ, Wang-Buhler JL, Cok I et al. Cloning, sequencing, and tissue expression of CYP3A27, a new member of the CYP3A subfamily from embryonic and adult rainbow trout livers. Arch Biochem Biophys 1998; 360:53-61.

Lee SK, Kang MJ, Jin C, In MK, Kim DH, Yoo HH. Flavin-containing monooxygenase 1-catalysed N,N-dimethylamphetamine N-oxidation. Xenobiotica 2009; 39:680-6.

Lee SK, Kim Y, Jin C et al. Inhibitory effects of deoxypodophyllotoxin from Anthriscus sylvestris on human CYP2C9 and CYP3A4. Planta Med 2010; 76:701-4.

Lee SK, Lee JH, Yoo HH, Kim DH, Jahng Y, Jeong TC. Characterization of human liver cytochrome P450 enzymes involved in the metabolism of rutaecarpine. J Pharm Biomed Anal 2006; 41:304-9.

Lee SL, Chau GY, Yao CT, Wu CW, Yin SJ. Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res 2006; 30:1132-42.

Lee SL, Höög JO, Yin SJ. Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism. Pharmacogenetics 2004; 14:725-32.

Lee SS, Cha EY, Jung HJ et al. Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity. Hepatology 2008; 48:635-45.

Lee SS, Jeong HE, Liu KH et al. Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity. Pharmacogenet Genomics 2005; 15:105-13.

Lee SS, Zhang B, He ML, Chang VS, Kung HF. Screening of active ingredients of herbal medicine for interaction with CYP450 3A4. Phytother Res 2007; 21:1096-9.

Lee SW, Chung LS, Huang HH, Chuang TY, Liou YH, Wu LS. NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis. Int J Tuberc Lung Dis 2010; 14:622-6.

Lee SY, Chen SL, Chen SH et al. The COMT and DRD3 genes interacted in bipolar I but not bipolar II disorder. World J Biol Psychiatry 2011; 12:385-91.

Lee SY, Ki CS, Hong KS, Kim JW. A case report of a poor metabolizer of CYP2D6 presented with unusual responses to nortriptyline medication. J Korean Med Sci 2004; 19:750-2.

Lee SY, Luk SK, Chuang CP, Yip SP, To SS, Yung YM. TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy. Br J Cancer 2010; 103:362-9.

Lee SY, Oh SJ, Yun KU et al. Expression of hepatic and ovarian cytochrome P450 during estrous cycle in rats. Arch Toxicol 2011. doi:10. 1007/s00204-011-0730-1.

Lee SY, Peckermann I, Abinet E, Okuda J, Henze G, Prokop A. The rare-earth yttrium complex [YR(mtbmp)(thf)] triggers apoptosis via the extrinsic pathway and overcomes multiple drug resistance in leukemic cells. Med Oncol 2010. doi:10. 1007/s12032-010-9787-6.

Lee SY, Rhee YH, Jeong SJ et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol 2011; 26:424-31.

Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO. Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation. Hepatology 2011; 53:160-70.

Lee TS, Pan CC, Peng CC et al. Anti-atherogenic effect of berberine on LXRalpha-ABCA1-dependent cholesterol efflux in macrophages. J Cell Biochem 2010; 111:104-10.

Lee VC, Tang OS, Ng EH, Yeung WS, Ho PC. A pilot study on the use of letrozole with either misoprostol or mifepristone for termination of pregnancy up to 63 days. Contraception 2011; 83:62-7.

Lee VM-Y. Tauists and baptists united – well almost. Science 2001; 293:1446-7.

Lee VW, Chau TS, Chan AK et al. Pharmacogenetics of esomeprazole or rabeprazole-based triple therapy in Helicobacter pylori eradication in Hong Kong non-ulcer dyspepsia Chinese subjects. J Clin Pharm Ther 2010; 35:343-50.

Lee WK, Torchalski B, Kohistani N, Thévenod F. ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: Roles of cadmium and ceramide transport. Toxicol Sci 2011; 121:343-56.

Lee WY, Cheung CC, Liu KW et al. Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells. J Nat Prod 2010; 73:854-9.

Lee YC, Lin HH, Wang CJ et al. The associations among GNB3 C825T polymorphism, erectile dysfunction, and related risk factors. J Sex Med 2008; 5:2061-8.

Lee YG, Kim I, Kim JH et al. Impact of cytokine gene polymorphisms on risk and treatment outcomes of aplastic anemia. Ann Hematol 2011; 90:515-21.

Lee YH, Bae SC, Choi SJ, Ji JD, Song GG. Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Mol Biol Rep 2011; 38:3643-51.

Lee YH, Harley JB, Nath SK. Meta-analysis of TNF-alpha promoter -308A/G polymorphism and SLE susceptibility. Europ J Hum Genet 2006; 14:364-71.

Lee YH, Ji JD, Song GG. Associations between FCGR3A polymorphisms and susceptibility to rheumatoid arthritis: a metaanalysis. J Rheumatol 2008; 35:2129-35.

Lee YJ, Kang SW, Song JK et al. Associations between interferon regulatory factor-1 polymorphisms and Behçet’s disease. Hum Immunol 2007; 68:770-8.

Lee YJ, Lee MG, Lim LA, Jang SB, Chung JY. Effects of SLCO1B1 and ABCB1 genotypes on the pharmacokinetics of atorvastatin and 2-hydroxyatorvastatin in healthy Korean subjects. Int J Clin Pharmacol Ther 2010; 48:36-45.

Lee YK, Moore DD. Liver receptor homolog-1, an emerging metabolic modulator. Front Biosci 2008; 13:5950-8.

Lee YM, Sicinski P. Targeting cyclins and cyclin-dependent kinases in cancer: lessons from mice, hopes for therapeutic applications in human. Cell Cycle 2006; 5:2110-4.

Lee YS, Choi YH, Kim TK, Ryu KH, Lee BY, Lee MG. Pharmacokinetics of mirodenafil and its two metabolites, SK3541 and SK3544, after intravenous and oral administration of mirodenafil to streptozotocin-induced diabetes mellitus rats. Xenobiotica 2010; 40:129-37.

Lee YS, Kim H, Wu TX, Wang XM, Dionne RA. Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs. Clin Pharmacol Ther 2006; 79:407-18.

Leeder JS, Gaedigk R, Marcucci KA et al. Variability of CYP3A7 expression in human fetal liver. J Pharmacol Exp Ther 2005; 314:626-35.

Leeder JS, Lu X, Timsit Y, Gaedigk A. Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions. Pharmacogenetics 1998; 8:211-25.

Leeflang EP, Tavare S, Marjoram P et al. Analysis of germine mutations spectra at the Huntington’s disease locus supports a mitotic mutations mechanism. Hum Molec Genet 1999; 8:173-83.

Leeflang EP, Tavare S, Marjoram P et al. Single sperm analysis of the trinucleotide repeats in the Huntington’s disease gene: quantification of the mutation frequency spectrum. Hum Molec Genet 1995; 4:1519-26.

Leemann T, Transon C, Dayer P. Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4’-hydroxylation in human liver. Life Sci 1993; 52:29-34.

Lee-Rueckert M, Lappalainen J, Leinonen H, Pihlajamaa T, Jauhiainen M, Kovanen PT. Acidic extracellular environments strongly impair ABCA1-mediated cholesterol efflux from human macrophage foam cells. Arterioscler Thromb Vasc Biol 2010; 30:1766-72.

Lefebvre J, Poirier L, Poirier P, Turgeon J, Lacourciere Y. The influence of CYP2D6 phenotype on the clinical response of nebivolol in patients with essential hypertension. Br J Clin Pharmacol 2007; 63:575-82.

Lefebvre T, Foster BC, Drouin CE, Krantis A, Livesey JF, Jordan SA. In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. J Pharm Pharm Sci 2004; 7:265-73.

Lefebvre T, Guinez C, Dehennaut V, Beseme-Dekeyser O, Morelle W, Michalski JC. Does O-GlcNAc play a role in neurodegenerative diseases? Expert Rev Proteomics 2005; 2:265-75.

Lefèvre C, Bouadjar B, Ferrand V et al. Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3. Hum Mol Genet 2006; 15:767-76.

Lefèvre G, Bindschedler M, Ezzet F, Schaeffer N, Meyer I, Thomsen MS. Pharmacokinetic interaction trial between co-artemether and mefloquine. Eur J Pharm Sci 2000; 10:141-51.

Lefèvre G, Carpenter P, Souppart C, Schmidli H, McClean M, Stypinski D. Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects. Br J Clin Pharmacol 2002; 54:485-92.

Lefkowitz JB, Haver T, Clarke S et al. The prothrombin Denver patient has two different prothrombin point mutations resulting in Glu-300->Lys and Glu-309->Lys substitutions. Br J Haematol 2000; 108:182-7.

Legan SK, Rebrin I, Mockett RJ et al. Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster. J Biol Chem 2008; 283:32492-9.

