General References

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Caballero F, Fernández A, de Lacy AM, Fernández-Checa JC, Caballería J, García-Ruiz C. Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. J Hepatol 2009; 50:789-96.

Cabaret O, Puel O, Botterel F et al. Metabolic detoxication pathways for sterigmatocystin in primary tracheal epithelial cells. Chem Res Toxicol 2010; 23:1673-81.

Cable EE, Finn PD, Stebbins JW et al. Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist. Hepatology 2009; 49:407-17.

Caboni P, Sammelson RE, Casida JE. Phenylpyrazole insecticide photochemistry, metabolism, and GABAergic action: ethiprole compared with fipronil. J Agric Food Chem 2003; 51:7055-61.

Cabrera SE, Santos D, Valverde MP et al. Influence of the cytochrome P450 2B6 genotype on population pharmacokinetics of efavirenz in human immunodeficiency virus patients. Antimicrob Agents Chemother 2009; 53:2791-8.

Cacabelos R. Dementia. In: Jobe TH, Gaviria M, Kovilparambil A (Eds). Clinical Neuropsychiatry. Blackwell Science, Massachussetts, 1997:73-122.

Cacabelos R. Neurogeriatrics Handbook. Alzheimer’s disease and other dementias. Epidemiology and Genetics. Masson, Barcelona, 1999.

Cacabelos R. Psychogeriatric research. A conceptual introduction to geriatric neuroscience. Psychogeriatrics 2001; 1:158-88.

Cacabelos R. Pharmacogenomics in Alzheimer’s disease. Mini Rev Med Chem 2002; 2:59-84.

Cacabelos R. Pharmacogenomics for the treatment of dementia. Ann Med 2002; 34:357-79.

Cacabelos R. The application of functional genomics to Alzheimer’s disease. Pharmacogenomics 2003; 4:597-621.

Cacabelos R. Genomic characterization of Alzheimer’s disease and genotype-related phenotypic analysis of biological markers in dementia. Pharmacogenomics 2004; 5:1049-105.

Cacabelos R. Pharmacogenomics, nutrigenomics and therapeutic optimization in Alzheimer’s disease. Aging Health 2005; 1:303-48.

Cacabelos R. Pharmacogenomics and therapeutic prospects in Alzheimer’s disease. Exp Opin Pharmacother 2005; 6:1967-87.

Cacabelos R. Molecular genetics of Alzheimer’s disease and aging. Methods Find Exper Clin Pharmacol 2005; 27 Suppl A:1-573.

Cacabelos R. Donepezil in Alzheimer’s disease: From conventional trials to pharmacogenetics. Neuropsychiat Dis Treat 2007; 3:303-33.

Cacabelos R. Pharmacogenetic basis for therapeutic optimization in Alzheimer’s disease. Mol Diagn Ther 2007; 11:385-405.

Cacabelos R. Molecular pathology and pharmacogenomics in Alzheimer’s disease: polygenic-related effects of multifactorial treatments on cognition, anxiety, and depression. Methods Find Exper Clin Pharmacol 2007; 29(Suppl B):1-91.

Cacabelos R. Pharmacogenomics in Alzheimer’s disease. Methods Mol Biol 2008; 448:213-357.

Cacabelos R. Pharmacogenomics and therapeutic prospect in dementia. Eur Arch Psychiatry Clin Neurosci 2008; 258 Suppl 1:28-47.

Cacabelos R. Pharmacogenomics and therapeutic strategies for dementia. Expert Rev Mol Diagn 2009; 9:567-611.

Cacabelos R, Álvarez A, Fernández-Novoa L, Lombardi VRM. A pharmacogenomic approach to Alzheimer’s disease. Acta Neurol Scand Suppl 2000; 176:12-9.

Cacabelos R, Álvarez XA, Franco-Maside A, Fernández-Novoa L, Caamaño J. Effect of CDP-choline on cognition and immune function in Alzheimer’s disease and multi-infarct dementia. Ann N Y Acad Sci 1993; 695:321-3.

Cacabelos R, Álvarez XA, Lombardi V et al. Pharmacological treatment of Alzheimer disease: From phychotropic drugs and cholinesterase inhibitors to pharmacogenomics. Drugs Today 2000; 36:415-99.

Cacabelos R, Corzo L, Fernández-Novoa L, Lombardi V. Histamine in Alzheimer’s disease pathogenesis: Biochemistry and functional genomics. Methods Find Exper Clin Pharmacol 2004; 26(Suppl 2):9-16.

Cacabelos R, Fernández-Novoa L, Álvarez A et al. Cholinesterase inhibitors in dementia. Tem years of Donepezil in Alzheimer’s disease and CNS disorders (1996-2006): Therapeutic assessment and pharmacogenetics. Gen-T EuroEspes J 2007; (Suppl 1):1-52.

Cacabelos R, Fernández-Novoa L, Corzo L et al. Phenotypic profiles and functional genomics in Alzheimer’s disease and in dementia with a vascular component. Neurol Res 2004; 26:459-80.

Cacabelos R, Fernández-Novoa L, Corzo L et al. Phenotypic profiles and functional genomics in dementia with a vascular component. Neurol Res 2004; 26:459-80.

Cacabelos R, Fernández-Novoa L, Corzo L, Pichel V, Lombardi V, Kubota Y. Genomics and phenotypic profiles in dementia: implications for pharmacological treatment. Methods Find Exp Clin Pharmacol 2004; 26:421-44.

Cacabelos R, Fernández-Novoa L, Kubota Y, Lombardi V, Takeda M. Molecular genetics of Alzheimer’s disease and aging. Methods Find Exp Clin Pharmacol 2005; 27:1-573.

Cacabelos R, Fernández-Novoa L, Lombardi V, Corzo L, Pichel V, Kubota Y. Cerebrovascular risk factors in Alzheimer’s disease: Brain hemodynamics and pharmacogenomic implications. Neurol Res 2003; 25:567-80.

Cacabelos R, Fernández-Novoa L, Lombardi V, Kubota Y, Takeda M. Molecular genetics of Alzheimer’s disease and aging. Methods Find Exp Clin Pharmacol 2005; 27 Suppl A:1-573.

Cacabelos R, Fernández-Novoa L, Pichel V, Lombardi V, Kubota Y, Takeda M. Pharmacogenomic studies with a combination therapy in Alzheimer’s disease. In: Cacabelos R, Tanaka T, Takeda M (Eds). Molecular neurobiology of Alzheimer´s disease and related disorders. Basel, Karger, 2004:94-107.

Cacabelos R, Hashimoto R, Takeda M. Pharmacogenomics of antipsychotics efficacy for schizophrenia. Psychiatry Clin Neurosci 2011; 65:3-19.

Cacabelos R, Lombardi V, Fernández-Novoa L et al. A functional genomics approach to the analysis of biological markers in Alzheimer disease. In: Cacabelos R, Tanaka T, Takeda M (Eds). Molecular neurobiology of Alzheimer´s disease and related disorders. Basel, Karger, 2004:236-85.

Cacabelos R, Llovo R, Fraile C, Fernández-Novoa L. Pharmacogenetic aspects of therapy with cholinesterase inhibitors: the role of CYP2D6 in Alzheimer’s disease pharmacogenetics. Curr Alzheimer Res 2007; 4:479-500.

Cacabelos R, Martínez-Bouza R. Genomics and pharmacogenomics of schizophrenia. CNS Neurosci Ther 2011; 17:541-65.

Cacabelos R, Martínez-Bouza R. Genomics and pharmacogenomics of dementia. CNS Neurosci Ther 2011; 17:566-76.

Cacabelos R, Rodríguez B, Carrera C et al. APOE-Related frequency of cognitive and noncognitive symptoms in dementia. Methods Find Exp Clin Pharmacol 1996; 18:693-706.

Cacabelos R, Takeda M. Pharmacogenomics, nutrigenomics and future therapeutics in Alzheimer’s disease. Drugs Future 2006; 31(Suppl B):5-146.

Caccia S. Biotransformation of post-clozapine antipsychotics: pharmacological implications. Clin Pharmacokinet 2000; 38:393-414.

Caccia S. New antipsychotic agents for schizophrenia: pharmacokinetics and metabolism update. Curr Opin Investig Drugs 2002; 3:1073-80.

Caccia S. Metabolism of the newest antidepressants: comparisons with related predecessors. IDrugs 2004; 7:143-50.

Caccia S. N-dealkylation of arylpiperazine derivatives: disposition and metabolism of the 1-aryl-piperazines formed. Curr Drug Metab 2007; 8:612-22.

Caglayan AO, Dundar M, Tanriverdi F et al. Idiopathic hirsutism: local and peripheral expression of aromatase (CYP19A) and 5α-reductase genes (SRD5A1 and SRD5A2). Fertil Steril 2011; 96:479-82.

Cai J, Zhao Y, Liu Y et al. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology 2007; 45:1229-39.

Cai P, Tsao R, Ruppen ME. In vitro metabolic study of temsirolimus: preparation, isolation, and identification of the metabolites. Drug Metab Dispos 2007; 35:1554-63.

Cai SY, He H, Nguyen T, Mennone A, Boyer JL. Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms. J Lipid Res 2010; 51:2265-74.

Cai T, Dufour JF, Muellhaupt B et al. Viral genotype-specific role of PNPLA3, PPARG, MTTP and IL28B in Hepatitis C virus-associated steatosis. J Hepatol 2011; 55:529-35.

Cai WM, Chen B, Cai MH, Zhang YD. CYP2D6 phenotype determines pharmacokinetic variability of propafenone enantiomers in 16 HAN Chinese subjects. Zhongguo Yao Li Xue Bao 1999; 20:720-4.

Cai WM, Chen B, Zhang WX. Frequency of CYP2D6*10 and *14 alleles and their influence on the metabolic activity of CYP2D6 in a healthy Chinese population. Clin Pharmacol Ther 2007; 81:95-8.

Cai WM, Chen B, Zhou Y, Zhang YD. Fluoxetine impairs the CYP2D6-mediated metabolism of propafenone enantiomers in healthy Chinese volunteers. Clin Pharmacol Ther 1999; 66:516-21.

Cai WM, Nikoloff DM, Pan RM et al. CYP2D6 genetic variation in healthy adults and psychiatric African-American subjects: implications for clinical practice and genetic testing. Pharmacogenomics J 2006; 6:343-50.

Cai X, Wang RW, Edom RW et al. Validation of (-)-N-3-benzyl-phenobarbital as a selective inhibitor of CYP2C19 in human liver microsomes. Drug Metab Dispos 2004; 32:584-6.

Cai Y, Shen XZ, Zhou CH, Wang JY. Abnormal expression of Smurf2 during the process of rat liver fibrosis. Chin J Dig Dis 2006; 7:237-45.

Caillier B, Lépine J, Tojcic J et al. A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3. Pharmacogenet Genomics 2007; 17:481-95.

Cain JW, Hauptschein RS, Stewart JK, Bagci T, Sahagian GG, Jay DG. Identification of CD44 as a surface biomarker for drug resistance by surface proteome signature technology. Mol Cancer Res 2011; 9:637-47.

Cairns W, Smith CA, McLaren AW, Wolf CR. Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family. J Biol Chem 1996; 271:25269-76.

Calabresi L, Nilsson P, Pinotti E et al. A novel homozygous mutation in CETP gene as a cause of CETP deficiency in a Caucasian kindred. Atherosclerosis 2009; 205:506-11.

Calabresi L, Pazzucconi F, Ferrara S, Di Paolo A, Tacca MD, Sirtori C. Pharmacokinetic interactions between omeprazole/pantoprazole and clarithromycin in health volunteers. Pharmacol Res 2004; 49:493-9.

Calaf GM, Emenaker NJ, Hei TK. Effect of retinol on radiation- and estrogen-induced neoplastic transformation of human breast epithelial cells. Oncol Rep 2005; 13:1017-27.

Calarge CA, Ellingrod VL, Acion L et al. Variants of the dopamine D2 receptor gene and risperidone-induced hyperprolactinemia in children and adolescents. Pharmacogenet Genomics 2009; 19:373-82.

Calarge CA, Miller del D. Predictors of risperidone and 9-hydroxyrisperidone serum concentration in children and adolescents. J Child Adolesc Psychopharmacol 2011; 21:163-9.

Calayir E, Becker TM, Kratzer A et al. LXR-agonists regulate ApoM expression differentially in liver and intestine. Curr Pharm Biotechnol 2008; 9:516-21.

Calcagno AM, Fostel JM, To KK et al. Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes. Br J Cancer 2008; 98:1515-24.

Caldas C, Hahn SA, da Costa LT et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 1994; 8:27-32.

Caldas YA, Giral H, Cortázar MA et al. Liver X receptor-activating ligands modulate renal and intestinal sodium-phosphate transporters. Kidney Int 2011; 80:535-44.

Caldwell MD, Awad T, Johnson JA et al. CYP4F2 genetic variant alters required warfarin dose. Blood 2008; 111:4106-12.

Caley CF, Cooper CK. Ziprasidone: the fifth atypical antipsychotic. Ann Pharmacother 2002; 36:839-51.

Calhoun ME, Wiederhold KH, Abramowski D et al. Neuron loss in APP transgenic mice. Nature 1998; 395:755-6.

Cali JJ, Hsieh CL, Francke U, Russell DW. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. J Biol Chem 1991; 266:7779-83.

Calissano P, Matrone C, Amadoro G. Apoptosis and in vitro Alzheimer disease neuronal models. Commun Integr Biol 2009; 2:163-9.

Calixto LA, de Oliveira AR, Jabor VA, Bonato PS. In vitro characterization of rosiglitazone metabolites and determination of the kinetic parameters employing rat liver microsomal fraction. Eur J Drug Metab Pharmacokinet 2011; 36:159-66.

Callaghan JT, Bergstrom RF, Ptak LR, Beasley CM. Olanzapine. Pharmacokinetic and pharmacodynamic profile. Clin Pharmacokinet 1999; 37:177-93.

Callaghan JT, Cerimele BJ, Kassahun KJ et al. Olanzapine: interaction study with imipramine. J Clin Pharmacol 1997; 37:971-8.

Callahan SM, Wonganan P, Croyle MA. Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infection. Virol J 2008; 5:111.

Callard GV, Tarrant AM, Novillo A et al. Evolutionary origins of the estrogen signaling system: Insights from amphioxus. J Steroid Biochem Mol Biol 2011. doi:10. 1016/j. jsbmb. 2011. 03. 022.

Callegari E, Malhotra B, Bungay PJ et al. A comprehensive nonclinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder. Br J Clin Pharmacol 2011; 72:235-46.

Camargo SM, Singer D, Makrides V et al. Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations. Gastroenterology 2009; 136:872-82.

Camci L, Kilic Z, Dinleyici EC, Muslumanoglu H, Tepeli E, Ucar B. Angiotensin-converting enzyme gene insertion/deletion polymorphism frequency in normotensive children with a positive family history of essential hypertension. J Paediatr Child Health 2009; 45:742-6.

Camenzind RS, Chip S, Gutmann H, Kapfhammer JP, Nitsch C, Bendfeldt K. Preservation of transendothelial glucose transporter 1 and P-glycoprotein transporters in a cortical slice culture model of the blood-brain barrier. Neuroscience 2010; 170:361-71.

Cameron MD, Wen B, Allen KE et al. Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study. Biochemistry 2005; 44:14143-51.

Cameron MD, Wen B, Roberts AG, Atkins WM, Campbell AP, Nelson SD. Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site. Chem Res Toxicol 2007; 20:1434-41.

Cameron MD, Wright J, Black CB, Ye N. In vitro prediction and in vivo verification of enantioselective human tofisopam metabolite profiles. Drug Metab Dispos 2007; 35:1894-902.

Camidge DR, Pemberton M, Growcott J et al. A phase I pharmacodynamic study of the effects of the cyclin-dependent kinase-inhibitor AZD5438 on cell cycle markers within the buccal mucosa, plucked scalp hairs and peripheral blood mononucleocytes of healthy male volunteers. Cancer Chemother Pharmacol 2007; 60:479-88.

Camilleri M, Busciglio I, Carlson P et al. Pharmacogenetics of low dose clonidine in irritable bowel syndrome. Neurogastroenterol Motil 2009; 21:399-410.

Campa D, Zienolddiny S, Maggini V, Skaug V, Haugen A, Canzian F. Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. Carcinogenesis 2004; 25:229-35.

Campalani E, Allen MH, Fairhurst D et al. Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. Br J Dermatol 2006; 154:345-52.

Campayo M, Viñolas N, Navarro A et al. Single nucleotide polymorphisms in tobacco metabolism and DNA repair genes and prognosis in resected non-small-cell lung cancer. J Surg Res 2011; 167:5-12.

Campbell CM, Edwards RR, Carmona C et al. Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain. Pain 2009; 141:114-8.

Campbell CY, Fang BF, Guo X et al. Associations between genetic variants in the ACE, AGT, AGTR1 and AGTR2 genes and renal function in the multi-ethnic study of atherosclerosis. Am J Nephrol 2010; 32:156-62.

Campbell DB, Ebert PJ, Skelly T et al. Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia. Biol Psychiatry 2008; 63:32-41.

Campbell DB, Sutcliffe JS, Ebert PJ et al. A genetic variant that disrupts MET transcription is associated with autism. Proc Natl Acad Sci USA 2006; 103:16834-9.

Campbell DJ, Woodward M, Chalmers JP et al. Soluble vascular cell adhesion molecule 1 and N-terminal pro-B-type natriuretic peptide in predicting ischemic stroke in patients with cerebrovascular disease. Arch Neurol 2006; 63:60-5.

Campbell IG, Russell SE, Choong DY et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 2004; 64:7678-81.

Campbell MC, Tishkoff SA. African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu Rev Genomics Hum Genet 2008; 9:403-33.

Campbell TA, Palmer MS, Will RG, Gibb WRG, Luther PJ, Collinge J. A prion disease with a novel 96-base pair insertional mutations in the prion protein gene. Neurology 1996; 46:761-6.

Campia U, Cardillo C, Panza JA. Ethnic differences in the vasoconstrictor activity of endogenous endothelin-1 in hypertensive patients. Circulation 2004; 109:3191-5.

Campo G, Miccoli M, Tebaldi M et al. Genetic determinants of on-clopidogrel high platelet reactivity. Platelets 2011; 22:399-407.

Campos SB, Miranda DM, Souza BR et al. Association study of tryptophan hydroxylase 2 gene polymorphisms in bipolar disorder patients with panic disorder comorbidity. Psychiatr Genet 2011; 21:106-11.

Canaparo R, Finnström N, Serpe L et al. Expression of CYP3A isoforms and P-glycoprotein in human stomach, jejunum and ileum. Clin Exp Pharmacol Physiol 2007; 34:1138-44.

Canaparo R, Nordmark A, Finnström N et al. Expression of cytochromes P450 3A and P-glycoprotein in human large intestine in paired tumour and normal samples. Basic Clin Pharmacol Toxicol 2007; 100:240-8.

Candela P, Gosselet F, Saint-Pol J et al. Apical-to-basolateral transport of amyloid-β peptides through blood-brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein. J Alzheimers Dis 2010; 22:849-59.

Candeliere GA, Glorieux FH, Prud’homme J, St-Arnaud R. Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia. N Engl J Med 1995; 332:1546-51.

Candide C, Morlière P, Mazière JC et al. In vitro interaction of the photoactive anticancer porphyrin derivative photofrin II with low density lipoprotein, and its delivery to cultured human fibroblasts. FEBS Lett 1986; 207:133-8.

Candiloro IL, Dobrovic A. Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism. Cancer Prev Res 2009; 2:862-7.

Candini C, Schimmel AW, Peter J et al. Identification and characterization of novel loss of function mutations in ATP-binding cassette transporter A1 in patients with low plasma high-density lipoprotein cholesterol. Atherosclerosis 2010; 213:492-8.

Candiotti KA, Yang Z, Rodriguez Y et al. The impact of CYP2D6 genetic polymorphisms on postoperative morphine consumption. Pain Med 2009; 10:799-805.

Candy G, Samani N, Norton G et al. Association analysis of beta2 adrenoceptor polymorphisms with hypertension in a Black African population. J Hypertens 2000; 18:167-72.

Cantarini L, Volpi N, Galeazzi M et al. Colchicine myopathy and neuromyopathy: two cases with different characteristics. J Clin Rheumatol 2010; 16:229-32.

Cantonwine D, Hu H, Téllez-Rojo MM et al. HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico. Environ Health 2010; 9:43.

Cantor KP, Villanueva CM, Silverman DT et al. Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain. Environ Health Perspect 2010; 118:1545-50.

Cantrell MA, Bream-Rouwenhorst HR, Hemerson P, Magera JS Jr. Silodosin for benign prostatic hyperplasia. Ann Pharmacother 2010; 44:302-10.

Canturk P, Caner V, Oruc N et al. The mRNA expression of cytochrome P450 isoforms in human gastric tissue. Hepatogastroenterology 2010; 57:372-6.

Canu B, Fioravanti A, Orlandi P et al. Irinotecan synergistically enhances the antiproliferative and proapoptotic effects of axitinib in vitro and improves its anticancer activity in vivo. Neoplasia 2011; 13:217-29.

Canu N, Possenti R, Ricco AS, Rocchi M, Levi A. Cloning, structural organization analysis, and chromosomal assignment of the human gene for the neurosecretory protein VGF. Genomics 1997; 45:443-6.

Canzian F, McKay JD, Cleveland RJ et al. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. Cancer Epidemiol Biomarkers Prev 2005; 14:2316-25.

Cañete JD, Suárez B, Hernández MV et al. Influence of variants of Fc gamma receptors IIA and IIIA on the American College of Rheumatology and European League Against Rheumatism responses to anti-tumour necrosis factor alpha therapy in rheumatoid arthritis. Ann Rheum Dis 2009; 68:1547-52.

Cao A, Galanello R. Beta-thalassemia. Genet Med 2010; 12:61-76.

Cao FF, Chen XD, Wang QS et al. Associations of the genetic polymorphisms in CYP11B2 gene with nonfamilial structural atrial fibrillation. Zhonghua Liu Xing Bing Xue Za Zhi 2009; 30:1069-72.

Cao H, Qiu C, Zhu P et al. The relationship between left ventricular hypervoltage and CYP11B2 (344T/C) polymorphism in Keriyans. J Renin Angiotensin Aldosterone Syst 2011; 12:375-9.

Cao J, Patisaul HB, Petersen SL. Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression. Mol Cell Endocrinol 2011; 333:151-9.

Cao J, Zhang L, Ye Q et al. YQ36: a novel bisindolylmaleimide analogue induces KB/VCR cell death. J Biomed Biotechnol 2009. doi:10. 1155/2009/535072.

Cao JX, Hu J, Ye XM et al. Association between the 5-HTR1B gene polymorphisms and alcohol dependence in a Han Chinese population. Brain Res 2011; 1376:1-9.

Cao W, Cao YJ, Hu ZY et al. Inhibition of 1,3,8-trihydroxy-5-methoxyxanthone on cytochrome P450s. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2006; 31:858-61.

Cao W, Strnatka D, McQueen CA, Hunter RJ, Erickson RP. N-acetyltransferase 2 activity and folate levels. Life Sci 2010; 86:103-6.

Cao X, Gibbs ST, Fang L et al. Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharm Res 2006; 23:1675-86.

Cao X, Sudhof TC. A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 2001; 293:115-20.

Cao XL, Yin RX, Wu DF et al. Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis 2011; 10:14.

Cao YF, Zhang YY, Li J et al. CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes. Xenobiotica 2010; 40:38-47.

Capeau J, Magré J, Caron-Debarle M et al. Human lipodystrophies: genetic and acquired diseases of adipose tissue. Endocr Dev 2010; 19:1-20.

Capeau J, Magré J, Lascols O et al. Diseases of adipose tissue: genetic and acquired lipodystrophies. Biochem Soc Trans 2005; 33:1073-7.

Capon F, Di Meglio P, Szaub J et al. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet 2007; 122:201-6.

Caporaso N, Gu F, Chatterjee N et al. Genome-wide and candidate gene association study of cigarette smoking behaviors. PLoS One 2009. doi:10. 1371/journal. pone. 0004653.

Capozzo MA, Schillani G, Aguglia E et al. Serotonin transporter 5-HTTLPR polymorphism and response to citalopram in terminally ill cancer patients: report of twenty-one cases. Tumori 2009; 95:479-83.

