General References

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Nagaoka R, Iwasaki T, Rokutanda N et al. Tamoxifen activates CYP3A4 and MDR1 genes through steroid and xenobiotic receptor in breast cancer cells. Endocrine 2006; 30:261-8.

Nagar S, Saha A. Modeling of diarylalkyl-imidazole and diarylalkyl-triazole derivatives as potent aromatase inhibitors for treatment of hormone-dependent cancer. J Comput Chem 2010; 31:2342-53.

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Nagar S, Zalatoris JJ, Blanchard RL. Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics 2004; 14:487-99.

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Nagila A, Permpongpaiboon T, Tantrarongroj S et al. Effect of atorvastatin on paraoxonase1 (PON1) and oxidative status. Pharmacol Rep 2009; 61:892-8.

Nagy J, Schipper HG, Koopmans RP, Butter JJ, van Boxtel CJ, Kager PA. Effect of grapefruit juice or cimetidine coadministration on albendazole bioavailability. Am J Trop Med Hyg 2002; 66:260-3.

Nagy LD, Mocny CS, Diffenderfer LE et al. Substituted imidazole of 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates cytochrome P450 2D6 by protein adduction. Drug Metab Dispos 2011; 39:974-83.

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Nait Chabane M, Al Ahmad A, Peluso J, Muller CD, Ubeaud G. Quercetin and naringenin transport across human intestinal Caco-2 cells. J Pharm Pharmacol 2009; 61:1473-83.

Naito T, Takashina Y, Yamamoto K et al. CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone. J Clin Pharmacol 2011; 51:1529-38.

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Najar IA, Sharma SC, Singh GD, Koul S, Gupta PN, Javed S, Johri RK. Involvement of P-glycoprotein and CYP 3A4 in the enhancement of etoposide bioavailability by a piperine analogue. Chem Biol Interact 2011; 190:84-90.

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Nakade S, Yamauchi A, Komaba J et al. Effect of clarithromycin on the pharmacokinetics of pranlukast in healthy volunteers. Drug Metab Pharmacokinet 2008; 23:428-33.

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Nakagami T, Yasui-Furukori N, Saito M et al. Thioridazine inhibits risperidone metabolism: a clinically relevant drug interaction. J Clin Psychopharmacol 2005; 25:89-91.

Nakagami T, Yasui-Furukori N, Saito M, Tateishi T, Kaneo S. Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: in vivo evidence of involvement of P-glycoprotein in risperidone disposition. Clin Pharmacol Ther 2005; 78:43-51.

Nakagawa H, Toyoda Y, Wakabayashi-Nakao K, Tamaki H, Osumi M, Ishikawa T. Ubiquitin-mediated proteasomal degradation of ABC transporters: a new aspect of genetic polymorphisms and clinical impacts. J Pharm Sci 2011; 100:3602-19.

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Nakai K, Tsuboi J, Okabayashi H et al. Ethnic differences in the VKORC1 gene polymorphism and an association with warfarin dosage requirements in cardiovascular surgery patients. Pharmacogenomics 2007; 8:713-9.

Nakajima H, Nakanishi T, Naba H et al. Studies on the metabolic fate of M17055, a novel diuretic (6). Assessment for drug-drug interactions of M17055 in metabolism, distribution and excretion. Xenobiotica 2002; 32:1161-72.

Nakajima H, Nakanishi T, Nakai K et al. Studies on the metabolic fate of M17055, a novel diuretic (4): species difference in metabolic pathway and identification of human CYP isoform responsible for the metabolism of M17055. Drug Metab Pharmacokinet 2002; 17:60-74.

Nakajima K, Tanaka Y, Nomiyama T et al. Chemokine receptor genotype is associated with diabetic nephropathy in Japanese with type 2 diabetes. Diabetes 2002; 51:238-42.

Nakajima M, Fujiki Y, Kyo S et al. Pharmacokinetics of paclitaxel in ovarian cancer patients and genetic polymorphisms of CYP2C8, CYP3A4, and MDR1. J Clin Pharmacol 2005; 45:674-82.

Nakajima M, Fukami T, Yamanaka H et al. Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations. Clin Pharmacol Ther 2006; 80:282-97.

Nakajima M, Hattori E, Yamada K et al. Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenics. J Hum Genet 2007; 52:86-91.

Nakajima M, Inoue T, Shimada N, Tokudome S, Yamamoto T, Kuroiwa Y. Cytochrome P450 2C9 catalyzes indomethacin O-demethylation in human liver microsomes. Drug Metab Dispos 1998; 26:261-6.

Nakajima M, Kobayashi K, Oshima K et al. Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes. Xenobiotica 1999; 29:885-98.

Nakajima M, Kobayashi K, Shimada N, Tokudome S, Yamamoto T, Kuroiwa Y. Involvement of CYP1A2 in mexiletine metabolism. Br J Clin Pharmacol 1998; 46:55-62.

Nakajima M, Komagata S, Fujiki Y et al. Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients. Pharmacogenet Genomics 2007; 17:431-45.

Nakajima M, Kwon JT, Tanaka N et al. Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans. Clin Pharmacol Ther 2001; 69:72-8.

Nakajima M, Nakamura S, Tokudome S, Shimada N, Yamazaki H, Yokoi T. Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs. Drug Metab Dispos 1999; 27:1381-91.

Nakajima M, Ohyama K, Nakamura S, Shimada N, Yamazaki H, Yokoi T. Inhibitory effects of azelastine and its metabolites on drug oxidation catalyzed by human cytochrome P-450 enzymes. Drug Metab Dispos 1999; 27:792-7.