Legault C, Maki PM, Resnick SM et al. Effects of tamoxifen and raloxifene on memory and other cognitive abilities: cognition in the study of tamoxifen and raloxifene. J Clin Oncol 2009; 27:5144-52.

Legay C. Why so many forms of acetylcholinesterase? Microsc Res Tech 2000; 49:56-72.

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Lehmann DJ, Cortina-Borja M, Warden DR et al. Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer’s disease. Am J Epidemiol 2005; 162:305-17.

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Lehr T, Staab A, Trommeshauser D, Schaefer HG, Kloft C. Semi-mechanistic population pharmacokinetic drug-drug interaction modelling of a long half-life substrate and itraconazole. Clin Pharmacokinet 2010; 49:53-66.

Lehr T, Yuan J, Hall D et al. Integration of absorption, distribution, metabolism, and elimination genotyping data into a population pharmacokinetic analysis of nevirapine. Pharmacogenet Genomics 2011; 21:721-30.

Lehtonen P, Sten T, Aitio O et al. Glucuronidation of racemic O-desmethyltramadol, the active metabolite of tramadol. Eur J Pharm Sci 2010; 41:523-30.

Lei HP, Ji W, Lin J et al. Effects of Ginkgo biloba extract on the pharmacokinetics of bupropion in healthy volunteers. Br J Clin Pharmacol 2009; 68:201-6.

Leigh Pearce C, Near AM, Butler JL et al. Comprehensive evaluation of ESR2 variation and ovarian cancer risk. Cancer Epidemiol Biomarkers Prev 2008; 17:393-6.

Leikin-Frenkel A, Gonen A, Shaish A et al. Fatty acid bile acid conjugate inhibits hepatic stearoyl coenzyme A desaturase and is non-atherogenic. Arch Med Res 2010; 41:397-404.

Leikin-Frenkel A, Parini P, Konikoff FM et al. Hypocholesterolemic effects of fatty acid bile acid conjugates (FABACs) in mice. Arch Biochem Biophys 2008; 471:63-71.

Leineweber K, Bogedain P, Wolf C et al. In patients chronically treated with metoprolol, the demand of inotropic catecholamine support after coronary artery bypass grafting is determined by the Arg389Gly-beta 1-adrenoceptor polymorphism. Naunyn Schmiedebergs Arch Pharmacol 2007; 375:303-9.

Leineweber K, Bruck H, Temme T, Heusch G, Philipp T, Brodde OE. The Arg389Gly beta1-adrenoceptor polymorphism does not affect cardiac effects of exercise after parasympathetic inhibition by atropine. Pharmacogenet Genomics 2006; 16:9-13.

Leineweber K, Frey UH, Tenderich G et al. The Arg16Gly-β(2)-adrenoceptor single nucleotide polymorphism: exercise capacity and survival in patients with end-stage heart failure. Naunyn Schmiedebergs Arch Pharmacol 2010; 382:357-65.

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Li C, Lim SC, Kim J, Choi JS. Effects of myricetin, an anticancer compound, on the bioavailability and pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats. Eur J Drug Metab Pharmacokinet 2011; 36:175-82.

Li C, Schwarz UI, Ritchie MD, Roden DM, Stein CM, Kurnik D. Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy. Blood 2009; 113:3925-30.

Li C, Shi Y, You L, Wang L, Chen ZJ. Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome. Mol Hum Reprod 2011; 17:193-8.

Li CK, Pender SL, Pickard KM et al. Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice. J Immunol 2004; 173:5171-9.

Li CM, Narayanan R, Lu Y et al. 2-Arylthiazolidine-4-carboxylic acid amides (ATCAA) target dual pathways in cancer cells: 5’-AMP-activated protein kinase (AMPK)/mTOR and PI3K/Akt/mTOR pathways. Int J Oncol 2010; 37:1023-30.

Li CM, Wang Z, Lu Y et al. Biological activity of 4-substituted methoxybenzoyl-aryl-thiazole: an active microtubule inhibitor. Cancer Res 2011; 71:216-24.

Li CY, Yu Q, Ye ZQ et al. A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. Cell Res 2007; 17:357-62.

Li D, Abudula A, Abulahake M, Zhu AP, Lou YQ, Zhang GL. Influence of CYP3A5 and MDR1 genetic polymorphisms on urinary 6 beta-hydroxycortisol/cortisol ratio after grapefruit juice intake in healthy Chinese. J Clin Pharmacol 2010; 50:775-84.

Li D, Dandara C, Parker MI. The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer. BMC Genet 2010; 11:47.

Li D, He L. Association study between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia: a meta-analysis. Schizophr Res 2007; 96:112-8.

Li D, Huang X, Han K, Zhan CG. Catalytic mechanism of cytochrome P450 for 5’-hydroxylation of nicotine: fundamental reaction pathways and stereoselectivity. J Am Chem Soc 2011; 133:7416-27.

Li D, Parks SB, Kushner JD et al. Mutations of presenilin genes in dilated cardiomyopathy and heart failure. Am J Hum Genet 2006; 79:1030-9.

Li D, Tanaka M, Brunicardi FC, Fisher WE, Gibbs RA, Gingras MC. Association between somatostatin receptor 5 gene polymorphisms and pancreatic cancer risk and survival. Cancer 2011; 117:2863-72.

Li D, Tang J, Xu H, Fan X, Bai Y, Yang L. Decreased hippocampal cell proliferation correlates with increased expression of BMP4 in the APPswe/PS1DeltaE9 mouse model of Alzheimer’s disease. Hippocampus 2008; 18:692-8.

Li D, Wang D, Wang Y, Ling W, Feng X, Xia M. Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem 2010; 285:33499-509.

Li D, Wang X, Ren W et al. High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 rats. Mol Cell Endocrinol 2011; 344:69-80.

Li D, Zhu JY, Gao J, Wang X, Lou YQ, Zhang GL. Polymorphisms of tumor necrosis factor-alpha, interleukin-10, cytochrome P450 3A5 and ABCB1 in Chinese liver transplant patients treated with immunosuppressant tacrolimus. Clin Chim Acta 2007; 383:133-9.

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Li DW, Gao S, Shen B, Dong P. Effect of apoptotic and proliferative indices, P-glycoprotein and survivin expression on prognosis in laryngeal squamous cell carcinoma. Med Oncol 2010. doi:10. 1007/s12032-010-9686-x.

Li E, Hu JP, Wang BL, Li Y. Effect of buagafuran on liver microsomal cytochrome P450 in rats. J Asian Nat Prod Res 2010; 12:371-81.

Li F, Wang L, Guo GL, Ma X. Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. Drug Metab Dispos 2010; 38:871-8.

Li F, Ye L, Lin SM, Leung LK. Dietary flavones and flavonones display differential effects on aromatase (CYP19) transcription in the breast cancer cells MCF-7. Mol Cell Endocrinol 2011; 344:51-8.

Li F, Zeng H, Ying K. The combination of stem cell markers CD133 and ABCG2 predicts relapse in stage I non-small cell lung carcinomas. Med Oncol 2010. doi:10. 1007/s12032-010-9646-5.

Li G, Yin H, Kuret J. Casein kinesin 1 delta phosphorylates tau and its binding to microtubules. J Biol Chem 2004; 279:15938-45.

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Li GX, Pei QL, Gao Y et al. Protective effects of hepatocellular canalicular conjugate export pump (Mrp2) on sodium arsenite-induced hepatic dysfunction in rats. Exp Toxicol Pathol 2007; 58:447-53.

Li GY, Liu JZ, Chen SG, Zhang B, Wang CB, Wang LX. Tegillarca granosa extract Haishengsu inhibits the expression of P-glycoprotein and induces apoptosis in drug-resistant K562/ADM cells. Pharm Biol 2010; 48:529-33.

Li H, Asberom T, Bara TA et al. Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors. Bioorg Med Chem Lett 2007; 17:6290-4.

Li H, Förstermann U. Prevention of atherosclerosis by interference with the vascular nitric oxide system. Curr Pharm Des 2009; 15:3133-45.

Li H, Gao Q, Guo L, Lu SH. The PTEN/PI3K/Akt pathway regulates stem-like cells in primary esophageal carcinoma cells. Cancer Biol Ther 2011; 11:950-8.

Li H, Huo M, Zhou J et al. Enhanced oral absorption of paclitaxel in N-deoxycholic acid-N, O-hydroxyethyl chitosan micellar system. J Pharm Sci 2010; 99:4543-53.

Li H, Kantoff PW, Giovannucci E et al. Manganese superoxide dismutase polymorphism, prediagnostic antioxidant status, and risk of clinical significant prostate cancer. Cancer Res 2005; 65:2498-504.

Li H, Li SH, Johnston H, Shelbourne PF, Li XJ. Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity. Nat Genet 2000; 25:385-9.

Li H, Mukherjee N, Soundararajan U et al. Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia. Am J Hum Genet 2007; 81:842-6.

Li H, Myeroff L, Smiraglia D et al. SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. Proc Natl Acad Sci USA 2003; 100:8412-7.