Caprioli J, Mele C, Mossali C et al. Polymorphisms of EDNRB, ATG, and ACE genes in salt-sensitive hypertension. Can J Physiol Pharmacol 2008; 86:505-10.

Capron A, Mourad M, de Meyer M et al. CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation. Pharmacogenomics 2010; 11:703-14.

Caputo M, Zirpoli H, Torino G, Tecce MF. Selective regulation of UGT1A1 and SREBP-1c mRNA expression by docosahexaenoic, eicosapentaenoic, and arachidonic acids. J Cell Physiol 2011; 226:187-93.

Caracciolo B, Bäckman L, Monastero R, Winblad B, Fratiglioni L. The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population. J Neurol Neurosurg Psychiatry 2011; 82:788-93.

Caraci F, Crupi R, Drago F, Spina E. Metabolic drug interactions between antidepressants and anticancer drugs: Focus on selective serotonin reuptake inhibitors and Hypericum extract. Curr Drug Metab 2011; 12:570-7.

Caraco Y. Genetic determinants of drug responsiveness and drug interactions. Ther Drug Monit 1998; 20:517-24.

Caraco Y, Lagerstrom PO, Wood AJ. Ethnic and genetic determinants of omeprazole disposition and effect. Clin Pharmacol Ther 1996; 60:157-67.

Caraco Y, Muszkat M, Wood AJ. Phenytoin metabolic ratio: a putative marker of CYP2C9 activity in vivo. Pharmacogenetics 2001; 11:587-96.

Caraco Y, Sheller J, Wood AJ. Pharmacogenetic determination of the effects of codeine and prediction of drug interactions. J Pharmacol Exp Ther 1996; 278:1165-74.

Caraco Y, Sheller J, Wood AJ. Pharmacogenetic determinants of codeine induction by rifampin: the impact on codeine’s respiratory, psychomotor and miotic effects. J Pharmacol Exp Ther 1997; 281:330-6.

Caraco Y, Sheller J, Wood AJ. Impact of ethnic origin and quinidine coadministration on codeine’s disposition and pharmacodynamic effects. J Pharmacol Exp Ther 1999; 290:413-22.

Caraco Y, Tateishi T, Guengerich FP, Wood AJ. Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity. Drug Metab Dispos 1996; 24:761-4.

Caraco Y, Wilkinson GR, Wood AJ. Differences between white subjects and Chinese subjects in the in vivo inhibition of cytochrome P450s 2C19, 2D6, and 3A by omeprazole. Clin Pharmacol Ther 1996; 60:396-404.

Carbonell N, Verstuyft C, Massard J et al. CYP2C9*3 loss-of-function allele is associated with acute upper gastrointestinal bleeding related to the use of NSAIDs other than aspirin. Clin Pharmacol Ther 2010; 87:693-8.

Carcaboso AM, Elmeliegy MA, Shen J et al. Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas. Cancer Res 2010; 70:4499-508.

Carcangiu V, Vacca GM, Mura MC et al. Relationship between MTNR1A melatonin receptor gene polymorphism and seasonal reproduction in different goat breeds. Anim Reprod Sci 2009; 110:71-8.

Cardona F, Guardiola M, Queipo-Ortuño MI, Murri M, Ribalta J, Tinahones FJ. The -1131T>C SNP of the APOA5 gene modulates response to fenofibrate treatment in patients with the metabolic syndrome: a postprandial study. Atherosclerosis 2009; 206:148-52.

Cardona Pera D. Drug-food interactions. Nutr Hosp 1999; 14 Suppl 2:129-40.

Cardoso CC, Pereira AC, Brito-de-Souza VN et al. IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians. Hum Genet 2010; 128:481-90.

Carew JA, Pollak ES, High KA, Bauer KA. Severe factor VII deficiency due to a mutation disrupting an Sp1 binding site in the factor VII promoter. Blood 1998; 92:1639-45.

Carew JA, Pollak ES, Lopaciuk S, Bauer KA. A new mutation in the HNF4 binding region of the factor VII promoter in a patient with severe factor VII deficiency. Blood 2000; 96:4370-2.

Carew MW, Leslie EM. Selenium-dependent and -independent transport of arsenic by the human multidrug resistance protein 2 (MRP2/ABCC2): implications for the mutual detoxification of arsenic and selenium. Carcinogenesis 2010; 31:1450-5.

Cariello L, de Cristofaro T, Zanetti L et al. Transglutaminase activity is related to CAG repeat lengh in patients with Huntington’s disease. Hum Genet 1996; 98:633-5.

Carletti E, Colletier JP, Dupeux F, Trovaslet M, Masson P, Nachon F. Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation. J Med Chem 2010; 53:4002-8.

Carlini LE, Meropol NJ, Bever J et al. UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin Cancer Res 2005; 11:1226-36.

Carlson CS, Aldred SF, Lee PK et al. Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am J Hum Genet 2005; 77:64-77.

Carlson RW, Theriault R, Schurman CM et al. Phase II trial of anastrozole plus goserelin in the treatment of hormone receptor-positive, metastatic carcinoma of the breast in premenopausal women. J Clin Oncol 2010; 28:3917-21.

Carlsson LE, Santoso S, Spitzer C, Kessler C, Greinacher A. The alpha2 gene coding sequence T807/A873 of the platelet collagen receptor integrin alpha2beta1 might be a genetic risk factor for the development of stroke in younger patients. Blood 1999; 93:3583-6.

Carmo H, Brulport M, Hermes M et al. Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine (‘Ecstasy’) cytotoxicity. Pharmacogenet Genomics 2006; 16:789-99.

Carmo H, Brulport M, Hermes M et al. CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA). Toxicology 2007; 229:236-44.

Carmona O, Masuet C, Alía P et al. Apolipoprotein alleles and the response to interferon-β-1b in multiple sclerosis. Eur Neurol 2011; 65:132-7.

Caro AA, Cederbaum AI. Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1. Mol Pharmacol 2001; 60:742-52.

Caro AA, Cederbaum AI. Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol 2005; 69:1081-93.

Caro AA, Thompson S, Tackett J. Increased oxidative stress and cytotoxicity by hydrogen sulfide in HepG2 cells overexpressing cytochrome P450 2E1. Cell Biol Toxicol 2011; 27:439-53.

Caron G, Ermondi G, Testa B. Predicting the oxidative metabolism of statins: an application of the MetaSite algorithm. Pharm Res 2007; 24:480-501.

Caronia D, Martin M, Sastre J et al. A polymorphism in the cytidine deaminase promoter predicts severe capecitabine-induced Hand-Foot syndrome. Clin Cancer Res 2011; 17:2006-13.

Caronia D, Patiño-García A, Milne RL et al. Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients. Pharmacogenomics J 2009; 9:347-53.

Carr B, Norcross R, Fang Y et al. Characterization of the rhesus monkey CYP3A64 enzyme: species comparisons of CYP3A substrate specificity and kinetics using baculovirus-expressed recombinant enzymes. Drug Metab Dispos 2006; 34:1703-12.

Carr BA, Ramakanth S, Dannan GA, Yost GS. Characterization of pulmonary CYP4B2, specific catalyst of methyl oxidation of 3-methylindole. Mol Pharmacol 2003; 63:1137-47.

Carr DF, la Porte CJ, Pirmohamed M, Owen A, Cortes CP. Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. J Antimicrob Chemother 2010; 65:1889-93.

Carr EJ, Niederer HA, Williams J et al. Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. BMC Med Genet 2009; 10:121.

Carr LG, Zeng D, Li TK. Failure to find exon 7 polymorphism of the ADH7 gene in Chinese, Japanese, African-Americans, and Caucasians. Alcohol Clin Exp Res 1996; 20:418-9.

Carr LGC, Foroud T, Stewart T, Castelluccio P, Edenberg HJ, Li TK. Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish population. Am J Med Genet 2002; 112:138-43.

Carrasco-Portugal Mdel C, Aguilar-Carrasco JC, Luján M, Reyes-García G, Medina-Santillán R, Flores-Murrieta FJ. Further evidence for interethnic differences in the oral pharmacokinetics of meloxicam. Clin Drug Investig 2005; 25:307-13.

Carrasco-Portugal Mdel C, Luján M, Flores-Murrieta FJ. Evaluation of gender in the oral pharmacokinetics of clindamycin in humans. Biopharm Drug Dispos 2008; 29:427-30.

Carrascosa A, Audí L, Esteban C et al. Growth hormone (GH) dose, but not exon 3-deleted/full-length GH receptor polymorphism genotypes, influences growth response to two-year GH Therapy in Short Small-for-Gestational-Age Children. J Clin Endocrinol Metab 2008; 93:147-53.

Carrasquillo MM, Belbin O, Hunter TA et al. Replication of BIN1 association with Alzheimer’s disease and evaluation of genetic interactions. J Alzheimers Dis 2011; 23:1-8.

Carreau S, Bois C, Zanatta L, Silva FR, Bouraima-Lelong H, Delalande C. Estrogen signaling in testicular cells. Life Sci 2011; 89:584-7.

Carregaro F, Carta A, Cordeiro JA, Lobo SM, Silva EH, Leopoldino AM. Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients. Mem Inst Oswaldo Cruz 2010; 105:649-56.

Carrier JS, Turgeon D, Journault K, Hum DW, Belanger A. Isolation and characterization of the human UGT2B7 gene. Biochem Biophys Res Commun 2000; 272:616-21.

Carrillo JA, Dahl ML, Svensson JO, Alm C, Rodríguez I, Bertilsson L. Disposition of fluvoxamine in humans is determined by the polymorphic CYP2D6 and also by the CYP1A2 activity. Clin Pharmacol Ther 1996; 60:183-90.

Carrillo JA, Herráiz AG, Ramos SI, Gervasini G, Vizcaíno S, Benítez J. Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine. J Clin Psychopharmacol 2003; 23:119-27.

Carrillo JA, Ramos SI, Herraiz AG et al. Pharmacokinetic interaction of fluvoxamine and thioridazine in schizophrenic patients. J Clin Psychopharmacol 1999; 19:494-9.

Carrington M, Kissner T, Gerrard B, Ivanov S, O’Brien SJ, Dean M. Novel alleles of the chemokine-receptor gene CCR5. Am J Hum Genet 1997; 61:1261-7.

Carrington M, Nelson GW, Martin MP et al. HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage. Science 1999; 283:1748-52.

Carrodeguas JA, Rodolosse A, Garza MV et al. The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing. Neuroscience 2005; 134:1285-300.

Carrol ED, Payton A, Payne D et al. The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1. J Immunol 2011; 186:2329-35.

Carroll CL, Stoltz P, Schramm CM, Zucker AR. Beta2-adrenergic receptor polymorphisms affect response to treatment in children with severe asthma exacerbations. Chest 2009; 135:1186-92.

Carrozzo R, Bellini C, Lucioli S et al. Peroxisomal acyl-CoA-oxidase deficiency: two new cases. Am J Med Genet A 2008; 146:1676-81.

Carstea ED, Morris JA, Coleman KG et al. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science 1997; 277:228-31.

Carta C, Pantaleoni F, Bocchinfuso G et al. Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. Am J Hum Genet 2006; 79:129-35.

Carter AM, Ossei-Gerning N, Wilson IJ, Grant PJ. Association of the platelet Pl(A) polymorphism of glycoprotein IIb/IIIa and the fibrinogen Bbeta 448 polymorphism with myocardial infarction and extent of coronary artery disease. Circulation 1997; 96:1424-31.

Carter CJ. Convergence of genes implicated in Alzheimer’s disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis. Neurochem Int 2007; 50:12-38.

Carter NJ, McCormack PL. Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS Drugs 2009; 23:523-41.

Cartron G, Dacheux L, Salles G et al. Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene. Blood 2002; 99:754-8.

Carvajal CA, Stehr CB, González PA et al. A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I. J Endocrinol Invest 2011; 34:140-4.

Carvalho RS, Friedrich K, de-Oliveira AC, Suarez-Kurtz G, Paumgartten FJ. Malaria downmodulates mRNA expression and catalytic activities of CYP1A2, 2E1 and 3A11 in mouse liver. Eur J Pharmacol 2009; 616:265-9.

Casabar RC, Das PC, Dekrey GK et al. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor. Toxicol Appl Pharmacol 2010; 245:335-43.

Casabar RC, Wallace AD, Hodgson E, Rose RL. Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4. Drug Metab Dispos 2006; 34:1779-85.

Casado M, Vallet VS, Kahn A, Vaulont S. Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver. J Biol Chem 1999; 274:2009-13.

Casarejos MJ, Solano RM, Menéndez J et al. Differential effects of l-DOPA on monoamine metabolism, cell survival and glutathione production in midbrain neuronal-enriched cultures from parkin knockout and wild-type mice. J Neurochem 2005; 94:1005-14.

Casari G, de Fusco M, Ciarmatori S et al. Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease. Cell 1998; 93:973-83.

Casas JP, Bautista LE, Humphries SE, Hingorani AD. Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Circulation 2004; 109:1359-65.

Casas JP, Hingorani AD, Bautista LE, Sharma P. Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18000 cases and 58000 controls. Arch Neurol 2004; 61:1652-62.

Cascorbi I. P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations. Handb Exp Pharmacol 2011:261-83.

Cascorbi I, Brockmöller J, Bauer S, Reum T, Roots I. NAT2*12A (803A→G) codes for rapid arylamine n-acetylation in humans. Pharmacogenetics 1996; 6:257-9.

Cascorbi I, Drakoulis N, Brockmöller J, Maurer A, Sperling K, Roots I. Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity. Am J Hum Genet 1995; 57:581-92.

Cascorbi I, Paul M, Kroemer HK. Pharmacogenomics of heart failure – focus on drug disposition and action. Cardiovasc Res 2004; 64:32-9.

Caselli RJ, Dueck AC, Locke DE et al. Cerebrovascular risk factors and preclinical memory decline in healthy APOE ε4 homozygotes. Neurology 2011; 76:1078-84.

Caselli RJ, Dueck AC, Locke DE et al. Longitudinal modeling of frontal cognition in APOE {varepsilon}4 homozygotes, heterozygotes, and noncarriers. Neurology 2011; 76:1383-8.

Cash HL, Tao L, Yuan JM et al. LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese. Int J Cancer 2011. doi:10. 1002/ijc. 26098.

Cashman JR, Zhang J. Human flavin-containing monooxygenases. Annu Rev Pharmacol Toxicol 2006; 46:65-100.

Caslake MJ, Stewart G, Day SP et al. Phenotype-dependent and -independent actions of rosuvastatin on atherogenic lipoprotein subfractions in hyperlipidaemia. Atherosclerosis 2003; 171:245-53.

Casp CB, She JX, McCormack WT. Genetic association of the catalase gene (CAT) with vitiligo susceptibility. Pigment Cell Res 2002; 15:62-6.

Caspi A, McClay J, Moffitt TE et al. Role of genotype in the cycle of violence in maltreated children. Science 2002; 297:851-4.

Cassio D, Macias RI, Grosse B, Marin JJ, Monte MJ. Expression, localization, and inducibility by bile acids of hepatobiliary transporters in the new polarized rat hepatic cell lines, Can 3-1 and Can 10. Cell Tissue Res 2007; 330:447-60.

Castano R, Bossé Y, Endam LM, Filali-Mouhim A, Desrosiers M. c-MET pathway involvement in chronic rhinosinusitis: a genetic association analysis. Otolaryngol Head Neck Surg 2010; 142:665-71.

Castberg I, Helle J, Aamo TO. Prolonged pharmacokinetic drug interaction between terbinafine and amitriptyline. Ther Drug Monit 2005; 27:680-2.

Castberg I, Spigset O. Effects of comedication on the serum levels of aripiprazole: evidence from a routine therapeutic drug monitoring service. Pharmacopsychiatry 2007; 40:107-10.

Castell JV, Donato MT, Gómez-Lechón MJ. Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach. Exp Toxicol Pathol 2005; 57 Suppl 1:189-204.

Castellano JM, Kim J, Stewart FR et al. Human apoE Isoforms Differentially Regulate Brain Amyloid-{beta} Peptide Clearance. Sci Transl Med 2011; 3:89ra57.

Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS. Prostaglandin E2 promotes colon cancer cell growth through a GS-axin-beta-catenin signaling axis. Science 2005; 310:1504-10.

Castellucci L, Jamieson SE, Miller EN et al. CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study. BMC Med Genet 2010; 11:10.

Castilla LH, Couch FJ, Erdos MR et al. Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer. Nat Genet 1994; 8:387-91.

Castrioto A, Tambasco N, Rossi A, Calabresi P. Acute dystonia induced by the combination of midodrine and perphenazine. J Neurol 2008; 255:767-8.

Castro J, Ribó M, Puig T, Colomer R, Vilanova M, Benito A. A cytotoxic ribonuclease reduces the expression level of P-glycoprotein in multidrug-resistant cell lines. Invest New Drugs 2011. doi:10. 1007/s10637-011-9636-2.

Castro R, Rivera I, Ravasco P et al. 5,10-Methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation. J Med Genet 2004; 41:454-8.

Catalano A, Procopio A. New aspects on the role of lipoxygenases in cancer progression. Histol Histopathol 2005; 20:969-75.

Catalano S, Malivindi R, Giordano C et al. Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells. J Biol Chem 2010; 285:5581-93.

Catano G, Kulkarni H, He W et al. HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles. PLoS One 2008. doi:10. 1371/journal. pone. 0003636.

Catapano AL. Pitavastatin-pharmacological profile from early phase studies. Atheroscler Suppl 2010; 11:3-7.

Cater MA, McInnes KT, Li QX et al. Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms. Biochem J 2008; 412:141-52.

Cattaneo A, Bocchio-Chiavetto L, Zanardini R, Milanesi E, Placentino A, Gennarelli M. Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment. Int J Neuropsychopharmacol 2010; 13:103-8.

Cattaneo M, Zighetti ML, Lombardi R et al. Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding. Proc Nat Acad Sci USA 2003; 100:1978-83.

Catteau-Jonard S, Dewailly D. Anti-Mullerian hormone and polycystic ovary syndrome. Gynecol Obstet Fertil 2011; 39:514-7.

Cattelotte J, Tournier N, Rizzo-Padoin N, Schinkel AH, Scherrmann JM, Cisternino S. Changes in dipole membrane potential at the mouse blood-brain barrier enhance the transport of 99mTechnetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2. J Neurochem 2009; 108:767-75.

Caulfield M, Lavender P, Farrall M et al. Linkage of the angiotensinogen gene to essential hypertension. New Eng J Med 1994; 330:1629-33.

Cavaco I, Gil JP, Gil-Berglund E, Ribeiro V. CYP3A4 and MDR1 alleles in a Portuguese population. Clin Chem Lab Med 2003; 41:1345-50.

Cavaco I, Reis R, Gil JP, Ribeiro V. CYP3A4*1B and NAT2*14 alleles in a native African population. Clin Chem Lab Med 2003; 41:606-9.

Cavaliere C, Corvigno S, Galgani M, Limite G, Nardone A, Veneziani BM. Combined inhibitory effect of formestane and herceptin on a subpopulation of CD44+/CD24low breast cancer cells. Cancer Sci 2010; 101:1661-9.

Cavallari LH, Limdi NA. Warfarin pharmacogenomics. Curr Opin Mol Ther 2009; 11:243-51.

Cavallari U, Trabetti E, Malerba G et al. Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease. BMC Med Genet 2007; 8:59.

Cavanillas ML, Alcina A, Núñez C et al. Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk. Eur J Hum Genet 2010; 18:794-9.

Cazali N, Tran A, Treluyer JM et al. Inhibitory effect of stiripentol on carbamazepine and saquinavir metabolism in human. Br J Clin Pharmacol 2003; 56:526-36.

Cecchin E, Agostini M, Pucciarelli S et al. Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy. Pharmacogenomics J 2011; 11:214-26.

Cecchin E, Innocenti F, D’Andrea M et al. Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. J Clin Oncol 2009; 27:2457-65.

Cecil JE, Palmer CN, Fischer B et al. Variants of the peroxisome proliferator-activated receptor gamma- and beta-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children. Am J Clin Nutr 2007; 86:167-73.

Ceckova M, Vackova Z, Radilova H, Libra A, Buncek M, Staud F. Effect of ABCG2 on cytotoxicity of platinum drugs: interference of EGFP. Toxicol In Vitro 2008; 22:1846-52.

Cederbaum A. Nrf2 and antioxidant defense against CYP2E1 toxicity. Expert Opin Drug Metab Toxicol 2009; 5:1223-44.

Cederbaum AI. Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells. J Gastroenterol Hepatol 2006; 21 Suppl 3:22-5.

Cederbaum AI. Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury. World J Gastroenterol 2010; 16:1366-76.

Cejas P, López-Gómez M, Aguayo C et al. KRAS mutations in primary colorectal cancer tumors and related metastases: a potential role in prediction of lung metastasis. PLoS One 2009. doi:10. 1371/journal. pone. 0008199.

Celhay O, Yacoub M, Irani J, Dore B, Cussenot O, Fromont G. Expression of estrogen related proteins in hormone refractory prostate cancer: association with tumor progression. J Urol 2010; 184:2172-8.

Celius T, Matthews J. Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines. Toxicology 2010; 277:59-65.

Celius T, Roblin S, Harper PA et al. Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver. Drug Metab Dispos 2008; 36:2499-505.

Cen J, Qi Y, Tao YF et al. HZ08, a great regulator to reverse multidrug resistance via cycle arrest and apoptosis sensitization in MCF-7/ADM. Eur J Pharmacol 2010; 647:21-30.

Cenarro A, Artieda M, Castillo S et al. A common variant in the ABCA1 gene is associated with a lower risk for premature coronary heart disease in familial hypercholesterolaemia. J Med Genet 2003; 40:163-8.

Cénit MC, Alcina A, Márquez A et al. STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility. Genes Immun 2010; 11:264-8.

Ceppa F, Fontan E, Cremades S et al. Role of pharmacogenetics in chemotherapy of colorectal cancers. Rev Med Interne 2007; 28:594-602.

Cerda A, Genvigir FD, Arazi SS et al. Influence of SCARB1 polymorphisms on serum lipids of hypercholesterolemic individuals treated with atorvastatin. Clin Chim Acta 2010; 411:631-7.

Cerf E, Gustot A, Goormaghtigh E, Ruysschaert JM, Raussens V. High ability of apolipoprotein E4 to stabilize amyloid-{beta} peptide oligomers, the pathological entities responsible for Alzheimer’s disease. FASEB J 2011; 25:1585-95.

Cermanova J, Fuksa L, Brcakova E et al. Up-regulation of renal Mdr1 and Mrp2 transporters during amiodarone pretreatment in rats. Pharmacol Res 2010; 61:129-35.

Cerne JZ, Novakovic S, Frkovic-Grazio S, Pohar-Perme M, Stegel V, Gersak K. Estrogen metabolism genotypes, use of long-term hormone replacement therapy and risk of postmenopausal breast cancer. Oncol Rep 2011; 26:479-85.

Cerri AP, Arosio B, Viazzoli C, Confalonieri R, Vergani C, Annoni G. The -308 (G/A) single nucleotide polymorphism in the TNF-alpha gene and the risk of major depression in the elderly. Int J Geriatr Psychiatry 2010; 25:219-23.

Cerveny L, Pavek P, Malakova J, Staud F, Fendrich Z. Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents. Epilepsia 2006; 47:461-8.

Cerveny L, Svecova L, Anzenbacherova E et al. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. Drug Metab Dispos 2007; 35:1032-41.

César TB, Manthey JA, Myung K. Minor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4. J Nat Prod 2009; 2:1702-4.

Cesari M, Narkiewicz K, de Toni R et al. Heritability of plasma adiponectin levels and body mass index in twins. J Clin Endocr Metab 2007; 92:3082-8.

Cesari R, Martin ES, Calin GA et al. Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. Proc Natl Acad Sci USA 2003; 100:5956-61.

Cetinkalp S, Karadeniz M, Erdoğan M et al. Human multidrug resistance-1 gene expression levels in graves-basedow disease. Exp Clin Endocrinol Diabetes 2010; 118:158-60.

