General References

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W
Waade RB, Christensen H, Rudberg I, Refsum H, Hermann M. Influence of comedication on serum concentrations of aripiprazole and dehydroaripiprazole. Ther Drug Monit 2009; 31:233-8.

Wacker DW, Wingfield JC, Davis JE, Meddle SL. Seasonal changes in aromatase and androgen receptor, but not estrogen receptor mRNA expression in the brain of the free-living male song sparrow, Melospiza melodia morphna. J Comp Neurol 2010; 518:3819-35.

Wacher VJ, Salphati L, Benet LZ. Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv Drug Deliv Rev 2001; 46:89-102.

Wacher VJ, Silverman JA, Zhang Y, Benet LZ. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J Pharm Sci 1998; 87:1322-30.

Wada K, Takada M, Ueda T et al. Drug interactions between tacrolimus and phenytoin in Japanese heart transplant recipients: 2 case reports. Int J Clin Pharmacol Ther 2007; 45:524-8.

Wada M. Single nucleotide polymorphisms in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response. Cancer Lett 2006; 234:40-50.

Wada M, Toh S, Taniguchi K et al. Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. Hum Molec Genet 1998; 7:203-7.

Wada T, Kang HS, Angers M et al. Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol 2008; 73:891-9.

Wade AE. Effects of dietary fat on drug metabolism. J Environ Pathol Toxicol Oncol 1986; 6:161-89.

Wadelius M, Chen LY, Downes K et al. Common VKORC1 and GGCX polymorphisms associated with warfarin dose. Pharmacogenomics J 2005; 5:262-70.

Wadelius M, Chen LY, Eriksson N et al. Association of warfarin dose with genes involved in its action and metabolism. Hum Genet 2007; 121:23-34.

Wadelius M, Chen LY, Lindh JD et al. The largest prospective warfarin-treated cohort supports genetic forecasting. Blood 2009; 113:784-92.

Wadelius M, Darj E, Frenne G, Rane A. Induction of CYP2D6 in pregnancy. Clin Pharmacol Ther 1997; 62:400-7.

Wadsworth JDF, Joiner S, Linehan JM et al. Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice. Proc Nat Acad Sci USA 2008; 105:3885-90.

Waelter S, Scherzinger E, Hasenbank R et al. The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis. Hum Molec Genet 2001; 10:1807-17.

Wafford KA, Thompson SA, Thomas D, Sikela J, Wilcox AS, Whiting PJ. Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Mol Pharmacol 1996; 50:670-8.

Wagner AD, Kolb JM, Ozbal CC et al. Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P-glycoprotein (P-gp) inhibition screen. Rapid Commun Mass Spectrom 2011; 25:1231-40.

Wagner CC, Bauer M, Karch R et al. A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET. J Nucl Med 2009; 50:1954-61.

Wagner EF. Functions of AP1 (Fos/Jun) in bone development. Ann Rheum Dis 2002; 61 Suppl 2:40-2.

Wagner JA, Wright EC, Ennis MM et al. Utility of adiponectin as a biomarker predictive of glycemic efficacy is demonstrated by collaborative pooling of data from clinical trials conducted by multiple sponsors. Clin Pharmacol Ther 2009; 86:619-25.

Wagstaff AJ, Ormrod D, Spencer CM. Tianeptine: a review of its use in depressive disorders. CNS Drugs 2001; 15:231-59.

Wahawisan J, Kolluru S, Nguyen T, Molina C, Speake J. Methadone toxicity due to smoking cessation-A case report on the drug-drug interaction involving cytochrome P450 isoenzyme 1A2. Ann Pharmacother 2011; 45:34.

Waheed A, Grubb JH, Zhou XY et al. Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci USA 2002; 99:3117-22.

Wahlbeck K, Ahokas A, Nikkilä H, Miettinen K, Rimón R. Cerebrospinal fluid angiotensin-converting enzyme (ACE) correlates with length of illness in schizophrenia. Schizophr Res 2000; 41:335-40.

Wahrle SE, Jiang H, Parsadanian M et al. ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. J Biol Chem 2004; 279:40987-93.

Wakamatsu N, Hayashi M, Kawai H et al. Mutations producing premature termination of translation and an amino acid substitution in the sterol 27-hydroxylase gene cause cerebrotendinous xanthomatosis associated with parkinsonism. J Neurol Neurosurg Psychiatry 1999; 67:195-8.

Wakefield L, Cornish V, Long H et al. Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system. Biomarkers 2008; 13:106-18.

Wakeno M, Kato M, Okugawa G et al. The alpha 2A-adrenergic receptor gene polymorphism modifies antidepressant responses to milnacipran. J Clin Psychopharmacol 2008; 28:518-24.

Wakisaka N, Taira Y, Ishikawa M et al. Effectiveness of finasteride on patients with male pattern baldness who have different androgen receptor gene polymorphism. J Investig Dermatol Symp Proc 2005; 10:293-4.

Waldman ID, Nigg JT, Gizer IR, Park L, Rappley MD, Friderici K. The adrenergic receptor alpha-2A gene (ADRA2A) and neuropsychological executive functions as putative endophenotypes for childhood ADHD. Cogn Affect Behav Neurosci 2006; 6:18-30.

Walenga JM, Adiguzel C. Drug and dietary interactions of the new and emerging oral anticoagulants. Int J Clin Pract 2010; 64:956-67.

Walenkamp MJ, Karperien M, Pereira AM et al. Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation. J Clin Endocrinol Metab 2005; 90:2855-64.

Walisser JA, Glover E, Pande K, Liss AL, Bradfield CA. Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types. Proc Nat Acad Sci USA 2005; 102:17858-63.

Walker AA, Dickmann L, Isoherranen N. Pregnancy decreases rat CYP1A2 activity and expression. Drug Metab Dispos 2011; 39:4-7.

Walker AH, Jaffe JM, Gunasegaram S et al. Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: ethnic distribution and implications for prostate cancer risk. Mutations in brief no. 191. Online. Hum Mutat 1998; 12:289.

Walker AH, Najarian D, White DL, Jaffe JF, Kanetsky PA, Rebbeck TR. Collection of genomic DNA by buccal swabs for polymerase chain reaction-based biomarker assays. Environ Health Perspect 1999; 107:517-20.

Walker AM, Szneke P, Weatherby LB et al. The risk of serious cardiac arrhythmias among cisapride users in the United Kingdom and Canada. Am J Med 1999; 107:356-62.

Walker D, Flinois JP, Monkman SC et al. Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide. Biochem Pharmacol 1994; 47:1157-63.

Walker DA, Harper PS, Wells CEC, Tyler A, Davies K, Newcombe RG. Huntington’s chorea in South Wales: a genetic and epidemiological study. Clin Genet 1981; 19:213-21.

Walker DK, Alabaster CT, Congrave GS et al. Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data. Drug Metab Dispos 1996; 24:447-55.

Walker DW, Muffat J, Rundel C, Benzer S. Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. Curr Biol 2006; 16:674-9.

Walsh N, Kennedy S, Larkin AM et al. Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis. Br J Cancer 2010; 102:1157-62.

Walsh N, Larkin A, Kennedy S et al. Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma. BMC Urol 2009; 9:6.

Walsky RL, Gaman EA, Obach RS. Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol 2005; 45:68-78.

Walsky RL, Obach RS. Validated assays for human cytochrome P450 activities. Drug Metab Dispos 2004; 32:647-60.

Walstab J, Hammer C, Bönisch H, Rappold G, Niesler B. Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors. Pharmacogenet Genomics 2008; 18:793-802.

Walter DH, Schächinger V, Elsner M, Dimmeler S, Zeiher AM. Platelet glycoprotein IIIa polymorphisms and risk of coronary stent thrombosis. Lancet 1997; 350:1217-9.

Walters BJ, Alexiades NG, Saldanha CJ. Intracerebral estrogen provision increases cytogenesis and neurogenesis in the injured zebra finch brain. Dev Neurobiol 2011; 71:170-81.

Walton JR, Wang MX. APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer’s disease. J Inorg Biochem 2009; 103:1548-54.

Walz C, Haferlach C, Hänel A et al. Identification of a MYO18A-PDGFRB fusion gene in an eosinophilia-associated atypical myeloproliferative neoplasm with a t(5; 17)(q33-34; q11. 2). Genes Chromosomes Cancer 2009; 48:179-83.

Walz R, Castro RMRPS, Velasco TR et al. Surgical outcome in mesial temporal sclerosis correlates with prion protein gene variant. Neurology 2003; 61:1204-10.

Wall JS, Richey T, Allen A, Donnell R, Kennel SJ, Solomon A. Quantitative tomography of early-onset spontaneous AA amyloidosis in interleukin 6 transgenic mice. Comp Med 2008; 58:542-50.

Wallace K, Cowie DE, Konstantinou DK et al. The PXR is a drug target for chronic inflammatory liver disease. J Steroid Biochem Mol Biol 2010; 120:137-48.

Wallace RH, Wang DW, Singh R et al. Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. Nat Genet 1998; 19:366-70.

Walle UK, Walle T. Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. Drug Metab Dispos 2007; 35:1985-9.

Wallenstein EJ, Barminko J, Schloss RS, Yarmush ML. Serum starvation improves transient transfection efficiency in differentiating embryonic stem cells. Biotechnol Prog 2010; 26:1714-23.

Wallentin L, James S, Storey RF et al. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial. Lancet 2010; 376:1320-8.

Wallerand H, Rémy-Martin A, Chabannes E, Bermont L, Adessi GL, Bittard H. Relationship between expansion of the CAG repeat in exon 1 of the androgen receptor gene and idiopathic male infertility. Fertil Steril 2001; 76:769-74.

Wallerstedt SM, Skrtic S, Eriksson AL, Ohlsson C, Hedner T. Association analysis of the polymorphism T1128C in the signal peptide of neuropeptide Y in a Swedish hypertensive population. J Hypertens 2004; 22:1277-81.

Wallin R, Wajih N, Hutson SM. VKORC1: a warfarin-sensitive enzyme in vitamin K metabolism and biosynthesis of vitamin K-dependent blood coagulation factors. Vitam Horm 2008; 78:227-46.

Wallon D, Guyant-Maréchal L, Laquerrière A et al. Clinical imaging and neuropathological correlations in an unusual case of cerebrotendinous xanthomatosis. Clin Neuropathol 2010; 29:361-4.

Wallukat G, Homuth V, Fischer T et al. Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT-1 receptor. J Clin Invest 1999; 103:945-52.

Wan CK, Tse AK, Yu ZL, Zhu GY, Wang H, Fong DW. Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from Fructus Schisandrae chinensis. Phytomedicine 2010; 17:702-5.

Wan HY, Chen B, Yang JF, Dong XM. NQ01 gene polymorphism C609T associated with an increased risk for cognitive dysfunction and sporadic Alzheimer’s disease in Chinese. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2005; 27:285-8.

Wan J, Fu AK, Ip FC et al. Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer’s disease. J Neurosci 2010; 30:6873-81.

Wan J, Shi J, Hui L et al. Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning. Environ Health Perspect 2002; 110:1213-8.

Wan W, Lim JK, Lionakis MS et al. Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice. Circ Res 2011; 109:374-81.

Wan YJ, Poland RE, Han G et al. Analysis of the CYP2D6 gene polymorphism and enzyme activity in African-Americans in southern California. Pharmacogenetics 2001; 11:489-99.

Wand GS, McCaul M, Yang X et al. The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade. Neuropsychopharmacology 2002; 26:106-14.

Wandel C, Böcker RH, Böhrer H et al. Relationship between hepatic cytochrome P450 3A content and activity and the disposition of midazolam administered orally. Drug Metab Dispos 1998; 26:110-4.

Wandel C, Lang CC, Cowart DC et al. Effect of CYP3A inhibition on vesnarinone metabolism in humans. Clin Pharmacol Ther 1998; 63:506-11.

Wandel C, Witte JS, Hall JM, Stein CM, Wood AJ, Wilkinson GR. CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5’-promoter region polymorphism. Clin Pharmacol Ther 2000; 68:82-91.

Wang A, Yu BN, Luo CH et al. Ile118Val genetic polymorphism of CYP3A4 and its effects on lipid-lowering efficacy of simvastatin in Chinese hyperlipidemic patients. Eur J Clin Pharmacol 2005; 60:843-8.

Wang AX, Hu Y, Liu HX et al. C5-hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2. Xenobiotica 2011; 41:349-57.

Wang B, Bai M, Bai Y, Li Q. Liver injury following renal ischemia reperfusion in rats. Transplant Proc 2010; 42:3422-6.

Wang B, Jin F, Yang Z et al. The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease. J Mol Neurosci 2006; 30:267-71.

Wang B, Qian H, Yang H, Xu L, Xu W, Yan J. Regression of atherosclerosis plaques in apolipoprotein E(-/-) mice after lentivirus-mediated RNA interference of CD40. Int J Cardiol 2011. doi:10. 1016/j. ijcard. 2011. 05. 053.

Wang B, Sánchez RI, Franklin RB, Evans DC, Huskey SE. The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol. Drug Metab Dispos 2004; 32:1209-12.

Wang B, Wang D, Zhang D et al. Pro variant of TP53 Arg72Pro contributes to esophageal squamous cell carcinoma risk: evidence from a meta-analysis. Eur J Cancer Prev 2010; 19:299-307.

Wang B, Wang J, Zheng Y et al. A study of TNF-alpha-238 and -308 polymorphisms with different outcomes of persistent hepatitis B virus infection in China. Pathology 2010; 42:674-80.

Wang B, Yang LP, Zhang XZ, Huang SQ, Bartlam M, Zhou SF. New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme. Drug Metab Rev 2009; 41:573-643.

Wang B, Zhang G, Ouyang J et al. Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas. Urology 2010; 76:1018. e1-7.

Wang B, Zhou SF. Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem 2009; 16:4066-218.

Wang CJ, Shao H, Shang M, Zhang W. Association between CYP2B6, CYP2D6, GSTP1 genetic polymorphisms and urinary styrene metabolites in professional workers. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2009; 27:589-92.

Wang CP, Hung WC, Yu TH et al. Genetic variation in the G-50T polymorphism of the cytochrome P450 epoxygenase CYP2J2 gene and the risk of younger onset type 2 diabetes among Chinese population: potential interaction with body mass index and family history. Exp Clin Endocrinol Diabetes 2010; 118:346-52.

Wang CY, Nguyen ND, Morrison NA, Eisman JA, Center JR, Nguyen TV. Beta3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES). BMC Med Genet 2006; 7:57.

Wang CY, Zhong WB, Chang TC, Lai SM, Tsai YF. Lovastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, induces apoptosis and differentiation in human anaplastic thyroid carcinoma cells. J Clin Endocrinol Metab 2003; 88:3021-6.

Wang CH, Wu KH, Yang YL et al. Association study of cyclooxygenase 2 single nucleotide polymorphisms and childhood acute lymphoblastic leukemia in Taiwan. Anticancer Res 2010; 30:3649-53.

Wang D, Chen H, Momary KM, Cavallari LH, Johnson JA, Sadée W. Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement. Blood 2008; 112:1013-21.

Wang D, Guo Y, Wrighton SA, Cooke GE, Sadee W. Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs. Pharmacogenomics J 2011; 11:274-86.

Wang D, Li L, Fuhrman J, Ferguson S, Wang H. The role of constitutive androstane receptor in oxazaphosphorine-mediated induction of drug-metabolizing enzymes in human hepatocytes. Pharm Res 2011; 28:2034-44.

Wang D, Wei X, Yan X, Jin T, Ling W. Protocatechuic acid, a metabolite of anthocyanins, inhibits monocyte adhesion and reduces atherosclerosis in apolipoprotein E-deficient mice. J Agric Food Chem 2010; 58:12722-8.

Wang D, Zou T, Yang Y, Yan X, Ling W. Cyanidin-3-O-β-glucoside with the aid of its metabolite protocatechuic acid, reduces monocyte infiltration in apolipoprotein E-deficient mice. Biochem Pharmacol 2011; 82:713-9.