Li H, Zhang ZS, Liu W et al. Association of a functional polymorphism in the MMP-3 gene with Moyamoya Disease in the Chinese Han population. Cerebrovasc Dis 2010; 30:618-25.

Li HY, Xu W, Zhang X, Zhang WD, Hu LW. Bufalin inhibits CYP3A4 activity in vitro and in vivo. Acta Pharmacol Sin 2009; 30:646-52.

Li J, Cusatis G, Brahmer J et al. Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients. Cancer Biol Ther 2007; 6:432-8.

Li J, Gödecke T, Chen SN et al. In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4. Xenobiotica 2011. doi:10. 3109/00498254. 2011. 603385.

Li J, Liu Y, Zhang JW, Wei H, Yang L. Characterization of hepatic drug-metabolizing activities of Bama miniature pigs (Sus scrofa domestica): comparison with human enzyme analogs. Comp Med 2006; 56:286-90.

Li J, Ma Z, Tang ZL, Stevens T, Pitt B, Li S. CpG DNA-mediated immune response in pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol 2004; 287:552-8.

Li J, Siegel M, Yuan M et al. Estrogen enhances neurogenesis and behavioral recovery after stroke. J Cereb Blood Flow Metab 2011; 31:413-25.

Li J, Volpe DA, Wang Y et al. Use of transporter knockdown caco-2 cells to investigate the in vitro efflux of statin drugs. Drug Metab Dispos 2011; 39:1196-202.

Li J, Wang LF, Li ZQ, Pan W. Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease. Clin Exp Pharmacol Physiol 2009; 36:567-70.

Li J, Xia Z, Ding J. Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme. Protein Sci 2005; 14:2361-9.

Li J, Xie ZZ, Tang YB, Zhou JG, Guan YY. Ginsenoside-Rd, a purified component from panax notoginseng saponins, prevents atherosclerosis in apoE knockout mice. Eur J Pharmacol 2011; 652:104-10.

Li J, Zhang X, Wang Y et al. The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects. Am J Med Genet B Neuropsychiatr Genet 2006; 141:874-6.

Li J, Zhao M, He P, Hidalgo M, Baker SD. Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res 2007; 13:3731-7.

Li J, Zhao X, Zhang S, Wang S, Du P, Qi G. ApoB-100 and HSP60 peptides exert a synergetic role in inhibiting early atherosclerosis in immunized ApoE-null mice. Protein Pept Lett 2011; 18:733-40.

Li JK, He F, Bi HC et al. Inhibition of human cytochrome P-450 CYP1A2 by flavonoids: a quantitative structure-activity relationship study. Yao Xue Xue Bao 2008; 43:1198-204.

Li JL, Canham RM, Vongpatanasin W, Leonard D, Auchus RJ, Victor RG. Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks? Hypertension 2006; 47:1140-6.

Li JL, Hayden MR, Almqvist EW et al. A genome scan for modifiers of age at onset in Huntington disease: the HD MAPS study. Am J Hum Genet 2003; 73:682-7.

Li KY, Li X, Cheng ZN, Li HD. Metabolic mechanism of quetiapine in vivo with clinical therapeutic dose. Methods Find Exp Clin Pharmacol 2005; 27:83-6.

Li L, Hassan HE, Tolson AH, Ferguson SS, Eddington ND, Wang H. Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells. J Pharmacol Exp Ther 2010; 335:562-71.

Li L, Kwon HJ, Harada H, Ohshima H, Cho SW, Jung HS. Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor. Gene Expr Patterns 2011; 11:163-70.

Li L, Liu J, Suo WZ. GRK5 deficiency exaggerates inflammatory changes in TgAPPsw mice. J Neuroinflammation 2008; 5:24.

Li L, Najafi AH, Kitlinska JB et al. Of mice and men: neuropeptide Y and its receptors are associated with atherosclerotic lesion burden and vulnerability. J Cardiovasc Transl Res 2011; 4:351-62.

Li L, Pan RM, Porter TD et al. New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes. Drug Metab Dispos 2006; 34:1411-6.

Li L, Porter TD. Chlorzoxazone hydroxylation in microsomes and hepatocytes from cytochrome P450 oxidoreductase-null mice. J Biochem Mol Toxicol 2009; 23:357-63.

Li L, Shukla S, Lee A et al. The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Cancer Res 2010; 70:4509-19.

Li L, Stanton JD, Tolson AH, Luo Y, Wang H. Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res 2009; 26:872-82.

Li L, Tan CM, Koo SH, Chong KT, Lee EJ. Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. Pharmacogenet Genomics 2007; 17:783-6.

Li L, Wei XH, Pan YP et al. LAPTM4B: a novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling. Oncogene 2010; 29:5785-95.

Li L, Zhang ZH, Zhao WD. Apoptosis of MR2 cells induced by Tanshinone II A combined with arsenic trioxide. Sichuan Da Xue Xue Bao Yi Xue Ban 2009; 40:812-6.

Li LO, Ellis JM, Paich HA et al. Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. J Biol Chem 2009; 284:27816-26.

Li LL, Kang XL, Ran XJ et al. Associations between 45T/G polymorphism of the adiponectin gene and plasma adiponectin levels with type 2 diabetes. Clin Exp Pharmacol Physiol 2007; 34:1287-90.

Li M, Huang Y, Ma AA, Lin E, Diamond MI. Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice. Neurobiol Dis 2009; 36:413-20.

Li M, Si L, Pan H et al. Excipients enhance intestinal absorption of ganciclovir by P-gp inhibition: assessed in vitro by everted gut sac and in situ by improved intestinal perfusion. Int J Pharm 2011; 403:37-45.

Li M, Wang W, Soroka CJ et al. NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. J Biol Chem 2010; 285:19299-307.

Li PY, Lai PS, Hung WC, Syu WJ. Poly(L-lactide)-vitamin E TPGS nanoparticles enhanced the cytotoxicity of doxorubicin in drug-resistant MCF-7 breast cancer cells. Biomacromolecules 2010; 11:2576-82.

Li Q, Chen BL, Ozdemir V et al. Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin. Pharmacogenomics 2007; 8:577-86.

Li Q, Huang HH, Dong Y, Zhong DF. Investigation on the hydroxylation metabolism of imrecoxib in vitro by using recombinant human CYPs. Yao Xue Xue Bao 2005; 40:912-5.

Li Q, Jiang Q, Uitto J. Pseudoxanthoma elasticum: oxidative stress and antioxidant diet in a mouse model (Abcc6-/-). J Invest Dermatol 2008; 128:1160-4.

Li Q, Larusso J, Grand-Pierre AE, Uitto J. Magnesium carbonate-containing phosphate binder prevents connective tissue mineralization in Abcc6(-/-) mice-potential for treatment of pseudoxanthoma elasticum. Clin Transl Sci 2009; 2:398-404.

Li Q, Liu F, Zheng TS, Tang JL, Lu HJ, Jia WP. SLC22A2 gene 808 G/T variant is related to plasma lactate concentration in Chinese type 2 diabetics treated with metformin. Acta Pharmacol Sin 2010; 31:184-90.

Li Q, Sadowski S, Frank M et al. The abcc6a gene expression is required for normal zebrafish development. J Invest Dermatol 2010; 130:2561-8.

Li Q, Sai Y, Kato Y, Tamai I, Tsuji A. Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cell lines. Pharm Res 2003; 20:1119-24.

Li Q, Schurgers LJ, Smith AC, Tsokos M, Uitto J, Cowen EW. Co-existent pseudoxanthoma elasticum and vitamin K-dependent coagulation factor deficiency: compound heterozygosity for mutations in the GGCX gene. Am J Pathol 2009; 174:534-40.

Li Q, Uitto J. Expression of the Abca-subfamily of genes in Abcc6(-/-) mice – upregulation of Abca4. Exp Dermatol 2011; 20:452-4.

Li Q, Yin W, Cai M et al. NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF1 and CYP7A1. J Endocrinol 2010; 204:47-56.

Li QD, Li H, Wang MS et al. Multi-susceptibility genes associated with the risk of the development stages of esophageal squamous cell cancer in Feicheng County. BMC Gastroenterol 2011; 11:74.

Li QF, Yao RY, Liu KW, Lv HY, Jiang T, Liang J. Genetic polymorphism of GSTP1: prediction of clinical outcome to oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer. J Korean Med Sci 2010; 25:846-52.

Li R, Xing G, Yan M et al. Cosegregation of C-insertion at position 961 with the A1555G mutation of the mitochondrial 12S rRNA gene in a large Chinese family with maternally inherited hearing loss. Am J Med Genet 2004; 124:113-7.

Li RC, Haribabu B, Mathis SP, Kim J, Gozal D. Leukotriene B4 receptor-1 mediates intermittent hypoxia-induced atherogenesis. Am J Respir Crit Care Med 2011; 184:124-31.

Li RJ, Zhang GS, Chen YH et al. Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance. Ann Oncol 2010; 21:1506-14.