Cetta F, Chiappetta G, Melillo RM et al. The ret/ptc1 oncogene is activated in familial adenomatous polyposis-associated thyroid papillary carcinomas. J Clin Endocrinol Metab 1998; 83:1003-6.

Ceyhan ST, Onguru O, Fidan U et al. Comparison of aromatase inhibitor (letrozole) and immunomodulators (infliximab and etanercept) on the regression of endometriotic implants in a rat model. Eur J Obstet Gynecol Reprod Biol 2011; 154:100-4.

Cha J, Ivanov V, Ivanova S, Kalinovsky T, Rath M, Niedzwiecki A. Evolution of angiotensin II-mediated atherosclerosis in ApoE KO mice. Mol Med Report 2010; 3:565-70.

Cha PC, Mushiroda T, Takahashi A et al. Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. Hum Mol Genet 2010; 19:4735-44.

Cha PC, Mushiroda T, Zembutsu H et al. Single nucleotide polymorphism in ABCG2 is associated with irinotecan-induced severe myelosuppression. J Hum Genet 2009; 54:572-80.

Cha SH, Kim HT, Jang Y et al. Association of alpha-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population. J Hypertens 2007; 25:2413-20.

Chacko BK, Srivastava A, Johnson MS et al. Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis. Hepatology 2011; 54:153-63.

Chae SC, Shim SC, Chung HT. Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis. Exp Mol Med 2009; 41:33-41.

Chai L, McLaren RP, Byrne A et al. The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function. Int J Oncol 2011; 38:701-11.

Chai YG, Oh DY, Chung EK et al. Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and type II alcoholism. Am J Psychiat 2005; 162:1003-5.

Chainuvati S, Nafziger AN, Leeder JS et al. Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the “Cooperstown 5+1 cocktail”. Clin Pharmacol Ther 2003; 74:437-47.

Chakrabarti S, Ghanekar Y, Kaur K et al. A polymorphism in the CYP1B1 promoter is functionally associated with primary congenital glaucoma. Hum Mol Genet 2010; 19:4083-90.

Chakraborty PK, Scharner B, Jurasovic J, Messner B, Bernhard D, Thévenod F. Chronic cadmium exposure induces transcriptional activation of the Wnt pathway and upregulation of epithelial-to-mesenchymal transition markers in mouse kidney. Toxicol Lett 2010; 198:69-76.

Chakrapani BP, Kumar S, Subramaniam JR. Development and evaluation of an in vivo assay in Caenorhabditis elegans for screening of compounds for their effect on cytochrome P450 expression. J Biosci 2008; 33:269-77.

Chalasani N, Chowdhury NR, Chowdhury JR, Boyer TD. Kernicterus in an adult who is heterozygous for Crigler-Najjar syndrome and homozygous for Gilbert-type genetic defect. Gastroenterology 1997; 112:2099-103.

Chalkiadis GA, Anderson BJ, Tay M, Bjorksten A, Kelly JJ. Pharmacokinetics of levobupivacaine after caudal epidural administration in infants less than 3 months of age. Br J Anaesth 2005; 95:524-9.

Chamberlin KW, Cottle M, Neville R, Tan J. Oral oxymorphone for pain management. Ann Pharmacother 2007; 41:1144-52.

Chambers SK, Ivins CM, Carcangiu ML. Plasminogen activator inhibitor-1 is an independent poor prognostic factor for survival in advanced stage epithelial ovarian cancer patients. Int J Cancer 1998; 79:449-54.

Chambers SK, Kacinski BM, Ivins CM, Carcangiu ML. Overexpression of epithelial macrophage colony-stimulating factor (CSF-1) and CSF-1 receptor: a poor prognostic factor in epithelial ovarian cancer, contrasted with a protective effect of stromal CSF-1. Clin Cancer Res 1997; 3:999-1007.

Chan AM, Miki T, Meyers KA, Aaronson SA. A human oncogene of the RAS superfamily unmasked by expression cDNA cloning. Proc Natl Acad Sci USA 1994; 91:7558-62.

Chan AT, Tranah GJ, Giovannucci EL, Hunter DJ, Fuchs CS. Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma. J Natl Cancer Inst 2005; 97:457-60.

Chan AT, Zauber AG, Hsu M et al. Cytochrome P450 2C9 variants influence response to celecoxib for prevention of colorectal adenoma. Gastroenterology 2009; 136:2127-36.

Chan CY, New LS, Ho HK, Chan EC. Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivation. Toxicol Lett 2011; 206:314-24.

Chan DKY, Lam MKP, Wong R, Hung WT, Wilcken DEL. Strong association between N-acetyltransferase 2 genotype and PD in Hong Kong Chinese. Neurology 2003; 60:1002-5.

Chan E, Hegde A, Chen X. Effect of rutin on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats. J Pharm Pharmacol 2009; 61:451-8.

Chan GN, Bendayan R. Molecular and functional characterization of P-glycoprotein in vitro. Methods Mol Biol 2011; 686:313-36.

Chan GN, Tozammel Hoque M, Cummins CL, Bendayan R. Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells. J Neurochem 2011; 118:163-75.

Chan IH, Tang NL, Leung TF et al. Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children. Allergy 2007; 62:802-9.

Chan J, Donalson LM, Kushwaha RS, Ferdinandusse S, VandeBerg JF, VandeBerg JL. Differential expression of hepatic genes involved in cholesterol homeostasis in high- and low-responding strains of laboratory opossums. Metabolism 2008; 57:718-24.

Chan JD. Pharmacokinetic drug interactions of vinca alkaloids: summary of case reports. Pharmacotherapy 1998; 18:1304-7.

Chan JL, Oral EA. Clinical classification and treatment of congenital and acquired lipodystrophy. Endocr Pract 2010; 16:310-23.

Chan KY, Ching JC, Xu MS et al. Association of ICAM3 genetic variant with severe acute respiratory syndrome. J Infect Dis 2007; 196:271-80.

Chan LM, Cooper AE, Dudley AL, Ford D, Hirst BH. P-glycoprotein potentiates CYP3A4-mediated drug disappearance during Caco-2 intestinal secretory detoxification. J Drug Target 2004; 12:405-13.

Chan MY, Huang H, Leung LK. 2,3,7,8-Tetrachlorodibenzo-para-dioxin increases aromatase (CYP19) mRNA stability in MCF-7 cells. Mol Cell Endocrinol 2010; 317:8-13.

Chan WH, Liao JW, Chou CP, Chan PK, Wei CF, Ueng TH. Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. Toxicol Lett 2009; 190:150-5.

Chan WK, Delucchi AB. Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4. Life Sci 2000; 67:3103-12.

Chan WK, Nguyen LT, Miller VP, Harris RZ. Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine. Life Sci 1998; 62:135-42.

Chan WP, Lee CK, Kwong YL, Lam CK, Liang R. A novel mutation of Arg306 of factor V gene in Hong Kong Chinese. Blood 1998; 91:1135-9.

Chand AL, Herridge KA, Howard TL, Simpson ER, Clyne CD. Tissue-specific regulation of aromatase promoter II by the orphan nuclear receptor LRH-1 in breast adipose stromal fibroblasts. Steroids 2011; 76:741-4.

Chand AL, Herridge KA, Thompson EW, Clyne CD. The orphan nuclear receptor LRH-1 promotes breast cancer motility and invasion. Endocr Relat Cancer 2010; 17:965-75.

Chanda D, Xie YB, Choi HS. Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation. Nucleic Acids Res 2010; 38:4607-19.

Chandrasekaran K, Swaminathan K, Kumar SM, Chatterjee S, Clemens DL, Dey A. Elevated glutathione level does not protect against chronic alcohol mediated apoptosis in recombinant human hepatoma cell line VL-17A over-expressing alcohol metabolizing enzymes-alcohol dehydrogenase and Cytochrome P450 2E1. Toxicol In Vitro 2011; 25:969-78.

Chang CH, Chen CY, Chiou JY, Peng RY, Peng CH. Astaxanthine secured apoptotic death of PC12 cells induced by beta-amyloid peptide 25-35: its molecular action targets. J Med Food 2010; 13:548-56.

Chang DJ, Chang TK, Yamanishi SS et al. Molecular cloning, genomic characterization and expression of novel human alpha-1A-adrenoceptor isoforms. FEBS Lett 1998; 422:279-83.

Chang EJ, Ha J, Kang SS, Lee ZH, Kim HH. AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling. Int J Biochem Cell Biol 2011; 43:1612-20.

Chang H, Rha SY, Jeung HC et al. Association of the ABCB1 gene polymorphisms 2677G>T/A and 3435C>T with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients. Ann Oncol 2009; 20:272-7.

Chang H, Rha SY, Jeung HC et al. Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy. Oncol Rep 2010; 23:271-8.

Chang HC, Chen TL, Chen RM. Cytoskeleton interruption in human hepatoma HepG2 cells induced by ketamine occurs possibly through suppression of calcium mobilization and mitochondrial function. Drug Metab Dispos 2009; 37:24-31.

Chang JH, Kochansky CJ, Shou M. The role of P-glycoprotein in the bioactivation of raloxifene. Drug Metab Dispos 2006; 34:2073-8.

Chang JW, Lee WY, Milstien S, Kang UJ. A site-specific mutation of tyrosine hydroxylase reduces feedback inhibition by dopamine in genetically modified cells grafted in parkinsonian rats. J Neurochem 2002; 83:141-9.

Chang JY, Liu JF, Juang SH, Liu TW, Chen LT. Novel mutation of topoisomerase I in rendering cells resistant to camptothecin. Cancer Res 2002; 62:3716-21.

Chang MH, Yesupriya A, Ned RM, Mueller PW, Dowling NF. Genetic variants associated with fasting blood lipids in the U. S. population: Third National Health and Nutrition Examination Survey. BMC Med Genet 2010; 11:62.

Chang PF, Lin YC, Liu K, Yeh SJ, Ni YH. Risk of hyperbilirubinemia in breast-fed infants. J Pediatr 2011; 159:561-5.

Chang S, Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y. Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc Nat Acad Sci USA 2005; 102:18694-99.

Chang SC, Ehresman DJ, Bjork JA et al. Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: toxicokinetics, thyroid hormone status, and related gene expression. Reprod Toxicol 2009; 27:387-99.

Chang SJ, Chen CJ, Tsai FC et al. Associations between gout tophus and polymorphisms 869T/C and -509C/T in transforming growth factor beta1 gene. Rheumatology 2008; 5:617-21.

Chang SY, Chen C, Yang Z, Rodrigues AD. Further assessment of 17alpha-ethinyl estradiol as an inhibitor of different human cytochrome P450 forms in vitro. Drug Metab Dispos 2009; 37:1667-75.

Chang SY, Fancher RM, Zhang H, Gan J. Mechanism-based inhibition of human cytochrome P4503A4 by domperidone. Xenobiotica 2010; 40:138-45.

Chang SY, Li W, Traeger SC et al. Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro. Drug Metab Dispos 2008; 36:2513-22.

Chang TJ, Tsai MH, Jiang YD et al. The Arg16Gly polymorphism of human beta2-adrenoreceptor is associated with type 2 diabetes in Taiwanese people. Clin Endocrinol 2002; 57:685-90.

Chang TK, Chen J, Yang G, Yeung EY. Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin. J Pineal Res 2010; 48:55-64.

Chang TK, Yeung RK. Effect of trans-resveratrol on 7-benzyloxy-4-trifluoromethylcoumarin O-dealkylation catalyzed by human recombinant CYP3A4 and CYP3A5. Can J Physiol Pharmacol 2001; 79:220-6.

Chang TK, Yu L, Maurel P, Waxman DJ. Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res 1997; 57:1946-54.

Chang W, Tu C, Chen TH, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal 2008; 1:1.

Chang WL, Chang CS, Chiang PC et al. 2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase. Br J Pharmacol 2010; 160:1677-89.

Chang X, Cui Y, Zong M et al. Identification of proteins with increased expression in rheumatoid arthritis synovial tissues. J Rheumatol 2009; 36:872-80.

Chang XL, Mao XY, Li HH et al. Association of GWAS loci with PD in China. Am J Med Genet B Neuropsychiatr Genet 2011; 156:334-9.

Chang XT, Wang ZH, Du X et al. Effect of polymorphism of human intestinal fatty acid binding protein gene on the therapeutic efficacy of fenofibrate. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2006; 28:230-3.

Chang Y, Fang WB, Lin SN, Moody DE. Stereo-selective metabolism of methadone by human liver microsomes and cDNA-expressed cytochrome P450s: a reconciliation. Basic Clin Pharmacol Toxicol 2011; 108:55-62.

Chang YT, Sharma R, Marsh JL et al. Levodopa-responsive aromatic L-amino acid decarboxylase deficiency. Ann Neurol 2004; 55:435-8.

Chang YT, Sun HS, Fann CS et al. Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han. Mol Psychiatry 2002; 7:828-9.

Chang YY, Chou CH, Chiu CH et al. Preventive effects of taurine on development of hepatic steatosis induced by a high-fat/cholesterol dietary habit. J Agric Food Chem 2011; 59:450-7.

Chang-Claude J, Ambrosone CB, Lilla C et al. Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer. Br J Cancer 2009; 100:1680-6.

Chanmahasathien W, Ampasavate C, Greger H, Limtrakul P. Stemona alkaloids, from traditional Thai medicine, increase chemosensitivity via P-glycoprotein-mediated multidrug resistance. Phytomedicine 2011; 18:199-204.

Chanplakorn N, Chanplakorn P, Suzuki T et al. Increased 5α-reductase type 2 expression in human breast carcinoma following aromatase inhibitor therapy: the correlation with decreased tumor cell proliferation. Horm Cancer 2011; 2:73-81.

Chantarangsu S, Cressey TR, Mahasirimongkol S et al. Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women. J Antimicrob Chemother 2009; 64:1265-73.

Chao YC, Young TH, Chang WK, Tang HS, Hsu CT. An investigation of whether polymorphisms of cytochrome P4502E1 are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population. Hepatology 1995; 22:1409-14.

Chapman J, Arlazoroff A, Goldfarb LG et al. Fatal insomnia in a case of familial Creutzfeldt-Jakob disease with the codon 200(lys) mutation. Neurology 1996; 46:758-61.

Chapman J, Korczyn AD, Karussis DM, Michaelson DM. The effects of APOE genotype on age at onset and progression of neurodegenerative diseases. Neurology 2001; 57:1482-5.

Chapman J, Vinokurov S, Achiron A et al. APOE genotype is a major predictor of long-term progression of disability in MS. Neurology 2001; 56:312-6.

Chapman JV, Gouazé-Andersson V, Cabot MC. Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity. Int J Oncol 2010; 37:1591-7.

Chapman JV, Gouazé-Andersson V, Karimi R, Messner MC, Cabot MC. P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells. Exp Cell Res 2011; 317:1736-45.

Chapman TM, Goa KL. Cilostazol: a review of its use in intermittent claudication. Am J Cardiovasc Drugs 2003; 3:117-38.

Charasson V, Haaz MC, Robert J. Determination of drug interactions occurring with the metabolic pathways of irinotecan. Drug Metab Dispos 2002; 30:731-3.

Charbit B, Becquemont L, Lepère B, Peytavin G, Funck-Brentano C. Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine. Clin Pharmacol Ther 2002; 72:514-23.

Charles KA, Rivory LP, Brown SL, Liddle C, Clarke SJ, Robertson GR. Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer. Clin Cancer Res 2006; 12:7492-7.

Charlier TD, Newman AE, Heimovics SA, Po KW, Saldanha CJ, Soma KK. Rapid effects of aggressive interactions on aromatase activity and oestradiol in discrete brain regions of wild male white-crowned sparrows. J Neuroendocrinol 2011; 23:742-53.

Charmandari E, Kino T, Ichijo T et al. A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance. J Clin Endocrinol Metab 2007; 92:3986-90.

Charmandari E, Kino T, Ichijo T, Zachman K, Alatsatianos A, Chrousos GP. Functional characterization of the natural human glucocorticoid receptor (hGR) mutants hGRalphaR477H and hGRalphaG679S associated with generalized glucocorticoid resistance. J Clin Endocrinol Metab 2006; 91:1535-43.

Charmandari E, Raji A, Kino T et al. A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity. J Clin Endocrinol Metab 2005; 90:3696-705.

Chartier-Harlin M-C, Crawford F, Houlden H et al. Early-onset Alzheimer’s disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature 1991; 353:844-6.

Charvet C, Liao WL, Heo GY et al. Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1. J Biol Chem 2011; 286:20413-22.

Charvin D, Roze E, Perrin V et al. Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo. Neurobiol Dis 2008; 29:22-9.

Chasman DI, Posada D, Subrahmanyan L, Cook NR, Stanton VP Jr, Ridker PM. Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA 2004; 291:2821-7.

Chassaing N, Martin L, Calvas P, Le Bert M, Hovnanian A. Pseudoxanthoma elasticum: a clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations. J Med Genet 2005; 42:881-92.

Chasseraud M, Liabeuf S, Mozar A et al. Tumor necrosis factor-related apoptosis-inducing ligand and vascular calcification. Ther Apher Dial 2011; 15:140-6.

Chaste P, Clement N, Mercati O et al. Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population. PLoS One 2010. doi:10. 1371/journal. pone. 0011495.

Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003; 31:1391-7.

Chatterjee S, Dhar S, Sengupta B et al. Polymorphisms of CYP1A1, GSTM1 and GSTT1 loci as the genetic predispositions of oral cancers and other oral pathologies: tobacco and alcohol as risk modifiers. Indian J Clin Biochem 2010; 25:260-72.

Chatterjee S, Lyle N, Mandal A, Kundu S. GSTT1 and GSTM1 gene deletions are not associated with hepatotoxicity caused by antitubercular drugs. J Clin Pharm Ther 2010; 35:465-70.

Chatuphonprasert W, Kondo S, Jarukamjorn K, Kawasaki Y, Sakuma T, Nemoto N. Potent modification of inducible CYP1A1 expression by flavonoids. Biol Pharm Bull 2010; 33:1698-703.

Chatzikyriakidou A, Georgiou I, Voulgari PV, Papadopoulos CG, Tzavaras T, Drosos AA. Transcription regulatory polymorphism -43T>C in the 5’-flanking region of SLC19A1 gene could affect rheumatoid arthritis patient response to methotrexate therapy. Rheumatol Int 2007; 11:1057-61.

Chatzikyriakidou A, Vakalis KV, Kolaitis N et al. Distinct association of SLC19A1 polymorphism -43T>C with red cell folate levels and of MTHFR polymorphism 677C>T with plasma folate levels. Clin Biochem 2008; 3:174-76.

Chaudhry AS, Kochhar R, Kohli KK. Importance of CYP2C19 genetic polymorphism in the eradication of Helicobacter pylori in north Indians. Indian J Med Res 2009; 130:437-43.

Chaudhry AS, Urban TJ, Lamba JK et al. CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose. J Pharmacol Exp Ther 2010; 332:599-611.

Chauhan PS, Ihsan R, Yadav DS et al. Association of glutathione S-transferase, EPHX, and p53 codon 72 gene polymorphisms with adult acute myeloid leukemia. DNA Cell Biol 2011; 30:39-46.

Chaung WW, Jacob A, Ji Y, Wang P. Suppression of PGC-1 alpha by ethanol: implications of its role in alcohol induced liver injury. Int J Clin Exp Med 2008; 1:161-70.

Chauret N, Yergey JA, Brideau C et al. In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663). Bioorg Med Chem Lett 2001; 11:1059-62.

Chavarria-Soley G, Sticht H, Aklillu E et al. Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme. Hum Mutat 2008; 29:1147-53.

Chave KJ, Ryan TJ, Chmura SE, Galivan J. Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms. Gene 2003; 319:167-75.

Chaves FJ, Corella D, Sorli JV, Marin-Garcia P, Guillen M, Redon J. Polymorphisms of the renin-angiotensin system influence height in normotensive women in a Spanish population. J Clin Endocr Metab 2004; 89:2301-5.

Chavez C, Gogos A, Hill R et al. Differential effect of amphetamine on c-fos expression in female aromatase knockout (ArKO) mice compared to wildtype controls. Psychoneuroendocrinology 2011; 36:761-8.

Checkoway H, Franklin GM, Costa-Mallen P et al. A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson’s disease. Neurology 1998; 50:1458-61.

Cheer SM, Goa KL. Fluoxetine: a review of its therapeutic potential in the treatment of depression associated with physical illness. Drugs 2001; 61:81-110.

Chefson A, Auclair K. CYP3A4 activity in the presence of organic cosolvents, ionic liquids, or water-immiscible organic solvents. Chembiochem 2007; 8:1189-97.

Chefson A, Zhao J, Auclair K. Sugar-mediated lyoprotection of purified human CYP3A4 and CYP2D6. J Biotechnol 2007; 130:436-40.

Chen AA, Marsit CJ, Christensen BC et al. Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer. Carcinogenesis 2009; 30:977-81.

Chen AC, Manz N, Tang Y et al. Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. Alcohol Clin Exp Res 2010; 34:988-96.

Chen AY, Lee AJ, Jiang XR, Zhu BT. Chemical synthesis of six novel 17beta-estradiol and estrone dimers and study of their formation catalyzed by human cytochrome P450 isoforms. J Med Chem 2007; 50:5372-81.

Chen B, Bronson RT, Klaman LD et al. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet 2000; 24:296-9.

Chen B, Cai WM. Influence of CYP2D6*10B genotype on pharmacokinetics of propafenone enantiomers in Chinese subjects. Acta Pharmacol Sin 2003; 24:1277-80.

Chen B, Hu Y, Jin T et al. The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ 2007; 381:38-46.

Chen B, Mi S, Wright B, Connon CJ. Investigation of K14/K5 as a stem cell marker in the limbal region of the bovine cornea. PLoS One 2010. doi:10. 1371/journal. pone. 0013192.

Chen B, Nie S, Luo S, Zhang W, Xiao C. Association of the human CYP11B2 gene and essential hypertension in southwest Han Chinese population: a haplotype-based case-control study. Clin Exp Hypertens 2011; 33:106-12.

Chen B, Nie S, Yue Z, Shou W, Xiao C. Haplotype-based case-control study of the human CYP11B2 gene and essential hypertension in Yi and Hani minorities of China. Biochem Genet 2011; 49:122-37.

Chen B, Qiu LX, Li Y et al. The CYP1B1 Leu432Val polymorphism contributes to lung cancer risk: evidence from 6501 subjects. Lung Cancer 2010; 70:247-52.

Chen B, Yin L, Cheng J et al. Effect of D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and tetrandrine on the reversion of multidrug resistance in K562/A02 cells. Hematology 2011; 16:24-30.

Chen B, Zhang W, Fang J et al. Influence of the MDR1 haplotype and CYP3A5 genotypes on cyclosporine blood level in Chinese renal transplant recipients. Xenobiotica 2009; 39:931-8.

Chen BA, Mao PP, Cheng J et al. Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and MDR1 shRNA expression vector in leukemia cells. Int J Nanomedicine 2010; 5:437-44.

Chen BA, Shan XY, Chen J, Xia GH, Xu WL, Schmit M. Effects of imatinib and 5-bromotetrandrine on the reversal of multidrug resistance of the K562/A02 cell line. Chin J Cancer 2010; 29:591-5.

Chen BA, Wang F, Cheng J et al. Effect of hypoxia inducible factor1-α inhibitor on reversal of multidrug resistance of K562/A02 cell line. Zhonghua Xue Ye Xue Za Zhi 2010; 31:389-93.

Chen BL, Chen Y, Tu JH et al. Clopidogrel inhibits CYP2C19-dependent hydroxylation of omeprazole related to CYP2C19 genetic polymorphisms. J Clin Pharmacol 2009; 49:574-81.

Chen C, Chen Y, Pontillo J et al. Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity. Bioorg Med Chem Lett 2008; 18:3301-5.

Chen C, Han YH, Yang Z, Rodrigues AD. Effect of interferon-α2b on the expression of various drug-metabolizing enzymes and transporters in co-cultures of freshly prepared human primary hepatocytes. Xenobiotica 2011; 41:476-85.

Chen C, Hanson E, Watson JW, Lee JS. P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos 2003; 31:312-8.

Chen C, Li G, Liao W et al. Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo. J Pharmacol Exp Ther 2009; 329:908-18.

Chen C, Mireles RJ, Campbell SD et al. Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos 2005; 33:537-46.