Wang DL, Liang Y, Chen WD, Xie L, Wang GJ, Liu XD. Identification of ginkgolide B metabolites in urine and rat liver cytochrome P450 enzymes responsible for their formation in vitro. Acta Pharmacol Sin 2008; 29:376-84.

Wang E, Casciano CN, Clement RP, Johnson WW. HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. Pharm Res 2001; 18:800-6.

Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW. Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol 2001; 14:1596-603.

Wang EJ, Barecki-Roach M, Johnson WW. Quantitative characterization of direct P-glycoprotein inhibition by St John’s wort constituents hypericin and hyperforin. J Pharm Pharmacol 2004; 56:123-8.

Wang EJ, Casciano CN, Clement RP, Johnson WW. Inhibition of P-glycoprotein transport function by grapefruit juice psoralen. Pharm Res 2001; 18:432-8.

Wang EJ, Lew K, Casciano CN, Clement RP, Johnson WW. Interaction of common azole antifungals with P glycoprotein. Antimicrob Agents Chemother 2002; 46:160-5.

Wang F, Han XY, Ren Q et al. Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population. Chin Med J 2009; 122:2477-82.

Wang F, He Y, Guo H et al. Genetic variants of nucleotide excision repair genes are associated with DNA damage in coke oven workers. Cancer Epidemiol Biomarkers Prev 2010; 19:211-8.

Wang F, Liang YJ, Wu XP et al. Prognostic value of the multidrug resistance transporter ABCG2 gene polymorphisms in Chinese patients with de novo acute leukaemia. Eur J Cancer 2011; 47:1990-9.

Wang F, Lu Y, Kong L. Compatibility of Banxia Houpo decoction on hepatic CYP450 and renal organicion transporters in mice. Zhongguo Zhong Yao Za Zhi 2011; 36:60-5.

Wang F, Okamoto Y, Inoki I et al. Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. J Clin Invest 2010; 120:3979-95.

Wang F, Xue X, Wei J et al. hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations. Br J Cancer 2010; 103:567-74.

Wang F, Zhou F, Kruh GD, Gallo JM. Influence of blood-brain barrier efflux pumps on the distribution of vincristine in brain and brain tumors. Neuro Oncol 2010; 12:1043-9.

Wang F, Zou YF, Sun GP, Su H, Huang F. Association of CYP1B1 gene polymorphisms with susceptibility to endometrial cancer: a meta-analysis. Eur J Cancer Prev 2011; 20:112-20.

Wang G, Rong J, Zhou Z, Duo J. Novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2 and Bax in osteosarcoma cells. Mol Biol 2010; 44:1010-7.

Wang G, Xiao CQ, Li Z et al. Effect of soy extract administration on losartan pharmacokinetics in healthy female volunteers. Ann Pharmacother 2009; 43:1045-9.

Wang G, Zhang H, He F, Fang X. Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population. Eur J Clin Pharmacol 2006; 62:927-31.

Wang GJ, Chang L, Volkow ND et al. Decreased brain dopaminergic transporters in HIV-associated dementia patients. Brain 2004; 127:2452-8.

Wang H, An N, Wang H et al. Evaluation of the effects of 20 nonsynonymous single nucleotide polymorphisms of CYP2C19 on S-mephenytoin 4’-hydroxylation and omeprazole 5’-hydroxylation. Drug Metab Dispos 2011; 39:830-7.

Wang H, Bian T, Liu D et al. Association analysis of CYP2A6 genotypes and haplotypes with 5-fluorouracil formation from tegafur in human liver microsomes. Pharmacogenomics 2011; 12:481-92.

Wang H, Ding K, Zhang Y, Jin L, Kullo IJ, He F. Comparative and evolutionary pharmacogenetics of ABCB1: complex signatures of positive selection on coding and regulatory regions. Pharmacogenet Genomics 2007; 17:667-78.

Wang H, Goland S, Burton K, Czer LS, Schwarz ER, Trento A. An agonist of liver X receptor slows valvular disease in a hypercholesterolemia mouse model. J Heart Valve Dis 2010; 19:653-64.

Wang H, Jiang Y, Liu Y et al. CYP2J2*7 single nucleotide polymorphism in a Chinese population. Clin Chim Acta 2006; 365:125-8.

Wang H, Jin G, Wang H et al. Genetic susceptibility of lung cancer associated with common variants in the 3’ untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export. Cancer 2009; 115:595-607.

Wang H, Kim RA, Sun D et al. Evaluation of the effects of 18 non-synonymous single-nucleotide polymorphisms of CYP450 2C19 on in vitro drug inhibition potential by a fluorescence-based high-throughput assay. Xenobiotica 2011; 41:826-35.

Wang H, LeCluyse EL. Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Clin Pharmacokinet 2003; 42:1331-57.

Wang H, Lee EW, Zhou L et al. Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. Mol Pharmacol 2008; 73:845-54.

Wang H, Leung LK. The carotenoid lycopene differentially regulates phase I and II enzymes in dimethylbenz[a]anthracene-induced MCF-7 cells. Nutrition 2010; 26:1181-7.

Wang H, Li H, Moore LB et al. The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. Mol Endocrinol 2008; 22:838-57.

Wang H, Li Q, Wang T et al. A common polymorphism in the human aromatase gene alters the risk for polycystic ovary syndrome and modifies aromatase activity in vitro. Mol Hum Reprod 2011; 17:386-91.

Wang H, Negishi M. Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors. Curr Drug Metab 2003; 4:515-25.

Wang H, Tompkins LM. CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme. Curr Drug Metab 2008; 9:598-610.

Wang H, Wang L, Erdjument-Bromage H et al. Role of histone H2A ubiquitination in Polycomb silencing. Nature 2004; 431:873-8.

Wang H, Yamamoto JF, Caberto C et al. Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia. Carcinogenesis 2011; 32:203-9.

Wang H, Yuan L, Zeng S. Characterizing the effect of UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A9 genetic polymorphisms on enantioselective glucuronidation of flurbiprofen. Biochem Pharmacol 2011. doi:10. 1016/j. bcp. 2011. 08. 004.

Wang HH, Liao YW, Chiang HL, Wu JY, Chen YT. Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population. Pharmacogenomics 2009; 10:359-74.

Wang HL, Lopategui J, Amin MB, Patterson SD. KRAS mutation testing in human cancers: The pathologist’s role in the era of personalized medicine. Adv Anat Pathol 2010; 17:23-32.

Wang J. CYP3A polymorphisms and immunosuppressive drugs in solid-organ transplantation. Expert Rev Mol Diagn 2009; 9:383-90.

Wang J, Ban MR, Kennedy BA et al. APOA5 genetic variants are markers for classic hyperlipoproteinemia phenotypes and hypertriglyceridemia. Nat Clin Pract Cardiovasc Med 2008; 5:730-7.

Wang J, Freeman DJ, Grundy SM, Levine DM, Guerra R, Cohen JC. Linkage between cholesterol 7-alpha-hydroxylase and high plasma low-density lipoprotein cholesterol concentrations. J Clin Invest 1998; 101:1283-91.

Wang J, Gao QS, Wang Y, Lafyatis R, Stamm S, Adreadis A. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricated interplay of cis elements and trans factors. J Neurochem 2004; 88:1078-90.

Wang J, Hu Y, Nekvindova J, Ingelman-Sundberg M, Neve EP. IL-4-mediated transcriptional regulation of human CYP2E1 by two independent signaling pathways. Biochem Pharmacol 2010; 80:1592-600.

Wang J, Joshi AD, Corral R et al. Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk. Int J Cancer 2011. doi:10. 1002/ijc. 26199.

Wang J, Lippman SM, Lee JJ et al. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. Carcinogenesis 2010; 31:1755-61.

Wang J, Nuite M, McAlindon TE. Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus. Lupus 2010; 19:734-40.

Wang J, Qu H, Jin L et al. Pegylated phosphotidylethanolamine inhibiting P-glycoprotein expression and enhancing retention of doxorubicin in MCF7/ADR cells. J Pharm Sci 2011; 100:2267-77.

Wang J, Shi X, Du Y, Zhou B. Effects of xenoestrogens on the expression of vitellogenin (vtg) and cytochrome P450 aromatase (cyp19a and b) genes in zebrafish (Danio rerio) larvae. J Environ Sci Health A Tox Hazard Subst Environ Eng 2011; 46:960-7.

Wang J, Sönnerborg A, Rane A et al. Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz. Pharmacogenet Genomics 2006; 16:191-8.

Wang J, Spitz MR, Amos CI, Wilkinson AV, Wu X, Shete S. Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk. Cancer 2010; 116:3458-62.

Wang J, Tang S, Shen H. Association of genetic polymorphisms in the IL12-IFNG pathway with susceptibility to and prognosis of pulmonary tuberculosis in a Chinese population. Eur J Clin Microbiol Infect Dis 2010; 29:1291-5.

Wang J, Wang B, Bi J. Significant association between ABCB1 gene C3435T polymorphism and breast cancer risk. Breast Cancer Res Treat 2011; 126:815-7.

Wang J, Wang B, Bi J, Di J. The association between two polymorphisms in the TYMS gene and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 2011; 128:203-9.

Wang J, Wang H, Zhao L et al. Down-regulation of P-glycoprotein is associated with resistance to cisplatin and VP-16 in human lung cancer cell lines. Anticancer Res 2010; 30:3593-8.

Wang J, Zhao Y, Jiang J et al. Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: a case-control study in an Indian population. J Cancer Res Clin Oncol 2010; 136:1517-25.

Wang J, Zhu X, Yang L, Liu Y, Zhou W, Li H. Relationship between angiotensinogen gene M235T variant with diabetic nephropathy in Chinese NIDDM. Chin Med J 1999; 112:797-800.

Wang JA, Chen WA, Wang Y et al. Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms. Atherosclerosis 2011; 217:90-6.

Wang JC, Kwon JM, Shah P, Morris JC, Goate A. Effect of APOE genotype and promoter polymorphism on risk of Alzheimer’s disease. Neurology 2000; 55:1644-9.

Wang JH, Tuohimaa P. Calcitriol and TO-901317 interact in human prostate cancer LNCaP Cells. Gene Regul Syst Bio 2008; 2:97-105.

Wang JL, Li Xue, Hao PP, Feng Xu, Chen YG, Yun Zhang. Angiotensin II type 1 receptor gene A1166C polymorphism and essential hypertension in Chinese: a meta-analysis. J Renin Angiotensin Aldosterone Syst 2010; 11:127-35.

Wang JS, Backman JT, Kivistö KT, Neuvonen PJ. Effects of metronidazole on midazolam metabolism in vitro and in vivo. Eur J Clin Pharmacol 2000; 56:555-9.

Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivistö KT. Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos 2000; 28:959-65.

Wang JS, Backman JT, Wen X, Taavitsainen P, Neuvonen PJ, Kivistö KT. Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro. Pharmacol Toxicol 1999; 85:201-5.

Wang JS, DeVane CL. Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro. Drug Metab Dispos 2003; 31:742-7.

Wang JS, DeVane CL, Gibson BB, Donovan JL, Markowitz JS, Zhu HJ. Population pharmacokinetic analysis of drug-drug interactions among risperidone, bupropion, and sertraline in CF1 mice. Psychopharmacology 2006; 183:490-9.

Wang JS, Hu XY, Zhang W, Yuan J, Yang Y, Fang Q. Construction of CYP2E1 recombinant adenovirus vector and its anti-tumor effects. Zhonghua Yi Xue Za Zhi 2010; 90:2130-5.

Wang JS, Neuvonen M, Wen X, Backman JT, Neuvonen PJ. Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. Drug Metab Dispos 2002; 30:1352-6.

Wang JS, Wang W, Xie HG, Huang SL, Zhou HH. Effect of troleandomycin on the pharmacokinetics of imipramine in Chinese: the role of CYP3A. Br J Clin Pharmacol 1997; 44:195-8.

Wang JS, Wen X, Backman JT, Taavitsainen P, Neuvonen PJ, Kivistö KT. Midazolam alpha-hydroxylation by human liver microsomes in vitro: inhibition by calcium channel blockers, itraconazole and ketoconazole. Pharmacol Toxicol 1999; 85:157-61.

Wang JS, Zhu HJ, Markowitz JS, Donovan JL, DeVane CL. Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology 2006; 187:415-23.

Wang K, Chen S, Xie W, Wan YJ. Retinoids induce cytochrome P450 3A4 through RXR/VDR-mediated pathway. Biochem Pharmacol 2008; 75:2204-13.

Wang K, Mendy AJ, Dai G, Luo HR, He L, Wan YJ. Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci 2006; 92:51-60.

Wang KS, Mullersman JE, Liu XF. Family-based association analysis of the MAPT gene in Parkinson disease. Appl Genet 2010; 51:509-14.

Wang KY, Tanimoto A, Guo X et al. Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level. Arterioscler Thromb Vasc Biol 2011; 31:800-7.

Wang L, Christopher LJ, Cui D et al. Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos 2008; 36:1828-39.

Wang L, He K, Maxwell B et al. Tissue distribution and elimination of [14C]apixaban in rats. Drug Metab Dispos 2011; 39:256-64.

Wang L, Raghavan N, He K et al. Sulfation of o-demethyl apixaban: enzyme identification and species comparison. Drug Metab Dispos 2009; 37:802-8.

Wang L, Xu J, Ji C et al. Cloning, expression and characterization of human glutathione S-transferase Omega 2. Int J Mol Med 2005; 16:19-27.

Wang L, Yao J, Chen L, Chen J, Xue J, Jia W. Expression and possible functional roles of cytochromes P450 2J1 (zfCyp 2J1) in zebrafish. Biochem Biophys Res Commun 2007; 352:850-5.

Wang L, Yin F, Du Y et al. Depression of MAD2 inhibits apoptosis and increases proliferation and multidrug resistance in gastric cancer cells by regulating the activation of phosphorylated survivin. Tumour Biol 2010; 31:225-32.

Wang L, Yu L, Zhang AP et al. Serum prolactin levels, plasma risperidone levels, polymorphism of cytochrome P450 2D6 and clinical response in patients with schizophrenia. J Psychopharmacol 2007; 21:837-42.

Wang L, Zhang D, Raghavan N et al. In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies. Drug Metab Dispos 2010; 38:448-58.

Wang LH, Peck RW, Yin Y, Allanson J, Wiggs R, Wire MB. Phase I safety and pharmacokinetic trials of 1263W94, a novel oral anti-human cytomegalovirus agent, in healthy and human immunodeficiency virus-infected subjects. Antimicrob Agents Chemother 2003; 47:1334-42.

Wang LQ, James MO. Inhibition of sulfotransferases by xenobiotics. Curr Drug Metab 2006; 7:83-104.

Wang LS, Zhou G, Zhu B et al. St John’s wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole. Clin Pharmacol Ther 2004; 75:191-7.

Wang LZ, Tian Y, Yu JT et al. Association between late-onset Alzheimer’s disease and microsatellite polymorphisms in intron II of the human toll-like receptor 2 gene. Neurosci Lett 2011; 489:164-7.

Wang LZ, Yu JT, Miao D et al. Genetic association of TLR4/11367 polymorphism with late-onset Alzheimer’s disease in a Han Chinese population. Brain Res 2011; 1381:202-7.

Wang M, Chen M, Zheng G et al. Transcriptional activation by growth hormone of HNF-6-regulated hepatic genes, a potential mechanism for improved liver repair during biliary injury in mice. Am J Physiol Gastrointest Liver Physiol 2008; 295:357-66.

Wang M, Gao M, Miller KD, Sledge GW, Hutchins GD, Zheng QH. Synthesis of carbon-11-labeled casimiroin analogues as new potential PET agents for imaging of quinone reductase 2 and aromatase expression in breast cancer. Steroids 2010; 75:967-73.

Wang M, Qin C, Zhu J et al. Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer. DNA Cell Biol 2010; 29:303-11.

Wang M, Song H, Jia J. Interleukin-6 receptor gene polymorphisms were associated with sporadic Alzheimer’s disease in Chinese Han. Brain Res 2010; 1327:1-5.