Li S, Hu ZH, Miao XH. Effects of chronic HBV infection on human hepatic cytochrome P450 3A4. Zhonghua Yi Xue Za Zhi 2006; 86:2703-6.

Li S, Miao XH. Induction of CYP3A4 by 1alpha,25-dyhydroxyvitamin D3 in HepG2 cells. Zhonghua Gan Zang Bing Za Zhi 2008; 16:220-3.

Li S, Zhang H, Gao P, Chen Z, Wang C, Li J. A functional mutation at position -155 in porcine APOE promoter affects gene expression. BMC Genet 2011; 12:40.

Li S, Zhao JH, Luan J et al. Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. PLoS Med 2010. doi:10. 1371/journal. pmed. 1000332.

Li SB, Xue Y, Lv XY et al. In vitro effect of ozagrel on mushroom tyrosinase. Protein J 2009; 28:182-8.

Li S-H, Hosseini SH, Gutekunst C-A, Hersch SM, Ferrante RJ, Li X-J. A human HAP1 homologue: cloning, expression, and interaction with huntingtin. J Biol Chem 1998; 273:19220-7.

Li SX, Pequignot E, Panebianco D et al. Lack of effect of aprepitant on hydrodolasetron pharmacokinetics in CYP2D6 extensive and poor metabolizers. J Clin Pharmacol 2006; 46:792-801.

Li T, Chanda D, Zhang Y, Choi HS, Chiang JY. Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. J Lipid Res 2010; 51:832-42.

Li T, Chen W, Chiang JY. PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. J Lipid Res 2007; 48:373-84.

Li T, Chiang JY. Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription. Am J Physiol Gastrointest Liver Physiol 2005; 288:74-84.

Li T, Chiang JY. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression. Drug Metab Dispos 2006; 34:756-64.

Li T, Kong X, Owsley E, Ellis E, Strom S, Chiang JY. Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c. J Biol Chem 2006; 281:28745-54.

Li T, Lange LA, Li X et al. Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation. J Med Genet 2006; 43:740-4.

Li T, Li N, Guo Q et al. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. Eur J Drug Metab Pharmacokinet 2011. doi:10. 1007/s13318-011-0050-0.

Li T, Ma H, Chiang JY. TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression. J Lipid Res 2008; 49:1981-9.

Li T, Ma H, Park YJ et al. Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice. Biochim Biophys Acta 2009; 1791:991-6.

Li T, Matozel M, Boehme S et al. Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. Hepatology 2011; 53:996-1006.

Li T, Owsley E, Matozel M, Hsu P, Novak CM, Chiang JY. Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice. Hepatology 2010; 52:678-90.

Li W, Ichihara G, Wang H et al. Change of gonad gene expression profile in male F344 rats after exposure to 1-bromopropane. Wei Sheng Yan Jiu 2010; 39:191-6.

Li W, Liu H, Luo X et al. Possible pathway(s) of metyrapone egress from the active site of cytochrome P450 3A4: a molecular dynamics simulation. Drug Metab Dispos 2007; 35:689-96.

Li W, Liu Y, He YQ et al. Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes. Xenobiotica 2008; 38:1551-65.

Li W, Zhang Q, Oiso N et al. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat Genet 2003; 35:84-9.

Li WQ, Li YM, Tao BB et al. Downregulation of ABCG2 expression in glioblastoma cancer stem cells with miRNA-328 may decrease their chemoresistance. Med Sci Monit 2010; 16:27-30.

Li X, Chen X, Li Q, Wang L, Zhong D. Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 852:128-37.

Li X, Delzer J, Voorman R, de Morais SM, Lao Y. Disposition and drug-drug interaction potential of veliparib (ABT-888), a novel and potent inhibitor of poly(ADP-ribose) polymerase. Drug Metab Dispos 2011; 39:1161-9.

Li X, He Y, Ruiz CH, Koenig M, Cameron MD, Vojkovsky T. Characterization of dasatinib and its structural analogs as CYP3A4 mechanism-based inactivators and the proposed bioactivation pathways. Drug Metab Dispos 2009; 37:1242-50.

Li X, Kamenecka TM, Cameron MD. Bioactivation of the epidermal growth factor receptor inhibitor gefitinib: implications for pulmonary and hepatic toxicities. Chem Res Toxicol 2009; 22:1736-42.

Li X, Kamenecka TM, Cameron MD. Cytochrome P450-mediated bioactivation of the epidermal growth factor receptor inhibitor erlotinib to a reactive electrophile. Drug Metab Dispos 2010; 38:1238-45.

Li X, Li S, Sharp A et al. A huntingtin-association protein enriched in brain with implications for pathology. Nature 1995; 378:398-402.

Li X, Millson SH, Coker RD, Evans IH. Cloning and expression of Penicillium minioluteum dextranase in Saccharomyces cerevisiae and its exploitation as a reporter in the detection of mycotoxins. Biotechnol Lett 2006; 28:1955-64.

Li X, Millson S, Coker R, Evans I. A sensitive bioassay for the mycotoxin aflatoxin B(1), which also responds to the mycotoxins aflatoxin G(1) and T-2 toxin, using engineered baker’s yeast. J Microbiol Methods 2009; 77:285-91.

Li X, Pan YZ, Seigel GM, Hu ZH, Huang M, Yu AM. Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328, -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells. Biochem Pharmacol 2011; 81:783-92.

Li X, Pandak WM, Erickson SK et al. Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes. J Lipid Res 2007; 48:2587-96.

Li X, Shang L, Wu Y et al. Identification of the human UDP-glucuronosyltransferase isoforms involved in the glucuronidation of the phytochemical ferulic acid. Drug Metab Pharmacokinet 2011; 26:341-50.

Li X, Yang Y, Zhou F et al. SLC11A1 (NRAMP1) Polymorphisms and Tuberculosis Susceptibility: Updated Systematic Review and Meta-Analysis. PLoS One 2011. doi:10. 1371/journal. pone. 0015831.

Li X, Yun JK, Choi JS. Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos 2007; 28:151-6.

Li X, Zhang X, Leathers R et al. Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med 2009; 15:1289-97.

Li XM, Ling Y, Lu DR et al. Association of the aldosterone synthase gene -344T>C polymorphism with essential hypertension and glucose homeostasis: A case-control study in a Han Chinese population. Clin Exp Pharmacol Physiol 2011; 38:598-604.

Li XM, Wei YF, Hao HL et al. Hyperhomocysteinemia and the MTHFR C677T mutation in Budd-Chiari syndrome. Am J Hematol 2002; 71:11-4.

Li XQ, Andersson TB, Ahlström M, Weidolf L. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos 2004; 32:821-7.

Li XQ, Li J, Shi SB, Chen P, Yu LC, Bao QL. Expression of MRP1, BCRP, LRP and ERCC1 as prognostic factors in non-small cell lung cancer patients receiving postoperative cisplatin-based chemotherapy. Int J Biol Markers 2009; 24:230-7.

Li XQ, Weidolf L, Simonsson R, Andersson TB. Enantiomer/enantiomer interactions between the S- and R- isomers of omeprazole in human cytochrome P450 enzymes: major role of CYP2C19 and CYP3A4. J Pharmacol Exp Ther 2005; 315:777-87.

Li Y, Cui Y, Hart SN, Klaassen CD, Zhong XB. Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation. Mol Pharmacol 2009; 75:1171-9.

Li Y, Fu L, Wong AM et al. Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. PLoS One 2011. doi:10. 1371/journal. pone. 0014562.

Li Y, He W, Liu T, Zhang Q. A new Cyclo-oxygenase-2 gene variant in the Han Chinese population is associated with an increased risk of gastric carcinoma. Mol Diagn Ther 2010; 14:351-5.

Li Y, Jiang Z, Xiao Y, Li L, Gao Y. Metabolism of thalidomide by human liver microsome cytochrome CYP2C19 is required for its antimyeloma and antiangiogenic activities in vitro. Hematol Oncol 2011. doi:10. 1002/hon. 992.

Li Y, Liu W, Oo TF et al. Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson’s disease. Nat Neurosci 2009; 12:826-8.

Li Y, Ren G, Wang YX et al. Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes. J Transl Med 2011; 9:62.

Li Y, Ross-Viola JS, Shay NF, Moore DD, Ricketts ML. Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. J Nutr 2009; 139:898-904.

Li Y, Slatter JG, Zhang Z et al. In vitro metabolic activation of lumiracoxib in rat and human liver preparations. Drug Metab Dispos 2008; 36:469-73.

Li Y, Wang Q, Yao X, Li Y. Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor-and pregnane X receptor-mediated pathways. Eur J Pharmacol 2010; 640:46-54.

Li Y, Yue H, Xing Y, Sun H, Pan Z, Xie G. Oxymatrine inhibits development of morphine-induced tolerance associated with decreased expression of P-glycoprotein in rats. Integr Cancer Ther 2010; 9:213-8.

Li Y, Zhou D, Ferguson SS, Dorff P, Simpson TR, Grimm SW. In vitro assessment of metabolic drug-drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P(450) enzyme identification, inhibition, and induction studies. Xenobiotica 2010; 40:721-9.