Chen C, Shen HL, Yang J, Chen QY, Xu WL. Preventing chemoresistance of human breast cancer cell line, MCF-7 with celecoxib. J Cancer Res Clin Oncol 2011; 137:9-17.

Chen C, Thakker DR. The fallacy of using adrenochrome reaction for measurement of reactive oxygen species formed during cytochrome p450-mediated metabolism of xenobiotics. J Pharmacol Exp Ther 2002; 300:417-20.

Chen C, Wei X, Rao X et al. Cytochrome P450 2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth. J Pharmacol Exp Ther 2011; 336:344-55.

Chen C, Westenbroek RE, Xu X et al. Mice lacking sodium channel beta-1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci 2004; 24:4030-42.

Chen C, Wu D, Guo Z et al. Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. J Med Chem 2008; 51:7478-85.

Chen C, Zhao W, Lu Y et al. High-throughput detection of highly benzimidazole-resistant allele E198A with mismatch primers in allele-specific real-time polymerase chain reaction. Pest Manag Sci 2009; 65:413-9.

Chen CC, Lu RB, Chen YC et al. Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am J Hum Genet 1999; 65:795-807.

Chen CJ, Hsu LI, Wang CH et al. Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan. Toxicol Appl Pharmacol 2005; 206:198-206.

Chen CL, Liu Q, Pui CH et al. Higher frequency of glutathione S-transferase deletions in black children with acute lymphoblastic leukemia. Blood 1997; 89:1701-7.

Chen CP, Lin SP, Chern SR et al. A de novo 7. 9 Mb deletion in 22q13. 2→qter in a boy with autistic features, epilepsy, developmental delay, atopic dermatitis and abnormal immunological findings. Eur J Med Genet 2010; 53:329-32.

Chen CS, Jounaidi Y, Waxman DJ. Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450. Drug Metab Dispos 2005; 33:1261-7.

Chen CS, Ouyang P, Yeh YC et al. Apolipoprotein E polymorphism and behavioral and psychological symptoms of dementia in patients with Alzheimer disease. Alzheimer Dis Assoc Disord 2011. doi:10. 1097/WAD. 0b013e31821f5787.

Chen CW, Cheng HH. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J Nutr 2006; 136:1472-6.

Chen CY, Shyue SK, Ching LC et al. Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. J Nutr Biochem 2011; 22:1015-21.

Chen D, Reierstad S, Fang F, Bulun SE. JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters. Mol Endocrinol 2011; 25:767-75.

Chen D, Tian T, Wang H et al. Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population. Pharmacogenet Genomics 2009; 19:25-34.

Chen DY, Chih HM, Lan JL, Chang HY, Chen WW, Chiang EP. Blood lipid profiles and peripheral blood mononuclear cell cholesterol metabolism gene expression in patients with and without methotrexate treatment. BMC Med 2011; 9:4.

Chen F, Ritter JK, Wang MG, McBride OW, Lubet RA, Owens IS. Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms. Biochemistry 1993; 32:10648-57.

Chen G, Paka L, Kako Y, Singhal P, Duan W, Pillarisetti S. A protective role for kidney apolipoprotein E: regulation of mesangial cell proliferation and matrix expansion. J Biol Chem 2001; 276:49142-7.

Chen G, Wang P, Zhao G et al. Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice. Prostaglandins Other Lipid Mediat 2011. doi:10. 1016/j. prostaglandins. 2011. 06. 009.

Chen H, Bi W, Cao B et al. A novel podophyllotoxin derivative (YB-1EPN) induces apoptosis and down-regulates express of P-glycoprotein in multidrug resistance cell line KBV200. Eur J Pharmacol 2010; 627:69-74.

Chen H, Chen W, Gan LS, Mutlib AE. Metabolism of (S)-5,6-difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3, 4-dihydro-2(1H)-quinazolinone, a non-nucleoside reverse transcriptase inhibitor, in human liver microsomes. Metabolic activation and enzyme kinetics. Drug Metab Dispos 2003; 31:122-32.

Chen H, Hernandez W, Shriver MD, Ahaghotu CA, Kittles RA. ICAM gene cluster SNPs and prostate cancer risk in African Americans. Hum Genet 2006; 120:69-76.

Chen H, Howald WN, Juchau MR. Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes. Drug Metab Dispos 2000; 28:315-22.

Chen H, Huang Q, Dong J, Zhai DZ, Wang AD, Lan Q. Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in vivo. BMC Cancer 2008; 8:29.

Chen H, Sandler DP, Taylor JA et al. Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect. Lancet 1996; 347:295-7.

Chen H, Wang L, Beretov J, Hao J, Xiao W, Li Y. Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression. Clin Exp Metastasis 2010; 27:557-69.

Chen H, Zientek M, Jalaie M, Zhang Y, Bigge C, Mutlib A. Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes. Chem Res Toxicol 2009; 22:1603-12.

Chen HC, Sytwu HK, Chang JL et al. Hypoxia enhances the stemness markers of cochlear stem/progenitor cells and expands sphere formation through activation of hypoxia-inducible factor-1alpha. Hear Res 2011; 275:43-52.

Chen HR, Yang HC, Hsieh DJ, Liu Z, Tsai KJ. Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status. Chem Biol Interact 2011; 189:192-7.

Chen J, Cai SP, Yu W et al. Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of primary open-angle glaucoma. Mol Vis 2011; 17:1431-5.

Chen J, Hong CJ, Chiu HJ et al. Apoliprotein E genotype and schizophrenia. Biol Psychiatry 1999; 39:141-3.

Chen J, Huang XF. The effects of diets enriched in beta-glucans on blood lipoprotein concentrations. J Clin Lipidol 2009; 3:154-8.

Chen J, Lu L, Feng Y et al. PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expression. Cancer Lett 2011; 300:48-56.

Chen J, Sun J, Ma Q et al. CYP2B6 polymorphism and nonnucleoside reverse transcriptase inhibitor plasma concentrations in Chinese HIV-infected patients. Ther Drug Monit 2010; 32:573-8.

Chen J, Tran C, Xiao L et al. Co-induction of CYP3A12 and 3A26 in dog liver slices by xenobiotics: species difference between human and dog CYP3A induction. Drug Metab Lett 2009; 3:61-6.

Chen J, Yang XX, Huang M et al. Small interfering RNA-mediated silencing of cytochrome P450 3A4 gene. Drug Metab Dispos 2006; 34:1650-7.

Chen J, Zhao H, Yang Y, Liu B, Ni J, Wang W. Lipid-lowering and antioxidant activities of Jiang-Zhi-Ning in Traditional Chinese Medicine. J Ethnopharmacol 2011; 134:919-30.

Chen JT, Chen RM. Mechanisms of ketamine-involved regulation of cytochrome P450 gene expression. Expert Opin Drug Metab Toxicol 2010; 6:273-81.

Chen K, Wang R, Wen SY, Li J, Wang SQ. Relationship of P450 2C9 genetic polymorphisms in Chinese and the pharmacokinetics of tolbutamide. J Clin Pharm Ther 2005; 30:241-9.

Chen KG, Valencia JC, Gillet JP, Hearing VJ, Gottesman MM. Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. Pigment Cell Melanoma Res 2009; 22:740-9.

Chen KH, Lin BR, Chien CT, Ho CH. Emblica officinalis Gaertn. Attentuates N-Nitrosodiethylamine-induced apoptosis, autophagy, and inflammation in rat livers. J Med Food 2011; 14:746-55.

Chen KX, Vibulbhan B, Liu T et al. The role of P-glycoprotein in the pharmacokinetics and tissue distribution of a hepatitis C virus protease inhibitor. Drug Metab Lett 2009; 3:290-5.

Chen L, Li Y, Zhao Q, Peng H, Hou T. ADME evaluation in drug discovery. 10. Predictions of P-glycoprotein inhibitors using recursive partitioning and naive Bayesian classification techniques. Mol Pharm 2011; 8:889-900.

Chen L, Meyers D, Javorsky G et al. Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol. Pharmacogenet Genomics 2007; 17:941-9.

Chen L, Qin S, Xie J et al. Genetic polymorphism analysis of CYP2C19 in Chinese Han populations from different geographic areas of mainland China. Pharmacogenomics 2008; 9:691-702.

Chen L, Yoshino G, Maeda E, Zeng S. Effect of microsomal triglyceride transfer protein gene polymorphism in the promoter region on dyslipidemia in type 2 diabetic subjects. Chin Med J 2003; 116:215-7.

Chen LM, Liang YJ, Zhang X et al. Reversal of P-gp-mediated multidrug resistance by bromotetrandrine in vivo is associated with enhanced accumulation of chemotherapeutical drug in tumor tissue. Anticancer Res 2009; 29:4597-604.

Chen ML, Tsai SH, Ip SP, Ko KM, Che CT. Long-term treatment with a “Yang-invigorating” Chinese herbal formula, Wu-Zi-Yan-Zong-Wan, reduces mortality and liver oxidative damage in chronic alcohol-intoxicated rats. Rejuvenation Res 2010; 13:459-67.

Chen PL, Yeh KT, Tsai YY et al. XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium. Mol Vis 2010; 16:991-6.

Chen Q, Gruber H, Pakenham C, Ratnayake WM, Scoggan KA. Dietary phytosterols and phytostanols alter the expression of sterol-regulatory genes in SHRSP and WKY inbred rats. Ann Nutr Metab 2009; 55:341-50.

Chen Q, Reis SE, Kammerer C et al. Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women’s Ischemia Syndrome Evaluation study. J Lipid Res 2011; 52:801-7.

Chen Q, Wu J, Yu Y. Establishment of transgenic cell line CHL-3A4 and its metabolic activation. Zhonghua Yu Fang Yi Xue Za Zhi 1998; 32:281-4.

Chen Q, Zhou J, Jiang C, Chen J. Reversal of P-glycoprotein-mediated multidrug resistance in SGC7901/VCR cells by PPARgamma activation by troglitazone. J Huazhong Univ Sci Technolog Med Sci 2010; 30:326-31.

Chen QJ, Lu L, Jin C et al. Insertion/insertion genotype of α(2B)-adrenergic receptor gene polymorphism is associated with silent myocardial ischemia in patients with type 2 diabetes mellitus. Clin Biochem 2010; 43:1201-4.

Chen S, Ferrone F, Wetzel R. Hungtington’s disease age-of-onset linked to polyglutamine aggregation nucleation. Proc Nat Acad Sci USA 2002; 99:11884-9.

Chen S, Huo X, Lin Y et al. Association of MDR1 and ERCC1 polymorphisms with response and toxicity to cisplatin-based chemotherapy in non-small-cell lung cancer patients. Int J Hyg Environ Health 2010; 213:140-5.

Chen S, Li X. Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes. BMC Evol Biol 2007; 7:46.

Chen S, Tsybouleva N, Ballantyne CM, Gotto AM Jr, Marian AJ. Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. Pharmacogenetics 2004; 14:61-71.

Chen S, Wang K, Wan YJ. Retinoids activate RXR/CAR-mediated pathway and induce CYP3A. Biochem Pharmacol 2010; 9:270-6.

Chen S, Ye J, Kijima I, Evans D. The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression. Proc Natl Acad Sci USA 2010; 107:11032-7.

Chen SC, Slavin MA, Sorrell TC. Echinocandin antifungal drugs in fungal infections: a comparison. Drugs 2011; 71:11-41.

Chen SF, Shen YC, Chen CH. Effects of the DRD3 Ser9Gly polymorphism on aripiprazole efficacy in schizophrenic patients as modified by clinical factors. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33:470-4.

Chen SF, Shen YC, Chen CH. HTR2A A-1438G/T102C polymorphisms predict negative symptoms performance upon aripiprazole treatment in schizophrenic patients. Psychopharmacology 2009; 205:285-92.

Chen SG, Xiao J, Liu XH et al. Ibrolipim increases ABCA1/G1 expression by the LXRα signaling pathway in THP-1 macrophage-derived foam cells. Acta Pharmacol Sin 2010; 31:1343-9.

Chen SH, Chou FF, Ko JY. The use of simvastatin with aromasin in an ovariectomized rat model: effects on the skeletal system. Chang Gung Med J 2010; 33:509-14.

Chen SP, Chiu SC, Wu CC et al. The association of methylation in the promoter of APC and MGMT and the prognosis of Taiwanese CRC patients. Genet Test Mol Biomarkers 2009; 13:67-71.

Chen SP, Wu CC, Lin SZ et al. Prognostic significance of interaction between somatic APC mutations and 5-fluorouracil adjuvant chemotherapy in Taiwanese colorectal cancer subjects. Am J Clin Oncol 2009; 32:122-6.

Chen W, Stambolian D, Edwards AO et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci USA 2010; 107:7401-6.

Chen WY, Chang WL, Tsai YC, Cheng HC, Lu CC, Sheu BS. Double-dosed pantoprazole accelerates the sustained symptomatic response in overweight and obese patients with reflux esophagitis in Los Angeles grades A and B. Am J Gastroenterol 2010; 105:1046-52.

Chen X, Chen Y, Wang L et al. Confirmation and further mapping of the GLC3C locus in primary congenital glaucoma. Front Biosci 2011; 17:2052-9.

Chen X, Jiang R, Geng Z. Cold stress in broiler: global gene expression analyses suggest a major role of CYP genes in cold responses. Mol Biol Rep 2011. doi:10. 1007/s11033-011-0754-x.

Chen X, Sun CK, Han GZ et al. Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression. World J Gastroenterol 2009; 15:1829-35.

Chen X, Wang H, Zhou G et al. Molecular population genetics of human CYP3A locus: signatures of positive selection and implications for evolutionary environmental medicine. Environ Health Perspect 2009; 117:1541-8.

Chen X, Wang X, Hossain S et al. Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia. Hum Mol Genet 2006; 15:3329-42.

Chen X, Zhang M, Liu LX. The overexpression of multidrug resistance-associated proteins and gankyrin contribute to arsenic trioxide resistance in liver and gastric cancer cells. Oncol Rep 2009; 22:73-80.

Chen X, Zhao Y, Guo Z, Zhou L, Okoro EU, Yang H. Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway. J Biol Chem 2011; 286:8917-23.

Chen XC, Huang SP, Wang XY. Effect of astrocytes with different degrees of proliferation on multidrug resistance gene expression in rats with epilepsy. Zhongguo Dang Dai Er Ke Za Zhi 2010; 12:908-11.

Chen XC, Xu MT, Zhou W, Han CL, Chen WQ. A meta-analysis of relationship between beta-fibrinogen gene -148C/T polymorphism and susceptibility to cerebral infarction in Han Chinese. Chin Med J 2007; 120:1198-202.

Chen XH, Li XQ, Chen Y, Feng YM. Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China. Breast Cancer Res Treat 2011; 125:575-82.

Chen XP, Tan ZR, Huang SL, Huang Z, Ou-Yang DS, Zhou HH. Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects. Clin Pharmacol Ther 2003; 73:264-71.

Chen XW, Serag ES, Sneed KB, Zhou SF. Herbal bioactivation, molecular targets and the toxicity relevance. Chem Biol Interact 2011; 192:161-76.

Chen Y, Bai Y, Yuan J et al. Association of polymorphisms in AhR, CYP1A1, GSTM1, and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers. Cancer Epidemiol Biomarkers Prev 2006; 15:1703-7.

Chen Y, Chen C, Shi S et al. Endometriotic implants regress in rat models treated with puerarin by decreasing estradiol level. Reprod Sci 2011; 18:886-91.

Chen Y, Goldstein JA. The transcriptional regulation of the human CYP2C genes. Curr Drug Metab 2009; 10:567-78.

Chen Y, Huang C, Zhou T, Zhang S, Chen G. Biochanin A induction of sulfotransferases in rats. J Biochem Mol Toxicol 2010; 24:102-14.

Chen Y, Jia L, Wei C, Wang F, Lv H, Jia J. Association between polymorphisms in the apolipoprotein D gene and sporadic Alzheimer’s disease. Brain Res 2008; 1233:196-202.

Chen Y, Kang Z, Yan J et al. Liu wei di huang wan, a well-known traditional Chinese medicine, induces CYP1A2 while suppressing CYP2A6 and N-acetyltransferase 2 activities in man. J Ethnopharmacol 2010; 132:213-8.

Chen Y, Li G, Yin S et al. Genetic polymorphisms involved in toxicant-metabolizing enzymes and the risk of chronic benzene poisoning in Chinese occupationally exposed populations. Xenobiotica 2007; 37:103-12.

Chen Y, Liu HF, Liu L, Nguyen K, Jones EB, Fretland AJ. The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19. Xenobiotica 2010; 40:536-46.

Chen Y, Liu L, Laille E, Kumar G, Surapaneni S. In vitro assessment of cytochrome P450 inhibition and induction potential of azacitidine. Cancer Chemother Pharmacol 2010; 65:995-1000.

Chen Y, Liu WH, Chen BL et al. Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers. Ann Pharmacother 2010; 44:1038-45.

Chen Y, Pawlikowska L, Yao JS et al. Interleukin-6 involvement in brain arteriovenous malformations. Ann Neurol 2006; 59:72-80.

Chen Y, Tang Y, Chen S, Nie D. Regulation of drug resistance by human pregnane X receptor in breast cancer. Cancer Biol Ther 2009; 8:1265-72.

Chen Y, Tang Y, Wang MT, Zeng S, Nie D. Human pregnane X receptor and resistance to chemotherapy in prostate cancer. Cancer Res 2007; 67:10361-7.

Chen Y, Tu JH, He YJ et al. Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers. Xenobiotica 2009; 39:508-13.

Chen Y, Xiao CQ, He YJ et al. Genistein alters caffeine exposure in healthy female volunteers. Eur J Clin Pharmacol 2011; 67:347-53.

Chen Y, Xiao P, Ou-Yang DS et al. Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers. Clin Exp Pharmacol Physiol 2009; 36:828-33.

Chen YC, Kraft P, Bretsky P et al. Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Cancer Epidemiol Biomarkers Prev 2007; 16:1973-81.

Chen YK, Chen SQ, Li X, Zeng S. Quantitative regioselectivity of glucuronidation of quercetin by recombinant UDP-glucuronosyltransferases 1A9 and 1A3 using enzymatic kinetic parameters. Xenobiotica 2005; 35:943-54.

Chen YL, Cheng TS, Lung FW. Prolactin levels in olanzapine treatment correlate with positive symptoms of schizophrenia: Results from an open-label, flexible-dose study. Prim Care Companion J Clin Psychiatry 2009; 11:16-20.

Chen YL, Tseng HS, Kuo WH, Yang SF, Chen DR, Tsai HT. Glutathione S-Transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma. BMC Med Genet 2010; 11:46.

Chen YW, Lin GJ, Chuang YP et al. Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells. Anticancer Drugs 2010; 21:502-13.

Chen YX, Cabana B, Kivel N, Pieniaszek H, Gilman S, Michaelis A. Lack of effect of rifalazil on ethinyl estradiol pharmacokinetics in healthy postmenopausal women. Int J Clin Pharmacol Ther 2007; 45:418-22.

Chen Z, Dunning LA, Anderson KE, Holtzman JL, Zheng W. Within-person variability of urinary 6beta-hydroxycortisol to urinaryl ratios in Caucasian women. Steroids 2004; 69:67-70.

Chen Z, Li Z, Niu X et al. The effect of CYP1A1 polymorphisms on the risk of lung cancer: a global meta-analysis based on 71 case-control studies. Mutagenesis 2011; 26:437-46.

Chen Z, Simmons MS, Perry RT, Wiener HW, Harrell LE, Go RC. Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer’s disease. Am J Med Genet B Neuropsychiatr Genet 2008; 147:363-9.

Chen ZH, Zhang H, Savarese TM. Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy. Cancer Res 1996; 56:1083-90.

Chen ZR, Somogyi AA, Reynolds G, Bochner F. Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers. Br J Clin Pharmacol 1991; 31:381-90.

Chen ZS, Lee K, Walther S et al. Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res 2002; 62:3144-50.

Chenel M, Bouzom F, Aarons L, Ogungbenro K. Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 1: comparison of uniresponse and multiresponse designs using PopDes. J Pharmacokinet Pharmacodyn 2008; 35:635-59.

Chenel M, Bouzom F, Cazade F, Ogungbenro K, Aarons L, Mentré F. Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results. J Pharmacokinet Pharmacodyn 2008; 35:661-81.

Cheng CH, Leung AY, Chen CF. The effects of two different Ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells. Nutr Cancer 2010; 62:648-58.

Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ. Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab Dispos 2009; 37:1611-21.

Cheng J, Meziani MJ, Sun YP, Cheng SH. Poly(ethylene glycol)-conjugated multi-walled carbon nanotubes as an efficient drug carrier for overcoming multidrug resistance. Toxicol Appl Pharmacol 2011; 250:184-93.

Cheng J, Wan DF, Gu JR et al. Establishment of a yeast system that stably expresses human cytochrome P450 reductase: application for the study of drug metabolism of cytochrome P450s in vitro. Protein Expr Purif 2006; 47:467-76.

Cheng J, Wang JQ, Chen BA et al. MDR reversal activity of bromotetrandrine in vitro and in vivo. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009; 17:1183-91.

Cheng J, Wang T, Chen BA et al. Effect of desferioxamine on K562/A02 cell line and its mechanism. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011; 19:337-41.

Cheng JW. Bosentan. Heart Dis 2003; 5:161-9.

Cheng LC, Su KH, Kou YR et al. α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1. Free Radic Biol Med 2011; 50:47-54.

Cheng N, Wauthier E, Reid LM. Mature human hepatocytes from ex vivo differentiation of alginate-encapsulated hepatoblasts. Tissue Eng 2008; 14:1-7.

Cheng Q, Cheng C, Crews KR et al. Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells. Am J Hum Genet 2006; 79:264-74.

Cheng Q, Sohl CD, Guengerich FP. High-throughput fluorescence assay of cytochrome P450 3A4. Nat Protoc 2009; 4:1258-61.

Cheng Q, Wu B, Kager L et al. A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells. Pharmacogenetics 2004; 14:557-67.

Cheng X, Taleb S, Wang J et al. Inhibition of IL-17A in atherosclerosis. Atherosclerosis 2011; 215:471-4.

Cheng X, Xu G. A systemic review of the relationship between aldosterone synthase – 344 C/T polymorphism and hypertension in Han. Clin Exp Hypertens 2010; 32:301-7.

Cheng XD, Lu WG, Ye F, Wan XY, Xie X. The association of XRCC1 gene single nucleotide polymorphisms with response to neoadjuvant chemotherapy in locally advanced cervical carcinoma. J Exp Clin Cancer Res 2009; 28:91.

Cheng XW, Song H, Sasaki T et al. Angiotensin type 1 receptor blocker reduces intimal neovascularization and plaque growth in apolipoprotein e-deficient mice. Hypertension 2011; 57:981-9.

Cheng Y, Austin SC, Rocca B et al. Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 2002; 296:539-41.

Cheng Y, Liu G, Pan Q, Guo S, Yang X. Elevated expression of liver X receptor alpha (LXRα) in myocardium of streptozotocin-induced diabetic rats. Inflammation 2010. doi:10. 1007/s10753-010-9281-5.

Cheng Z, Zhang J, Liu H, Li Y, Zhao Y, Yang E. Central nervous system penetration for small molecule therapeutic agents does not increase in multiple sclerosis- and Alzheimer’s disease-related animal models despite reported blood-brain barrier disruption. Drug Metab Dispos 2010; 38:1355-61.

Cheng Z, Zhou H, Luther M, Yin JJ, Yu LL. Effects of wheat antioxidants on oxygen diffusion-concentration products in liposomes and mRNA levels of HMG-CoA reductase and cholesterol 7alpha-hydroxylase in primary rat hepatocytes. J Agric Food Chem 2008; 56:5033-42.

Cheng ZN, Shu Y, Liu ZQ, Wang LS, Ou-Yang DS, Zhou HH. Role of cytochrome P450 in estradiol metabolism in vitro. Acta Pharmacol Sin 2001; 22:148-54.

Cheng ZN, Zhou HH. Contribution of genetic variations in estradiol biosynthesis and metabolism enzymes to osteoporosis. Acta Pharmacol Sin 2000; 21:587-90.

Chenhsu RY, Loong CC, Chou MH, Lin MF, Yang WC. Renal allograft dysfunction associated with rifampin-tacrolimus interaction. Ann Pharmacother 2000; 34:27-31.