Wang M, Zheng DX, Luo MB et al. Synthesis of carbon-11-labeled tariquidar derivatives as new PET agents for imaging of breast cancer resistance protein (ABCG2). Appl Radiat Isot 2010; 68:1098-103.

Wang MZ, Saulter JY, Usuki E et al. CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. Drug Metab Dispos 2006; 34:1985-94.

Wang MZ, Wu JQ, Bridges AS et al. Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. Drug Metab Dispos 2007; 35:2067-75.

Wang N, Chen W, Linsel-Nitschke P et al. A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. J Clin Invest 2003; 111:99-107.

Wang N, Han JL, Mi YC et al. Relationships between the gene polymorphisms of drug metabolizing enzymes and the outcome of the first induction chemotherapy in patients with de novo acute myeloid leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011; 19:327-31.

Wang N, Tsuruoka S, Yamamoto H et al. The bioreactor with CYP3A4- and glutamine synthetase-introduced HepG2 cells: treatment of hepatic failure dog with diazepam overdosage. Artif Organs 2005; 29:681-4.

Wang P, Koehle MS, Rupert JL. Genotype at the missense G894T polymorphism (Glu298Asp) in the NOS3 gene is associated with susceptibility to acute mountain sickness. High Alt Med Biol 2009; 10:261-7.

Wang P, Mao Y, Razo J et al. Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients. Pharmacogenomics 2010; 11:1389-402.

Wang P, Tang JT, Peng YS, Chen XY, Zhang YJ, Fang JY. XRCC1 downregulated through promoter hypermethylation is involved in human gastric carcinogenesis. J Dig Dis 2010; 11:343-51.

Wang Q, Ji F, Sun Y et al. Genetic polymorphisms of XRCC1, HOGG1 and MGMT and micronucleus occurrence in Chinese vinyl chloride-exposed workers. Carcinogenesis 2010; 31:1068-73.

Wang Q, Li H, Tao P et al. Soy isoflavones, CYP1A1, CYP1B1, and COMT polymorphisms, and breast cancer: A case-control study in Southwestern China. DNA Cell Biol 2011; 30:585-95.

Wang Q, Wang YP, Li JY, Yuan P, Yang F, Li H. Polymorphic catechol-O-methyltransferase gene, soy isoflavone intake and breast cancer in postmenopausal women: a case-control study. Chin J Cancer 2010; 29:683-8.

Wang Q, Zhao H, Xiang Q et al. Effect of Yikun Neiyi Wan on the expression of aromatase P450, COX-2, and ER related receptor in endometrial cells in vitro from patients with endometriosis. J Tradit Chin Med 2009; 29:296-300.

Wang QL, Li BH, Liu B et al. Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer. J Exp Clin Cancer Res 2009; 28:139.

Wang QS, Wang XF, Chen XD et al. Genetic polymorphism of KCNH2 confers predisposition of acquired atrial fibrillation in Chinese. J Cardiovasc Electrophysiol 2009; 20:1158-62.

Wang R, Chen K, Wen SY, Li J, Wang SQ. Pharmacokinetics of glimepiride and cytochrome P450 2C9 genetic polymorphisms. Clin Pharmacol Ther 2005; 78:90-2.

Wang R, Wang B, He W, Zheng H. Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology. J Biol Chem 2006; 281:15330-6.

Wang R, Zhong B, Liu Y, Wang C. Association between alpha-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis. J Appl Genet 2010; 51:87-94.

Wang RH, Zheng Y, Kim HS et al. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell 2008; 32:11-20.

Wang RW, Liu L, Cheng H. Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos 1996; 24:786-91.

Wang RW, Lu AY. Inhibitory anti-peptide antibody against human CYP3A4. Drug Metab Dispos 1997; 25:762-7.

Wang RW, Newton DJ, Liu N, Atkins WM, Lu AY. Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent. Drug Metab Dispos 2000; 28:360-6.

Wang RW, Newton DJ, Liu NY, Shou M, Rushmore T, Lu AY. Inhibitory anti-CYP3A4 peptide antibody: mapping of inhibitory epitope and specificity toward other CYP3A isoforms. Drug Metab Dispos 1999; 27:167-72.

Wang RW, Newton DJ, Scheri TD, Lu AY. Human cytochrome P450 3A4-catalyzed testosterone 6 beta-hydroxylation and erythromycin N-demethylation. Competition during catalysis. Drug Metab Dispos 1997; 25:502-7.

Wang S, Chanock S, Tang D et al. Effect of gene-environment Interactions on mental development in African American, Dominican, and Caucasian mothers and newborns. Ann Hum Genet 2010; 74:46-56.

Wang S, Fu C, Wang H et al. Polymorphisms of the peroxisome proliferator-activated receptor-gamma coactivator-1alpha gene are associated with hypertrophic cardiomyopathy and not with hypertension hypertrophy. Clin Chem Lab Med 2007; 45:962-7.

Wang S, Huang D, Sun S, Ma W, Zhen Q. Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis B to interferon alfa. Virol J 2011; 8:28.

Wang S, Wan NC, Harrison J et al. Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance. J Med Chem 2004; 47:1339-50.

Wang SC, Ho IK, Tsou HH et al. CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone S-enantiomer. J Clin Psychopharmacol 2011; 31:463-9.

Wang SL, Huang JD, Lai MD, Liu BH, Lai ML. Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6. Clin Pharmacol Ther 1993; 53:410-8.

Wang SL, Lai MD, Huang JD. G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese. Drug Metab Dispos 1999; 27:385-8.

Wang SS, Gonzalez P, Yu K et al. Common genetic variants and risk for HPV persistence and progression to cervical cancer. PLoS One 2010. doi:10. 1371/journal. pone. 0008667.

Wang SX, Fu CY, Zou YB et al. Polymorphisms of angiotensin-converting enzyme 2 gene associated with magnitude of left ventricular hypertrophy in male patients with hypertrophic cardiomyopathy. Chin Med J 2008; 121:27-31.

Wang SY, Xue J, Zhou J. Preliminary effects of alcohol and Curcuma longa upon CYP2E1 and hematotoxicity in benzene-induced mice. Zhonghua Yi Xue Za Zhi 2009; 89:2429-31.

Wang T, Chen FY, Han JY, Zhong JH, Teng Y, Ouyang RR. The relationship between cytochrome P450, subfamily IIIA, polypeptide 5 gene and drug resistance in leukemia cell lines. Zhonghua Nei Ke Za Zhi 2004; 43:527-9.

Wang T, Chen ZB, Jin SJ, Su QJ. Correlation between angiotensinogen gene and primary hypertension with cerebral infarction in the Li nationality of China. Neurosci Bull 2007; 23:287-92.

Wang T, Satoh F, Morimoto R et al. Gene expression profiles in aldosterone-producing adenomas and adjacent adrenal glands. Eur J Endocrinol 2011; 164:613-9.

Wang T, Yu HT, Wang W, Pan YY, He LX, Wang ZY. Genetic polymorphisms of cytochrome P450 and glutathione S-transferase associated with antituberculosis drug-induced hepatotoxicity in Chinese tuberculosis patients. J Int Med Res 2010; 38:977-86.

Wang TN, Chu YT, Chen WY et al. Association of interferon-gamma and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan. Clin Exp Allergy 2006; 36:1147-52.

Wang W, Chen X, Li X et al. Interference RNA-based silencing of endogenous SMAD4 in porcine granulosa cells resulted in decreased FSH-mediated granulosa cells proliferation and steroidogenesis. Reproduction 2011; 141:643-51.

Wang W, Li JJ, Foster PS, Hansbro PM, Yang M. Potential therapeutic targets for steroid-resistant asthma. Curr Drug Targets 2010; 11:957-70.

Wang W, Qiu YL, Ji F et al. Genetic polymorphisms in metabolizing enzymes and susceptibility of chromosomal damage induced by vinyl chloride monomer in a Chinese worker population. J Occup Environ Med 2010; 52:163-8.

Wang WYS, Zee RYL, Morris BJ. Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension. Clin Genet 1997; 51:31-4.

Wang X, Abdelrahman DR, Fokina VM, Hankins GD, Ahmed MS, Nanovskaya TN. Metabolism of bupropion by baboon hepatic and placental microsomes. Biochem Pharmacol 2011; 82:295-303.

Wang X, Abdelrahman DR, Zharikova OL et al. Bupropion metabolism by human placenta. Biochem Pharmacol 2010; 79:1684-90.

Wang X, Baba M. The role of breast cancer resistance protein (BCRP/ABCG2) in cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Antivir Chem Chemother 2005; 16:213-6.

Wang X, Chen J, Wang M, Gu Y, Xiao Y. Influence of scorpion alcoholic extraction on mdr1 mRNA and P-gp expression in brain of phenytoin-resistant convulsive rats. Zhongguo Zhong Yao Za Zhi 2009; 34:2223-7.

Wang X, Cheung CM, Lee WY, Or PM, Yeung JH. Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro. Phytomedicine 2010; 17:868-75.

Wang X, Dong J, Zhao Y, Li Y, Wu M. Adenovirus-mediated sphingomyelin synthase 2 increases atherosclerotic lesions in ApoE KO mice. Lipids Health Dis 2011; 10:7.

Wang X, Furukawa T, Nitanda T et al. Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol 2003; 63:65-72.

Wang X, Goode EL, Fredericksen ZS et al. Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2008; 17:2101-8.

Wang X, Hawkins BT, Miller DS. Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier. FASEB J 2011; 25:644-52.

Wang X, Hawkins BT, Miller DS. Activating PKC-β1 at the blood-brain barrier reverses induction of P-glycoprotein activity by dioxin and restores drug delivery to the CNS. J Cereb Blood Flow Metab 2011; 31:1371-5.

Wang X, Imura T, Sofroniew MV, Fushiki S. Loss of adenomatous polyposis coli in Bergmann glia disrupts their unique architecture and leads to cell nonautonomous neurodegeneration of cerebellar Purkinje neurons. Glia 2011; 59:857-68.

Wang X, Lee WY, Or PM, Yeung JH. Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates. Phytomedicine 2009; 16:712-25.

Wang X, Medzihradszky KF, Maltby D, Correia MA. Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: a mass spectrometric characterization of the phosphorylated peptides. Biochemistry 2001; 40:11318-26.

Wang X, Nitanda T, Shi M et al. Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance protein. Biochem Pharmacol 2004; 68:1363-70

Wang X, Sykes DB, Miller DS. Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier. Mol Pharmacol 2010; 78:376-83.

Wang X, Wu D, Yang L, Cederbaum AI. Hepatotoxicity mediated by pyrazole (CYP2E1) Plus TNF-α treatment occurs in jnk2(-/-) but not in jnk1(-/-) mice. Hepatology 2011. doi:10. 1002/hep. 24540.

Wang X, Wu X, Wang C et al. Transcriptional suppression of breast cancer resistance protein (BCRP) by wild-type p53 through the NF-kappaB pathway in MCF-7 cells. FEBS Lett 2010; 584:3392-7.

Wang X, Yeung JH. Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats. J Pharm Pharmacol 2010; 62:1077-83.

Wang X, Zhang S, Chen Y et al. APM1 gene variants -11377C/G and 4545G/C are associated respectively with obesity and with non-obesity in Chinese type 2 diabetes. Diabetes Res Clin Pract 2009; 84:205-10.

Wang X, Zuckerman B, Pearson C. Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight. JAMA 2002; 287:195-202.

Wang XB, Wang SS, Zhang QF et al. Inhibition of tetramethylpyrazine on P-gp, MRP2, MRP3 and MRP5 in multidrug resistant human hepatocellular carcinoma cells. Oncol Rep 2010; 23:211-5.

Wang XD. Alcohol, vitamin A, and cancer. Alcohol 2005; 35:251-8.

Wang XD, Li JL, Lu Y et al. Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry: Application to a clinical herb-drug interaction study. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 852:534-44.

Wang XD, Li JL, Su QB et al. Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John’s wort-induced activity of cytochrome P450 3A4 enzyme. Br J Clin Pharmacol 2009; 67:255-61.

Wang XD, Zeng S. The transport of gastrodin in Caco-2 cells and uptake in Bcap37 and Bcap37/MDR1 cells. Yao Xue Xue Bao 2010; 45:1497-502.

Wang XK, Fu LW. Interaction of tyrosine kinase inhibitors with the MDR- related ABC transporter proteins. Curr Drug Metab 2010; 11:618-28.

Wang XL, Oosterhof J, Duarte N. Peroxisome proliferator-activated receptor gamma C161→T polymorphism and coronary artery disease. Cardiovasc Res 1999; 44:588-94.

Wang XQ, Ongkeko WM, Chen L et al. Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway. Hepatology 2010; 52:528-39.

Wang XR, Qu ZQ, Li XD et al. Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection. Cancer Sci 2010; 101:412-5.

Wang Y, Ao H, Qian Z, Zheng Y. Intestinal transport of scutellarein and scutellarin and first-pass metabolism by UDP-glucuronosyltransferase-mediated glucuronidation of scutellarein and hydrolysis of scutellarin. Xenobiotica 2011; 41:538-48.

Wang Y, Berbee JF, Stroes ES et al. CETP expression reverses the reconsitituted HDL-induced increase in VLDL. J Lipid Res 2011; 52:1533-41.

Wang Y, Fu W, Xie F et al. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. J Hum Genet 2010; 55:490-4.

Wang Y, Guan S, Acharya P et al. Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination. J Biol Chem 2011; 286:9443-56.

Wang Y, Hayward SW, Donjacour AA et al. Sex hormone-induced carcinogenesis in Rb-deficient prostate tissue. Cancer Res 2000; 60:6008-17.

Wang Y, Jia X, Ghanam K, Beaurepaire C, Zidichouski J, Miller L. Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters. Atherosclerosis 2010; 209:111-7.

Wang Y, Liao M, Hoe N et al. A role for protein phosphorylation in cytochrome P450 3A4 ubiquitin-dependent proteasomal degradation. J Biol Chem 2009; 284:5671-84.

Wang Y, Lu C, Sheng Z et al. Enhanced hepatotoxicity induced by repeated exposure to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin in combination in male rats. J Environ Sci 2011; 23:119-24.

Wang Y, Ni Y, Wei H, Wang FC, Ge LP, Gao X. Stable skin-specific overexpression of human CTLA4-Ig in transgenic mice through seven generations. Acta Biochim Biophys Sin 2006; 38:171-8.

Wang Y, Niu XL, Qu Y et al. Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells. Cancer Lett 2010; 295:110-23.

Wang Y, Seitz HK, Wang XD. Moderate alcohol consumption aggravates high-fat diet induced steatohepatitis in rats. Alcohol Clin Exp Res 2010; 34:567-73.

Wang Y, Unadkat JD. Enzymes in addition to CYP3A4 and 3A5 mediate N-demethylation of dextromethorphan in human liver microsomes. Biopharm Drug Dispos 1999; 20:341-6.

Wang Y, Wang JN, Liu ZJ, Wei X, Xiao X, Wang DW. Arachidonic acid epoxygenases and their metabolites promote angiogenesis. Zhonghua Xin Xue Guan Bing Za Zhi 2005; 33:1122-31.

Wang Y, Wu Q, Yang XW, Yang X, Wang K. The membrane transport of flavonoids from Crossostephium chinense across the Caco-2 monolayer. Biopharm Drug Dispos 2011; 32:16-24.

Wang Y, Yang H, Li L et al. Association between CYP2E1 genetic polymorphisms and lung cancer risk: a meta-analysis. Eur J Cancer 2010; 46:758-64.

Wang Y, Zhang H, Meng L et al. Influence of CYP2C19 on the relationship between pharmacokinetics and intragastric pH of omeprazole administered by successive intravenous infusions in Chinese healthy volunteers. Eur J Clin Pharmacol 2010; 66:563-9.

Wang Y, Zhou L, Dutreix C et al. Effects of imatinib (Glivec) on the pharmacokinetics of metoprolol, a CYP2D6 substrate, in Chinese patients with chronic myelogenous leukaemia. Br J Clin Pharmacol 2008; 65:885-92.

Wang YC, Bai YM, Chen JY, Lin CC, Lai IC, Liou YJ. Genetic association between TNF-alpha -308 G>A polymorphism and longitudinal weight change during clozapine treatment. Hum Psychopharmacol 2010; 25:303-9.