Li Y, Zhou Y, Yang P et al. Interaction of ACE and CYP11B2 genes on blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients. Clin Exp Hypertens 2011; 33:141-6.

Li YH, Zhang YQ, Li L, Wang Q, Wang NS. Effect of Danggui and Honghua on cytochrome P450 1A2, 2C11, 2E1 and 3A1 mRNA expression in liver of rats. Am J Chin Med 2008; 36:1071-81.

Li YJ, Oliveira SA, Xu P et al. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Hum Mol Genet 2003; 12:3259-67.

Li YJ, Scott WK, Hedges DJ et al. Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet 2002; 70:985-93.

Li YJ, Scott WK, Zhang L, et al. Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases. Neurobiol Aging 2006; 27:1087-93.

Li YM, Xu M, Lai MT et al. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 2000; 405:689-94.

Li Z, Agellon LB, Vance DE. The role of phosphatidylethanolamine methyltransferase in a mouse model of intrahepatic cholestasis. Biochim Biophys Acta 2011; 1811:278-83.

Li Z, He Z, Tang W et al. No genetic association between polymorphisms in the kainate-type glutamate receptor gene, GRIK4, and schizophrenia in the Chinese population. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32:876-80.

Li Z, Hu S, Wang J et al. MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells. Gynecol Oncol 2010; 119:125-30.

Li ZH, Zlabek V, Velisek J et al. Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): effects on antioxidant responses, hematological parameters and hepatic EROD. Ecotoxicol Environ Saf 2011; 74:319-27.

Li ZM, Hu S, Xiao L et al. Expression of microRNA 27a and its correlation with drug resistance in human ovarian cancer A2780/Taxol cells. Zhonghua Fu Chan Ke Za Zhi 2010; 45:372-5.

Liadaki K, Petinaki E, Skoulakis C et al. Toll-like receptor 4 gene (TLR4), but not TLR2, polymorphisms modify the risk of Tonsillar disease due to Streptococcus pyogenes and Haemophilus influenzae. Clin Vaccine Immunol 2011; 18:217-22.

Lian LH, Wu YL, Song SZ et al. Gentiana manshurica Kitagawa reverses acute alcohol-induced liver steatosis through blocking sterol regulatory element-binding protein-1 maturation. J Agric Food Chem 2010; 58:13013-9.

Liang D, Shi Y. Aldehyde dehydrogenase-1 is a specific marker for stem cells in human lung adenocarcinoma. Med Oncol 2011. doi:10. 1007/s12032-011-9933-9.

Liang DY, Liao G, Wang J et al. A genetic analysis of opioid-induced hyperalgesia in mice. Anesthesiology 2006; 104:1054-62.

Liang DY, Shi X, Li X, Li J, Clark JD. The beta2 adrenergic receptor regulates morphine tolerance and physical dependence. Behav Brain Res 2007; 181:118-26.

Liang F, Seyrantepe V, Landry K et al. Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments. J Biol Chem 2006; 281:27526-38.

Liang G, Tang A, Lin X et al. Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer. Int J Oncol 2010; 37:111-23.

Liang Q, Sheng Y, Ji L, Min Y, Xia Y, Wang Z. Acetaminophen-induced cytotoxicity on human normal liver L-02 cells and the protection of antioxidants. Toxicol Mech Methods 2010; 20:273-8.

Liang R, Xiong H, Wang Z, Chen XQ. Effect of rapamycin on proliferation of acute myeloid leukemia cell lines HL-60 and HL-60/VCR. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010; 18:1464-8.

Liang S, Yang N, Pan Y et al. Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation. PLoS One 2009. doi:10. 1371/journal. pone. 0004295.

Liang SH, Hassett C, Omiecinski CJ. Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1). Mol Pharmacol 2005; 67:220-30.

Liang X, Hao L, Chen X et al. Effects of bone marrow stromal cells and umbilical cord blood-derived stromal cells on daunorubicin-resistant residual Jurkat cells. Transplant Proc 2010; 42:3767-72.

Liang X, Schnetz-Boutaud N, Bartlett J et al. Association analysis of genetic polymorphisms in the CDC2 gene with late-onset Alzheimer disease. Dement Geriatr Cogn Disord 2007; 23:126-32.

Liang X, Wang Q, Shi J et al. The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis. Ann Neurol 2008; 64:304-14.

Liang Y, Liu JL, Wu Y, Zhang ZY, Wu R. Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis. Tohoku J Exp Med 2011; 223:137-44.

Liang Y, Zhong Z, Huang Y et al. Stem-like cancer cells are inducible by increasing genomic instability in cancer cells. J Biol Chem 2010; 285:4931-40.

Liang Z, Wu H, Xia J et al. Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1. Biochem Pharmacol 2010; 79:817-24.

Liangpunsakul S, Kolwankar D, Pinto A, Gorski JC, Hall SD, Chalasani N. Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics. Hepatology 2005; 41:1144-50.

Liao C, Cao Y, Wu L, Huang J, Gao F. An updating meta-analysis of the glutathione S-transferase T1 polymorphisms and colorectal cancer risk: a HuGE review. Int J Colorectal Dis 2010; 25:25-37.

Liao DL, Yeh YC, Chen HM, Chen H, Hong CJ, Tsai SJ. Association between the Ser9Gly polymorphism of the dopamine D3 receptor gene and tardive dyskinesia in Chinese schizophrenic patients. Neuropsychobiology 2001; 44:95-8.

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Lin B, Dan W, Jiang L, Yin XH, Wu HT, Sun XC. Association of APOE polymorphism with the change of brain function in the early stage of aneurysmal subarachnoid hemorrhage. Acta Neurochir Suppl 2011; 110:39-42.

Lin CC, Fang C, Benetton S, Xu GF, Yeh LT. Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer. Antimicrob Agents Chemother 2006; 50:2926-31.

Lin CC, Yang WC, Chung MY, Lee PC. Functional polymorphisms in matrix metalloproteinases-1, -3, -9 are associated with arteriovenous fistula patency in hemodialysis patients. Clin J Am Soc Nephrol 2010; 5:1805-14.

Lin CC, Yeh LT, Vitarella D, Hong Z, Erion MD. Remofovir mesylate: a prodrug of PMEA with improved liver-targeting and safety in rats and monkeys. Antivir Chem Chemother 2004; 15:307-17.

Lin CY, Lee TS, Chen CC et al. Endothelin-1 exacerbates lipid accumulation by increasing the protein degradation of the ATP-binding cassette transporter G1 in macrophages. J Cell Physiol 2011; 226:2198-205.

Lin E, Chen PS. Pharmacogenomics with antidepressants in the STAR*D study. Pharmacogenomics 2008; 9:935-46.

Lin E, Chen PS, Chang HH et al. Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33:1167-72.

Lin E, Hong CJ, Hwang JP et al. Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression. Rejuvenation Res 2009; 12:387-93.

Lin GF, Du H, Chen JG et al. Association of XPD/ERCC2 G23591A and A35931C polymorphisms with skin lesion prevalence in a multiethnic, arseniasis-hyperendemic village exposed to indoor combustion of high arsenic coal. Arch Toxicol 2010; 84:17-24.

Lin GF, Ma QW, Zhang DS, Zha YL, Lou KJ, Shen JH. Polymorphism of alpha-estrogen receptor and aryl hydrocarbon receptor genes in dementia patients in Shanghai suburb. Acta Pharmacol Sin 2003; 24:651-6.

Lin HF, Lai CL, Tai CT, Lin RT, Liu CK. Apolipoprotein E polymorphism in ischemic cerebrovascular disease and vascular dementia patients in Taiwan. Neuroepidemiology 2004; 23:129-34.

Lin HJ, Han CY, Lin BK, Hardy S. Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene. Pharmacogenetics 1994; 4:125-34.

Lin HL, Zhang H, Hollenberg PF. Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6. J Pharmacol Exp Ther 2009; 329:26-37.

Lin J, Hu FB, Qi L, Curhan GC. Genetic polymorphisms of angiotensin-2 type 1 receptor and angiotensinogen and risk of renal dysfunction and coronary heart disease in type 2 diabetes mellitus. BMC Nephrol 2009; 10:9.

Lin J, Zee RY, Liu KY et al. Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women. Cancer Causes Control 2010; 21:897-908.

Lin J, Zhao J, Li T, Zhou J, Hu J, Hong Z. Hepatoprotection in a rat model of acute liver damage through inhibition of CY2E1 activity by total alkaloids extracted from Rubus alceifolius Poir. Int J Toxicol 2011; 30:237-43.

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Lin JH, Chen IW, Chiba M, Nishime JA, Deluna FA. Route-dependent nonlinear pharmacokinetics of a novel HIV protease inhibitor: involvement of enzyme inactivation. Drug Metab Dispos 2000; 28:460-6.

Lin JH, Chiba M, Balani SK et al. Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor. Drug Metab Dispos 1996; 24:1111-20.