Chenn A, Walsh CA. Cranking it up a Notch. Science 1999; 286:689-90.

Cheok MH, Yang W, Pui CH et al. Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. Nat Genet 2003; 34:85-90.

Cheon KA, Cho DY, Koo MS, Song DH, Namkoong K. Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder. Biol Psychiatry 2009; 65:564-70.

Cheong JY, Cho SW, Choi JY et al. RANTES, MCP-1, CCR2, CCR5, CXCR1 and CXCR4 gene polymorphisms are not associated with the outcome of hepatitis B virus infection: results from a large scale single ethnic population. J Korean Med Sci 2007; 22:529-35.

Cherezov V, Rosenbaum DM, Hanson MA et al. High-resolution crystal structure of an engineered human beta-2-adrenergic G protein-coupled receptor. Science 2007; 318:1258-65.

Cherner M, Bousman C, Everall I et al. Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findings. J Int Neuropsychol Soc 2010; 16:890-901.

Cherstniakova SA, Bi D, Fuller DR, Mojsiak JZ, Collins JM, Cantilena LR. Metabolism of vanoxerine,1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, by human cytochrome P450 enzymes. Drug Metab Dispos 2001; 29:1216-20.

Cheshire WP, Tsuboi Y, Wszolek ZK. Physiologic assessment of automatic dysfunction in pallidopontonigral degeneration with N279K mutation in the tau gene on chromosome 17. Auton Neurosci 2002; 102:71-7.

Chesné C, Guyomard C, Guillouzo A, Schmid J, Ludwig E, Sauter T. Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4. Xenobiotica 1998; 28:1-13.

Chetty M, d’Esposito F, Zhang WV et al. In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation. Br J Clin Pharmacol 2009; 68:574-9.

Chetty M, Murray M. CYP-mediated clozapine interactions: how predictable are they? Curr Drug Metab 2007; 8:307-13.

Cheung C, Gonzalez FJ. Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment. J Pharmacol Exp Ther 2008; 327:288-99.

Cheung C, Loy S, Li GX, Liu AB, Yang CS. Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. Carcinogenesis 2011; 32:233-9.

Cheung C, Yu AM, Chen CS et al. Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. J Pharmacol Exp Ther 2006; 316:1328-34.

Cheung ST, Cheung PF, Cheng CK, Wong NC, Fan ST. Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance. Gastroenterology 2011; 140:344-55.

Chew SC, Singh O, Chen X et al. The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients. Cancer Chemother Pharmacol 2011, 67:1471-8.

Chew SC, Singh O, Chen X et al. The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients. Cancer Chemother Pharmacol 2011; 67:1471-8.

Chew WM, Xu MJ, Cordova CA, Chow HH. Quantification of a cytochrome P450 3A4 substrate, buspirone, in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2006; 844:235-9.

Chhun S, Verstuyft C, Rizzo-Padoin N et al. Gefitinib-phenytoin interaction is not correlated with the C-erythromycin breath test in healthy male volunteers. Br J Clin Pharmacol 2009; 68:226-37.

Chi AC, Appleton K, Henriod JB et al. Differential induction of CYP1A1 and CYP1B1 by benzo[a]pyrene in oral squamous cell carcinoma cell lines and by tobacco smoking in oral mucosa. Oral Oncol 2009; 45:980-5.

Chianella C, Gragnaniello D, Maisano Delser P et al. BCHE and CYP2D6 genetic variation in Alzheimer’s disease patients treated with cholinesterase inhibitors. Eur J Clin Pharmacol 2011; 67:1147-57.

Chiang CP, Wu CW, Lee SP et al. Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: implications for pathogenesis of alcohol-induced pancreatic injury. Alcohol Clin Exp Res 2009; 33:1059-68.

Chiang HC, Wang CY, Lee HL, Tsou TC. Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation-a mammalian cell-based mutagenesis approach. Toxicol Appl Pharmacol 2011; 253:145-52.

Chiang JY. Bile acids: regulation of synthesis. J Lipid Res 2009; 50:1955-66.

Chiba K, Morimoto K. Genetic marker of statin-induced rhabdomyolysis. Yakugaku Zasshi 2011; 131:247-53.

Chiba M, Hensleigh M, Nishime JA, Balani SK, Lin JH. Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. Drug Metab Dispos 1996; 24:307-14.

Chiba M, Jin L, Neway W et al. P450 interaction with HIV protease inhibitors: relationship between metabolic stability, inhibitory potency, and P450 binding spectra. Drug Metab Dispos 2001; 29:1-3.

Chiba M, Nishime JA, Lin JH. Potent and selective inactivation of human liver microsomal cytochrome P-450 isoforms by L-754,394, an investigational human immune deficiency virus protease inhibitor. J Pharmacol Exp Ther 1995; 275:1527-34.

Chiba M, Nishime JA, Neway W, Lin Y, Lin JH. Comparative in vitro metabolism of indinavir in primates-a unique stereoselective hydroxylation in monkey. Xenobiotica 2000; 30:117-29.

Chiba M, Tang C, Neway WE et al. P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes. Biochem Pharmacol 2001; 62:773-6.

Chiba M, Xu X, Nishime JA, Balani SK, Lin JH. Hepatic microsomal metabolism of montelukast, a potent leukotriene D4 receptor antagonist, in humans. Drug Metab Dispos 1997; 25:1022-31.

Chiba-Falek O, Nichols M, Suchindran S et al. Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study. BMC Med Genet 2010; 11:9.

Chico LK, Behanna H, Hu W, Zhong G, Roy SM, Watterson DM. Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database. Drug Metab Dispos 2009; 37:2204-11.

Chida D, Hashimoto O, Kuwahara M et al. Increased fat:carbohydrate oxidation ratio in Il1ra (-/-) mice on a high-fat diet is associated with increased sympathetic tone. Diabetologia 2008; 51:1698-706.

Chida M, Yokoi T, Nemoto N, Inaba M, Kinoshita M, Kamataki T. A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion in exon 5 in a Japanese population associated with a poor metabolizer phenotype. Pharmacogenetics 1999; 9:287-93.

Chieli E, Romiti N, Rodeiro I, Garrido G. In vitro modulation of ABCB1/P-glycoprotein expression by polyphenols from Mangifera indica. Chem Biol Interact 2010; 186:287-94.

Chien CC, Yen BL, Lee FK et al. In vitro differentiation of human placenta-derived multipotent cells into hepatocyte-like cells. Stem Cells 2006; 24:1759-68.

Chien CF, Wu YT, Lee WC, Lin LC, Tsai TH. Herb-drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats. Chem Biol Interact 2010; 184:458-65.

Chien KL, Lin YL, Wen HC et al. Common sequence variant in lipoprotein lipase gene conferring triglyceride response to fibrate treatment. Pharmacogenomics 2009; 10:267-76.

Chihara T, Shimpo K, Kaneko T, Beppu H, Tomatsu A, Sonoda S. Inhibitory effects of high temperature- and pressure-treated garlic on formation of 1,2-dimethylhydrazine-induced mucin-depleted foci and O(6)-methylguanine DNA adducts in the rat colorectum. Asian Pac J Cancer Prev 2009; 10:827-31.

Chijimatsu T, Tatsuguchi I, Abe K, Oda H, Mochizuki S. A freshwater clam (Corbicula fluminea) extract improves cholesterol metabolism in rats fed on a high-cholesterol diet. Biosci Biotechnol Biochem 2008; 72:2566-71.

Chikazawa N, Tanaka H, Tasaka T et al. Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells. Anticancer Res 2010; 30:2041-8.

Childs E, Hohoff C, Deckert J, Xu K, Badner J, de Wit H. Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology 2008; 33:2791-800.

Chillón M, Casals T, Mercier B et al. Mutations in the cystic fibrosis gene in patients with congenital absence of the vas deferens. N Engl J Med 1995; 332:1475-80.

Chimento A, Sirianni R, Zolea F et al. Nandrolone and stanozolol induce Leydig cell tumor proliferation through an estrogen-dependent mechanism involving IGF-I system. J Cell Physiol 2011. doi:10. 1002/jcp. 22936.

Chin J, Hong JY, Lee J et al. Selective peroxisome proliferator-activated receptor Δ isosteric selenium agonists as potent anti-atherogenic agents in vivo. Bioorg Med Chem Lett 2010; 20:7239-42.

Chinetti-Gbaguidi G, Baron M, Bouhlel MA et al. Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways. Circ Res 2011; 108:985-95.

Chiney MS, Schwarzenberg SJ, Johnson LA. Altered xanthine oxidase and N-acetyltransferase activity in obese children. Br J Clin Pharmacol 2011; 72:109-15.

Chinta SJ, Pai HV, Upadhya SC, Boyd MR, Ravindranath V. Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain. Brain Res Mol Brain Res 2002; 103:49-61.

Chiodini BD, Specchia C, Gori F et al. Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population. Ther Adv Cardiovasc Dis 2010; 4:223-30.

Chiras T, Papadakis ED, Katopodi A et al. Platelet GP IIIA polymorphism HPA-1 (PLA1/2) is associated with hypertension as the primary cause for end-stage renal disease in hemodialysis patients from Greece. In Vivo 2009; 23:177-81.

Chirgwin J, Sun Z, Smith I et al. The advantage of letrozole over tamoxifen in the BIG 1-98 trial is consistent in younger postmenopausal women and in those with chemotherapy-induced menopause. Breast Cancer Res Treat 2011. doi:10. 1007/s10549-011-1741-6.

Chiron C. Stiripentol. Expert Opin Investig Drugs 2005; 14:905-11.

Chiron C. Stiripentol. Neurotherapeutics 2007; 4:123-5.

Chisaki I, Kobayashi M, Itagaki S, Hirano T, Iseki K. Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver. Biochim Biophys Acta 2009; 1788:2396-403.

Chishti MA, Yang DS, Janus C et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem 2001; 276:21562-70.

Chistiakov DA, Savost’anov KV, Turakulov RI. Screening of SNPs at 18 positional candidate genes, located within the GD-1 locus on chromosome 14q23-q32, for susceptibility to Graves’ disease: a TDT study. Mol Genet Metab 2004; 83:264-70.

Chiu HJ, Wang YC, Liou JH et al. Serotonin 6 receptor polymorphism in schizophrenia: frequency, age at onset and cognitive function. Neuropsychobiology 2001; 43:113-6.

Chiu KW, Nakano T, Hu TH et al. Influence of CYP2C19 genotypes on graft pathological findings and postoperative liver function in recipients after living-donor liver transplantation. Ann Transplant 2010; 15:38-43.

Chiu KW, Tai WC, Nakano T et al. Donor graft does not affect the P450 2C19 genotype expressed in peripheral blood in recipients of living donor liver transplantation. Clin Transplant 2010; 24:830-4.

Chiu LY, Ko JL, Lee YJ, Yang TY, Tee YT, Sheu GT. L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett 2010; 192:408-18.

Cho CG, Lee SK, Nam SY et al. Association of the GSTP1 and NQO1 polymorphisms and head and neck squamous cell carcinoma risk. J Korean Med Sci 2006; 21:1075-9.

Cho H, Choi MK, Cho DY et al. Effect of CYP2C19 genetic polymorphism on pharmacokinetics and pharmacodynamics of a new proton pump inhibitor, ilaprazole. J Clin Pharmacol 2011. doi:10. 1177/0091270011408611.

Cho HJ, Park YS, Kang WK, Kim JW, Lee SY. Thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) polymorphisms in the Korean population for prediction of 5-fluorouracil-associated toxicity. Ther Drug Monit 2007; 2:190-6.

Cho HY, Lee YB. Pharmacokinetics and bioequivalence evaluation of risperidone in healthy male subjects with different CYP2D6 genotypes. Arch Pharm Res 2006; 29:525-33.

Cho HY, Yoo HD, Lee YB. Influence of ABCB1 genetic polymorphisms on the pharmacokinetics of levosulpiride in healthy subjects. Neuroscience 2010; 169:378-87.

Cho HY, Yoon H, Park GK, Lee YB. Pharmacokinetics and bioequivalence of two formulations of rebamipide 100-mg tablets: a randomized, single-dose, two-period, two-sequence crossover study in healthy Korean male volunteers. Clin Ther 2009; 31:2712-21.

Cho IH, Yoo HJ, Park M, Lee YS, Kim SA. Family-based association study of 5-HTTLPR and the 5-HT2A receptor gene polymorphisms with autism spectrum disorder in Korean trios. Brain Res 2007; 1139:34-41.

Cho KH, Lee SM. Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion. Arch Pharm Res 2007; 30:50-7.

Cho SC, Kim JW, Kim BN et al. Association between the alpha-2C-adrenergic receptor gene and attention deficit hyperactivity disorder in a Korean sample. Neurosci Lett 2008; 446:108-11.

Cho SH, Oh SY, Bahn JW et al. Association between bronchodilating response to short-acting beta-agonist and non-synonymous single-nucleotide polymorphisms of beta-adrenoceptor gene. Clin Exp Allergy 2005; 35:1162-7.

Cho TM, Rose RL, Hodgson E. In vitro metabolism of naphthalene by human liver microsomal cytochrome P450 enzymes. Drug Metab Dispos 2006; 34:176-83.

Cho TM, Rose RL, Hodgson E. The effect of chlorpyrifos-oxon and other xenobiotics on the human cytochrome P450-dependent metabolism of naphthalene and deet. Drug Metabol Drug Interact 2007; 22:235-62.

Choi BS, Alberti DB, Schelman WR et al. The maximum tolerated dose and biologic effects of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) in combination with irinotecan for patients with refractory solid tumors. Cancer Chemother Pharmacol 2010; 66:973-80.

Choi CI, Kim MJ, Chung EK et al. CYP2C9*3 and *13 alleles significantly affect the pharmacokinetics of irbesartan in healthy Korean subjects. Eur J Clin Pharmacol 2011. doi:10. 1007/s00228-011-1098-0.

Choi CI, Kim MJ, Jang CG, Park YS, Bae JW, Lee SY. Effects of the CYP2C9*1/*13 genotype on the pharmacokinetics of lornoxicam. Basic Clin Pharmacol Toxicol 2011. doi:10. 1111/j. 1742-7843. 2011. 00751. x.

Choi DH, Chang KS, Hong SP, Choi JS, Han HK. Effect of atorvastatin on the intravenous and oral pharmacokinetics of verapamil in rats. Biopharm Drug Dispos 2008; 29:45-50.

Choi DH, Chung JH, Choi JS. Pharmacokinetic interaction between oral lovastatin and verapamil in healthy subjects: role of P-glycoprotein inhibition by lovastatin. Eur J Clin Pharmacol 2010; 66:285-90.

Choi DH, Li C, Choi JS. Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats. Eur J Drug Metab Pharmacokinet 2009; 34:163-8.

Choi DH, Li C, Choi JS. Effects of myricetin, an antioxidant, on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats: possible role of cytochrome P450 3A4, cytochrome P450 2C9 and P-glycoprotein inhibition by myricetin. J Pharm Pharmacol 2010; 62:908-14.

Choi DH, Shin WG, Choi JS. Drug interaction between oral atorvastatin and verapamil in healthy subjects: effects of atorvastatin on the pharmacokinetics of verapamil and norverapamil. Eur J Clin Pharmacol 2008; 64:445-9.

Choi EM, Lee MG, Lee SH, Choi KW, Choi SH. Association of ABCB1 polymorphisms with the efficacy of ondansetron for postoperative nausea and vomiting. Anaesthesia 2010; 65:996-1000.

Choi H, Shin DW, Kim W, Doh SJ, Lee SH, Noh M. Asian dust storm particles induce a broad toxicological transcriptional program in human epidermal keratinocytes. Toxicol Lett 2011; 200:92-9.

Choi HK, Zhu Y, Mount DB. Genetics of gout. Curr Opin Rheumatol 2010; 22:144-51.

Choi I, Kim SY, Kim H et al. Classification models for CYP450 3A4 inhibitors and non-inhibitors. Eur J Med Chem 2009; 44:2354-60.

Choi JH, Lee YJ, Jang SB, Lee JE, Kim KH, Park K. Influence of the CYP3A5 and MDR1 genetic polymorphisms on the pharmacokinetics of tacrolimus in healthy Korean subjects. Br J Clin Pharmacol 2007; 64:185-91.

Choi JS, Boralevi F, Brissaud O et al. Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons. Nat Rev Neurol 2011; 7:51-5.

Choi JS, Burm JP. Effect of pioglitazone on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rats. Arch Pharm Res 2008; 31:1200-4.

Choi JS, Burm JP. Effects of oral epigallocatechin gallate on the pharmacokinetics of nicardipine in rats. Arch Pharm Res 2009; 32:1721-5.

Choi JS, Choi BC, Kang KW. Effect of resveratrol on the pharmacokinetics of oral and intravenous nicardipine in rats: possible role of P-glycoprotein inhibition by resveratrol. Pharmazie 2009; 64:49-52.

Choi JS, Han HK. The effect of quercetin on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rabbits. J Pharm Pharmacol 2004; 56:1537-42.

Choi JS, Han HK. Pharmacokinetic interaction between diltiazem and morin, a flavonoid, in rats. Pharmacol Res 2005; 52:386-91.

Choi JS, Kang KW. Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin. Arch Pharm Res 2008; 31:1631-6.

Choi JS, Kang NS, Min YK, Kim SH. Euphorbiasteroid reverses P-glycoprotein-mediated multi-drug resistance in human sarcoma cell line MES-SA/Dx5. Phytother Res 2010; 24:1042-6.

Choi JS, Lee WJ, Baik SH et al. Array CGH reveals genomic aberrations in human emphysema. Lung 2009; 187:165-72.

Choi JS, Li X. The effect of verapamil on the pharmacokinetics of paclitaxel in rats. Eur J Pharm Sci 2005; 24:95-100.

Choi JY, Abel J, Neuhaus T et al. Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development. Pharmacogenetics 2003; 13:67-72.

Choi JY, Lee KM, Park SK et al. Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer. Cancer Epidemiol Biomarkers Prev 2005; 14:1090-5.

Choi KH, Chen C-J, Kriegler M, Roninson IB. An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene. Cell 1988; 53:519-29.

Choi MH, Skipper PL, Wishnok JS, Tannenbaum SR. Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450. Drug Metab Dispos 2005; 33:714-8.

Choi MJ, Kang RH, Ham BJ, Jeong HY, Lee MS. Serotonin receptor 2A gene polymorphism (-1438A/G) and short-term treatment response to citalopram. Neuropsychobiology 2005; 52:155-62.

Choi MJ, Lee HJ, Lee HJ et al. Association between major depressive disorder and the -1438A/G polymorphism of the serotonin 2A receptor gene. Neuropsychobiology 2004; 49:38-41.

Choi MK, Kim H, Han YH, Song IS, Shim CK. Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human. Xenobiotica 2009; 39:171-81.

Choi SJ, Ji HY, Lee HY, Lee DH, Lim H, Lee HS. In vitro metabolism of a new H(+)/K(+) ATPase inhibitor DBM-819 in liver microsomes using HPLC and electrospray mass spectrometry. Biomed Chromatogr 2001; 15:503-6.

Choi SJ, Shin SC, Choi JS. Effects of myricetin on the bioavailability of doxorubicin for oral drug delivery in rats: Possible role of CYP3A4 and P-glycoprotein inhibition by myricetin. Arch Pharm Res 2011; 34:309-15.

Choi SY, Fischer L, Yang K, Chung H, Jeong H. Isoform-specific regulation of cytochrome P450 expression and activity by estradiol in female rats. Biochem Pharmacol 2011; 81:777-82.

Choi YH, Lee YS, Lee MG, Kim TK, Lee BY. Pharmacokinetics of mirodenafil, a new erectogenic, and its metabolite, SK3541, in rats: involvement of CYP1A1/2, 2B1/2, 2D subfamily, and 3A1/2 for the metabolism of both mirodenafil and SK3541. J Pharm Pharm Sci 2010; 13:93-106.

Choi YH, Suh JH, Lee JH, Cho IH, Lee MG. Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P-glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats. J Pharm Pharmacol 2010; 62:1084-8.

Chompret A, Kannengiesser C, Barrois M et al. PDGFRA germline mutation in a family with multiple cases of gastrointestinal stromal tumor. Gastroenterology 2004; 126:318-21.

Chong E, Ensom MH. Pharmacogenetics of the proton pump inhibitors: a systematic review. Pharmacotherapy 2003; 23:460-71.

Chong S, Almqvist E, Telenius H et al. Contribution of DNA sequence and CAG size to mutation frequencies of intermediate alleles for Huntington disease: evidence from single sperm analyses. Hum Molec Genet 1997; 6:301-9.

Chonlahan J, Halloran MA, Hammonds A. Leflunomide and warfarin interaction: case report and review of the literature. Pharmacotherapy 2006; 26:868-71.

Chopra V, Metzler M, Rasper D et al. HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin. Mammalian Genome 2000; 11:1006-15.

Chou IC, Lin HC, Wang CH et al. Polymorphisms of interleukin 1 gene IL1RN are associated with Tourette syndrome. Pediatr Neurol 2010; 42:320-4.

Chou M, Bertrand J, Segeral O et al. Population pharmacokinetic-pharmacogenetic study of nevirapine in HIV-infected Cambodian patients. Antimicrob Agents Chemother 2010; 54:4432-9.

Chou YC, Chung YT, Liu TY et al. The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes. J Pharm Sci 2010; 99:1063-77.

Chouchane S, Snow ET. In vitro effect of arsenical compounds on glutathione-related enzymes. Chem Res Toxicol 2001; 14:517-22.

Choudhary C, Schwäble J, Brandts C et al. AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations. Blood 2005; 106:265-73.

Choudhary D, Jansson I, Schenkman JB. CYP1B1, a developmental gene with a potential role in glaucoma therapy. Xenobiotica 2009; 39:606-15.

Choudhary S, Xiao T, Vergara LA et al. Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. Invest Ophthalmol Vis Sci 2005; 46:259-67.

Choudhry S, Ung N, Avila PC et al. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med 2005; 171:563-70.

Choudhuri S, Valerio LG Jr. Usefulness of studies on the molecular mechanism of action of herbals/botanicals: The case of St. John’s wort. J Biochem Mol Toxicol 2005; 19:1-11.

Chougnet A, Grinkova Y, Ricard D, Sligar S, Woggon WD. Fluorescent probes for rapid screening of potential drug-drug interactions at the CYP3A4 level. ChemMedChem 2007; 2:717-24.

Chouinard G, Lefko-Singh K, Teboul E. Metabolism of anxiolytics and hypnotics: benzodiazepines, buspirone, zoplicone, and zolpidem. Cell Mol Neurobiol 1999; 19:533-52.

Choura M, Frikha F, Kharrat N, Aifa S, Rebaï A. Investigating the function of three non-synonymous SNPs in EGFR gene: structural modelling and association with breast cancer. Protein J 2010; 29:50-4.

Chourasia D, Achyut BR, Tripathi S, Mittal B, Mittal RD, Ghoshal UC. Genotypic and functional roles of IL-1B and IL-1RN on the risk of gastroesophageal reflux disease: the presence of IL-1B-511*T/IL-1RN*1 (T1) haplotype may protect against the disease. Am J Gastroenterol 2009; 104:2704-13.

Chow EC, Maeng HJ, Liu S, Khan AA, Groothuis GM, Pang KS. 1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo. Biopharm Drug Dispos 2009; 30:457-75.

Chow EC, Sondervan M, Jin C, Groothuis GM, Pang KS. Comparative effects of doxercalciferol (1α-hydroxyvitamin D(2)) versus calcitriol (1α,25-dihydroxyvitamin D(3)) on the expression of transporters and enzymes in the rat in vivo. J Pharm Sci 2010; 100:1594-604.

Chow HH, Garland LL, Hsu CH et al. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res 2010; 3:1168-75.

Chow HH, Hakim IA, Vining DR et al. Effects of repeated green tea catechin administration on human cytochrome P450 activity. Cancer Epidemiol Biomarkers Prev 2006; 15:2473-6.

Chow JD, Jones ME, Prelle K, Simpson ER, Boon WC. A selective estrogen receptor {alpha} agonist ameliorates hepatic steatosis in the male aromatase knockout mouse. J Endocrinol 2011; 210:323-34.