Wang YH, Chen YF, Chen SR et al. Aspirin increases apolipoprotein-A-I-mediated cholesterol efflux via enhancing expression of ATP-binding cassette transporter A1. Pharmacology 2010; 86:320-6.

Wang YH, Jones DR, Hall SD. Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites. Drug Metab Dispos 2004; 32:259-66.

Wang YH, Jones DR, Hall SD. Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab Dispos 2005; 33:664-71.

Wang YH, Yeh SD, Shen KH et al. A significantly joint effect between arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma. Toxicol Appl Pharmacol 2009; 241:111-8.

Wang YL, Yan YL, Zhou NJ et al. Mechanism of multidrug resistance of human small cell lung cancer cell line H446/VP. Chin Med J 2010; 123:3299-303.

Wang YP, Zhai JB, Zhu F, Zhang WW, Yang XJ, Qu CY. A three-year follow-up study on the transfer of mild cognitive impairment to Alzheimer’s disease among the elderly in Taiyuan city. Zhonghua Liu Xing Bing Xue Za Zhi 2011; 32:105-9.

Wang YX, Martin-McNulty B, Huw LY et al. Anti-atherosclerotic effect of simvastatin depends on the presence of apolipoprotein E. Atherosclerosis 2002; 162:23-31.

Wang YX, Meng XW, Wang YD, Liu Y. MRNA levels of two different enzymes in hepatocellular carcinoma. Hepatogastroenterology 2010; 57:1187-90.

Wang Z, Dahiya S, Provencher H et al. The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer. Clin Cancer Res 2007; 13:6327-34.

Wang Z, Lee B, Pearce D et al. Meclizine metabolism and pharmacokinetics: formulation on its absorption. J Clin Pharmacol 2011. doi:10. 1177/0091270011414575.

Wang Z, Luque RM, Kineman RD et al. Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat. Endocrinology 2008; 149:1366-76.

Wang Z, Ravula R, Cao M, Chow M, Huang Y. Transporter-mediated multidrug resistance and its modulation by Chinese medicines and other herbal products. Curr Drug Discov Technol 2010; 7:54-66.

Wang Z, Smith KS, Murphy M et al. Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. Nature 2008; 455:1205-9.

Wang Z, Xu B, Lin D et al. XRCC1 polymorphisms and severe toxicity in lung cancer patients treated with cisplatin-based chemotherapy in Chinese population. Lung Cancer 2008; 62:99-104.

Wang ZX, Lin J, Chen B, He SL, Ma XM, Li DZ. Effects of FOXP3 on the progression of atherosclerosis plaque in ApoE-knock out mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011; 27:154-7.

Wangensteen H, Molden E, Christensen H, Malterud KE. Identification of epoxybergamottin as a CYP3A4 inhibitor in grapefruit peel. Eur J Clin Pharmacol 2003; 58:663-8.

Wanger-Baumann CA, Mu L, Honer M et al. In vitro and in vivo evaluation of [(18)F]-FDEGPECO as a PET tracer for imaging the metabotropic glutamate receptor subtype 5 (mGluR5). Neuroimage 2011; 56:984-91.

Wani NA, Kaur J. Reduced levels of folate transporters (PCFT and RFC) in membrane lipid rafts result in colonic folate malabsorption in chronic alcoholism. J Cell Physiol 2011; 226:579-87.

Wanker E, Rovira C, Scherzinger E et al. HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system. Hum Molec Genet 1997; 6:487-95.

Wanwimolruk S, Paine MF, Pusek SN, Watkins PB. Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4? Br J Clin Pharmacol 2002; 54:643-51.

Wanwimolruk S, Wong K, Wanwimolruk P. Variable inhibitory effect of different brands of commercial herbal supplements on human cytochrome P-450 CYP3A4. Drug Metabol Drug Interact 2009; 24:17-35.

Warby SC, Montpetit A, Hayden AR et al. CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup. Am J Hum Genet 2009; 84:351-66.

Ward BA, Morocho A, Kandil A, Galinsky RE, Flockhart DA, Desta Z. Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro. Br J Clin Pharmacol 2004; 58:277-87.

Ward MB, Kotasek D, McKinnon RA. Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy. Pharmacogenomics 2008; 9:1027-33.

Ward NC, Tsai IJ, Barden A et al. A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. Hypertension 2008; 51:1393-8.

Ward RM, Tammara B, Sullivan SE et al. Single-dose, multiple-dose, and population pharmacokinetics of pantoprazole in neonates and preterm infants with a clinical diagnosis of gastroesophageal reflux disease (GERD). Eur J Clin Pharmacol 2010; 66:555-61.

Ward S, Back DJ. Metabolism of gestodene in human liver cytosol and microsomes in vitro. J Steroid Biochem Mol Biol 1993; 46:235-43.

Wardell SE, Marks JR, McDonnell DP. The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy. Biochem Pharmacol 2011; 82:122-30.

Ware SM, El-Hassan N, Kahler SG et al. Infantile cardiomyopathy caused by a mutation in the overlapping region of mitochondrial ATPase 6 and 8 genes. J Med Genet 2009; 46:308-14.

Waring SC, O’Brien PC, Kurland LT et al. Apolipoprotein E allele in Chamorros with amyotrophic lateral sclerosis/parkinsonism-dementia complex. Lancet 1994; 343:611.

Warner A, Privitera M, Bates D. Standards of laboratory practice: antiepileptic drug monitoring. National Academy of Clinical Biochemistry. Clin Chem 1998; 44:1085-95.

Warner SC, Finta C, Zaphiropoulos PG. Intergenic transcripts containing a novel human cytochrome P450 2C exon 1 spliced to sequences from the CYP2C9 gene. Mol Biol Evol 2001; 18:1841-8.

Warner TD, Mitchell JA. Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. FASEB J 2004; 18:790-804.

Warodomwichit D, Shen J, Arnett DK et al. ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study. Obesity 2009; 17:510-7.

Warren MS, Zerangue N, Woodford K et al. Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human. Pharmacol Res 2009; 59:404-13.

Warren RB, Smith RL, Campalani E et al. Genetic variation in efflux transporters influences outcome to methotrexate therapy in patients with psoriasis. J Invest Dermatol 2008; 128:1925-9.

Warren RB, Smith RL, Campalani E et al. Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms. Br J Dermatol 2009; 160:438-41.

Warrington JS, Shader RI, von Moltke LL, Greenblatt DJ. In vitro biotransformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactions. Drug Metab Dispos 2000; 28:392-7.

Wartenberg M, Richter M, Datchev A et al. Glycolytic pyruvate regulates P-glycoprotein expression in multicellular tumor spheroids via modulation of the intracellular redox state. J Cell Biochem 2010; 109:434-46.

Washio I, Maeda M, Sugiura C et al. Cigarette smoke extract induces CYP2B6 through constitutive androstane receptor in hepatocytes. Drug Metab Dispos 2011; 39:1-3.

Washio T, Arisawa H, Kohsaka K, Yasuda H. Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011. Biol Pharm Bull 2001; 24:1263-6.

Wasilewska A, Zalewski G, Chyczewski L, Zoch-Zwierz W. MDR-1 gene polymorphisms and clinical course of steroid-responsive nephrotic syndrome in children. Pediatr Nephrol 2007; 22:44-51.

Wasmuth HE, Werth A, Mueller T et al. CC chemokine receptor 5 delta32 polymorphism in two independent cohorts of hepatitis C virus infected patients without hemophilia. J Mol Med 2004; 82:64-9.

Wassel CL, Pankow JS, Jacobs DR Jr, Steffes MW, Li N, Schreiner PJ. Variants in the Adiponectin Gene and Serum Adiponectin: The Coronary Artery Development in Young Adults (CARDIA) Study. Obesity 2010; 18:2333-8.

Wassenaar CA, Dong Q, Wei Q, Amos CI, Spitz MR, Tyndale RF. Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. J Natl Cancer Inst 2011; 103:1342-6.

Wassenberg T, Willemsen MA, Geurtz PB et al. Urinary dopamine in aromatic L-amino acid decarboxylase deficiency: the unsolved paradox. Mol Genet Metab 2010; 101:349-56.

Wassmur B, Gräns J, Kling P, Celander MC. Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss). Aquat Toxicol 2010; 100:91-100.

Watabe M, Isogai Y, Numazawa S, Yoshida T. Role of c-Myc in nitric oxide-mediated suppression of cytochrome P450 3A4. Life Sci 2003; 74:99-108.

Watanabe H, Koopmann TT, Le Scouarnec S et al. Sodium channel beta1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J Clin Invest 2008; 118:2260-8.

Watanabe J, Harada N, Suemasu K, Higashi Y, Gotoh O, Kawajiri K. Arginine-cysteine polymorphism at codon 264 of the human CYP19 gene does not affect aromatase activity. Pharmacogenetics 1997; 7:419-24.

Watanabe J, Hayashi S, Nakachi K et al. PstI and RsaI RFLPs in complete linkage disequilibrium at the CYP2E gene. Nucleic Acids Res 1990; 18:7194.

Watanabe J, Suzuki Y, Fukui N et al. Dose-dependent effect of the CYP2D6 genotype on the steady-state fluvoxamine concentration. Ther Drug Monit 2008; 30:705-8.

Watanabe K, Matsunaga T, Kimura T et al. Major cytochrome P450 enzymes responsible for microsomal aldehyde oxygenation of 11-oxo-Delta8-tetrahydrocannabinol and 9-anthraldehyde in human liver. Drug Metab Pharmacokinet 2002; 17:516-21.

Watanabe K, Yamaori S, Funahashi T, Kimura T, Yamamoto I. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sci 2007; 80:1415-9.

Watanabe M, Ayugase J. Effects of buckwheat sprouts on plasma and hepatic parameters in type 2 diabetic db/db mice. J Food Sci 2010; 75:294-9.

Watanabe M, Kumai T, Matsumoto N et al. Expression of CYP3A4 mRNA is correlated with CYP3A4 protein level and metabolic activity in human liver. J Pharmacol Sci 2004; 94:459-62.

Watanabe T, Sakuyama K, Sasaki T et al. Functional characterization of 26 CYP2B6 allelic variants (CYP2B6. 2-CYP2B6. 28, except CYP2B6. 22). Pharmacogenet Genomics 2010; 20:459-62.

Watanabe Y, Metoki H, Ohkubo T et al. Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study. Hypertens Res 2010; 33:129-34.

Watanabe Y, Nakajima M, Yokoi T. Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos 2002; 30:1462-9.

Watari Y, Yamaguchi S, Takahashi M, Nagaoka M, Numazawa M. 4- and 6-(p-Sulphamoylphenyl)androstenediones: Studies of aromatase inhibitor-based oestrone sulphatase inhibition. Steroids 2010; 75:891-6.

Waterhouse P, Penninger JM, Timms E et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995; 270:985-8.

Waterkotte B, Hambruch N, Döring B, Geyer J, Tinneberg HR, Pfarrer C. P-glycoprotein is functionally expressed in the placenta-derived bovine caruncular epithelial cell line 1 (BCEC-1). Placenta 2011; 32:146-52.

Watfa G, Marteau JB, Rossignol P et al. Association study of gene polymorphisms involved in vascular alterations in elderly hypertensives with subjective memory complaints. Dement Geriatr Cogn Disord 2010; 30:440-8.

Watkins D, Ru M, Hwang HY et al. Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L. Am J Hum Genet 2002; 71:143-53.

Watkins PB. Erythromycin breath test and clinical transplantation. Ther Drug Monit 1996; 18:368-71.

Watkins PB. The barrier function of CYP3A4 and P-glycoprotein in the small bowel. Adv Drug Deliv Rev 1997; 27:161-170.

Watkins RE, Noble SM, Redinbo MR. Structural insights into the promiscuity and function of the human pregnane X receptor. Curr Opin Drug Discov Devel 2002; 5:150-8.

Watkins WS, Hunt SC, Williams GH et al. Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes. J Hypertens 2010; 28:65-75.

Watkins WS, Rohrwasser A, Peiffer A, Leppert MF, Lalouel JM, Jorde LB. AGT genetic variation, plasma AGT, and blood pressure: An analysis of the Utah Genetic Reference Project pedigrees. Am J Hypertens 2010; 23:917-23.

Watson AM, Soro-Paavonen A, Sheehy K et al. Delayed intervention with AGE inhibitors attenuates the progression of diabetes-accelerated atherosclerosis in diabetic apolipoprotein E knockout mice. Diabetologia 2011; 54:681-9.

Watson JB, Hatami A, David H et al. Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein. Neuroscience 2009; 159:501-13.

Watson KJ, Davis J, Jones HM. The application of physiologically based pharmacokinetic modelling to understanding the clinical pharmacokinetics of UK-369,003. Drug Metab Dispos 2011; 39:1203-13.

Watson R, Jiang Y, Bermudez I et al. Absence of antibodies to glutamate receptor type 3 (GluR3) in Rasmussen encephalitis. Neurology 2004; 63:43-50.

Watson RG, Muhale F, Thorne LB et al. Amplification of thymidylate synthetase in metastatic colorectal cancer patients pretreated with 5-fluorouracil-based chemotherapy. Eur J Cancer 2010; 46:3358-64.

Watt NT, Whitehouse IJ, Hooper NM. The role of zinc in Alzheimer’s disease. Int J Alzheimers Dis 2010. doi:10. 4061/2011/971021.

Watzka M, Geisen C, Bevans CG et al. Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment. J Thromb Haemost 2011; 9:109-18.

Wauters M, Mertens I, Rankinen T, Chagnon M, Bouchard C, van Gaal L. Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance. J Clin Endocrinol Metab 2001; 86:3227-32.

Waxman DJ, Holloway MG. Sex differences in the expression of hepatic drug metabolizing enzymes. Mol Pharmacol 2009; 76:215-28.

Weaver RJ, Thompson S, Smith G et al. A comparative study of constitutive and induced alkoxyresorufin O-dealkylation and individual cytochrome P450 forms in cynomolgus monkey (Macaca fascicularis), human, mouse, rat and hamster liver microsomes. Biochem Pharmacol 1994; 47:763-73.

Webb A, Lind PA, Kalmijn J et al. The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis. Alcohol Clin Exp Res 2011; 35:10-8.

Weber A, Kaplan M, Chughtai SA, Cohn LA, Smith AL, Unadkat JD. CYP3A inductive potential of the rifamycins, rifabutin and rifampin, in the rabbit. Biopharm Drug Dispos 2001; 22:157-68.

Weber SN, Wasmuth HE. Liver fibrosis: from animal models to mapping of human risk variants. Best Pract Res Clin Gastroenterol 2010; 24:635-46.

Wechsler ME, Kunselman SJ, Chinchilli VM et al. Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet 2009; 374:1754-64.

Wechsler ME, Lehman E, Lazarus SC et al. beta-Adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med 2006; 173:519-26.

Wedemeyer N, Peoples R, Himmelbauer H, Lehrach H, Francke U, Wanker E. Localization of the human HIP1 gene close to the elastin (ELN) locus on 7q11. 23. Genomics 1997; 46:313-5.

Weedon MN, Lango H, Lindgren CM et al. Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet 2008; 40:575-83.

Weems JM, Yost GS. 3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively. Chem Res Toxicol 2010; 23:696-704.

Weerachayaphorn J, Chuncharunee A, Jariyawat S et al. Protection of centrilobular necrosis by Curcuma comosa Roxb. in carbon tetrachloride-induced mice liver injury. J Ethnopharmacol 2010; 129:254-60.

Weger M, Stanger O, Deutschmann H et al. The role of hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with retinal artery occlusion. Am J Ophthalmol 2002; 134:57-61.

Weggen S, Eriksen JL, Das P et al. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 2001; 414:212-6.

Weggen S, Eriksen JL, Sagi SA et al. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem 2003; 278:31831-7.

Wegman P, Elingarami S, Carstensen J, Stål O, Nordenskjöld B, Wingren S. Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res 2007; 9:7.