Lin JH, Manson JE, Kraft P et al. Estrogen and progesterone-related gene variants and colorectal cancer risk in women. BMC Med Genet 2011; 12:78.

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Lin JJ, Yueh KC, Lin SZ, Harn HJ, Liu JT. Genetic polymorphism of the angiotensin converting enzyme and L-dopa-induced adverse effects in Parkinson’s disease. J Neurol Sci 2007; 252:130-4.

Lin KM, Chiu YF, Tsai IJ et al. ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment. Pharmacogenet Genomics 2011; 21:163-70.

Lin KM, Tsou HH, Tsai IJ et al. CYP1A2 genetic polymorphisms are associated with treatment response to the antidepressant paroxetine. Pharmacogenomics 2010; 11:1535-43.

Lin LS, Lanza T, Jewell JP et al. Discovery of N-{N-[(3-cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(L)-prolyl}-4-[(3’,5’-dichloroisonicotinoyl) amino]-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4. J Med Chem 2009; 52:3449-52.

Lin M, Aquilante C, Johnson JA, Wu R. Sequencing drug response with HapMap. Pharmacogenomics J 2005; 5:149-56.

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Lin MT, Storer B, Martin PJ et al. Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. N Engl J Med 2003; 349:2201-10.

Lin N, Lin J, Bo L, Weidong P, Chen S, Xu R. Differentiation of bone marrow-derived mesenchymal stem cells into hepatocyte-like cells in an alginate scaffold. Cell Prolif 2010; 43:427-34.

Lin R, Wang X, Zhou W et al. Association of polymorphisms in the solute carrier organic anion transporter family member 1B1 gene with essential hypertension in the Uyghur population. Ann Hum Genet 2011; 75:305-11.

Lin S, del Razo LM, Styblo M, Wang C, Cullen WR, Thomas DJ. Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes. Chem Res Toxicol 2001; 14:305-11.

Lin S, Shi Q, Nix FB et al. A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol. J Biol Chem 2002; 277:10795-803.

Lin SP, Wu PP, Hou YC et al. Different influences on tacrolimus pharmacokinetics by coadministrations of zhi ke and zhi shi in rats. Evid Based Complement Alternat Med 2011. doi:10. 1155/2011/751671.

Lin SY, Sheu WH, Lee WJ, Song YM, Chen YT. Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated with increased plasma leptin levels in obese Chinese women. Zhonghua Yi Xue Za Zhi 1999; 62:569-76.

Lin T, Pan K, Mordenti J, Pan L. In vitro assessment of cytochrome P450 inhibition: strategies for increasing LC/MS-based assay throughput using a one-point IC(50) method and multiplexing high-performance liquid chromatography. J Pharm Sci 2007; 96:2485-93.

Lin TH, Chiu HC, Su HM et al. D-allele of ACE polymorphism is associated with increased magnitude of QT dispersion prolongation in elderly Chinese: 4-year follow-up study. Circ J 2007; 71:39-45.

Lin TH, Su HM, Wang CL et al. Vascular endothelial growth factor polymorphisms and extent of coronary atherosclerosis in Chinese population with advanced coronary artery disease. Am J Hypertens 2010; 23:960-6.

Lin W, Rahman NA, Lin J et al. Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1). Am J Pathol 2011; 178:1233-44.

Lin W, Weinberg EM, Tai AW et al. HIV increases HCV replication in a TGF-beta1-dependent manner. Gastroenterology 2008; 3:803-11.

Lin W, Wu J, Dong H, Bouck D, Zeng FY, Chen T. Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. J Biol Chem 2008; 283:30650-7.

Lin WL, Lewis J, Yen SH, Hutton M, Dickson DW. Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation. Am J Pathol 2003; 162:213-8.

Lin WR, Graham J, MacGowan M, Wilcock GK, Itzhaki RF. Alzheimer’s disease, herpes virus in brain, apolipoprotein E4 and herpes labialis. Alzheimer’s Rep 1998; 1:173-8.

Lin WR, Jennings R, Smith TL, Wozniak MA, Itzhaki RF. Vaccination prevents latent HSV1 infection of mouse brain. Neurobiol Aging 2001; 22:699-703.

Lin X, Parisiadou L, Gu XL et al. Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson’s-disease-related mutant alpha-synuclein. Neuron 2009; 64:807-27.

Lin Y, Anderson GD, Kantor E, Ojemann LM, Wilensky AJ. Differences in the urinary excretion of 6-beta-hydroxycortisol/cortisol between Asian and Caucasian women. J Clin Pharmacol 1999; 39:578-82.

Lin Y, Mao Q, Zheng X, Chen H, Yang K, Xie L. Vitamin D receptor genetic polymorphisms and the risk of urolithiasis: A meta-analysis. Urol Int 2011; 86:249-55.

Lin YH, Peng FC. Predicting the contribution of rat cytochrome P-450 3A1, 3A2 and human cytochrome P-450 3A4, 3A5 to territrem a 4beta-C hydroxylation using the relative activity factor. J Toxicol Environ Health A 2008; 71:1407-14.

Lin YJ, Wan L, Huang CM et al. IL-10 and TNF-alpha promoter polymorphisms in susceptibility to systemic lupus erythematosus in Taiwan. Clin Exp Rheumatol 2010; 28:318-24.

Lin YK, Sheu MT, Tzen TZ, Ho HO. Biotransformation of sildenafil in the male rat: evaluation of drug interactions with testosterone and carbamazepine. Drug Dev Ind Pharm 2008; 34:1219-26.

Lin YP, Chen LR, Chen CF et al. Identification of early transcripts related to male development in chicken embryos. Theriogenology 2010; 74:1161-78.

Lin YS, Dowling AL, Quigley SD et al. Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism. Mol Pharmacol 2002; 62:162-72.

Lin YS, Yasuda K, Assem M et al. The major human pregnane X receptor (PXR) splice variant, PXR. 2, exhibits significantly diminished ligand-activated transcriptional regulation. Drug Metab Dispos 2009; 37:1295-304.

Lin YW, MacMullen C, Ganguly A, Stanley CA, Shyng SL. A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels. J Biol Chem 2006; 281:3006-12.

Lin Z, Zhang X, Tuo J et al. A variant of the Cockayne syndrome B gene ERCC6 confers risk of lung cancer. Hum Mutat 2008; 29:113-22.

Lin ZH, Xin YN, Dong QJ et al. Association between HLA-DRB1 alleles polymorphism and hepatocellular carcinoma: a meta-analysis. BMC Gastroenterol 2010; 10:145.

Lin ZP, Zhu YL, Johnson DR et al. Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response. Mol Pharmacol 2008; 73:243-51.

Lincoln MR, Ramagopalan SV, Chao MJ et al. Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. Proc Natl Acad Sci USA 2009; 106:7542-7.

Lind AB, Reis M, Bengtsson F et al. Steady-state concentrations of mirtazapine, N-desmethylmirtazapine, 8-hydroxymirtazapine and their enantiomers in relation to cytochrome P450 2D6 genotype, age and smoking behaviour. Clin Pharmacokinet 2009; 48:63-70.

Lind B, Koefoed P, Thorsen S. Symptomatic type 1 protein C deficiency caused by a de novo Ser270Leu mutation in the catalytic domain. Br J Haematol 2001; 113:642-8.

Lind JS, Dingemans AM, Groen HJ et al. A multicenter, phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer. Clin Cancer Res 2010; 16:3078-87.

Lindberg AL, Kumar R, Goessler W et al. Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms. Environ Health Perspect 2007; 115:1081-6.

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Linden HM, Kurland BF, Peterson LM et al. Fluoroestradiol positron emission tomography reveals differences in pharmacodynamics of aromatase inhibitors, tamoxifen, and fulvestrant in patients with metastatic breast cancer. Clin Cancer Res 2011; 17:4799-805.

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Liu C, Shi Y, Li H, Wang Y, Yang K. p,p’-DDE disturbs the homeostasis of thyroid hormones via thyroid hormone receptors, transthyretin, and hepatic enzymes. Horm Metab Res 2011; 43:391-6.

Liu C, Zhang X, Chang H et al. Effects of fluorotelomer alcohol 8:2 FTOH on steroidogenesis in H295R cells: targeting the cAMP signalling cascade. Toxicol Appl Pharmacol 2010; 247:222-8.

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Liu D, Gao Y, Wang H et al. Evaluation of the effects of cytochrome P450 nonsynonymous single-nucleotide polymorphisms on tanshinol borneol ester metabolism and inhibition potential. Drug Metab Dispos 2010; 38:2259-65.

Liu D, Wu L, Breyer R, Mattson MP, Andreasson K. Neuroprotection by the PGE2 EP2 receptor in permanent focal ischemia. Ann Neurol 2005; 57:758-61.

Liu DQ, Karanam BV, Doss GA, Sidler RR, Vincent SH, Hop CE. In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phenyl] methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. II. Identification of metabolites by liquid chromatography-tandem mass spectrometry. Drug Metab Dispos 2004; 32:1023-31.