Chow JD, Price JT, Bills MM, Simpson ER, Boon WC. A doxycycline-inducible, tissue-specific aromatase-expressing transgenic mouse. Transgenic Res 2011. doi:10. 1007/s11248-011-9525-7.

Chow LW, Yip AY, Chu WP, Loo WT, Toi M. Bone metabolism and quality-of-life of postmenopausal women with invasive breast cancer receiving neoadjuvant hormonal therapy: sub-analyses from celecoxib anti-aromatase neoadjuvant (CAAN) trial. J Steroid Biochem Mol Biol 2011; 125:112-9.

Chow MS, White CM, Lau CP, Fan C, Tang MO. Evaluation of CYP2D6 oxidation of dextromethorphan and propafenone in a Chinese population with atrial fibrillation. J Clin Pharmacol 2001; 41:92-6.

Chow T, Imaoka S, Hiroi T, Funae Y. Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver. Drug Metab Dispos 1999; 27:188-92.

Chow TW, Pollock BG, Milgram NW. Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer’s disease. Neuropsychiatr Dis Treat 2007; 3:627-36.

Chowbay B, Cumaraswamy S, Cheung YB, Zhou Q, Lee EJ. Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients. Pharmacogenetics 2003; 13:89-95.

Chowbay B, Zhou S, Lee EJ. An interethnic comparison of polymorphisms of the genes encoding drug-metabolizing enzymes and drug transporters: experience in Singapore. Drug Metab Rev 2005; 37:327-78.

Chowdari KV, Northup A, Pless L et al. DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia. Genes Brain Behav 2007; 6:229-39.

Chowdhury J, Kagiala GV, Pushpakom S et al. Microfluidic platform for single nucleotide polymorphism genotyping of the thiopurine S-methyltransferase gene to evaluate risk for adverse drug events. J Mol Diagnostics 2007; 4:521-9.

Chowdhury S, Pickering L, Ellis P. Controversies in the use of adjuvant trastuzumab (Herceptin). J Br Menopause Soc 2006; 12:172-4.

Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: metabolism. Endocrinol Metab Clin North Am 2010; 39:243-53.

Christen U, Hintermann E, Holdener M, von Herrath MG. Viral triggers for autoimmunity: Is the ‘glass of molecular mimicry’ half full or half empty? J Autoimmun 2010; 34:38-44.

Christen U, Holdener M, Hintermann E. Animal models for autoimmune hepatitis. Autoimmun Rev 2007; 6:306-11.

Christensen B, Arbour L, Tran P et al. Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects. Am J Med Genet 1999; 84:151-7.

Christensen H, Asberg A, Holmboe AB, Berg KJ. Coadministration of grapefruit juice increases systemic exposure of diltiazem in healthy volunteers. Eur J Clin Pharmacol 2002; 58:515-20.

Christensen H, Mathiesen L, Postvoll LW, Winther B, Molden E. Different enzyme kinetics of midazolam in recombinant CYP3A4 microsomes from human and insect sources. Drug Metab Pharmacokinet 2009; 24:261-8.

Christensen M, Andersson K, Dalén P et al. The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes. Clin Pharmacol Ther 2003; 73:517-28.

Christensen M, Tybring G, Mihara K et al. Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19). Clin Pharmacol Ther 2002; 71:141-52.

Christiansen A, Backensfeld T, Denner K, Weitschies W. Effects of non-ionic surfactants on cytochrome P450-mediated metabolism in vitro. Eur J Pharm Biopharm 2011; 78:166-72.

Christopher LJ, Hong H, Vakkalagadda BJ et al. Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans. Drug Metab Dispos 2010; 38:2049-59.

Christopoulos S, Bourdeau I, Lacroix A. Clinical and subclinical ACTH-independent macronodular adrenal hyperplasia and aberrant hormone receptors. Horm Res 2005; 64:119-31.

Chrousos GP, Renquist D, Brandon D et al. Glucocorticoid hormone resistance during primate evolution: receptor-mediated mechanisms. Proc Nat Acad Sci USA 1982; 79:2036-40.

Chroust K, Jowett T, Farid-Wajidi MF et al. Activation or detoxification of mutagenic and carcinogenic compounds in transgenic Drosophila expressing human glutathione S-transferase. IMutat Res 2001; 498:169-79.

Chrzanowska M, Kurzawski M, Drozdzik M, Mazik M, Oko A, Czekalski S. Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients. Pharmacological reports 2007; 6:973-78.

Chu CC, Pan KL, Yao HT, Hsu JT. Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism. Biotechnol Bioeng 2011; 108:2932-40.

Chu J, Dolnick BJ. Natural antisense (rTS-alpha) RNA induces site-specific cleavage of thymidylate synthase mRNA. Biochim Biophys Acta 2002; 1587:183-93.

Chu J, Praticò D. 5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo. Ann Neurol 2011; 69:34-46.

Chu LW, Zhu Y, Yu K et al. Correlation between circadian gene variants and serum levels of sex steroids and insulin-like growth factor-I. Cancer Epidemiol Biomarkers Prev 2008; 17:3268-73.

Chu PH, Huang TY, Williams J, Stafford DW. Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH(2). Proc Nat Acad Sci USA 2007; 103:19308-13.

Chu W, Fyles A, Sellers EM et al. Association between CYP3A4 genotype and risk of endometrial cancer following tamoxifen use. Carcinogenesis 2007; 28:2139-42

Chu X, Dong Y, Shen M et al. Polymorphisms in the ADRB2 gene and Graves disease: a case-control study and a meta-analysis of available evidence. BMC Med Genet 2009; 10:26.

Chu XY, Strauss JR, Mariano MA et al. Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2). J Pharmacol Exp Ther 2006; 317:579-89.

Chua SC Jr, Liu SM, Li Q et al. Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice. Am J Physiol Endocrinol Metab 2004; 286:384-92.

Chuah B, Goh BC, Lee SC et al. Comparison of the pharmacokinetics and pharmacodynamics of S-1 between Caucasian and East Asian patients. Cancer Sci 2011; 102:478-83.

Chugh R, Wagner T, Griffith KA et al. Assessment of ifosfamide pharmacokinetics, toxicity, and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcoma. Cancer 2007; 109:2315-22.

Chui D-H, Tanahashi H, Ozawa K et al. Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nat Med 1999; 5:560-564.

Chun J, Kent UM, Moss RM, Sayre LM, Hollenberg PF. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane. Drug Metab Dispos 2000; 28:905-11.

Chun YJ, Lee S, Yang SA, Park S, Kim MY. Modulation of CYP3A4 expression by ceramide in human colon carcinoma HT-29 cells. Biochem Biophys Res Commun 2002; 298:687-92.

Chun YJ, Oh YK, Kim BJ et al. Potent inhibition of human cytochrome P450 1B1 by tetramethoxystilbene. Toxicol Lett 2009; 189:84-9.

Chun YJ, Park S, Yang SA. Activation of Fas receptor modulates cytochrome P450 3A4 expression in human colon carcinoma cells. Toxicol Lett 2003; 146:75-81.

Chung CJ, Hsueh YM, Bai CH et al. Polymorphisms in arsenic metabolism genes, urinary arsenic methylation profile and cancer. Cancer Causes Control 2009; 20:1653-61.

Chung CJ, Pu YS, Su CT, Huang CY, Hsueh YM. Gene polymorphisms of glutathione S-transferase omega 1 and 2, urinary arsenic methylation profile and urothelial carcinoma. Sci Total Environ 2011; 409:465-70.

Chung CM, Wang RY, Chen JW et al. A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor. Pharmacogenomics J 2010; 10:537-44.

Chung HH, Kim MK, Kim JW et al. XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer. Gynecol Oncol 2006; 103:1031-7.

Chung HJ, Kang HE, Yang KH, Kim SY, Lee MG. Ipriflavone pharmacokinetics in mutant Nagase analbuminemic rats. Biopharm Drug Dispos 2009; 30:294-304.

Chung HW, Seo JS, Hur SE et al. Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. J Hum Genet 2003; 48:243-8.

Chung JW, Yang SH, Choi JS. Effects of lovastatin on the pharmacokinetics of nicardipine in rats. Biopharm Drug Dispos 2010; 31:436-41.

Chung JY, Cho JY, Lim HS et al. Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin. Drug Metab Dispos 2011; 39:92-7.

Chung JY, Cho JY, Yu KS et al. Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers. Clin Pharmacol Ther 2005; 77:486-94.

Chung JY, Jang SB, Lee YJ, Park MS, Park K. Effect of CYP2B6 genotype on the pharmacokinetics of sibutramine and active metabolites in healthy subjects. J Clin Pharmacol 2011; 51:53-9.

Chung MJ, Park KW, Kim KH et al. Asian plantain (Plantago asiatica) essential oils suppress 3-hydroxy-3-methyl-glutaryl-co-enzyme A reductase expression in vitro and in vivo and show hypocholesterolaemic properties in mice. Br J Nutr 2008; 99:67-75.

Chung MJ, Sung NJ, Park CS et al. Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice. Eur J Pharmacol 2008; 578:159-70.

Chung SJ, Armasu SM, Biernacka JM et al. Common variants in PARK loci and related genes and Parkinson’s disease. Mov Disord 2011; 26:280-8.

Chung SJ, Armasu SM, Biernacka JM et al. Variants in estrogen-related genes and risk of Parkinson’s disease. Mov Disord 2011; 26:1234-42.

Chung WH, Hung SI, Hong HS et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature 2004; 428:486.

Chung WK, Deng L, Carroll JS et al. Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension. J Heart Lung Transplant 2009; 28:373-9.

Chutinet A, Suwanwela NC, Snabboon T, Chaisinanunkul N, Furie KL, Phanthumchinda K. Association between genetic polymorphisms and sites of cervicocerebral artery atherosclerosis. J Stroke Cerebrovasc Dis 2011. doi:10. 1016/j. jstrokecerebrovasdis. 2010. 10. 002.

Chuu CP, Chen RY, Barkinge JL, Ciaccio MF, Jones RB. Systems-level analysis of ErbB4 signaling in breast cancer: a laboratory to clinical perspective. Mol Cancer Res 2008; 6:885-91.

Chyka PA, Erdman AR, Christianson G et al. Salicylate poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol 2007; 45:95-131.

Cianfriglia M, Mallano A, Ascione A, Dupuis ML. Multidrug transporter proteins and cellular factors involved in free and mAb linked calicheamicin-gamma1 (gentuzumab ozogamicin, GO) resistance and in the selection of GO resistant variants of the HL60 AML cell line. Int J Oncol 2010; 36:1513-20.

Ciccacci C, Borgiani P, Ceffa S et al. Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique. Pharmacogenomics 2010; 11:23-31.

Ciccacci C, Falconi M, Paolillo N et al. Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis in a warfarin hypersensitive patient. Pharmacogenet Genomics 2011; 21:344-6.

Ciccone PE, Ramabadran K, Jessen LM. Potential interactions of methylphenidate and atomoxetine with dextromethorphan. J Am Pharm Assoc 2006; 46:472-8.

Cicoira M, Rossi A, Bonapace S et al. Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure. Am J Med 2004; 116:657-61.

Cichoz-Lach H, Celiński K, Wojcierowski J, Słomka M, Lis E. Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish men. Braz J Med Biol Res 2010; 43:257-61.

Cichoz-Lach H, Partycka J, Nesina I, Celinski K, Słomka M, Wojcierowski J. Genetic polymorphism of alcohol dehydrogenase 3 in alcohol liver cirrhosis and in alcohol chronic pancreatitis. Alcohol Alcohol 2006; 41:14-7.

Cichoz-Lach H, Partycka J, Nesina I, Celinski K, Slomka M, Wojcierowski J. Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. Scand J Gastroenterol 2007; 42:493-8.

Ciervo CA, Shi J. Pharmacokinetics of telithromycin: application to dosing in the treatment of community-acquired respiratory tract infections. Curr Med Res Opin 2005; 21:1641-50.

Cigana C, Nicolis E, Pasetto M, Assael BM, Melotti P. Effects of azithromycin on the expression of ATP binding cassette transporters in epithelial cells from the airways of cystic fibrosis patients. J Chemother 2007; 19:643-9.

Cimino L, Boiardi L, Aldigeri R et al. G/R 241 polymorphism of intercellular adhesion molecule 1 (ICAM-1) is associated with Fuchs uveitis. Invest Ophthalmol Vis Sci 2010; 51:4447-50.

Cinar C, Yazici C, Ergünsu S et al. Genetic diagnosis in infertile men with numerical and constitutional sperm abnormalities. Genet Test 2008; 12:195-202.

Cindric M, Cipak A, Serly J et al. Reversal of multidrug resistance in murine lymphoma cells by amphiphilic dihydropyridine antioxidant derivative. Anticancer Res 2010; 30:4063-9.

Ciolino HP, Dai Z, Nair V. Retinol inhibits aromatase activity and expression in vitro. J Nutr Biochem 2011; 22:522-6.

Ciolino HP, Daschner PJ, Wang TT, Yeh GC. Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Biochem Pharmacol 1998; 56:197-206.

Ciotti M, Chen F, Rubaltelli FF, Owens IS. Coding defect and a TATA box mutation at the bilirubin UDP-glucuronosyltransferase gene cause Crigler-Najjar type I disease. Biochim Biophys Acta 1998; 1407:40-50.

Ciotti M, Marrone A, Potter C, Owens IS. Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications. Pharmacogenetics 1997; 7:485-95.

Ciotti M, Obaray R, Martín MG, Owens IS. Genetic defects at the UGT1 locus associated with Crigler-Najjar type I disease, including a prenatal diagnosis. Am J Med Genet 1997; 68:173-8.

Ciotti M, Werlin SL, Owens IS. Delayed response to phenobarbital treatment of a Crigler-Najjar type II patient with partially inactivating missense mutations in the bilirubin UDP-glucuronosyltransferase gene. J Pediatr Gastroenterol Nutr 1999; 28:210-3.

Ciotti M, Yeatman MT, Sokol RJ, Owens IS. Altered coding for a strictly conserved di-glycine in the major bilirubin UDP-glucuronosyltransferase of a Crigler-Najjar type I patient. J Biol Chem 1995; 270:3284-91.

Cipollone F, Fazia ML, Iezzi A et al. Association between prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in human. Arterioscler Thromb Vasc Biol 2005; 25:1925-31.

Cipollone F, Toniato E, Martinotti S et al. A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. JAMA 2004; 291:2221-8.

Cirrito JR, Disabato BM, Restivo JL et al. Serotonin signaling is associated with lower amyloid-{beta} levels and plaques in transgenic mice and humans. Proc Natl Acad Sci USA 2011; 108:14968-73.

Citrome L. Iloperidone: chemistry, pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability, regulatory affairs, and an opinion. Expert Opin Drug Metab Toxicol 2010; 6:1551-64.

Citron M. Beta-secretase inhibition for the treatment of Alzheimer’s disease- promise and challenge. Trends Pharmacol Sci 2004; 25:92-7.

Citron M, Westaway D, Xia W et al. Mutant presenilins of Alzheimer’s disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med 1997; 3:67-72.

Ciuclan L, Ehnert S, Ilkavets I et al. TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I. J Hepatol 2010; 52:407-16.

Ciusani E, Zullino DF, Eap CB, Brawand-Amey M, Brocard M, Baumann P. Combination therapy with venlafaxine and carbamazepine in depressive patients not responding to venlafaxine: pharmacokinetic and clinical aspects. J Psychopharmacol 2004; 18:559-66.

Cizmarikova M, Wagnerova M, Schonova L et al. MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcome. Pharmacogenomics J 2010; 10:62-9.

Claessens AJ, Risler LJ, Eyal S, Shen DD, Easterling TR, Hebert MF. CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos 2010; 38:1393-6.

Clappers N, van Oijen MG, Sundaresan S et al. The C50T polymorphism of the cyclooxygenase-1 gene and the risk of thrombotic events during low-dose therapy with acetyl salicylic acid. Thromb Haemost 2008; 100:70-5.

Clària J, Romano M. Pharmacological intervention of cyclooxygenase-2 and 5-lipoxygenase pathways. Impact on inflammation and cancer. Curr Pharm Des 2005; 11:3431-47.

Clark D, Morgan A, Hananeia L, Coulter D, Olds R. Drug metabolism genotypes and their association with adverse drug reactions in selected populations: a pilot study of methodology. Pharmacoepidemiol Drug Saf 2000; 9:393-400.

Clark DA, Mata I, Kerwin RW, Munro J, Arranz MJ. No association between ADRA2A polymorphisms and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2007; 144:341-3.

Clark JJ, Cools J, Curley DP et al. Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. Blood 2004; 104:2867-72.

Clark LN, Poorkaj P, Wszolek Z et al. Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17. Proc Nat Acad Sci USA 1998; 95:13103-7.

Clark MS, Neumaier JF. The 5-HT1B receptor: behavioral implications. Psychopharmacol Bull 2001; 35:170-85.

Clark TG, Fry AE, Auburn S et al. Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility. Eur J Hum Genet 2009; 17:1080-5.

Clark VJ, Metheny N, Dean M, Peterson RJ. Statistical estimation and pedigree analysis of CCR2-CCR5 haplotypes. Hum Genet 2001; 108:484-93.

Clarke G, Collins R, Leavitt B et al. A one-hit model of cell death in inherited neuronal degenerations. Nature 2000; 406:195-9.

Clarke JA, Cutler M, Gong I, Schwarz UI, Freeman D, Dasgupta M. Cytochrome P450 2D6 phenotyping in an elderly population with dementia and response to galantamine in dementia: a pilot study. Am J Geriatr Pharmacother 2011; 9:224-33.

Clarke MW, Burnett JR, Croft KD. Vitamin E in human health and disease. Crit Rev Clin Lab Sci 2008; 45:417-50.

Clarke MW, Burnett JR, Wu JH et al. Vitamin E supplementation and hepatic drug metabolism in humans. J Cardiovasc Pharmacol 2009; 54:491-6.

Clarke SJ, Rivory LP. Clinical pharmacokinetics of docetaxel. Clin Pharmacokinet 1999; 36:99-114.

Clarke TA, Waskell LA. The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin. Drug Metab Dispos 2003; 31:53-9.

Clarke TK, Dempster E, Docherty SJ et al. Multiple polymorphisms in genes of the adrenergic stress system confer vulnerability to alcohol abuse. Addict Biol 2010. doi:10. 1111/j. 1369-1600. 2010. 00263. x.

Clay PG, Adams MM. Pseudo-Parkinson disease secondary to ritonavir-buspirone interaction. Ann Pharmacother 2003; 37:202-5.

Clayton PT. Clinical consequences of defects in peroxisomal beta-oxidation. Biochem Soc Trans 2001; 29:298-305.

Cleary SP, Cotterchio M, Shi E, Gallinger S, Harper P. Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk. Am J Epidemiol 2010; 172:1000-14.

Cleary SP, Kim H, Croitoru ME et al. Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk. Dis Colon Rectum 2008; 51:1467-73.

Clement K, Boutin P, Froguel P. Genetics of obesity. Am J Pharmacogenomics 2002; 2:177-87.

Clément K, Vaisse C, Lahlou N et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392:398-401.

Clemente-Postigo M, Queipo-Ortuño M, Valdivielso P, Tinahones FJ, Cardona F. Effect of apolipoprotein C3 and apolipoprotein A1 polymorphisms on postprandial response to a fat overload in metabolic syndrome patients. Clin Biochem 2010; 43:1300-4.

Clerc RG, Stauffer A, Weibel F et al. Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor torcetrapib involve L-type calcium channels. J Hypertens 2010; 28:1676-86.

Clerici C, Castellani D, Asciutti S et al. 3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats. Toxicol Appl Pharmacol 2006; 214:199-208.

Cleveland RJ, Gammon MD, Long CM et al. Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival. Breast Cancer Res Treat 2010; 120:745-52.

Clinard F, Sgro C, Bardou M et al. Association between concomitant use of several systemic NSAIDs and an excess risk of adverse drug reaction. A case/non-case study from the French Pharmacovigilance system database. Eur J Clin Pharmacol 2004; 60:279-83.

Clodfelter JE, B Gentry M, Drotschmann K. MSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instability. Nucleic Acids Res 2005; 33:3323-30.

Close SL. Clopidogrel pharmacogenetics: metabolism and drug interactions. Drug Metabol Drug Interact 2011; 26:45-51.

Clot F, Grabli D, Cazeneuve C et al. Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia. Brain 2009; 132:1753-63.

Clouthier DE, Comerford SA, Hammer RE. Hepatic fibrosis, glomerulosclerosis, and lipodystrophy-like PEPCK-TGF-beta-1 transgenic mice. J Clin Invest 1997; 100:2697-2713.

Coate L, Cuffe S, Horgan A, Hung RJ, Christiani D, Liu G. Germline genetic variation, cancer outcome, and pharmacogenetics. J Clin Oncol 2010; 28:4029-37.

Cobaugh DJ, Erdman AR, Booze LL et al. Atypical antipsychotic medication poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol 2007; 45:918-42.

Cobb SA, Wider C, Ross OA et al. GCH1 in early-onset Parkinson’s disease. Mov Disord 2009; 24:2070-5.

Cobos-Trigueros N, Ateka O, Pitart C, Vila J. Macrolides and ketolides. Enferm Infecc Microbiol Clin 2009; 27:412-8.

Coburger C, Lage H, Molnár J, Langner A, Hilgeroth A. Multidrug resistance reversal properties and cytotoxic evaluation of representatives of a novel class of HIV-1 protease inhibitors. J Pharm Pharmacol 2010; 62:1704-10.

Coburger C, Wollmann J, Krug M et al. Novel structure-activity relationships and selectivity profiling of cage dimeric 1,4-dihydropyridines as multidrug resistance (MDR) modulators. Bioorg Med Chem 2010; 18:4983-90.

Cocco G, Chu DC, Pandolfi S. Colchicine in clinical medicine. A guide for internists. Eur J Intern Med 2010; 21:503-8.

Cockcroft JR, Gazis AG, Cross DJ et al. Beta(2)-adrenoceptor polymorphism determines vascular reactivity in humans. Hypertension 2000; 36:371-5.

Cocks G, Wilde JI, Graham SJ et al. The thiazolidinedione pioglitazone increases cholesterol biosynthetic gene expression in primary cortical neurons by a PPARgamma-independent mechanism. J Alzheimers Dis 2010; 19:631-46.

Cockshott ID. Bicalutamide: clinical pharmacokinetics and metabolism. Clin Pharmacokinet 2004; 43:855-78.

Cochrane WA, Payne WW, Simpkiss MJ, Woolf LI. Familial hypoglycemia precipitated by amino acids. J Clin Invest 1956; 35:411-2.

Code EL, Crespi CL, Penman BW, Gonzalez FJ, Chang TK, Waxman DJ. Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation. Drug Metab Dispos 1997; 25:985-93.

Coecke S, Bogni A, Langezaal I, Worth A, Hartung T, Monshouwer M. The use of genetically engineered cells for assessing CYP2D6-related polymorphic effects. Toxicol In Vitro 2001; 15:553-6.

Coen D, Zadro R, Honović L, Banfić L, Stavljenić Rukavina A. Prevalence and association of the factor V Leiden and prothrombin G20210A in healthy subjects and patients with venous thromboembolism. Croat Med J 2001; 42:488-92.

Coenen MJ, Toonen EJ, Scheffer H, Radstake TR, Barrera P, Franke B. Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis. Pharmacogenomics 2007; 8:761-73.

Cofán F, Gutiérrez R, Beardo P, Campistol JM, Oppenheimer F, Alcover J. Interaction between sildenafil and calcineurin inhibitors in renal transplant recipients with erectile dysfunction. Nefrologia 2002; 22:470-6.

Coffey GL, Botts SR, de Leon J. High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29:770-4.

Coffman BL, Tephly TR, Irshaid YM et al. Characterization and primary sequence of a human hepatic microsomal estriol UDP-glucuronosyltransferase. Arch Biochem Biophys 1990; 281:170-5.

Cohen BM, Lipinski JF. In vivo potencies of antipsychotic drugs in blocking alpha 1 noradrenergic and dopamine D2 receptors: implications for drug mechanisms of action. Life Sci 1986; 39:2571-80.

Cohen FE, Prusiner SB. Structural studies of prion proteins. In: Prusiner SB (Ed). Prion biology and diseases. Cold Spring Harbor Laboratory Press, New York, 1999:191-228.