Wegman P, Göthlin Eremo A, Lindlöf A, Karlsson M, Stål O, Wingren S. Expression of the forkhead transcription factor FOXL2 correlates with good prognosis in breast cancer patients treated with tamoxifen. Int J Oncol 2011; 38:1145-51.

Wegman P, Stal O, Askmalm MS, Nordenskjöld B, Rutqvist LE, Wingren S. p53 polymorphic variants at codon 72 and the outcome of therapy in randomized breast cancer patients. Pharmacogenet Genomics 2006; 16:347-51.

Wei KK, Zhang LR, Zhang Y, Hu XJ. Interactions between CYP7A1 A-204C and ABCG8 C1199A polymorphisms on lipid lowering with atorvastatin. J Clin Pharm Ther 2010. doi:10. 1111/j. 1365-2710. 2010. 01227. x.

Wei M, Wanibuchi H, Nakae D et al. Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21(Cip/WAF1). Cancer Sci 2011; 102:88-94.

Wei N, Sun H, Wang F, Liu G. H1, a novel derivative of tetrandrine reverse P-glycoprotein-mediated multidrug resistance by inhibiting transport function and expression of P-glycoprotein. Cancer Chemother Pharmacol 2011; 67:1017-25.

Wei Q, Lu XY, Liu L et al. Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability. Proc Nat Acad Sci USA 2004; 101:11851-6.

Wei X, McLeod HL, McMurrough J, Gonzalez FJ, Fernandez-Salguero P. Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J Clin Invest 1996; 98:610-5.

Weibel GL, Joshi MR, Alexander ET, Zhu P, Blair IA, Rothblat GH. Overexpression of human 15(S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport. Arterioscler Thromb Vasc Biol 2009; 29:837-42.

Weickert MO, Loeffelholz CV, Roden M et al. A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects. Am J Physiol Endocrinol Metab 2007; 293:1078-84.

Weijer S, Wieland CW, Florquin S, van der Poll T. A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis. Blood 2005; 106:2761-8.

Weiner DM, Goodman MW, Colpitts TM et al. Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias. Am J Pharmacogenomics 2004; 4:119-28.

Weiner M, Peloquin C, Burman W et al. Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations. Antimicrob Agents Chemother 2010; 54:4192-200.

Weingärtner O, Laufs U, Böhm M, Lütjohann D. An alternative pathway of reverse cholesterol transport: the oxysterol 27-hydroxycholesterol. Atherosclerosis 2010; 209:39-41.

Weingärtner O, Ulrich C, Lütjohann D et al. Differential effects on inhibition of cholesterol absorption by plant stanol and plant sterol esters in apoE-/- mice. Cardiovasc Res 2011; 90:484-92.

Weinshank RL, Adham N, Macchi M, Olsen MA, Branchek TA, Hartig PR. Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene. J Biol Chem 199; 266:22427-35.

Weinshilboum R. Inheritance and drug response. N Engl J Med 2003; 348:529-37.

Weinshilboum R. Pharmacogenomics of endocrine therapy in breast cancer. Adv Exp Med Biol 2008; 630:220-31.

Weinshilboum RM. Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase. Cell Mol Neurobiol 2006; 26:539-61.

Weinstock M. Sex-dependent changes induced by prenatal stress in cortical and hippocampal morphology and behaviour in rats: An update. Stress 2011; 14:604-13.

Weiringa GE, Burlinson S, Rafferty JA, Gowland E, Burns A. Apolipoprotein e genotypes and serum lipid levels in Alzheimer’s disease and multi-infarct dementia. Int J Geriat Psychiatry 1997; 12:349-62.

Weise A, Prause S, Eidens M et al. Prevalence of CYP450 gene variations in patients with type 2 diabetes. Clin Lab 2010; 56:311-8.

Weiss EP, Brown MD, Shuldiner AR, Hagberg JM. Fatty acid binding protein-2 gene variants and insulin resistance: gene and gene-environment interaction effects. Physiol Genomics 2002; 10:145-57.

Weiss J, Herzog M, Haefeli WE. Differential modulation of the expression of important drug metabolising enzymes and transporters by endothelin-1 receptor antagonists ambrisentan and bosentan in vitro. Eur J Pharmacol 2011; 660:298-304.

Weiss J, Herzog M, König S, Storch CH, Ketabi-Kiyanvash N, Haefeli WE. Induction of multiple drug transporters by efavirenz. J Pharmacol Sci 2009; 109:242-50.

Weiss J, Rose J, Storch CH et al. Modulation of human BCRP (ABCG2) activity by anti-HIV drugs. J Antimicrob Chemother 2007; 59:238-45.

Weiss J, Sauer A, Divac N et al. Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters. Biopharm Drug Dispos 2010; 31:150-61.

Weiss J, Sauer A, Frank A, Unger M. Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro. Drug Metab Dispos 2005; 33:1580-3.

Weiss J, Sauer A, Herzog M, Böger RH, Haefeli WE, Benndorf RA. Interaction of thiazolidinediones (glitazones) with the ATP-binding cassette transporters P-glycoprotein and breast cancer resistance protein. Pharmacology 2009; 84:264-70.

Weiss J, Sawa E, Riedel KD, Haefeli WE, Mikus G. In vitro metabolism of the opioid tilidine and interaction of tilidine and nortilidine with CYP3A4, CYP2C19, and CYP2D6. Naunyn Schmiedebergs Arch Pharmacol 2008; 378:275-82.

Weiss J, Theile D, Ketabi-Kiyanvash N, Lindenmaier H, Haefeli WE. Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors. Drug Metab Dispos 2007; 35:340-4.

Weiss JR, Baer MR, Ambrosone CB et al. Concordance of pharmacogenetic polymorphisms in tumor and germ line DNA in adult patients with acute myeloid leukemia. Cancer Epidemiol Biomarkers Prev 2007; 16:1038-41.

Weiss LA, Kosova G, Delahanty RJ et al. Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility. Eur J Hum Genet 2006; 14:923-31.

Weiss LA, Ober C, Cook EH Jr. ITGB3 shows genetic and expression interaction with SLC6A4. Hum Genet 2006; 120:93-100.

Weiss LA, Veenstra-Vanderweele J, Newman DL et al. Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin. Eur J Hum Genet 2004; 12:949-54.

Weiss M, Sermsappasuk P, Siegmund W. Modeling the kinetics of digoxin absorption: enhancement by P-glycoprotein inhibition. J Clin Pharmacol 2011. doi:10. 1177/0091270010396711.

Weiss RB, Baker TB, Cannon DS et al. A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet 2008. doi:10. 1371/journal. pgen. 1000125.

Weiss ST, Litonjua AA, Lange C et al. Overview of the pharmacogenetics of asthma treatment. Pharmacogenomics J 2006; 6:311-26.

Weissglas-Volkov D, Huertas-Vazquez A, Suviolahti E et al. Common hepatic nuclear factor-4alpha variants are associated with high serum lipid levels and the metabolic syndrome. Diabetes 2006; 55:1970-7.

Weissman C, Aguzzi A. Prp’s double causes trouble. Science 1999; 286:914-5.

Weisstein JS, Majeska RJ, Klein MJ, Einhorn TA. Detection of c-fos expression in benign and malignant musculoskeletal lesions. J Orthop Res 2001; 19:339-45.

Welker HA, Wiltshire H, Bullingham R. Clinical pharmacokinetics of mibefradil. Clin Pharmacokinet 1998; 35:405-23.

Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78.

Weller M, Felsberg J, Hartmann C et al. Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network. J Clin Oncol 2009; 27:5743-50.

Wen B, Chen Y, Fitch WL. Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4. Drug Metab Dispos 2009; 37:1557-62.

Wen B, Doneanu CE, Gartner CA, Roberts AG, Atkins WM, Nelson SD. Fluorescent photoaffinity labeling of cytochrome P450 3A4 by lapachenole: identification of modification sites by mass spectrometry. Biochemistry 2005; 44:1833-45.

Wen B, Doneanu CE, Lampe JN, Roberts AG, Atkins WM, Nelson SD. Probing the CYP3A4 active site by cysteine scanning mutagenesis and photoaffinity labeling. Arch Biochem Biophys 2005; 444:100-11.

Wen B, Lampe JN, Roberts AG, Atkins WM, David Rodrigues A, Nelson SD. Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase. Arch Biochem Biophys 2006; 454:42-54.

Wen B, Ma L, Rodrigues AD, Zhu M. Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine. Drug Metab Dispos 2008; 36:841-50.

Wen B, Ma L, Zhu M. Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact 2008; 173:59-67.

Wen B, Moore DJ. Bioactivation of glafenine by human liver microsomes and peroxidases: Identification of electrophilic iminoquinone species and GSH conjugates. Drug Metab Dispos 2011; 39:1511-21.

Wen B, Zhou M. Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s. Chem Biol Interact 2009; 181:220-6.

Wen H, Ding Q, Fang ZJ, Xia GW, Fang J. Population study of genetic polymorphisms and superficial bladder cancer risk in Han-Chinese smokers in Shanghai. Int Urol Nephrol 2009; 41:855-64.

Wen J, Xiong Y. OATP1B1 388A>G polymorphism and pharmacokinetics of pitavastatin in Chinese healthy volunteers. J Clin Pharm Ther 2010; 35:99-104.

Wen JH, Xiong YQ. The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats. Eur J Drug Metab Pharmacokinet 2011. doi:10. 1007/s13318-011-0048-7.

Wen MJ, Lin CJ, Hung YJ, Pei D, Kuo SW, Hsieh CH. Association study between Apolipoprotein E gene polymorphism and diabetic nephropathy in a Taiwanese population. Genet Test Mol Biomarkers 2011; 15:685-9.

Wen MS, Lee M, Chen JJ et al. Prospective study of warfarin dosage requirements based on CYP2C9 and VKORC1 genotypes. Clin Pharmacol Ther 2008; 84:83-9.

Wen PY, Yung WK, Lamborn KR et al. Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res 2006; 12:4899-907.

Wen S, Wang H, Ding Y, Liang H, Wang S. Screening of 12 SNPs of CYP3A4 in a Chinese population using oligonucleotide microarray. Genet Test 2004; 8:411-6.

Wen SY, Wang H, Sun OJ, Wang SQ. Rapid detection of the known SNPs of CYP2C9 using oligonucleotide microarray. World J Gastroenterol 2003; 9:1342-6.

Wen X, Wang JS, Backman JT, Kivistö KT, Neuvonen PJ. Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9. Drug Metab Dispos 2001; 29:1359-61.

Wen X, Wang JS, Backman JT, Laitila J, Neuvonen PJ. Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively. Drug Metab Dispos 2002; 30:631-5.

Wen X, Wang JS, Kivistö KT, Neuvonen PJ, Backman JT. In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9). Br J Clin Pharmacol 2001; 52:547-53.

Wen X, Wang JS, Neuvonen PJ, Backman JT. Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes. Eur J Clin Pharmacol 2002; 57:799-804.

Wen YH, Sahi J, Urda E et al. Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes. Drug Metab Dispos 2002; 30:977-84.

Wendt B, Mulbaier M, Wawro S et al. Toluidinesulfonamide hypoxia-induced factor 1 inhibitors: alleviating drug-drug interactions through use of PubChem data and comparative molecular field analysis guided synthesis. J Med Chem 2011; 54:3982-6.

Weng KP, Hsieh KS, Hwang YT et al. IL-10 polymorphisms are associated with coronary artery lesions in acute stage of Kawasaki disease. Circ J 2010; 74:983-9.

Weng SW, Lin TK, Wang PW et al. Gly482Ser polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha gene is associated with oxidative stress and abdominal obesity. Metabolism 2010; 59:581-6.

Weng X, Li Y, Yang Q et al. Effects of Wuji pill compound with different compatibility on cytochrome P450 CYP3A1/3A2 in rat liver microsomes in vitro. Zhongguo Zhong Yao Za Zhi 2010; 35:1164-9.

Wenge B, Geyer J, Bönisch H. Oxybutynin and trospium are substrates of the human organic cation transporters. Naunyn Schmiedebergs Arch Pharmacol 2011; 383:203-8.

Wenk M, Todesco L, Krähenbühl S. Effect of St John’s wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females. Br J Clin Pharmacol 2004; 57:495-9.

Wenker MA, Kezić S, Monster AC, de Wolff FA. Metabolism of styrene in the human liver in vitro: interindividual variation and enantioselectivity. Xenobiotica 2001; 31:61-72.

Wennerholm A, Allqvist A, Svensson JO, Gustafsson LL, Mirghani RA, Bertilsson L. Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects. Eur J Clin Pharmacol 2005; 61:113-8.

Wennerholm A, Dandara C, Sayi J et al. The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity. Clin Pharmacol Ther 2002; 71:77-88.

Wennerholm A, Johansson I, Hidestrand M, Bertilsson L, Gustafsson LL, Ingelman-Sundberg M. Characterization of the CYP2D6*29 allele commonly present in a black Tanzanian population causing reduced catalytic activity. Pharmacogenetics 2001; 11:417-27.

Wennerholm A, Johansson I, Massele AY et al. Decreased capacity for debrisoquine metabolism among black Tanzanians: analyses of the CYP2D6 genotype and phenotype. Pharmacogenetics 1999; 9:707-14.

Wennerholm A, Nordmark A, Pihlsgård M, Mahindi M, Bertilsson L, Gustafsson LL. Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo. Eur J Clin Pharmacol 2006; 62:539-46.

Went LN, Vegter-van der Vlis M, Bruyn GW. Parental transmission in Huntington’s disease. Lancet 1984; i:1100-2.

Wenzlaff AS, Cote ML, Bock CH, Land SJ, Schwartz AG. GSTM1, GSTT1 and GSTP1 polymorphisms, environmental tobacco smoke exposure and risk of lung cancer among never smokers: a population-based study. Carcinogenesis 2005; 26:395-401.

Werba JP, Cavalca V, Veglia F et al. A new compound-specific pleiotropic effect of statins: modification of plasma gamma-tocopherol levels. Atherosclerosis 2007; 193:229-33.

Werner U, Lamprecht C, Werner D et al. Valdecoxib does not interfere with the CYP2D6 substrate metoprolol. Int J Clin Pharmacol Ther 2006; 44:397-400.

Werner U, Werner D, Pahl A, Mundkowski R, Gillich M, Brune K. Investigation of the pharmacokinetics of celecoxib by liquid chromatography-mass spectrometry. Biomed Chromatogr 2002; 16:56-60.

Werner U, Werner D, Rau T, Fromm MF, Hinz B, Brune K. Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans. Clin Pharmacol Ther 2003; 74:130-7.

Weroha SJ, Oberg AL, Ziegler KL et al. Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma. Gynecol Oncol 2011; 122:116-20.

Weschules DJ, Bain KT, Richeimer S. Actual and potential drug interactions associated with methadone. Pain Med 2008; 9:315-44.

Wesołowska O, Molnar J, Ocsovszki I, Michalak K. Differential effect of phenothiazines on MRP1 and P-glycoprotein activity. In Vivo 2009; 23:943-7.

Wesolowska O, Wisniewski J, Bielawska-Pohl A et al. Stilbenes as multidrug resistance modulators and apoptosis inducers in human adenocarcinoma cells. Anticancer Res 2010; 30:4587-93.

Wesołowska O, Wiśniewski J, Sroda K et al. 8-Prenylnaringenin is an inhibitor of multidrug resistance-associated transporters, P-glycoprotein and MRP1. Eur J Pharmacol 2010; 644:32-40.

Wess J. More is not always better: alpha2A-adrenoceptor expression in type 2 diabetes. Cell Metab 2010; 11:3-5.

Wessels JA, van der Kooij SM, le Cessie S et al. A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis. Arthritis Rheum 2007; 56:1765-75.

West KL, McGrane M, Odom D, Keller B, Fernandez ML. SC-435, an ileal apical sodium-codependent bile acid transporter inhibitor alters mRNA levels and enzyme activities of selected genes involved in hepatic cholesterol and lipoprotein metabolism in guinea pigs. J Nutr Biochem 2005; 16:722-8.

West MJ, Bach G, Søderman A, Jensen JL. Synaptic contact number and size in stratum radiatum CA1 of APP/PS1DeltaE9 transgenic mice. Neurobiol Aging 2009; 30:1756-76.