Liu DY, Zhu HJ, Zheng YF, Zhu XQ. Human pregnane X receptor-mediated transcriptional regulation of cytochrome P450 3A4 by some phytochemicals. Zhejiang Da Xue Xue Bao Yi Xue Ban 2006; 35:8-13.

Liu DY, Zhu HJ, Zheng YF, Zhu XQ. Kaempferol activates human steroid and xenobiotic receptor-mediated cytochrome P450 3A4 transcription. Zhejiang Da Xue Xue Bao Yi Xue Ban 2006; 35:14-7.

Liu F, He Z, Deng S, Zhang H, Li N, Xu J. Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population. Mol Biol Rep 2011; 38:1983-8.

Liu F, Ichihara S, Mohideen SS, Sai U, Kitoh J, Ichihara G. Comparative study on susceptibility to 1-bromopropane in three mice strains. Toxicol Sci 2009; 112:100-10.

Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong CX. O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer’s disease. Proc Nat Acad Sci USA 2004; 101:10804-9.

Liu F, Liu S, He S, Xie Z, Zu X, Jiang Y. Survivin transcription is associated with P-glycoprotein/MDR1 overexpression in the multidrug resistance of MCF-7 breast cancer cells. Oncol Rep 2010; 23:1469-75.

Liu FJ, Song X, Yang D, Deng R, Yan B. The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha. Biochem J 2008; 409:243-50.

Liu G, Gurubhagavatula S, Zhou W et al. Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib. Pharmacogenomics J 2008; 8:129-38.

Liu G, Hu X, Premkumar L, Chakrabarty S. Nifedipine synergizes with calcium in activating the calcium sensing receptor, suppressing the expression of thymidylate synthase and survivin and promoting sensitivity to fluorouracil in human colon carcinoma cells. Mol Carcinog. 2011. doi:10. 1002/mc. 20752.

Liu G, Liu Y, Liu R, Dong F, Zhang Z. Effects of Flos carthami on CYP2D6 and on the pharmacokinetics of metoprolol in rats. Evid Based Complement Alternat Med 2011. doi:10. 1155/2011/207076.

Liu H, Zhang S, Jiang S et al. Renin-angiotensin-aldosterone system gene polymorphisms and antihypertensive response to irbesartan in Chinese hypertensives. Methods Find Exp Clin Pharmacol 2008; 30:307-12.

Liu H, Zhao Y, Nie D et al. Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension. J Am Soc Nephrol 2008; 19:714-21.

Liu HC, Hong CJ, Liu TY, Chi CW, Tsai SJ. Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer’s disease. Dement Geriatr Cogn Disord 2005; 19:42-5.

Liu HG, Pan YF, You J, Wang OC, Huang KT, Zhang XH. Expression of ABCG2 and its significance in colorectal cancer. Asian Pac J Cancer Prev 2010; 11:845-8.

Liu HL, Lin YG, Wu J et al. Impact of genetic polymorphisms of leptin and TNF-alpha on rosiglitazone response in Chinese patients with type 2 diabetes. Eur J Clin Pharmacol 2008; 64:663-71.

Liu HX, Hu Y, Liu Y, He YQ, Li W, Yang L. CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes. Xenobiotica 2009; 39:672-9.

Liu J, Chau CH, Liu H et al. Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth. J Cell Sci 2006; 119:933-42.

Liu J, Hu P, Qi XR, Meng FT, Kalsbeek A, Zhou JN. Acute restraint stress increases intrahypothalamic oestradiol concentrations in conjunction with increased hypothalamic oestrogen receptor β and aromatase mRNA expression in female rats. J Neuroendocrinol 2011; 23:435-43.

Liu J, Liu ZQ, Tan ZR et al. Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol. Clin Pharmacol Ther 2003; 74:372-9.

Liu J, Liu ZQ, Yu BN et al. beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension. Clin Pharmacol Ther 2006; 80:23-32.

Liu J, Rasul I, Sun Y et al. GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitisation. J Biol Chem 2009; 284:19564-71.

Liu J, Song B, Bai X et al. Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese. BMC Cancer 2010; 10:456.

Liu J, Yang XM, Liu G, Chang LS, Zhang LR, Song DK. Association between genetic polymorphism of UGT1A7 and susceptibility of bladder cancer. Zhonghua Yi Xue Za Zhi 2009; 89:3122-5.

Liu J, Yang Y, Yang Y, Zhang Y, Liu W. Disrupting effects of bifenthrin on ovulatory gene expression and prostaglandin synthesis in rat ovarian granulosa cells. Toxicology 2011; 282:47-55.

Liu JL, Liang Y, Wang ZN, Zhou X, Xing LL. Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: a meta-analysis. World J Gastroenterol 2010; 16:5510-7.

Liu KH, Kim MG, Lee DJ et al. Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos 2006; 34:1793-7.

Liu KH, Kim MJ, Jeon BH et al. Inhibition of human cytochrome P450 isoforms and NADPH-CYP reductase in vitro by 15 herbal medicines, including Epimedii herba. J Clin Pharm Ther 2006; 31:83-91.

Liu KH, Kim MJ, Shon JH et al. Stereoselective inhibition of cytochrome P450 forms by lansoprazole and omeprazole in vitro. Xenobiotica 2005; 35:27-38.

Liu KH, Lee YM, Shon JH et al. Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. Xenobiotica 2004; 34:429-38.

Liu L, Chen C, Gong W et al. Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation and apoptosis in carcinoma cells treated with arsenic trioxide. J Pharmacol Exp Ther 2011; 339:451-63.

Liu L, Derguini F, Gudas LJ. Metabolism and regulation of gene expression by 4-oxoretinol versus all-trans retinoic acid in normal human mammary epithelial cells. J Cell Physiol 2009; 220:771-9.

Liu L, Fan L, Peng X, Hu D, Zhou H. MDR1 C2005T polymorphism changes substrate specificity. Cancer Chemother Pharmacol 2010; 66:617-23.

Liu L, Xiang K, Zheng T, Zhang R, Li M, Li J. Co-inheritance of specific genotypes of HSPG and ApoE gene increases risk of type 2 diabetic nephropathy. Mol Cell Biochem 2003; 254:353-8.

Liu L, Xiao J, Peng ZH, Chen Y. In vitro metabolism of glycyrrhetic acid by human cytochrome P450. Yao Xue Xue Bao 2011; 46:81-7.

Liu L, Yang L, Zhang YC, Ai XF, Wang JX, Xiao ZJ. Polymorphisms of drug-metabolizing enzymes genes in a Han Chinese population. Zhonghua Yi Xue Za Zhi 2009; 89:2675-81.

Liu LG, Yan H, Zhang W et al. Induction of heme oxygenase-1 in human hepatocytes to protect them from ethanol-induced cytotoxicity. Biomed Environ Sci 2004; 17:315-26.

Liu M, Zhou L, Xu A et al. A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proc Natl Acad Sci USA 2008; 105:18302-7.

Liu P, Foster G, LaBadie RR, Gutierrez MJ, Sharma A. Pharmacokinetic interaction between voriconazole and efavirenz at steady state in healthy male subjects. J Clin Pharmacol 2008; 48:73-84.

Liu P, Meng XH, Wang H et al. Effects of pubertal fenvalerate exposure on testosterone and estradiol synthesis and the expression of androgen and estrogen receptors in the developing brain. Toxicol Lett 2011; 201:181-9.

Liu P, Wang X, Gao N et al. G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson’s disease, regulates bcl-2 expression. Brain Res 2010; 1307:134-41.

Liu PT, Stenger S, Li H et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006; 311:1770-3.

Liu Q, Li Y, Zhao J et al. Association of single nucleotide polymorphisms in VEGF gene with the risk of endometriosis and adenomyosis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009; 26:165-9.

Liu Q, Sobell JL, Heston LL, Sommer SS. Screening the dopamine D1 receptor gene in 131 schizophrenics and eight alcoholics: identification of polymorphisms but lack of functionally significant sequence changes. Am J Med Genet 1995; 60:165-71.

Liu Q, Yan YX, McClure M, Nakagawa H, Fujimura F, Rustgi AK. MTS-1 (CDKN2) tumor suppressor gene deletions are a frequent event in esophagus squamous cancer and pancreatic adenocarcinoma cell lines. Oncogene 1995; 10:619-22.

Liu R, Paxton WA, Choe S et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996; 86:367-77.

Liu R, Tang AM, Tan YL, Limenta LM, Lee EJ. Interethnic differences of PEPT2 (SLC15A2) polymorphism distribution and associations with cephalexin pharmacokinetics in healthy Asian subjects. Eur J Clin Pharmacol 2009; 65:65-70.

Liu R, Tang AM, Tan YL, Limenta LM, Lee EJ. Effects of sodium bicarbonate and ammonium chloride pre-treatments on the PEPT2 (SLC15A2) mediated renal clearance of cephalexin in healthy subjects. Drug Metab Pharmacokinet 2011; 26:87-93.