Cohen H, Neumann L, Glazer Y, Ebstein RP, Buskila D. The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia. Clin Exp Rheumatol 2009; 27(5 Suppl 56):51-6.

Cohen IL, Liu X, Schutz C et al. Association of autism severity with a monoamine oxidase A functional polymorphism. Clin Genet 2003; 64:190-7.

Cohen JC, Kiss RS, Pertsemlidis A, Marcel YL, McPherson R, Hobbs HH. Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science 2004; 305:869-72.

Cohen JI, Roychowdhury S, McMullen MR, Stavitsky AB, Nagy LE. Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice. Gastroenterology 2010; 139:664-74.

Cohen JS, Benton AS, Nwachukwu F, Ozedirne T, Teach SJ, Freishtat RJ. P-glycoprotein transporter expression on a549 respiratory epithelial cells is positively correlated with intracellular dexamethasone levels. J Investig Med 2010; 58:991-4.

Cohen K, Grant A, Dandara C et al. Effect of rifampicin-based antitubercular therapy and the cytochrome P450 2B6 516G>T polymorphism on efavirenz concentrations in adults in South Africa. Antivir Ther 2009; 14:687-95.

Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH. Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos 2000; 21:353-64.

Cohen MH, Williams GA, Sridhara R et al. United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tablets. Clin Cancer Res 2004; 10:1212-8.

Cohen RE, Wade J. Aromatase mRNA in the brain of adult green anole lizards: effects of sex and season. J Neuroendocrinol 2011; 23:254-60.

Cohn RD, van Erp C, Habashi JP et al. Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states. Nat Med 2007; 13:204-10.

Coindre JM. Molecular biology of soft-tissue sarcomas. Bull Cancer 2010; 97:1337-45.

Cojocaru V, Balali-Mood K, Sansom MS, Wade RC. Structure and dynamics of the membrane-bound cytochrome P450 2C9. PLoS Comput Biol 2011. doi:10. 1371/journal. pcbi. 1002152.

Colabufo NA, Berardi F, Perrone MG et al. Substrates, inhibitors and activators of P-glycoprotein: candidates for radiolabeling and imaging perspectives. Curr Top Med Chem 2010; 10:1703-14.

Colabufo NA, Contino M, Berardi F et al. A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents. Toxicol In Vitro 2011; 25:222-30.

Colabufo NA, Contino M, Niso M, Berardi F, Leopoldo M, Perrone R. EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives. Front Biosci 2011; 16:1811-23.

Colamonici OR, Domanski P, Platanias LC, Diaz MO. Correlation between interferon (IFN) alpha resistance and deletion of the IFN alpha/beta genes in acute leukemia cell lines suggests selection against the IFN system. Blood 1992; 80:744-9.

Colburn DE, Giles FJ, Oladovich D, Smith JA. In vitro evaluation of cytochrome P450-mediated drug interactions between cytarabine, idarubicin, itraconazole and caspofungin. Hematology 2004; 9:217-21.

Cole LK, Dolinsky VW, Dyck JR, Vance DE. Impaired phosphatidylcholine biosynthesis reduces atherosclerosis and prevents lipotoxic cardiac dysfunction in ApoE-/- Mice. Circ Res 2011; 108:686-94.

Cole SL, Vassar R. BACE1 structure and function in health and Alzheimer’s disease. Curr Alzheimer Res 2008; 5:100-20.

Cole SPC, Bhardwaj G, Gerlach JH et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 1992; 258:1650-4.

Cole TB, Jansen K, Park S, Li WF, Furlong CE, Costa LG. The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status. Adv Exp Med Biol 2010; 660:47-60.

Colella S, Nardo T, Mallery D et al. Alterations in the CSB gene in three Italian patients with the severe form of Cockayne syndrome (CS) but without clinical photosensitivity. Hum Mol Genet 1999; 8:935-41.

Coleman MD, Smith SN, Kelly DE, Kelly SL, Seydel JK. Studies on the toxicity of analogues of dapsone in-vitro using rat, human and heterologously expressed metabolizing systems. J Pharm Pharmacol 1996; 48:945-50.

Coleman S, Linderman R, Hodgson E, Rose RL. Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes. Environ Health Perspect 2000; 108:1151-7.

Coleman T, Ellis SW, Martin IJ, Lennard MS, Tucker GT. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4-implications for susceptibility to Parkinson’s disease. J Pharmacol Exp Ther 1996; 277:685-90.

Coles BF, Morel F, Rauch C et al. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. Pharmacogenetics 2001; 11:663-9.

Coletta DK, Sriwijitkamol A, Wajcberg E et al. Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial. Diabetologia 2009; 52:723-32.

Coley HM. Overcoming multidrug resistance in cancer: clinical studies of p-glycoprotein inhibitors. Methods Mol Biol 2010; 596:341-58.

Colin EM, Uitterlinden AG, Meurs JBJ et al. Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk. J Clin Endocr Metab 2003; 88:3777-84.

Colombo S, Buclin T, Cavassini M et al. Population pharmacokinetics of atazanavir in patients with human immunodeficiency virus infection. Antimicrob Agents Chemother 2006; 50:3801-8.

Colombo S, Buclin T, Décosterd LA et al. Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation. Clin Pharmacol Ther 2006; 80:307-18.

Colombo S, Rauch A, Rotger M et al. The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir. J Infect Dis 2008; 198:864-7.

Colombo S, Soranzo N, Rotger M et al. Swiss HIV Cohort Study. Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. Pharmacogenet Genomics 2005; 15:599-608.

Colomer V, Engelender S, Sharp A et al. Huntingtin-associated protein 1 (HAP) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domains. Hum Molec Genet 1997; 6:1519-25.

Colson NJ, Lea RA, Quinlan S, Griffiths LR. No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility. BMC Med Genet 2006; 7:12.

Colton CA, Needham LK, Brown C et al. APOE genotype-specific differences in human and mouse macrophage nitric oxide production. J Neuroimmunol 2004; 147:62-7.

Coll E, Campos B, González-Núñez D, Botey A, Poch E. Association between the A1166C polymorphism of the angiotensin II receptor type 1 and progression of chronic renal insufficiency. J Nephrol 2003; 16:357-64.

Coller JK. Oxidative metabolism of tamoxifen to Z-4-hydroxy-tamoxifen by cytochrome P450 isoforms: an appraisal of in vitro studies. Clin Exp Pharmacol Physiol 2003; 30:845-8.

Coller JK, Barratt DT, Dahlen K, Loennechen MH, Somogyi AA. ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals. Clin Pharmacol Ther 2006; 80:682-90.

Coller JK, Christrup LL, Somogyi AA. Role of active metabolites in the use of opioids. Eur J Clin Pharmacol 2009; 65:121-39.

Coller JK, Joergensen C, Foster DJ et al. Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone. Int J Clin Pharmacol Ther 2007; 45:410-7.

Coller JK, Krebsfaenger N, Klein K et al. The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver. Br J Clin Pharmacol 2002; 54:157-67.

Coller JK, Krebsfaenger N, Klein K et al. Large interindividual variability in the in vitro formation of tamoxifen metabolites related to the development of genotoxicity. Br J Clin Pharmacol 2004; 57:105-11.

Coller JK, Somogyi AA, Bochner F. Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4. Xenobiotica 1999; 29:973-86.

Coller JK, Somogyi AA, Bochner F. Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms. Br J Clin Pharmacol 1999; 48:158-67.

Colli ML, Gross JL, Canani LH. Mutation H63D in the HFE gene confers risk for the development of type 2 diabetes mellitus but not for chronic complications. J Diabetes Complications 2011; 25:25-30.

Collinge J. Human prion diseases and bovine spongiform encephalopathy (BSE) Hum Molec Genet 1997; 6:1699-705.

Collinge J. Variant Creutzfeldt-Jakob disease. Lancet 1999; 354:317-23.

Collinge J, Palmer MS, Dryden AJ. Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease. Lancet 1991; 337:1441-2.

Collinge J, Sidle KCL, Heads J, Ironside J, Hill AF. Molecular analysis of prion strain variation and the aetiology of ‘new variant’ CJD. Nature 1996; 383:685-90.

Collins SJ, Groudine MT. Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562. Proc Natl Acad Sci USA 1983; 80:4813-7.

Collnot EM, Baldes C, Schaefer UF, Edgar KJ, Wempe MF, Lehr CM. Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access. Mol Pharm 2010; 7:642-51.

Comasco E, Sylvén SM, Papadopoulos FC, Sundström-Poromaa I, Oreland L, Skalkidou A. Postpartum depression symptoms: a case-control study on monoaminergic functional polymorphisms and environmental stressors. Psychiatr Genet 2011; 21:19-28.

Combarros O, Infante J, Llorca J, Peña N, Fernández-Viadero C, Berciano J. The chemokine receptor CCR5-Delta32 gene mutation is not protective against Alzheimer’s disease. Neurosci Lett 2004; 366:312-4.

Combarros O, van Duijn CM, Hammond N et al. Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer’s disease. J Neuroinflammation 2009; 6:22.

Combrinck M, Gilbert JD, Byard RW. Pseudoxanthoma elasticum and sudden death. J Forensic Sci 2011; 56:418-22.

Combs TP, Wagner JA, Berger J et al. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology 2002; 143:998-1007.

Comen E, Davids M, Kirchhoff T, Hudis C, Offit K, Robson M. Relative contributions of BRCA1 and BRCA2 mutations to “triple-negative” breast cancer in Ashkenazi Women. Breast Cancer Res Treat 2011; 129:185-90.

Comincini S, Foti MG, Tranulis MA et al. Genomic organization, comparative analysis, and genetic polymorphisms of the bovine and ovine prion Doppel genes (PNRD). Mammalian Genome 2001; 12:729-33.

Comings DE, Gade-Andavolu R, Gonzalez N, Blake H, Wu S, MacMurray JP. Additive effect of three noradrenergic genes (ADRA2a, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects. Clin Genet 1999; 55:160-72.

Comley LH, Fuller HR, Wishart TM et al. ApoE isoform-specific regulation of regeneration in the peripheral nervous system. Hum Mol Genet 2011; 20:2406-21.

Compton MT, Miller AH. Priapism associated with conventional and atypical antipsychotic medications: a review. J Clin Psychiatry 2001; 62:362-6.

Comuzzie AG, Funahashi T, Sonnenberg G et al. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocr Metab 2001; 86:4321-5.

Conard J, Horellou MH, van Dreden P et al. Homozygous protein C deficiency with late onset and recurrent coumarin-induced skin necrosis. Lancet 1992; 339:743-4.

Conen D, Glynn RJ, Buring JE, Ridker PM, Zee RY. Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study. J Hypertens 2008; 26:1780-6.

Conen D, Glynn RJ, Buring JE, Ridker PM, Zee RY. Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study. J Intern Med 2008; 263:376-85.

Conesa-Zamora P, Santaclara V, Gadea-Niñoles E, Ortiz-Reina S, Perez-Guillermo M. Association of polymorphism in FcGR3A gene and progression of low-grade precursor lesions of cervical carcinoma. Hum Immunol 2010; 71:314-7.

Congiu M, Mashford ML, Slavin JL, Desmond PV. Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease. J Gastroenterol Hepatol 2009; 24:1038-44.

Connell JW, Gibb GM, Betts JC et al. Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3-beta identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes. FEBS 2001; 493:40-4.

Connelly SJ, Mukaetova-Ladinska EB, Abdul-All Z et al. Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype. Neuropathol Appl Neurobiol 2011; 37:366-80.

Conner TS, Jensen KP, Tennen H, Furneaux HM, Kranzler HR, Covault J. Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men. Am J Med Genet B Neuropsychiatr Genet 2010; 153:67-78.

Connor H. Serotonin syndrome after single doses of co-amoxiclav during treatment with venlafaxine. J R Soc Med 2003; 96:233-4.

Connor JR, Lee SY. HFE mutations and Alzheimer’s disease. J Alzheimers Dis 2006; 10:267-76.

Connors SL, Crowell DE, Eberhart CG et al. beta2-adrenergic receptor activation and genetic polymorphisms in autism: data from dizygotic twins. J Child Neurol 2005; 20:876-84.

Conrad C, Andreadis A, Trajanowski JQ et al. Genetic evidence for the involvement of tau in progressive supranuclear palsy. Ann Neurol 1997; 41:277-81.

Conrad C, Vianna C, Freeman M, Davies P. A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer’s disease. Proc Nat Acad Sci USA 2002; 99:7751-6.

Conrad DJ, Stenbit AE, Zettner EM, Wick I, Eckhardt C, Hardiman G. Frequency of mitochondrial 12S ribosomal RNA variants in an adult cystic fibrosis population. Pharmacogenet Genomics 2008; 18:1095-102.

Conrad S, Kauffmann HM, Ito K et al. Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution. J Hum Genet 2001; 46:656-63.

Conrad S, Kauffmann HM, Ito K et al. A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. Pharmacogenetics 2002; 12:321-30.

Conroy MC, Randinitis EJ, Turner JL. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain 1991; 7 Suppl 1:44-8.

Contardo-Jara V, Lorenz C, Pflugmacher S, Nützmann G, Kloas W, Wiegand C. Molecular effects and bioaccumulation of levonorgestrel in the non-target organism Dreissena polymorpha. Environ Pollut 2011; 159:38-44.

Contardo-Jara V, Pflugmacher S, Nützmann G, Kloas W, Wiegand C. The beta-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha. Environ Pollut 2010; 158:2059-66.

Contin M, Sangiorgi S, Riva R, Parmeggiani A, Albani F, Baruzzi A. Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam. Ther Drug Monit 2002; 24:737-41.

Contopoulos-Ioannidis DG, Manoli EN, Ioannidis JPA. Meta-analysis of the association of beta-2-adrenergic receptor polymorphisms with asthma phenotypes. J Allergy Clin Immun 2005; 115:963-72.

Contractor A, Swanson G, Heinemann SF. Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus. Neuron 2001; 29:209-16.

Contreras AV, Monge-Cazares T, Alfaro-Ruiz L et al. Resequencing, haplotype construction and identification of novel variants of CYP2D6 in Mexican mestizos. Pharmacogenomics 2011; 12:745-56.

Conus P, Bondolfi G, Eap CB, Macciardi F, Baumann P. Pharmacokinetic fluvoxamine-clomipramine interaction with favorable therapeutic consequences in therapy-resistant depressive patient. Pharmacopsychiatry 1996; 29:108-10.

Conway S, Mowat ES, Drew JE, Barrett P, Delagrange P, Morgan PJ. Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor. Biochem Biophys Res Commun 2001; 282:1229-36.

Cook CS, Berry LM, Kim DH, Burton EG, Hribar JD, Zhang L. Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: differential metabolism by CYP3A4 and CYP3A5. Drug Metab Dispos 2002; 30:1344-51.

Cook EH Jr, Scherer SW. Copy-number variations associated with neuropsychiatric conditions. Nature 2008; 455:919-23.

Cook JR, Semple RK. Hypoadiponectinemia-cause or consequence of human “insulin resistance”? J Clin Endocrinol Metab 2010; 95:1544-54.

Cooke GS, Aucan C, Walley AJ et al. Association of Fcgamma receptor IIa (CD32) polymorphism with severe malaria in West Africa. Am J Trop Med Hyg 2003; 69:565-8.

Cooke GS, Hill AV. Genetics of susceptibility to human infectious disease. Nat Rev Genet 2001; 2:967-77.

Cooke KR, Ferrara JL. A protective gene for graft-versus-host disease. N Engl J Med 2003; 349:2183-4.

Cools J, DeAngelo DJ, Gotlib J et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 2003; 348:1201-14.

Cooper A, Daly E, Foy C et al. Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer’s disease. J Neurol 2008; 255:1712-20.

Cooper BW, Cho TM, Thompson PM, Wallace AD. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression. Toxicol Sci 2008; 103:268-77.

Cooper DA, Heera J, Goodrich J et al. Maraviroc versus efavirenz, both in combination with zidovudine-lamivudine, for the treatment of antiretroviral-naive subjects with CCR5-tropic HIV-1 infection. J Infect Dis 2010; 201:803-13.

Cooper GM, Johnson JA, Langaee TY et al. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood 2008; 112:1022-7.

Cooper HL, Groves JT. Molecular probes of the mechanism of cytochrome P450. Oxygen traps a substrate radical intermediate. Arch Biochem Biophys 2011; 507:111-8.

Cooper JD, Smyth DJ, Walker NM et al. Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes 2011; 60:1624-31.

Cooper KJ, Martin PD, Dane AL, Warwick MJ, Raza A, Schneck DW. The effect of erythromycin on the pharmacokinetics of rosuvastatin. Eur J Clin Pharmacol 2003; 59:51-6.

Cooper KJ, Martin PD, Dane AL, Warwick MJ, Schneck DW, Cantarini MV. Effect of itraconazole on the pharmacokinetics of rosuvastatin. Clin Pharmacol Ther 2003; 73:322-9.

Cooper WO, Hernandez-Diaz S, Arbogast PG et al. Major congenital malformations after first-trimester exposure to ACE inhibitors. New Eng J Med 2006; 354:2443-51.

Cooper-Kazaz R, van der Deure WM, Medici M et al. Preliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine. J Affect Disord 2009; 116:113-6.

Copin B, Brezin AP, Valtot F, Dascotte JC, Bechetoille A, Garchon HJ. Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene. Am J Hum Genet 2002; 70:1575-81.

Coppedè F. One-carbon metabolism and Alzheimer’s disease: focus on epigenetics. Curr Genomics 2010; 11:246-60.

Coppedè F, Migheli F, Lo Gerfo A et al. Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2010; 11:122-4.

Corbalán MS, Marti A, Forga L, Martínez-González MA, Martínez JA. The 27Glu polymorphism of the beta-2-adrenergic receptor gene interacts with physical activity influencing obesity risk among female subjects. Clin Genet 2002; 6:305-7.

Corbera J, Vaño D, Martínez D et al. A medicinal-chemistry-guided approach to selective and druglike sigma 1 ligands. ChemMedChem 2006; 1:140-54.

Corbett AH, Lim ML, Kashuba AD. Kaletra (lopinavir/ritonavir). Ann Pharmacother 2002; 36:1193-203.

Corbin AS, La Rosée P, Stoffregen EP, Druker BJ, Deininger MW. Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib. Blood 2003; 101:4611-4.

Corbo RM, Scacchi R. Apolipoprotein E (APOE) allele distribution in the world: is APOE*4 a ‘thrifty’ allele? Ann Hum Genet 1999; 63:301-10.

Corbo RM, Scacchi R, Cresta M. Differential reproductive efficiency associated with common apolipoprotein e alleles in postreproductive-aged subjects. Fertil Steril 2004; 81:104-7.

Corbo RM, Ulizzi L, Positano L, Scacchi R. Association of CYP19 and ESR1 pleiotropic genes with human longevity. J Gerontol A Biol Sci Med Sci 2011; 66:51-5.

Corboz MR, Rivelli MA, McCormick KD et al. Pharmacological characterization of a novel {alpha}2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N’-methylurea (Compound A). J Pharmacol Exp Ther 2011; 337:256-66.

Corchero J, Granvil CP, Akiyama TE et al. The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse. Mol Pharmacol 2001; 60:1260-7.

Corchero J, Pimprale S, Kimura S, Gonzalez FJ. Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation. Pharmacogenetics 2001; 11:1-6.

Cordell B. b-Amyloid formation as a potential therapeutic target for Alzheimer’s disease. Annu Rev Pharmacol Toxicol 1994; 34:69-89.

Corder EH, Robertson K, Lannfelt L et al. HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy. Nat Med 1998; 4:1182-4.

Corder EH, Saunders AM, Risch NJ et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 1994; 7:180-4.

Corder EH, Saunders AM, Strittmatter WJ et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 1993; 261:921-3.

Cordts EB, Christofolini DM, dos Santos AA, Bianco B, Barbosa CP. Genetic aspects of premature ovarian failure: a literature review. Arch Gynecol Obstet 2011; 283:635-43.

Corella D, Arregui M, Coltell O et al. Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population. Obesity 2011; 19:1707-14.

Corella D, Guillén M, Portolés O et al. Gender specific associations of the Trp64Arg mutation in the beta3-adrenergic receptor gene with obesity-related phenotypes in a Mediterranean population: interaction with a common lipoprotein lipase gene variation. J Intern Med 2001; 250:348-60.

Corleto VD, Pagnini C, Margagnoni G et al. IL-1beta-511 and IL-1RN*2 polymorphisms in inflammatory bowel disease: An Italian population study and meta-analysis of European studies. Dig Liver Dis 2010; 42:179-84.

Cornelis MC, Bae SC, Kim I, El-Sohemy A. CYP1A2 genotype and rheumatoid arthritis in Koreans. Rheumatol Int 2010; 30:1349-54.

Cornelis MC, El-Sohemy A, Campos H. Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. Am J Clin Nutr 2007; 86:240-4.

Cornelis MC, Monda KL, Yu K et al. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genet 2011. doi:10. 1371/journal. pgen. 1002033.

Cornelissen JJ, Sonneveld P, Schoester M et al. MDR-1 expression and response to vincristine, doxorubicin, and dexamethasone chemotherapy in multiple myeloma refractory to alkylating agents. J Clin Oncol 1994; 12:115-9.

Corneveaux JJ, Myers AJ, Allen AN et al. Association of CR1, CLU and PICALM with Alzheimer’s disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet 2010; 19:3295-301.

Cornu JN, Merlet B, Cussenot O et al. Genetic susceptibility to urinary incontinence: implication of polymorphisms of androgen and oestrogen pathways. World J Urol 2011; 29:239-42.

Corominas R, Sobrido MJ, Ribasés M et al. Association study of the serotoninergic system in migraine in the Spanish population. Am J Med Genet B Neuropsychiatr Genet 2010; 153:177-84.

Corona C, Pensalfini A, Frazzini V, Sensi SL. New therapeutic targets in Alzheimer’s disease: brain deregulation of calcium and zinc. Cell Death Dis 2011. doi:10. 1038/cddis. 2011. 57.

Corona G, Razzoli E, Forti G, Maggi M. The use of phosphodiesterase 5 inhibitors with concomitant medications. J Endocrinol Invest 2008; 31:799-808.

Corpechot C, Ping C, Wendum D, Matsuda F, Barbu V, Poupon R. Identification of a novel 974C→G nonsense mutation of the MRP2/ABCC2 gene in a patient with Dubin-Johnson syndrome and analysis of the effects of rifampicin and ursodeoxycholic acid on serum bilirubin and bile acids. Am J Gastroenterol 2006; 101:2427-32.

Correale P, Marra M, Remondo C et al. Cytotoxic drugs up-regulate epidermal growth factor receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent cell-mediated-cytotoxicity (ADCC). Eur J Cancer 2010; 46:1703-11.

Correia AP, Pinto JP, Dias V, Mascarenhas C, Almeida S, Porto G. CAT53 and HFE alleles in Alzheimer’s disease: a putative protective role of the C282Y HFE mutation. Neurosci Lett 2009; 457:129-32.

Correia CT, Almeida JP, Santos PE et al. Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions. Pharmacogenomics J 2010; 10:418-30.

Correia MA, Sadeghi S, Mundo-Paredes E. Cytochrome P450 ubiquitination: branding for the proteolytic slaughter? Annu Rev Pharmacol Toxicol 2005; 45:439-64.

Corrigan CJ, Brown PH, Barnes NC, Tsai JJ, Frew AJ, Kay AB. Glucocorticoid resistance in chronic asthma. Peripheral blood T lymphocyte activation and comparison of the T lymphocyte inhibitory effects of glucocorticoids and cyclosporin A. Am Rev Respir Dis 1991; 144:1026-32.

Corso A, Lorenzi A, Terulla V et al. Modification of thrombomodulin plasma levels in refractory myeloma patients during treatment with thalidomide and dexamethasone. Ann Hematol 2004; 83:588-91.

Corso C, Parry EM. The application of comparative genomic hybridization and fluorescence in situ hybridization to the characterization of genotoxicity screening tester strains AHH-1 and MCL-5. Mutagenesis 1999; 14:417-26.

Cortes J, Jabbour E, Kantarjian H, et al. Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors. Blood 2007; 110:4005-11.

Cortés VA, Curtis DE, Sukumaran S et al. Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab 2009; 9:165-76.