Wester MR, Lasker JM, Johnson EF, Raucy JL. CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes. Drug Metab Dispos 2000; 28:354-9.

Westerbacka J, Cornér A, Kannisto K et al. Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects. Diabetologia 2006; 49:132-40.

Westerterp M, Koetsveld J, Yu S et al. Increased atherosclerosis in mice with vascular ATP-binding cassette transporter G1 deficiency-brief report. Arterioscler Thromb Vasc Biol 2010; 30:2103-5.

Westlind A, Löfberg L, Tindberg N, Andersson TB, Ingelman-Sundberg M. Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5’-upstream regulatory region. Biochem Biophys Res Commun 1999; 259:201-5.

Westlind A, Malmebo S, Johansson I et al. Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43. Biochem Biophys Res Commun 2001; 281:1349-55.

Westlind-Johnsson A, Hermann R, Huennemeyer A et al. Identification and characterization of CYP3A4*20, a novel rare CYP3A4 allele without functional activity. Clin Pharmacol Ther 2006; 79:339-49.

Westlind-Johnsson A, Malmebo S, Johansson A et al. Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism. Drug Metab Dispos 2003; 31:755-61.

Westlye ET, Lundervold A, Rootwelt H, Lundervold AJ, Westlye LT. Increased hippocampal default mode synchronization during rest in middle-aged and elderly APOE {varepsilon}4 carriers: Relationships with memory performance. J Neurosci 2011; 31:7775-83.

Wetmur JG, Kaya AH, Plewinska M, Desnick RJ. Molecular characterization of the human delta-aminolevulinate dehydratase 2 (ALAD2) allele: implications for molecular screening of individuals for genetic susceptibility to lead poisoning. Am J Hum Genet 1991; 49:757-63.

Wexler D, Courtney R, Richards W, Banfield C, Lim J, Laughlin M. Effect of posaconazole on cytochrome P450 enzymes: a randomized, open-label, two-way crossover study. Eur J Pharm Sci 2004; 21:645-53.

Whalen KE, Sotka EE, Goldstone JV, Hahn ME. The role of multixenobiotic transporters in predatory marine molluscs as counter-defense mechanisms against dietary allelochemicals. Comp Biochem Physiol C Toxicol Pharmacol 2010; 152:288-300.

Whaley-Connell A, Habibi J, Johnson M et al. Nebivolol reduces proteinuria and renal NADPH oxidase-generated reactive oxygen species in the transgenic Ren2 rat. Am J Nephrol 2009; 30:354-60.

Whatling C, McPheat W, Herslöf M. The potential link between atherosclerosis and the 5-lipoxygenase pathway: investigational agents with new implications for the cardiovascular field. Expert Opin Investig Drugs 2007; 16:1879-93.

Wheeler HE, Kim SK. Genetics and genomics of human ageing. Philos Trans R Soc Lond B Biol Sci 2011; 366:43-50.

Whetzel AM, Sturek JM, Nagelin MH et al. ABCG1 deficiency in mice promotes endothelial activation and monocyte-endothelial interactions. Arterioscler Thromb Vasc Biol 2010; 30:809-17.

Whiley P, Guidugli L, Walker L et al. Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary. Hum Mutat 2011; 32:678-87.

Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. Pharmacogenetics 2003; 13:131-44.

White AR, Enever P, Tayebi M et al. Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature 2003; 422:80-3.

White DL, Li D, Nurgalieva Z, El-Serag HB. Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis. Am J Epidemiol 2008; 167:377-89.

White IN. Tamoxifen: is it safe? Comparison of activation and detoxication mechanisms in rodents and in humans. Curr Drug Metab 2003; 4:223-39.

White IN, de Matteis F, Gibbs AH et al. Species differences in the covalent binding of [14C]tamoxifen to liver microsomes and the forms of cytochrome P450 involved. Biochem Pharmacol 1995; 49:1035-42.

White IN, Razvi N, Gibbs AH et al. Neoantigen formation and clastogenic action of HCFC-123 and perchloroethylene in human MCL-5 cells. Toxicol Lett 2001; 124:129-38.

Whitfield GK, Dang HT, Schluter SF et al. Cloning of a functional vitamin D receptor from the lamprey (Petromyzon marinus), an ancient vertebrate lacking a calcified skeleton and teeth. Endocrinology 2003; 144:2704-16.

Whitfield KE, Yao X, Boomer KB, Vogler GP, Hayward MD, Vandenbergh DJ. Analysis of candidate genes and hypertension in African American adults. Ethn Dis 2009; 19:18-22.

Whitman SP, Hackanson B, Liyanarachchi S et al. DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication. Blood 2008; 112:2013-6.

Whyte EM, Romkes M, Mulsant BH et al. CYP2D6 genotype and venlafaxine-XR concentrations in depressed elderly. Int J Geriatr Psychiatry 2006; 21:542-9.

Wickliffe JK, Abdel-Rahman SZ, Lee C et al. CYP1A2*1F and GSTM1 alleles are associated with susceptibility to porphyria cutanea tarda. Mol Med 2011; 17:241-7.

Wickremasinghe SS, Xie J, Lim J et al. Variants in the APOE gene are associated with improved treatment outcome following anti-VEGF therapy for neovascular AMD. Invest Ophthalmol Vis Sci 2011; 52:4072-9.

Wide K, Larsson H, Bertilsson L, Diczfalusy U. Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy. Br J Clin Pharmacol 2008; 65:708-15.

Wieczorek SJ, Tsongalis GJ. Pharmacogenomics: will it change the field of medicine? Clin Chim Acta 2001; 308:1-8.

Wiegand H, Boesch-Saadatmandi C, Wein S, Wolffram S, Frank J, Rimbach G. Dietary flavonoids do not affect vitamin E status in growing rats. J Anim Physiol Anim Nutr 2010; 94:307-18.

Wieland E, Shipkova M, Schütz E et al. Preliminary report on the effect of xenoperfusion with human blood on cyclosporin A metabolism and cytochrome-P-4503A4-mRNA expression in a pig liver perfusion model. Clin Biochem 2001; 34:53-7.

Wieling J, Tamminga WJ, Sakiman EP, Oosterhuis B, Wemer J, Jonkman JH. Evaluation of analytical and clinical performance of a dual-probe phenotyping method for CYP2D6 polymorphism and CYP3A4 activity screening. Ther Drug Monit 2000; 22:486-96.

Wiener D, Doerge DR, Fang JL, Upadhyaya P, Lazarus P. Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4. Drug Metab Dispos 2004; 32:72-9.

Wiener D, Fang JL, Dossett N, Lazarus P. Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes. Cancer Res 2004; 64:1190-6.

Wiener HW, Perry RT, Chen Z, Harrell LE, Go RC. A polymorphism in SOD2 is associated with development of Alzheimer’s disease. Genes Brain Behav 2007; 6:770-5.

Wienkers LC. Factors confounding the successful extrapolation of in vitro CYP3A inhibition information to the in vivo condition. Eur J Pharm Sci 2002; 15:239-42.

Wienkers LC, Allievi C, Hauer MJ, Wynalda MA. Cytochrome P-450-mediated metabolism of the individual enantiomers of the antidepressant agent reboxetine in human liver microsomes. Drug Metab Dispos 1999; 27:1334-40.

Wienkers LC, Steenwyk RC, Hauer MJ, Fleishaker JC, Pearson PG. Biotransformation of tirilazad in human: 3. tirilazad A-ring reduction by human liver microsomal 5alpha-reductase type 1 and type 2. J Pharmacol Exp Ther 1998; 287:583-90.

Wienkers LC, Steenwyk RC, Sanders PE, Pearson PG. Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes. J Pharmacol Exp Ther 1996; 277:982-90.

Wienkers LC, Wynalda MA. Multiple cytochrome P450 enzymes responsible for the oxidative metabolism of the substituted (S)-3-phenylpiperidine, (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, in human liver microsomes. Drug Metab Dispos 2002; 30:1372-7.

Wiercinska P, Squires EJ. Chlorzoxazone metabolism by porcine cytochrome P450 enzymes and the effect of cytochrome b5. Drug Metab Dispos 2010; 38:857-62.

Wiernicki I, Safranow K, Baranowska-Bosiacka I, Piatek J, Gutowski P. Haptoglobin 2-1 phenotype predicts rapid growth of abdominal aortic aneurysms. J Vasc Surg 2010; 52:691-6.

Wiersma H, Gatti A, Nijstad N, Kuipers F, Tietge UJ. Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice. J Lipid Res 2009; 50:1571-80.

Wiese C, Grosse Maestrup E, Schepmann D et al. Pharmacological and metabolic characterisation of the potent sigma1 receptor ligand 1’-benzyl-3-methoxy-3H-spiro[[2]benzofuran-1,4’-piperidine]. J Pharm Pharmacol 2009; 61:631-40.

Wiest D. Esmolol. A review of its therapeutic efficacy and pharmacokinetic characteristics. Clin Pharmacokinet 1995; 28:190-202.

Wigren M, Kolbus D, Dunér P et al. Evidence for a role of regulatory T cells in mediating the atheroprotective effect of apolipoprotein B peptide vaccine. J Intern Med 2011; 269:546-56.

Wijesuriya HC, Bullock JY, Faull RL, Hladky SB, Barrand MA. ABC efflux transporters in brain vasculature of Alzheimer’s subjects. Brain Res 2010; 1358:228-38.

Wijnen PA, Bekers O, Drent M. Development of cocaine-induced interstitial lung damage in two CYP2C and VKORC1 variant allele carriers. Mol Diagn Ther 2011; 15:177-80.

Wijnen PA, Op den Buijsch RA, Cheung SC et al. Genotyping with a dried blood spot method: a useful technique for application in pharmacogenetics. Clin Chim Acta 2008; 388:189-91.

Wijsman EM, Pankratz ND, Choi Y et al. Genome-wide association of familial late-onset Alzheimer’s disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. PLoS Genet 2011. doi:10. 1371/journal. pgen. 1001308.

Wilcox RA, Churchyard A, Dahl HH, Hutchison WM, Kirby DM, Thyagarajan D. Levodopa response in Parkinsonism with multiple mitochondrial DNA deletions. Mov Disord 2007; 22:1020-3.

Wild CP, Yin F, Turner PC et al. Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia. Int J Cancer 2000; 86:1-7.

Wilde S, Jetter A, Rietbrock S et al. Population pharmacokinetics of the BEACOPP polychemotherapy regimen in Hodgkin’s lymphoma and its effect on myelotoxicity. Clin Pharmacokinet 2007; 46:319-33.

Wilding G, Chen M, Gelmann EP. Aberrant response in vitro of hormone-responsive prostate cancer cells to antiandrogens. Prostate 1989; 14:103-15.

Wilk JB, Myers RH, Pankow JS et al. Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study. Ann Hum Genet 2006; 70:566-73.

Wilke RA, Moore JH, Burmester JK. Relative impact of CYP3A genotype and concomitant medication on the severity of atorvastatin-induced muscle damage. Pharmacogenet Genomics 2005; 15:415-21.

Wilkie MJ, Smith G, Day RK et al. Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy. Pharmacogenomics J 2009; 9:61-70.

Wilkins MR, Møller GM, Ren X, Wharton J. Developments in therapeutics for pulmonary arterial hypertension. Minerva Cardioangiol 2002; 50:175-87.

Wilkinson GR. Drug metabolism and variability among patients in drug response. N Engl J Med 2005; 352:2211-21.

Wilkinson KD, Tashayev VL, O’Connor LB, Larsen CN, Kasperek E, Pickart CM. Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T. Biochemistry 1995; 34:14535-46.

Wilms LC, Claughton TA, de Kok TM, Kleinjans JC. GSTM1 and GSTT1 polymorphism influences protection against induced oxidative DNA damage by quercetin and ascorbic acid in human lymphocytes in vitro. Food Chem Toxicol 2007; 45:2592-6.

Wilmshurst JM, Lillis S, Zhou H et al. RYR1 mutations are a common cause of congenital myopathies with central nuclei. Ann Neurol 2010; 68:717-26.

Wilner KD, Demattos SB, Anziano RJ, Apseloff G, Gerber N. Ziprasidone and the activity of cytochrome P450 2D6 in healthy extensive metabolizers. Br J Clin Pharmacol 2000; 49 Suppl 1:43-7.

Wilson A, Leclerc D, Saberi F et al. Functionally null mutations in patients with the cblG-variant form of methionine synthase deficiency. Am J Hum Genet 1998; 63:409-14.

Wilson C, Purcell C, Seaton A et al. Chemotherapy-induced CXC-chemokine/CXC-chemokine receptor signaling in metastatic prostate cancer cells confers resistance to oxaliplatin through potentiation of nuclear factor-kappaB transcription and evasion of apoptosis. J Pharmacol Exp Ther 2008; 327:746-59.

Wilson JE, Chandrasekharan NV, Westover KD, Eager KB, Simmons DL. Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res 2004; 65:810-8.

Wilson RS, Schneider JA, Barnes LL et al. The apolipoprotein E epsilon-4 allele and decline in different cognitive systems during a 6-years period. Arch Neurol 2002; 59:1154-60.

Wiltshire C, Singh BL, Stockley J et al. Docetaxel-resistant prostate cancer cells remain sensitive to S-trityl-L-cysteine-mediated Eg5 inhibition. Mol Cancer Ther 2010; 9:1730-9.

Wiltshire S, Powell BL, Jennens M et al. Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease. Hum Genet 2008; 123:307-13.

Will RG, Alpers MP, Dormont D, Schonberger LB, Tateishi J. Infectious and sporadic prion diseases. In: Prusiner SB (Ed). Prion biology and diseases. Cold Spring Harbor Laboratory Press, New York, 1999:465-507.

Willems L, Reichelt ME, Molina JG et al. Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts. Cardiovasc Res 2006; 71:79-87.

Willenberg HS, Späth M, Maser-Gluth C et al. Sporadic solitary aldosterone- and cortisol-co-secreting adenomas: endocrine, histological and genetic findings in a subtype of primary aldosteronism. Hypertens Res 2010; 33:467-72.

Willey JC, Coy E, Brolly C et al. Xenobiotic metabolism enzyme gene expression in human bronchial epithelial and alveolar macrophage cells. Am J Respir Cell Mol Biol 1996; 14:262-71.

Williams D, Feely J. Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors. Clin Pharmacokinet 2002; 41:343-70.

Williams E, Rumsby G. Selected exonic sequencing of the AGXT gene provides a genetic diagnosis in 50% of patients with primary hyperoxaluria type 1. Clin Chem 2007; 53:1216-21.

Williams EL, Acquaviva C, Amoroso A et al. Primary hyperoxaluria type 1: update and additional mutation analysis of the AGXT gene. Hum Mutat 2009; 30:910-7.

Williams ET, Leyk M, Wrighton SA et al. Estrogen regulation of the cytochrome P450 3A subfamily in humans. J Pharmacol Exp Ther 2004; 311:728-35.

Williams ET, Rodin AS, Strobel HW. Defining relationships between the known members of the cytochrome P450 3A subfamily, including five putative chimpanzee members. Mol Phylogenet Evol 2004; 33:300-8.

Williams GC, Liu A, Knipp G, Sinko PJ. Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2). Antimicrob Agents Chemother 2002; 46:3456-62.

Williams GC, Sinko PJ. Oral absorption of the HIV protease inhibitors: a current update. Adv Drug Deliv Rev 1999; 39:211-238.

Williams GH. Genetic factors associated with volume-sensitive hypertension. Mol Cell Endocrinol 2004; 217:41-4.

Williams GH, Hollenberg NK. Functional derangements in the regulation of aldosterone secretion in hypertension. Hypertension 1991; 18 (5 Suppl):143-9.

Williams JA, Andersson T, Andersson TB et al. PhRMA white paper on ADME pharmacogenomics. J Clin Pharmacol 2008; 48:849-89.

Williams JA, Cook J, Hurst SI. A significant drug-metabolizing role for CYP3A5? Drug Metab Dispos 2003; 31:1526-30.