Liu R, Zhang Y, Chen Y et al. A novel calmodulin antagonist O-(4-ethoxyl-butyl)-berbamine overcomes multidrug resistance in drug-resistant MCF-7/ADR breast carcinoma cells. J Pharm Sci 2010; 99:3266-75.

Liu S, Frye RF, Branch RA, Venkataramanan R, Fung JJ, Burckart GJ. Effect of age and postoperative time on cytochrome p450 enzyme activity following liver transplantation. J Clin Pharmacol 2005; 45:666-73.

Liu S, Neidhardt EA, Grossman TH, Ocain T, Clardy J. Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. Structure 2000; 8:25-33.

Liu T, David SP, Tyndale RF et al. Associations of CYP2A6 genotype with smoking behaviors in southern China. Addiction 2011; 106:985-94.

Liu T, Willmore-Payne C, Layfield LJ, Glasgow RE, Holden JA. A gastrointestinal stromal tumor of the stomach morphologically resembling a neurofibroma: demonstration of a novel platelet-derived growth factor receptor alpha exon 18 mutation. Hum Pathol 2008; 39:1849-53.

Liu T, Xu F, Du X et al. Establishment and characterization of multi-drug resistant, prostate carcinoma-initiating stem-like cells from human prostate cancer cell lines 22RV1. Mol Cell Biochem 2010; 340:265-73.

Liu W, Fu Y, Xu S et al. c-Met expression is associated with time to recurrence in patients with glioblastoma multiforme. J Clin Neurosci 2011; 18:119-21.

Liu W, He L, Ramirez J et al. Functional EGFR germline polymorphisms may confer risk for EGFR somatic mutations in non-small cell lung cancer, with a predominant effect on exon 19 microdeletions. Cancer Res 2011; 71:2423-7.

Liu X, Ogawa H, Kishida T, Ebihara K. The effect of high-amylose cornstarch on lipid metabolism in OVX rats is affected by fructose feeding. J Nutr Biochem 2010; 21:89-97.

Liu X, Plummer SJ, Nock NL, Casey G, Witte JS. Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: modification by lymphotoxin alpha. Am J Epidemiol 2006; 164:984-9.

Liu X, Qin D, Cui Y et al. The effect of calcium phosphate nanoparticles on hormone production and apoptosis in human granulosa cells. Reprod Biol Endocrinol 2010; 8:32.

Liu X, Sawauchi H, Ogawa H, Kishida T, Ebihara K. Retrograded tapioca starch prevents ovarian hormone deficiency-induced hypercholesterolemia. J Nutr Sci Vitaminol 2006; 52:134-41.

Liu X, Zhao Y, Wang L et al. Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure. Kidney Int 2009; 75:1288-96.

Liu XD, Sun H, Liu GT. 5-Bromotetrandrine enhances the sensitivity of doxorubicin-induced apoptosis in intrinsic resistant human hepatic cancer Bel7402 cells. Cancer Lett 2010; 292:24-31.

Liu XH, Xiao J, Mo ZC et al. Contribution of D4-F to ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells. J Cardiovasc Pharmacol 2010; 56:309-19.

Liu XL, Wang ZJ, Yang Q et al. Impact of CYP2C19 polymorphism and smoking on response to clopidogrel in patients with stable coronary artery disease. Chin Med J 2010; 123:3178-83.

Liu XY, Gabig TG, Bang NU. Combined heterozygosity of factor V leiden and the G20210A prothrombin gene mutation in a patient with cerebral cortical vein thrombosis. Am J Hematol 2000; 64:226-8.

Liu Y, Helms C, Liao W et al. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 2008. doi:10. 1371/journal. pgen. 1000041.

Liu Y, Ji W, Yin Y et al. The effects of splicing variant of PXR PAR-2 on CYP3A4 and MDR1 mRNA expressions. Clin Chim Acta 2009; 403:142-4.

Liu Y, Liang WB, Gao LB et al. CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. Hum Immunol 2010; 71:1141-6.

Liu Y, Ma H, Zhang JW, Deng MC, Yang L. Influence of ginsenoside Rh1 and F1 on human cytochrome p450 enzymes. Planta Med 2006; 72:126-31.

Liu Y, Ordovas JM, Gao G et al. Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study. Pharmacogenet Genomics 2009; 19:161-9.

Liu Y, Ramírez J, House L, Ratain MJ. Comparison of the drug-drug interactions potential of erlotinib and gefitinib via inhibition of UDP-glucuronosyltransferases. Drug Metab Dispos 2010; 38:32-9.

Liu Y, Ramírez J, Ratain MJ. Inhibition of paracetamol glucuronidation by tyrosine kinase inhibitors. Br J Clin Pharmacol 2011; 71:917-20.

Liu Y, Saccucci P, Qi H et al. ADA polymorphisms and asthma: a study in the Chinese Han population. J Asthma 2006; 43:203-6.

Liu Y, Wang Y, Jiang Y et al. Mild processing defect of porcine DeltaF508-CFTR suggests that DeltaF508 pigs may not develop cystic fibrosis disease. Biochem Biophys Res Commun 2008; 373:113-8.

Liu Y, Zeng BH, Shang HT, Cen YY, Wei H. Bama miniature pigs (Sus scrofa domestica) as a model for drug evaluation for humans: comparison of in vitro metabolism and in vivo pharmacokinetics of lovastatin. Comp Med 2008; 58:580-7.

Liu Y, Zhang JW, Li W et al. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicol Sci 2006; 91:356-64.

Liu YL, Fann CS, Liu CM et al. RASD2, MYH9, and CACNG2 genes at chromosome 22q12 associated with the subgroup of schizophrenia with non-deficit in sustained attention and executive function. Biol Psychiatry 2008; 64:789-96.

Liu YR, Loh EW, Lan TH et al. ADRA1A gene is associated with BMI in chronic schizophrenia patients exposed to antipsychotics. Pharmacogenomics J 2010; 10:30-9.

Liu YT, Hao HP, Liu CX, Wang GJ, Xie HG. Drugs as CYP3A probes, inducers, and inhibitors. Drug Metab Rev 2007; 39:699-721.

Liu YY, Gupta V, Patwardhan GA et al. Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. Mol Cancer 2010; 9:145.

Liu YZ, Tang BS, Yan XX et al. Association of the DRD2 and DRD3 polymorphisms with response to pramipexole in Parkinson’s disease patients. Eur J Clin Pharmacol 2009; 65:679-83.

Liu Z, Barnes SA, Sokolnicki LA et al. Beta-2 adrenergic receptor polymorphisms and the forearm blood flow response to mental stress. Clin Auton Res 2006; 16:105-12.

Liu Z, Li G, Wei S et al. Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck. Carcinogenesis 2010; 31:1977-81.

Liu Z, Mortimer O, Smith CA, Wolf CR, Rane A. Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism. Br J Clin Pharmacol 1995; 39:77-80.

Liu Z, Qiu M, Tang QL, Liu M, Lang N, Bi F. Establishment and biological characteristics of oxaliplatin-resistant human colon cancer cell lines. Chin J Cancer 2010; 29:661-7.

Liu ZH, He YP, Zhou Y, Zhang P, Qin H. Establishment and identification of the human multi-drug-resistant cholangiocarcinoma cell line QBC939/ADM. Mol Biol Rep 2011; 38:3075-82.

Liu ZH, Ma YL, He YP, Zhang P, Zhou YK, Qin H. Tamoxifen reverses the multi-drug-resistance of an established human cholangiocarcinoma cell line in combined chemotherapeutics. Mol Biol Rep 2011; 38:1769-75.

Liu ZQ, Shu Y, Huang SL, Wang LS, He N, Zhou HH. Effects of CYP2C19 genotype and CYP2C9 on fluoxetine N-demethylation in human liver microsomes. Acta Pharmacol Sin 2001; 22:85-90.

Liu ZQ, Zhu B, Tan YF et al. O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes. J Pharmacol Exp Ther 2002; 300:105-11.

Liu ZW, Hu ZH, Cai YY. The combined effect of isoniazid and rifampicin on the activities of CYP4501A2 and CYP4503A4 in primary hepatocytes from healthy human adults. Zhonghua Jie He He Hu Xi Za Zhi 2005; 28:785-8.

Liu ZY, Dai MH, Tao YF, Chen DM, Yuan ZH. Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes. J Vet Pharmacol Ther 2011; 34:424-9.

Liukas A, Hagelberg NM, Kuusniemi K, Neuvonen PJ, Olkkola KT. Inhibition of cytochrome P450 3A by clarithromycin uniformly affects the pharmacokinetics and pharmacodynamics of oxycodone in young and elderly volunteers. J Clin Psychopharmacol 2011; 31:302-8.

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Lu YF, Wu Q, Liang SX, Miao JW, Shi JS, Liu J. Evaluation of hepatotoxicity potential of cinnabar-containing An-Gong-Niu-Huang Wan, a patent traditional Chinese medicine. Regul Toxicol Pharmacol 2011; 60:206-11.

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