Cortes-Dericks L, Carboni GL, Schmid RA, Karoubi G. Putative cancer stem cells in malignant pleural mesothelioma show resistance to cisplatin and pemetrexed. Int J Oncol 2010; 37:437-44.

Cortez MA, Scrideli CA, Yunes JA et al. mRNA expression profile of multidrug resistance genes in childhood acute lymphoblastic leukemia. Low expression levels associated with a higher risk of toxic death. Pediatr Blood Cancer 2009; 53:996-1004.

Corti N, Heck A, Rentsch K et al. Effect of ritonavir on the pharmacokinetics of the benzimidazoles albendazole and mebendazole: an interaction study in healthy volunteers. Eur J Clin Pharmacol 2009; 65:999-1006.

Cortina H, Vidal J, Vallcanera A, Alberto C, Muro D, Dominguez F. Humero-spinal dysostosis. Pediatr Radiol 1979; 8:188-90.

Corvol H, Burchard EG. Pharmacogenetic response to albuterol among asthmatics. Pharmacogenomics 2008; 9:505-10.

Corvol H, de Giacomo A, Eng C et al. Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma. Pharmacogenet Genomics 2009; 19:489-96.

Corzo L, Fernández-Novoa L, Zas R et al. Apolipoprotein E genotype-related serum apolipoprotein E and lipid levels in Alzheimer’s disease. Ann Psychiatry 1999; 7:99-107.

Corzo L, Fernández-Novoa L, Zas R et al. Influence of the APOE genotype on serum ApoE levels in Alzheimer´s disease patients. In: Fisher A, Hanin I, Yoshida M (Eds). Progress in Alzheimer´s and Parkinson´s diseases. Plenum Press, New York, 1998:765-71.

Corzo L, Zas R, Rodríguez S, Fernández-Novoa L, Cacabelos R. Decreased levels of serum nitric oxide in different forms of dementia. Neurosci Lett 2007; 420:263-7.

Costa E, Vieira E, Martins M et al. Analysis of the UDP-glucuronosyltransferase gene in Portuguese patients with a clinical diagnosis of Gilbert and Crigler-Najjar syndromes. Blood Cells Mol Dis 2006; 36:91-7.

Costacou T, Ferrell RE, Orchard TJ. Haptoglobin genotype: a determinant of cardiovascular complication risk in type 1 diabetes. Diabetes 2008; 57:1702-6.

Costa-Mallen P, Costa LG, Smith-Weller T et al. Genetic polymorphism of dopamine D2 receptors in Parkinson’s disease and interactions with cigarette smoking and MAO-B intron 13 polymorphism. J Neurol Neurosurg Psychiatry 2000; 69:535-7.

Costas J, Carrera N, Domínguez E et al. A common haplotype of DRD3 affected by recent positive selection is associated with protection from schizophrenia. Hum Genet 2009; 124:607-13.

Costea I, Mack DR, Israel D et al. Genes involved in the metabolism of poly-unsaturated fatty-acids (PUFA) and risk for Crohn’s disease in children & young adults. PLoS One 2010. doi:10. 1371/journal. pone. 0015672.

Costea I, Moghrabi A, Krajinovic M. The influence of cyclin D1 (CCND1) 870A>G polymorphism and CCND1-thymidylate synthase (TS) gene-gene interaction on the outcome of childhood acute lymphoblastic leukaemia. Pharmacogenetics 2003; 13:577-80.

Costrop LM, Vanakker OO, van Laer L et al. Novel deletions causing pseudoxanthoma elasticum underscore the genomic instability of the ABCC6 region. J Hum Genet 2010; 55:112-7.

Côté CS, Kor C, Cohen J, Auclair K. Composition and biological activity of traditional and commercial kava extracts. Biochem Biophys Res Commun 2004; 322:147-52.

Cote ML, Chen W, Smith DW et al. Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review. Am J Epidemiol 2009; 169:802-14.

Coto E, Tavira B. Pharmacogenetics of calcineurin inhibitors in renal transplantation. Transplantation 2009; 88(3 Suppl):62-7.

Cotroneo MS, Haag JD, Zan Y et al. Characterizing a rat Brca2 knockout model. Oncogene 2007; 26:1626-35.

Cotte S, von Ahsen N, Kruse N et al. ABC-transporter gene-polymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis. Brain 2009; 132:2517-30.

Coughtrie MWH, Gilissen RA, Shek B et al. Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations. Biochem J 1999; 337:45-9.

Couillard CM, Légaré B, Bernier A, Dionne Z. Embryonic exposure to environmentally relevant concentrations of PCB126 affect prey capture ability of Fundulus heteroclitus larvae. Mar Environ Res 2011; 71:257-65.

Coulam CB, Jeyendran RS, Fishel LA, Roussev R. Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage. Am J Reprod Immunol 2006; 55:360-8.

Coulombe N, Lefebvre A, Lehoux JG. Characterization of the hamster CYP11B2 gene encoding adrenal cytochrome P450 aldosterone synthase. DNA Cell Biol 1997; 16:993-1002.

Coulouarn C, Factor VM, Thorgeirsson SS. Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer. Hepatology 2008; 6:2059-67.

Coultas L, Bouillet P, Stanley EG, Brodnicki TC, Adams JM, Strasser A. Proapoptotic BH3-only Bcl-2 family member Blk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death. Mol Cell Biol 2004; 24:1570-81.

Coulter-Mackie MB, Lian Q. Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations. Mol Genet Metab 2006; 89:349-59.

Coulter-Mackie MB, White CT, Hurley RM, Chew BH, Lange D Primary hyperoxaluria type 1. In: Pagon RA, Bird TC, Dolan CR, Stephens K (Eds). GeneReviews. University of Washington, Seattle, 1993-2003. Available from: http://www. ncbi. nlm. nih. gov/books/NBK1283/

Coumoul X, Diry M, Barouki R. PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides. Biochem Pharmacol 2002; 64:1513-9.

Couroucli XI, Liang YH, Jiang W et al. Prenatal administration of the cytochrome P4501A inducer, Β-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: Implications for bronchopulmonary dysplasia (BPD) in premature infants. Toxicol Appl Pharmacol 2011; 256:83-94.

Court MH, Duan SX, von Moltke LL et al. Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther 2001; 299:998-1006.

Court MH, Hao Q, Krishnaswamy S et al. UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver. J Pharmacol Exp Ther 2004; 310:656-65.

Cousein E, Barthélémy C, Poullain S et al. P-glycoprotein and cytochrome P450 3A4 involvement in risperidone transport using an in vitro Caco-2/TC7 model and an in vivo model. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31:878-86.

Coustou V, Deleu C, Saupe S, Begueret J. The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog. Proc Natl Acad Sci USA 1997; 94:9773-8.

Coutts RT, Su P, Baker GB. Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions. J Pharmacol Toxicol Methods 1994; 31:177-86.

Cowpland C, Su GM, Murray M, Puddey IB, Croft KD. Effect of alcohol on cytochrome p450 arachidonic acid metabolism and blood pressure in rats and its modulation by red wine polyphenolics. Clin Exp Pharmacol Physiol 2006; 33:183-8.

Cox A, Dunning AM, Garcia-Closas M et al. A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet 2007; 39:352-8.

Cox CD, Garbaccio RM. Discovery of allosteric inhibitors of kinesin spindle protein (KSP) for the treatment of taxane-refractory cancer: MK-0731 and analogs. Anticancer Agents Med Chem 2010; 10:697-712.

Cox DG, Pontes C, Guino E et al. Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. Br J Cancer 2004; 91:339-43.

Cox JJ, Reimann F, Nicholas AK et al. An SCN9A channelopathy causes congenital inability to experience pain. Nature 2006; 444:894-8.

Cox JJ, Sheynin J, Shorer Z et al. Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations. Hum Mutat 2010; 31:1670-86.

Cox MC, Low J, Lee J et al. Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel. Clin Cancer Res 2006; 12:4636-40.

Cox SE, Doherty C, Atkinson SH et al. Haplotype association between haptoglobin (Hp2) and Hp promoter SNP (A-61C) may explain previous controversy of haptoglobin and malaria protection. PLoS One 2007. doi:10. 1371/journal. pone. 0000362.

Coy DJ, Wooton-Kee CR, Yan B et al. ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats. Am J Physiol Gastrointest Liver Physiol 2010; 299:228-35.

Cozier GE, Leese MP, Lloyd MD et al. Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors. Biochemistry 2010; 49:3464-76.

Cozza A, Melissari E, Iacopetti P et al. SNPs in neurotrophin system genes and Alzheimer’s disease in an Italian population. J Alzheimers Dis 2008; 15:61-70.

Crabb DW, Matsumoto M, Chang D, You M. Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc Nutr Soc 2004; 63:49-63.

Crabbe P, Bogaert V, de Bacquer D, Goemaere S, Zmierczak H, Kaufman JM. Part of the interindividual variation in serum testosterone levels in healthy men reflects differences in androgen sensitivity and feedback set point: contribution of the androgen receptor polyglutamine tract polymorphism. J Clin Endocrinol Metab 2007; 92:3604-10.

Craig TJ, Shimomura K, Holl RW, Flanagan SE, Ellard S, Ashcroft FM. An in-frame deletion in Kir6. 2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6. 2 and SUR1. J Clin Endocrinol Metab 2009; 94:2551-7.

Craig ZR, Leslie TC, Hatfield KP, Gupta RK, Flaws JA. Mono-hydroxy methoxychlor alters levels of key sex steroids and steroidogenic enzymes in cultured mouse antral follicles. Toxicol Appl Pharmacol 2010; 249:107-13.

Cravchik A, Sibley DR, Gejman PV. Functional analysis of the human D2 dopamine receptor missense variants. J Biol Chem 1996; 271:26013-7.

Crawford FC, Vanderploeg RD, Freeman MJ et al. APOE genotype influences acquisition and recall following traumatic brain injury. Neurology 2002; 58:1115-8.

Crean S, Ward A, Mercaldi CJ et al. Apolipoprotein E ε4 prevalence in Alzheimer’s disease patients varies across global populations: a systematic literature review and meta-analysis. Dement Geriatr Cogn Disord 2011; 31:20-30.

Crecelius EA. Changes in the chemical speciation of arsenic following ingestion by man. Environ Health Perspect 1977; 19:147-50.

Cresci S, Jones PG, Sucharov CC et al. Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes. Pharmacogenomics 2008; 9:1403-17.

Crespi CL, Fox L, Stocker P, Hu M, Steimel DT. Analysis of drug transport and metabolism in cell monolayer systems that have been modified by cytochrome P4503A4 cDNA-expression. Eur J Pharm Sci 2000; 12:63-8.

Crespi CL, Langenbach R, Penman BW. Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450. Toxicology 1993; 82:89-104.

Crespi CL, Miller VP. The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH: cytochrome P450 oxidoreductase. Pharmacogenetics 1997; 7:203-10.

Crespi CL, Penman BW, Hu M. Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4. Pharm Res 1996; 13:1635-41.

Crespi CL, Penman BW, Steimel DT, Gelboin HV, Gonzalez FJ. The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3. Carcinogenesis 1991; 12:355-9.

Crespi CL, Penman BW. Use of cDNA-expressed human cytochrome P450 enzymes to study potential drug-drug interactions. Adv Pharmacol 1997; 43:171-88.

Crespo K, Chauvet C, Blain M, Ménard A, Roy J, Deng AY. Normotension in Lewis and Dahl salt-resistant rats is governed by different genes. J Hypertens 2011; 29:460-5.

Crespo M, Mir M, Marin M, Hurtado S et al. De novo kidney transplant recipients need higher doses of Advagraf compared with Prograf to get therapeutic levels. Transplant Proc 2009; 41:2115-7.

Cresteil T. Onset of xenobiotic metabolism in children: toxicological implications. Food Addit Contam 1998; 15 Suppl:45-51.

Cresteil T, Monsarrat B, Dubois J, Sonnier M, Alvinerie P, Gueritte F. Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship. Drug Metab Dispos 2002; 30:438-45.

Crettol S, Besson J, Croquette-Krokar M et al. Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32:1722-7.

Crettol S, Déglon JJ, Besson J et al. ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment. Clin Pharmacol Ther 2006; 80:668-81.

Crettol S, Venetz JP, Fontana M, Aubert JD, Pascual M, Eap CB. CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients. Ther Drug Monit 2008; 30:689-99.

Crew KD, Gammon MD, Terry MB et al. Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2007; 16:2033-41.

Crewe HK, Ellis SW, Lennard MS, Tucker GT. Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes. Biochem Pharmacol 1997; 53:171-8.

Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4’-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos 2002; 30:869-74.

Cribb A, Nuss C, Wang R. Antipeptide antibodies against overlapping sequences differentially inhibit human CYP2D6. Drug Metab Dispos 1995; 23:671-5.

Cripe LD, Uno H, Paietta EM et al. Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999. Blood 2010; 116:4077-85.

Criscitiello C, Fumagalli D, Saini KS, Loi S. Tamoxifen in early-stage estrogen receptor-positive breast cancer: overview of clinical use and molecular biomarkers for patient selection. Onco Targets Ther 2010; 4:1-11.

Cristalli G, Cacciari B, Dal Ben D et al. Highlights on the development of A(2A) adenosine receptor agonists and antagonists. ChemMedChem 2007; 2:260-81.

Cristalli G, Müller CE, Volpini R. Recent developments in adenosine A2A receptor ligands. Handb Exp Pharmacol 2009; 5:59-98.

Criswell LA, Lum RF, Turner KN et al. The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthritis Rheum 2004; 50:2750-6.

Crivello A, Giacalone A, Vaglica M et al. Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma. Ann N Y Acad Sci 2006; 1089:98-103.

Crivori P, Zamora I, Speed B, Orrenius C, Poggesi I. Model based on GRID-derived descriptors for estimating CYP3A4 enzyme stability of potential drug candidates. J Comput Aided Mol Des 2004; 18:155-66.

Croarkin PE, Emslie GJ, Mayes TL. Neuroleptic malignant syndrome associated with atypical antipsychotics in pediatric patients: a review of published cases. J Clin Psychiatry 2008; 69:1157-65.

Crobu F, Palumbo L, Franco E et al. Role of TGF-beta1 haplotypes in the occurrence of myocardial infarction in young Italian patients. BMC Med Genet 2008; 9:13.

Crocenzi FA, Sánchez Pozzi EJ, Pellegrino JM et al. Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets. Hepatology 2001; 34:329-39.

Crocq MA, Mant R, Asherson P et al. Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. J Med Genet 1992; 29:858-60.

Croera C, Ferrario D, Gribaldo L. In vitro toxicity of naphthalene, 1-naphthol, 2-naphthol and 1,4-naphthoquinone on human CFU-GM from female and male cord blood donors. Toxicol In Vitro 2008; 22:1555-61.

Croes EA, Alizadeh BZ, Bertoli-Avella AM et al. Polymorphisms in the prion gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease. Europ J Hum Genet 2004; 12:389-94.

Croes EA, Dermaut B, Houwing-Duistermaat JJ et al. Early cognitive decline is associated with prion protein codon 129 polymorphism. Ann Neurol 2003; 54:275-6.

Crook T, Vousden KH. Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens. EMBO J 1992; 11:3935-40.

Crooke PS, Justenhoven C, Brauch H; GENICA Consortium. Estrogen metabolism and exposure in a genotypic-phenotypic model for breast cancer risk prediction. Cancer Epidemiol Biomarkers Prev 2011; 20:1502-15.

Croom EL, Stevens JC, Hines RN, Wallace AD, Hodgson E. Human hepatic CYP2B6 developmental expression: the impact of age and genotype. Biochem Pharmacol 2009; 78:184-90.

Croom EL, Wallace AD, Hodgson E. Human variation in CYP-specific chlorpyrifos metabolism. Toxicology 2010; 276:184-91.

Crosier MD, Peter I, Booth SL, Bennett G, Dawson-Hughes B, Ordovas JM. Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status. J Nutr Sci Vitaminol 2009; 55:112-9.

Crosignani A, del Puppo M, Longo M et al. Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease. Clin Chim Acta 2007; 382:82-8.

Crotti L, Taravelli E, Girardengo G, Schwartz PJ. Congenital Short QT Syndrome. Indian Pacing Electrophysiol J 2010; 10:86-95.

Crouthamel MH, Wu D, Yang Z, Ho RJ. A novel MDR1 G1199T variant alters drug resistance and efflux transport activity of P-glycoprotein in recombinant Hek cells. J Pharm Sci 2006; 95:2767-77.

Crouthamel MH, Wu D, Yang Z, Ho RJ. A novel MDR1 GT1292-3TG (Cys431Leu) genetic variation and its effect on P-glycoprotein biologic functions. AAPS J 2010; 12:548-55.

Crowley E, McDevitt CA, Callaghan R. Generating inhibitors of P-glycoprotein: where to, now? Methods Mol Biol 2010; 596:405-32.

Crowley SD, Gurley SB, Herrera MJ et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Nat Acad Sci USA 2006; 103:17985-90.

Croxtall JD, McKeage K. Fulvestrant: a review of its use in the management of hormone receptor-positive metastatic breast cancer in postmenopausal women. Drugs 2011; 71:363-80.

Cruchaga C, Graff C, Chiang HH et al. Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels. Arch Neurol 2011; 68:581-6.

Cruts M, Backhovens H, Martin JJ, van Broeckhoven C. Genetic analysis of the cellular oncogene fos in patients with chromosome 14 encoded Alzheimer’s disease. Neurosci Lett 1994; 174:97-100.

Cruts M, Backhovens H, Theuns J et al. Genetic and physical characterization of the early-onset Alzheimer’s disease AD3 locus on chromosome 14q24. 3. Hum Mol Genet 1995; 4:1355-64.

Cruts M, Dermaut B, Koster MN et al. The alpha-2-macroglobulin gene in AD: a population-based study and meta-analysis. Neurology 2000; 55:678-84.

Cruz TD, Valdes AM, Santiago A et al. DPB1 alleles are associated with type 1 diabetes susceptibility in multiple ethnic groups. Diabetes 2004; 53:2158-63.

Cruz-Robles D, Chávez-González JP, Cavazos-Quero MM, Pérez-Méndez O, Reyes PA, Vargas-Alarcón G. Association between IL-1B and IL-1RN gene polymorphisms and Chagas’ disease development susceptibility. Immunol Invest 2009; 38:231-9.

Csáki KF. Synthetic surfactant food additives can cause intestinal barrier dysfunction. Med Hypotheses 2011; 76:676-81.

Csanaky IL, Lu H, Zhang Y, Ogura K, Choudhuri S, Klaassen CD. Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice. Hepatology 2011; 53:272-81.

Cuchel M, Bloedon LT, Szapary PO et al. Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. New Eng J Med 2007; 356:148-56.

Cuchel M, Rader DJ. Reply to Hegele Familial hypercholesterolemia. New Eng J Med 2007; 356:1779-80.

Cuda C, Badawi A, Karmali M, El-Sohemy A. Polymorphisms in Toll-like receptor 4 are associated with factors of the metabolic syndrome and modify the association between dietary saturated fat and fasting high-density lipoprotein cholesterol. Metabolism 2011; 60:1131-5.

Cudaback E, Li X, Montine KS, Montine TJ, Keene CD. Apolipoprotein E isoform-dependent microglia migration. FASEB J 2011; 25:2082-91.

Cuendet M, Pezzuto JM. The role of cyclooxygenase and lipoxygenase in cancer chemoprevention. Drug Metabol Drug Interact 2000; 17:109-57.

Cuesta de Juan S, Monte MJ, Macias RI, Wauthier V, Calderon PB, Marin JJ. Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis. J Lipid Res 2007; 48:1362-70.

Cui H, Okuhira K, Ohoka N et al. Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRalpha/RXR. Biochem Pharmacol 2011; 81:819-24.

Cui J, Eitzman DT, Westrick RJ et al. Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Blood 2000; 96:4222-6.

Cui J, Melista E, Chazaro I et al. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. J Hypertens 2005; 23:55-62.

Cui X, Thomas A, Gerlach V, White RE, Morrison RA, Cheng KC. Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers. Biochem Pharmacol 2008; 76:680-9.

Cui XR, Saito R, Kubo T, Kon D, Hirano Y, Saito S. Preparations of anthraquinone and naphthoquinone derivatives and their cytotoxic effects. Chem Pharm Bull 2011; 59:302-14.

Cuisset T, Frere C, Quilici J et al. Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome. Thromb Res 2007; 120:893-9.

Cummins CL, Jacobsen W, Benet LZ. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002; 300:1036-45.

Cummins CL, Jacobsen W, Christians U, Benet LZ. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. J Pharmacol Exp Ther 2004; 308:143-55.

Cummins CL, Mangravite LM, Benet LZ. Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Pharm Res 2001; 18:1102-9.

Cummins TD, Hawi Z, Hocking J et al. Dopamine transporter genotype predicts behavioural and neural measures of response inhibition. Mol Psychiatry 2011. doi:10. 1038/mp. 2011. 104.

Curley CR, Monsuur AJ, Wapenaar MC, Rioux JD, Wijmenga C. A functional candidate screen for coeliac disease genes. Eur J Hum Genet 2006; 14:1215-22.

Curran CP, Nebert DW, Genter MB et al. In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes. Environ Health Perspect 2011; 119:1286-93.

Curran T, Morgan JI. Fos: an immediate-early transcription factor in neurons. J Neurobiol 1995; 26:403-12.

Curry SC, Watts DJ, Katz KD, Bikin D, Bukaveckas BL. The effect of single-dose tramadol on oxycodone clearance. J Emerg Med 2007; 33:407-11.

Curry-McCoy TV, Osna NA, Nanji AA, Donohue TM Jr. Chronic ethanol consumption results in atypical liver injury in copper/zinc superoxide dismutase deficient mice. Alcohol Clin Exp Res 2010; 34:251-61.

Cury NM, Russo A, Galbiatti AL et al. Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk. Mol Biol Rep 2011. doi:10. 1007/s11033-011-0831-1.

Cusatis G, Gregorc V, Li J et al. Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst 2006; 98:1739-42.

Cusi D, Barlassina C, Azzani T et al. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet 1997; 349:1353-7.

Cusimano MD, Rewilak D, Stuss DT, Barrera-Martinez JC, Salehi F, Freedman M. Normal-pressure hydrocephalus: is there a genetic predisposition? Can J Neurol Sci 2011; 38:274-81.

Cussigh A, Falleti E, Fabris C et al. Interleukin 6 promoter polymorphisms influence the outcome of chronic hepatitis C. Immunogenetics 2011; 63:33-41.

Cust AE, Harland M, Makalic E et al. Melanoma risk for CDKN2A mutation carriers who are relatives of population-based case carriers in Australia and the UK. J Med Genet 2011; 48:266-72.

Custódio AC, Almeida LO, Pinto GR et al. GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas. Genet Mol Res 2010; 9:2328-34.

Cutler MJ, Urquhart BL, Velenosi TJ et al. In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol 2011. doi:10. 1177/0091270011400414.

Cvelbar M, Hocevar M, Vidmar G, Teugels E. BRCA1/2 status and clinicopathologic characteristics of patients with double primary breast and ovarian cancer. Neoplasma 2011; 58:198-204.

Cvetkovic RS, Goa KL. Lopinavir/ritonavir: a review of its use in the management of HIV infection. Drugs 2003; 63:769-802.

Cygnar KD, Zhao H. Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons. Nat Neurosci 2009; 12:454-62.

Cymbron T, Raposo M, Kazachkova N et al. Cross-sectional study of risk factors for atherosclerosis in the Azorean population. Ann Hum Biol 2011; 38:354-9.

Czerski PM, Rybakowski F, Kapelski P et al. Association of tumor necrosis factor -308G/A promoter polymorphism with schizophrenia and bipolar affective disorder in a Polish Population. Neuropsychobiology 2008; 57:88-94.

Czerwinski M, McLemore TL, Gelboin HV, Gonzalez FJ. Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors. Cancer Res 1994; 54:1085-91.

Czerwinski M, McLemore TL, Philpot RM et al. Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism. Cancer Res 1991; 51:4636-8.

Cziraky MJ, Willey VJ, McKenney JM et al. Statin safety: an assessment using an administrative claims database. Am J Cardiol 2006; 97:61-68.

Czirr E, Weggen S. Gamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds. Neurodegener Dis 2006; 3:298-304.

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