Williams JA, Ring BJ, Cantrell VE et al. Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos 2002; 30:883-91.

Williams JM, Gandhi KK, Benowitz NL. Carbamazepine but not valproate induces CYP2A6 activity in smokers with mental illness. Cancer Epidemiol Biomarkers Prev 2010; 19:2582-9.

Williams NM, O’Donovan MC, Owen MJ. Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia? Schizophr Bull 2005; 31:800-5.

Williams PA, Cosme J, Vinkovic DM et al. Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone. Science 2004; 305:683-6.

Williams PA, Cosme J, Ward A, Angove HC, Matak Vinković D, Jhoti H. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature 2003; 424:464-8.

Williams-Brown MY, Salih SM, Xu X et al. The effect of tamoxifen and raloxifene on estrogen metabolism and endometrial cancer risk. J Steroid Biochem Mol Biol 2011; 126:78-86.

Williamson D, Brown K, Luddington R, Baglin C, Baglin T. Factor V Cambridge: a new mutation (Arg306→Thr) associated with resistance to activated protein C. Blood 1998; 91:1140-4.

Williamson KM, Patterson JH, McQueen RH, Adams KF Jr, Pieper JA. Effects of erythromycin or rifampin on losartan pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1998; 63:316-23.

Williamson MP, Elder PA, Shaw ME, Devlin J, Knowles MA. p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer. Hum Mol Genet 1995; 4:1569-77.

Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ. Yeast genes that enhance the toxicity of mutants hungting fragment or alpha-synuclein. Science 2003; 302:1769-72.

Willour VL, Chen H, Toolan J et al. Family-based association of FKBP5 in bipolar disorder. Mol Psychiatry 2009; 14:261-8.

Willrich MA, Hirata MH, Hirata RD. Statin regulation of CYP3A4 and CYP3A5 expression. Pharmacogenomics 2009; 10:1017-24.

Wills LP, Matson CW, Landon CD, di Giulio RT. Characterization of the recalcitrant CYP1 phenotype found in Atlantic killifish (Fundulus heteroclitus) inhabiting a Superfund site on the Elizabeth River, VA. Aquat Toxicol 2010; 99:33-41.

Wimmer K, Etzler J. Constitutional mismatch repair-deficiency syndrome: have we so far seen only the tip of an iceberg? Hum Genet 2008; 124:105-22.

Wimmer R, Hohenester S, Pusl T, Denk GU, Rust C, Beuers U. Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. Gut 2008; 57:1448-54.

Windemuth A, Calhoun VD, Pearlson GD, Kocherla M, Jagannathan K, Ruaño G. Physiogenomic analysis of localized FMRI brain activity in schizophrenia. Ann Biomed Eng 2008; 36:877-88.

Windl O, Giese A, Schulz-Schaeffer W et al. Molecular genetics of human prion diseases in Germany. Hum Genet 1999; 105:244-52.

Windl O, Kretzschmar HA. Prion diseases. In: Pulst S-M (Ed). Neurogenetics. Oxford University Press, New York, 2000:191-218.

Windmill KF, McKinnon RA, Zhu X, Gaedigk A, Grant DM, McManus ME. The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. Mutat Res 1997; 376:153-60.

Winichagoon P, Fucharoen S, Chen P, Wasi P. Genetic factors affecting clinical severity in beta-thalassemia syndromes. J Pediatr Hematol Oncol 2000; 22:573-80.

Winitthana T, Niwattisaiwong N, Patarapanich C, Tantisira MH, Lawanprasert S. In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome P450. Toxicol In Vitro 2011; 25:890-6.

Wink J, Veering BT, Kruit M et al. The effect of a long term epidural infusion of ropivacaine on CYP2D6 activity. Anesth Analg 2008; 106:143-6.

Winkelmann BR, Nauck M, Klein B et al. Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with increased plasma angiotensin-converting enzyme activity but not with increased risk for myocardial infarction and coronary artery disease. Ann Intern Med 1996; 125:19-25.

Winnik S, Lohmann C, Richter EK et al. Dietary {alpha}-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. Eur Heart J 2011; 32:2573-84.

Winoto J, Song H, Hines C, Nagaraja H, Rovin BH. Cytochrome P450 polymorphisms and the response of lupus nephritis to cyclophosphamide therapy. Clin Nephrol 2011; 75:451-7.

Winter AG, Dorgan C, Melton DW. Expression of a splicing variant in the 5’-UTR of the human ERCC1 gene is not cancer related. Oncogene 2005; 24:2110-3.

Winter HR, Unadkat JD. Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism. Drug Metab Dispos 2005; 33:969-76.

Winter HR, Wang Y, Unadkat JD. CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone. Drug Metab Dispos 2000; 28:865-8.

Winter JC, Amorosi DJ, Rice KC, Cheng K, Yu AM. Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice. Pharmacol Biochem Behav 2011; 99:311-5.

Wintermantel TM, Bock D, Fleig V, Greiner EF, Schütz G. The epithelial glucocorticoid receptor is required for the normal timing of cell proliferation during mammary lobuloalveolar development but is dispensable for milk production. Mol Endocrinol 2005; 19:340-9.

Winterthun S, Ferrari G, He L et al. Autosomal recessive mitochondrial ataxic syndrome due to mitochondrial polymerase gamma mutations. Neurology 2005; 64:1204-8.

Wire MB, Shelton MJ, Studenberg S. Fosamprenavir: clinical pharmacokinetics and drug interactions of the amprenavir prodrug. Clin Pharmacokinet 2006; 45:137-68.

Wiseman H, Lewis DF. The metabolism of tamoxifen by human cytochromes P450 is rationalized by molecular modelling of the enzyme-substrate interactions: potential importance to its proposed anti-carcinogenic/carcinogenic actions. Carcinogenesis 1996; 17:1357-60.

Wishart HA, Roth RM, Saykin AJ et al. COMT Val158Met Genotype and individual differences in executive function in healthy adults. J Int Neuropsychol Soc 2011; 17:174-80.

Wiśniewska A, Mazerska Z. Cytochrome P450 isoenzymes in metabolism of endo- and exogenic compounds. Postepy Biochem 2009; 55:259-71.

Wit FW, van Rij RP, Weverling GJ, Lange JM, Schuitemaker H. CC chemokine receptor 5 delta32 and CC chemokine receptor 2 64I polymorphisms do not influence the virologic and immunologic response to antiretroviral combination therapy in human immunodeficiency virus type 1-infected patients. J Infect Dis 2002; 186:1726-32.

Witsch-Baumgartner M, Gruber M, Kraft HG et al. Maternal apo E genotype is a modifier of the Smith-Lemli-Opitz syndrome. J Med Genet 2004; 41:577-84.

Wittayalertpanya S, Chompootaweep S, Thaworn N. The pharmacokinetics of pioglitazone in Thai healthy subjects. J Med Assoc Thai 2006; 89:2116-22.

Witte LP, Mulder WM, de la Rosette JJ, Michel MC. Muscarinic receptor antagonists for overactive bladder treatment: does one fit all? Curr Opin Urol 2009; 19:13-9.

Woillard JB, Rerolle JP, Picard N et al. Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele. Br J Clin Pharmacol 2010; 69:675-83.

Woillard JB, Rerolle JP, Picard N et al. Donor P-gp polymorphisms strongly influence renal function and graft loss in a cohort of renal transplant recipients on cyclosporine therapy in a long-term follow-up. Clin Pharmacol Ther 2010; 88:95-100.

Woitas RP, Ahlenstiel G, Iwan A et al. Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C. Gastroenterology 2002; 122:1721-8.

Wojcik AJ, Skaflen MD, Srinivasan S, Hedrick CC. A critical role for ABCG1 in macrophage inflammation and lung homeostasis. J Immunol 2008; 180:4273-82.

Wójcikowski J, Boksa J, Daniel WA. Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver-A comparison with other phenothiazines. Biochem Pharmacol 2010; 80:1252-9.

Wójcikowski J, Daniel WA. Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism-an in vitro study. Pharmacol Rep 2009; 61:851-8.

Wójcikowski J, Maurel P, Daniel WA. Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine. Drug Metab Dispos 2006; 34:471-6.

Wójcikowski J, Pichard-Garcia L, Maurel P, Daniel WA. Perazine as a potent inhibitor of human CYP1A2 but not CYP3A4. Pol J Pharmacol 2002; 54:407-10.

Wójcikowski J, Pichard-Garcia L, Maurel P, Daniel WA. Effects of cytochrome P-450 inducers on the perazine metabolism in a primary culture of human hepatocytes. Pol J Pharmacol 2003; 55:655-8.

Wójcikowski J, Pichard-Garcia L, Maurel P, Daniel WA. Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. Br J Pharmacol 2003; 138:1465-74.

Wójcikowski J, Pichard-Garcia L, Maurel P, Daniel WA. The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes. Eur Neuropsychopharmacol 2004; 14:199-208.

Wojczynski MK, Gao G, Borecki I et al. Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study. J Lipid Res 2010; 51:3316-23.

Wojnowski L. Genetics of the variable expression of CYP3A in humans. Ther Drug Monit 2004; 26:192-9.

Wojnowski L, Kamdem LK. Clinical implications of CYP3A polymorphisms. Expert Opin Drug Metab Toxicol 2006; 2:171-82.

Wojnowski L, Kulle B, Schirmer M et al. NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Circulation 2005; 112:3754-62.

Wojnowski L, Turner PC, Pedersen B et al. Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa. Pharmacogenetics 2004; 14:691-700.

Wolbold R, Klein K, Burk O et al. Sex is a major determinant of CYP3A4 expression in human liver. Hepatology 2003; 38:978-88.

Wolbrette DL. Drugs that cause Torsades de pointes and increase the risk of sudden cardiac death. Curr Cardiol Rep 2004; 6:379-84.

Woldemichael GM, Turbyville TJ, Linehan WM, McMahon JB. Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells. Cancer Res 2011; 71:134-42.

Wolf CR, Smith G, Smith RL. Science, medicine, and the future: Pharmacogenetics. BMJ 2000; 320:987-90.

Wolf KK, Wood SG, Allard JL et al. Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice. Drug Metab Dispos 2007; 35:1223-31.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and g-secretase activity. Nature 1999; 398:513-7.

Wölfel T, Hauer M, Schneider J et al. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 1995; 269:1281-4.

Wolford JK, Gruber JD, Ossowski VM et al. A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians. Mol Genet Metab 2003; 78:136-44.

Wolk R, Snyder EM, Somers VK, Turner ST, Olson LJ, Johnson BD. Arginine 16 glycine beta2-adrenoceptor polymorphism and cardiovascular structure and function in patients with heart failure. J Am Soc Echocardiogr 2007; 20:290-7.

Wołuń-Cholewa M, Szymanowski K, Andrusiewicz M, Warchoł W. Studies on function of P-glycoprotein in photodynamic therapy of endometriosis. Photomed Laser Surg 2010; 28:735-40.

Wong AH, Buckle CE, van Tol HH. Polymorphisms in dopamine receptors: what do they tell us? Eur J Pharmacol 2000; 410:183-203.

Wong CA, McCarthy RJ, Blouin J, Landau R. Observational study of the effect of mu-opioid receptor genetic polymorphism on intrathecal opioid labor analgesia and post-cesarean delivery analgesia. Int J Obstet Anesth 2010; 19:246-53.

Wong CC, Barron D, Orfila C, Dionisi F, Krajcsi P, Williamson G. Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters. Mol Nutr Food Res 2011; 55:979-88.

Wong GW, Wang J, Hug C, Tsao TS, Lodish HF. A family of Acrp30/adiponectin structural and functional paralogs. Proc Nat Acad Sci USA 2004; 101:10302-7.

Wong H, Chen JZ, Chou B et al. Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor. Xenobiotica 2009; 39:850-61.

Wong HL, Peters U, Hayes RB et al. Polymorphisms in the adenomatous polyposis coli (APC) gene and advanced colorectal adenoma risk. Eur J Cancer 2010; 46:2457-66.

Wong IL, Chan KF, Tsang KH et al. Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives. J Med Chem 2009; 52:5311-22.

Wong JY, Seah ES, Lee EJ. Pharmacogenetics: the molecular genetics of CYP2D6 dependent drug metabolism. Ann Acad Med Singapore 2000; 29:401-6.

Wong ML, Dong C, Maestre-Mesa J, Licinio J. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. Mol Psychiatry 2008; 13:800-12.

Wong ML, Whelan F, Deloukas P et al. Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. Proc Natl Acad Sci USA 2006; 103:15124-9.

Wong SG, Fan PW, Subramanian R et al. Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interaction. Drug Metab Dispos 2010; 38:841-50.

Wong SL, Cao G, Mack R, Granneman GR. Lack of CYP3A inhibition effects of sertindole on terfenadine in healthy volunteers. Int J Clin Pharmacol Ther 1998; 36:146-51.

Wong SL, Goldberg MR, Ballow CH, Kitt MM, Barriere SL. Effect of Telavancin on the pharmacokinetics of the cytochrome P450 3A probe substrate midazolam: a randomized, double-blind, crossover study in healthy subjects. Pharmacotherapy 2010; 30:136-43.

Wong SL, Locke C, Staser J, Granneman GR. Lack of multiple dosing effect of sertindole on the pharmacokinetics of alprazolam in healthy volunteers. Psychopharmacology 1998; 135:236-41.

Wong YW, Prakash R, Chew DP. Antiplatelet therapy in percutaneous coronary intervention: recent advances in oral antiplatelet agents. Curr Opin Cardiol 2010; 25:305-11.

Wonganan P, Zamboni WC, Strychor S, Dekker JD, Croyle MA. Drug-virus interaction: effect of administration of recombinant adenoviruses on the pharmacokinetics of docetaxel in a rat model. Cancer Gene Ther 2009; 16:405-14.

Wongvijitsuk S, Navasumrit P, Vattanasit U, Parnlob V, Ruchirawat M. Low level occupational exposure to styrene: its effects on DNA damage and DNA repair. Int J Hyg Environ Health 2011; 214:127-37.

Woo CH, Shishido T, McClain C et al. Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells. Circ Res 2008; 102:538-45.

Woo HG, Wang XW, Budhu A et al. Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma. Gastroenterology 2011; 140:1063-70.

Woo KT, Chan CM, Choong HL et al. High dose Losartan and ACE gene polymorphism in IgA nephritis. Genomic Med 2008; 2:83-91.

Woo KT, Lau YK, Choong LH et al. Polymorphism of renin-angiotensin system genes in IgA nephropathy. Nephrology 2004; 9:304-9.

Woo KV, Qu X, Babaev VR et al. Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner. J Clin Invest 2011; 121:1624-35.

Woo LW, Purohit A, Potter BV. Development of steroid sulfatase inhibitors. Mol Cell Endocrinol 2011; 340:175-85.

Woo S, Gardner ER, Chen X et al. Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma. Clin Cancer Res 2009; 15:1496-503.

Woo SW, Bang S, Chung MW, Jin SK, Kim YS, Lee SH. Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans. J Clin Pharm Ther 2009; 34:561-7.

Woo SW, Kang TS, Park HJ, Lee JE, Roh J. Comparison of linkage disequilibrium patterns and haplotype structure of eight single nucleotide polymorphisms across the CYP1A2 gene between the Korean, and other populations registered in the International HapMap database. J Clin Pharm Ther 2009; 34:429-36.

Wood HM, Lee UJ, Vurbic D et al. Sexual development and fertility of Loxl1-/- male mice. J Androl 2009; 30:452-9.

Wood N, Tan K, Purkins L et al. Effect of omeprazole on the steady-state pharmacokinetics of voriconazole. Br J Clin Pharmacol 2003; 56 Suppl 1:56-61.

Wood PM, Woo LW, Labrosse JR et al. Bicyclic derivatives of the potent dual aromatase-steroid sulfatase inhibitor 2-bromo-4-{[(4-cyanophenyl)(4h-1,2,4-triazol-4-yl)amino]methyl}phenylsulfamate: synthesis, SAR, crystal structure, and in vitro and in vivo activities. ChemMedChem 2010; 5:1577-93.

Wood PM, Woo LW, Thomas MP, Mahon MF, Purohit A, Potter BV. Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates. ChemMedChem 2011; 6:1423-38.

Wood SJ, MacKenzie L, Maleeff B, Hurle MR, Wetzel R. Selective inhibition of Abeta fibril formation. J Biol Chem 1996; 271:4086-92.

Wood TC, Salavagionne OE, Mukherjee B et al. Human arsenic methyltransferase (AS3MT) pharmacogenetics: Gene resequencing and functional genomics studies. J Biol Chem 2006; 281:7364-73.

Woodahl EL, Yang Z, Bui T, Shen DD, Ho RJ. MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells. AIDS 2005; 19:1617-25.

Woodcock EA. Roles of alpha1A- and alpha1B-adrenoceptors in heart: insights from studies of genetically modified mice. Clin Exp Pharmacol Physiol 2007; 34:884-8.

Woodiwiss AJ, Nkeh B, Samani NJ et al. Functional variants of the angiotensinogen gene determine antihypertensive responses to angiotensin-converting enzyme inhibitors in subjects of African origin. J Hypertens 2006; 24:1057-64.

Woodley-Cook J, Shin LY, Swystun L, Caruso S, Beaudin S, Liaw PC. Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway. Mol Cancer Ther 2006; 5:3303-11.

Woodman SE, Trent JC, Stemke-Hale K et al. Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates. Mol Cancer Ther 2009; 8:2079-85.

Woodruff-Pak DS, Agelan A, del Valle L. A rabbit model of Alzheimer’s disease: valid at neuropathological, cognitive, and therapeutic levels. J Alzheimers Dis 2007; 11:371-83.

Woods DR, Brull D, Montgomery H. Increased QT dispersion with the D-allele of the ACE polymorphism. Eur Heart J 2001; 22:618-21.

Woods KA, Camacho-Hübner C, Savage MO, Clark AJ. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N Engl J Med 1996; 335:1363-7.

Woodward O, Köttgen A, Köttgen M. ABCG transporters and disease. FEBS J 2011; 278:3215-25.

Woolf AD, Erdman AR, Nelson LS et al. Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol 2007; 45:203-33.

Woolford LB, Southgate TD, Margison GP, Milsom MD, Fairbairn LJ. The P140K mutant of human O(6)-methylguanine-DNA-methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O(6)-(4-bromothenyl)guanine. J Gene Med 2006; 8:29-34.

Woolley ML, Bentley JC, Sleight AJ, Marsden CA, Fone KC. A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze. Neuropharmacology 2001; 41:210-9.

Woolley ML, Pemberton DJ, Bate S, Corti C, Jones DN. The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity. Psychopharmacology 2008; 196:431-40.

Wooton-Kee CR, Coy DJ, Athippozhy AT, Zhao T, Jones BR, Vore M. Mechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating rats. Hepatology 2010; 51:277-85.

Wormhoudt LW, Ploemen JH, de Waziers I et al. Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes. Chem Biol Interact 1996; 101:175-92.

Worrillow LJ, Smith AG, Scott K et al. Polymorphic MLH1 and risk of cancer after methylating chemotherapy for Hodgkin lymphoma. J Med Genet 2008; 45:142-6.

Worrillow LJ, Travis LB, Smith AG et al. An intron splice acceptor polymorphism in hMSH2 and risk of leukemia after treatment with chemotherapeutic alkylating agents. Clin Cancer Res 2003; 9:3012-20.

Wortelboer HM, Usta M, van der Velde AE et al. Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin. Chem Res Toxicol 2003; 16:1642-51.

Wortelboer HM, Usta M, van Zanden JJ, van Bladeren PJ, Rietjens IM, Cnubben NH. Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of alpha,beta-unsaturated carbonyl compounds. Biochem Pharmacol 2005; 69:1879-90.

Wray JA, Sugden MC, Zeldin DC et al. The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo. PLoS One 2009. doi:10. 1371/journal. pone. 0015666.

Wright AF, Rudan I, Hastie ND, Campbell H. A ‘complexity’ of urate transporters. Kidney Int 2010; 78:446-52.

Wright GE, Niehaus DJ, Drögemöller BI, Koen L, Gaedigk A, Warnich L. Elucidation of CYP2D6 genetic diversity in a unique African population: implications for the future application of pharmacogenetics in the Xhosa population. Ann Hum Genet 2010; 74:340-50.

Wright H, Still C, Abramson R. Huntington’s disease in black kindreds in South Carolina. Arch Neurol 1981; 38:412-4.

Wright ME, Andreotti G, Lissowska J et al. Genetic variation in sodium-dependent ascorbic acid transporters and risk of gastric cancer in Poland. Eur J Cancer 2009; 45:1824-30.

Wright RM, Vaitaitis GM, Wilson CM et al. cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase. Proc Nat Acad Sci USA 1993; 90:10690-4.

Wrishko RE, Dingemanse J, Yu A, Darstein C, Phillips DL, Mitchell MI. Pharmacokinetic interaction between tadalafil and bosentan in healthy male subjects. J Clin Pharmacol 2008; 48:610-8.

Wróbel A, Eklund P, Bobrowska-Hägerstrand M, Hägerstrand H. Lignans and norlignans inhibit multidrug resistance protein 1 (MRP1/ABCC1)-mediated transport. Anticancer Res 2010; 30:4423-8.

Wu AH. Use of genetic and nongenetic factors in warfarin dosing algorithms. Pharmacogenomics 2007; 8:851-61.

Wu AH, Wang P, Smith A et al. Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations. Pharmacogenomics 2008; 9:169-78.

Wu B, Ueno M, Onodera M et al. Age-related changes in P-glycoprotein expression in senescence-accelerated mouse. Curr Aging Sci 2009; 2:187-92.

Wu CK, Luo JL, Tsai CT et al. Demonstrating the pharmacogenetic effects of angiotensin-converting enzyme inhibitors on long-term prognosis of diastolic heart failure. Pharmacogenomics J 2010; 10:46-53.

Wu CK, Luo JL, Wu XM et al. A propensity score-based case-control study of renin-angiotensin system gene polymorphisms and diastolic heart failure. Atherosclerosis 2009; 205:497-502.

Wu CK, Tsai CT, Chang YC et al. Genetic polymorphisms of the angiotensin II type 1 receptor gene anddiastolic heart failure. J Hypertens 2009; 27:502-7.

Wu CP, Calcagno AM, Hladky SB, Ambudkar SV, Barrand MA. Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5). FEBS J 2005; 272:4725-40.

Wu CP, Klokouzas A, Hladky SB, Ambudkar SV, Barrand MA. Interactions of mefloquine with ABC proteins, MRP1 (ABCC1) and MRP4 (ABCC4) that are present in human red cell membranes. Biochem Pharmacol 2005; 70:500-10.

Wu D, Cederbaum AI. Removal of glutathione produces apoptosis and necrosis in HepG2 cells overexpressing CYP2E1. Alcohol Clin Exp Res 2001; 25:619-28.

Wu D, Cederbaum AI. Sodium salicylate increases CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes. Mol Pharmacol 2001; 59:795-805.

Wu D, Cederbaum AI. Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicol Appl Pharmacol 2005; 207(2 Suppl):70-6.

Wu D, Cederbaum A. Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha-induced liver injury through activation of mitogen-activated protein kinases in mice. Hepatology 2008; 47:1005-17.

Wu D, Cederbaum A. Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiated tumor necrosis factor alpha liver injury. Free Radic Biol Med 2010; 49:348-60.

Wu D, Kang YS, Bickel U, Pardridge WM. Blood-brain barrier permeability to morphine-6-glucuronide is markedly reduced compared with morphine. Drug Metab Dispos 1997; 25:768-71.

Wu D, Nishimura N, Kuo V et al. Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol 2011; 31:1260-7.

Wu D, Otton SV, Sproule BA et al. Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone. Br J Clin Pharmacol 1993; 35:30-4.

Wu D, Zou YF, Xu XY et al. The association of genetic polymorphisms with cerebral palsy: a meta-analysis. Dev Med Child Neurol 2011; 53:217-25

Wu F, Shao ZY, Zhai BJ, Zhao CL, Shen DM. Ultrasound reverses multidrug resistance in human cancer cells by altering gene expression of ABC transporter proteins and Bax protein. Ultrasound Med Biol 2011; 37:151-9.

Wu G, Guo Z, Chang X et al. LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer. Cancer Res 2007; 67:4123-9.

Wu H, Yu W, Huang L et al. Effect of sodium ozagrel on the activity of rat CYP2D6. Eur J Pharmacol 2007; 573:55-9.

Wu HM, Yang YM, Kim SG. Rimonabant, a CB1 inverse agonist, inhibits hepatocyte lipogenesis by activating LKB1 and AMPK axis Downstream of G{alpha}i/o inhibition. Mol Pharmacol 2011; 80:859-69.

Wu HT, Zhang XD, Su H, Jiang Y, Zhou S, Sun XC. Association of apolipoprotein E polymorphisms with cerebral vasospasm after spontaneous subarachnoid hemorrhage. Acta Neurochir Suppl 2011; 110:141-4.

Wu IC, Zhao Y, Zhai R et al. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Neoplasia 2011; 13:386-92.

Wu JH, Hodgson JM, Clarke MW et al. Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: in vitro and human studies. Hypertension 2009; 54:1151-8.

Wu JQ, Zhu LP, Ou XT, Xu B, Zhang QQ, Weng XH. The polymorphism of cytochrome P(450) 2C19 gene in patients with invasive fungal infections. Zhonghua Nei Ke Za Zhi 2010; 49:138-41.

Wu JY, Yue J, Feng YQ. Determination of brain cytochrome P450 2E1 activity in rat with the probe of chlorzoxazone by liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2011; 879:260-6.

Wu KL, Tu B, Li YQ, Wong CS. Role of intercellular adhesion molecule-1 in radiation-induced brain injury. Int J Radiat Oncol Biol Phys 2010; 76:220-8.

Wu L, Williams PM, Koch WH. Clinical applications of microarray-based diagnostic tests. Biotechniques 2005; 39:577-82.

Wu LM, Xie HY, Zhou L, Yang Z, Zhang F, Zheng SS. A single nucleotide polymorphism in the vascular endothelial growth factor gene is associated with recurrence of hepatocellular carcinoma after transplantation. Arch Med Res 2009; 40:565-70.

Wu MH, Chen P, Wu X et al. Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene. Pharmacogenetics 2004; 14:595-605.

Wu MT, Tzang BS, Chang YY et al. Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol. J Agric Food Chem 2011; 59:4248-54.

Wu N, Wu XW, Agama K et al. A novel DNA topoisomerase I inhibitor with different mechanism from camptothecin induces G2/M phase cell cycle arrest to K562 cells. Biochemistry 2010; 49:10131-6.

Wu RM, Cheng CW, Chen KH et al. The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese. Neurology 2001; 56:375-82.

Wu S, Xing Q, Gao R et al. Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. Neurosci Lett 2005; 376:1-4.

Wu SN, Gao R, Xing QH et al. Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. Acta Pharmacol Sin 2006; 27:966-70.

Wu SN, Zhang Y, Gardner CO et al. Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension. Ann Hum Genet 2007; 71:519-25.

Wu WH, Huo SJ, Cheng CY, Hong CJ, Tsai SJ. Association study of the 5-HT(6) receptor polymorphism (C267T) and symptomatology and antidepressant response in major depressive disorders. Neuropsychobiology 2001; 44:172-5.

Wu WN, McKown LA, Reitz AB. Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism. Eur J Drug Metab Pharmacokinet 2006; 31:277-83.

Wu X, Hawse JR, Subramaniam M, Goetz MP, Ingle JN, Spelsberg TC. The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res 2009; 69:1722-7.

Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005; 61:567-72.

Wu Y, Arai AC, Rumbaugh G et al. Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans. Proc Natl Acad Sci USA 2007; 104:18163-8.

Wu Y, Liu B, Lin W et al. HPV16 E6 variants and HLA class II polymorphism among Chinese women with cervical cancer. J Med Virol 2007; 79:439-46.

Wu Y, Luo Y. Transgenic C. elegans as a model in Alzheimer’s research. Curr Alzheimer Res 2005; 2:37-45.

Wu YG, Bennett J, Talla D, Stocco C. Testosterone, not 5α-dihydrotestosterone, stimulates LRH-1 leading to FSH-independent expression of Cyp19 and P450scc in granulosa cells. Mol Endocrinol 2011; 25:656-68.

Wu YJ, Davis CD, Dworetzky S et al. Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition. J Med Chem 2003; 46:3778-81.

Wu YT, Kao YL, Lin LC, Tsai TH. Effects of a P-glycoprotein modulator on the pharmacokinetics and distribution of free levobupivacaine and bupivacaine in rats. Int J Pharm 2010; 396:127-33.

Wu YT, Lin CW, Lin LC, Chiu AW, Chen KK, Tsai TH. Analysis of biliary excretion of icariin in rats. J Agric Food Chem 2010; 58:9905-11.

Wu Z, Boss O. Targeting PGC-1 alpha to control energy homeostasis. Expert Opin Ther Targets 2007; 11:1329-38.

Wu Z, Maric C, Roesch DM, Zheng W, Verbalis JG, Sandberg K. Estrogen regulates adrenal angiotensin AT1 receptors by modulating AT1 receptor translation. Endocrinology 2003; 144:3251-61.

Wu ZL, Huang SL, Ou-Yang DS, Xu ZH, Xie HG, Zhou HH. Clomipramine N-demethylation metabolism in human liver microsomes. Zhongguo Yao Li Xue Bao 1998; 19:433-6.

Wulff M, Högberg U, Sandström A. Cancer incidence for children born in a smelting community. Acta Oncol 1996; 35:179-83.

Wunsch A, Sonntag B, Simoni M. Polymorphism of the FSH receptor and ovarian response to FSH. Ann Endocrinol 2007; 68:160-6.

Wurm M, Woess C, Libiseller K, Beer B, Pavlic M. Challenging small human hepatocytes with opiates: further characterization of a novel prototype BAL. Tissue Eng Part A 2010; 16:807-13.

Wustrow DJ, Maynard GD, Yuan J et al. Aminopyrazine CB1 receptor inverse agonists. Bioorg Med Chem Lett 2008; 18:3376-81.

Wuttke H, Rau T, Heide R et al. Increased frequency of cytochrome P450 2D6 poor metabolizers among patients with metoprolol-associated adverse effects. Clin Pharmacol Ther 2002; 72:429-37.

Wyen C, Fuhr U, Frank D et al. Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients. Clin Pharmacol Ther 2008; 84:75-82.

Wyen C, Hendra H, Siccardi M et al. Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens. J Antimicrob Chemother 2011; 66:2092-8.

Wyllie JH. Histamine H2-receptor antagonist in treatment of peptic ulcer. Postgrad Med 1978; 63:91-6, 100.

Wynalda MA, Hauer MJ, Wienkers LC. Human biotransformation of bropirimine. Characterization of the major bropirimine oxidative metabolites formed in vitro. Drug Metab Dispos 1998; 26:1048-51.

Wynalda MA, Hauer MJ, Wienkers LC. Oxidation of the novel oxazolidinone antibiotic linezolid in human liver microsomes. Drug Metab Dispos 2000; 28:1014-7.

Wynalda MA, Hutzler JM, Koets MD, Podoll T, Wienkers LC. In vitro metabolism of clindamycin in human liver and intestinal microsomes. Drug Metab Dispos 2003; 31:878-87.

Wynalda MA, Wienkers LC. Assessment of potential interactions between dopamine receptor agonists and various human cytochrome P450 enzymes using a simple in vitro inhibition screen. Drug Metab Dispos 1997; 25:1211-4.

Wynne HA, Long A, Nicholson E, Ward A, Keir D. Are altered pharmacokinetics of non-steroidal anti-inflammatory drugs (NSAIDs) a risk factor for gastrointestinal bleeding? Br J Clin Pharmacol 1998; 45:405-8.

Wyska E. Pharmacokinetic interaction between verapamil and methylxanthine derivatives in mice. Drug Metab Lett 2010; 4:15-24.

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