Nakajima M, Sawada H, Yamada Y et al. The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas. Cancer 1999; 85:1894-902.

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Nakajima Y, Yoshitani T, Fukushima-Uesaka H et al. Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer. Clin Pharmacol Ther 2006; 80:179-91.

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Nakamura A, Hirota T, Morino A et al. Cytochrome P450 isoforms responsible for the N-deethylation and cyclohexane-hydroxylation of NS-21. Xenobiotica 1999; 29:243-52.

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Nakamura A, Tougou K, Kitazumi H et al. Effects of irsogladine on P450-isoform specific activities in human hepatic microsomes. Arzneimittelforschung 2006; 56:547-52.

Nakamura E, Kozaki K, Tsuda H et al. Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma. Cancer Sci 2008; 99:1390-400.

Nakamura H, Ariyoshi N, Okada K, Nakasa H, Nakazawa K, Kitada M. CYP1A1 is a major enzyme responsible for the metabolism of granisetron in human liver microsomes. Curr Drug Metab 2005; 6:469-80.

Nakamura H, Nakasa H, Ishii I et al. Effects of endogenous steroids on CYP3A4-mediated drug metabolism by human liver microsomes. Drug Metab Dispos 2002; 30:534-40.

Nakamura H, Ohtsuka T, Enomoto H et al. Effect of levofloxacin on theophylline clearance during theophylline and clarithromycin combination therapy. Ann Pharmacother 2001; 35:691-3.

Nakamura H, Torimoto N, Ishii I et al. CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids. Drug Metab Dispos 2003; 31:432-8.

Nakamura K, Ariyoshi N, Iwatsubo T et al. Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes. Biol Pharm Bull 2005; 28:882-5.

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Nakamura K, Yokoi T, Kodama T et al. Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. J Pharmacol Exp Ther 1998; 284:437-42.

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Nakamura S, Tezuka Y, Ushiyama A et al. Ipso substitution of bisphenol A catalyzed by microsomal cytochrome P450 and enhancement of estrogenic activity. Toxicol Lett 2011; 203:92-5.

Nakamura T, Okamura N, Yagi M et al. Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles. Genet Mol Res 2009; 8:397-403.

Nakamura T, Sakaeda T, Horinouchi M et al. Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects. Clin Pharmacol Ther 2002; 71:297-303.

Nakamura T, Yamamoto E, Kataoka K et al. Beneficial effects of pioglitazone on hypertensive cardiovascular injury are enhanced by combination with candesartan. Hypertension 2008; 51:296-301.

Nakamura Y. Chemoprevention by isothiocyanates: molecular basis of apoptosis induction. Forum Nutr 2009; 61:170-81.

Nakamura Y, Kanazawa M, Liyanage R et al. Effect of white wheat bread containing sugar beet fiber on serum lipids and hepatic mRNA in rats fed on a cholesterol-free diet. Biosci Biotechnol Biochem 2009; 73:1280-5.

Nakamura Y, Satoh F, Morimoto R et al. 18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism. J Clin Endocrinol Metab 2011; 96:1272-8.

Nakamura Y, Soda H, Oka M et al. Randomized phase II trial of irinotecan with paclitaxel or gemcitabine for non-small cell lung cancer: association of UGT1A1*6 and UGT1A1*27 with severe neutropenia. J Thorac Oncol 2011; 6:121-7.

Nakanishi H, Yamashiro K, Yamada R et al. Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci 2010; 51:6183-7.

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Nakanishi T, Chumsri S, Khakpour N et al. Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling. Br J Cancer 2010; 102:815-26.

Nakano T, Sekine S, Ito K, Horie T. Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine. Drug Metab Dispos 2009; 37:1521-7.

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Nakao M, Muramoto Y, Hisadome M et al. The effect of Shoseiryuto, a traditional Japanese medicine, on cytochrome P450s, N-acetyltransferase 2 and xanthine oxidase, in extensive or intermediate metabolizers of CYP2D6. Eur J Clin Pharmacol 2007; 63:345-53.

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Nakasa H, Nakamura H, Ono S et al. Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data. Eur J Clin Pharmacol 1998; 54:177-83.

Nakase T, Mizuno T, Harada S et al. Angiotensinogen gene polymorphism as a risk factor for ischemic stroke. J Clin Neurosci 2007; 14:943-7.

Nakashima A, Kawashita H, Masuda N et al. Identification of cytochrome P450 forms involved in the 4-hydroxylation of valsartan, a potent and specific angiotensin II receptor antagonist, in human liver microsomes. Xenobiotica 2005; 35:589-602.

Nakashima D, Takama H, Ogasawara Y et al. Effect of cinacalcet hydrochloride, a new calcimimetic agent, on the pharmacokinetics of dextromethorphan: in vitro and clinical studies. J Clin Pharmacol 2007; 47:1311-9.

Nakatsuka A, Nagai M, Yabe H et al. Effect of clarithromycin on the pharmacokinetics of cabergoline in healthy controls and in patients with Parkinson’s disease. J Pharmacol Sci 2006; 100:59-64.

Nakatsuma A, Fukami T, Suzuki T, Furuishi T, Tomono K, Hidaka S. Effects of kaempferol on the mechanisms of drug resistance in the human glioblastoma cell line T98G. Pharmazie 2010; 65:379-83.

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Nakayama K, Soemantri A, Jin F et al. Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians. Hum Genet 2006; 119:322-30.

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Nakayama M, Yoshimura M, Sakamoto T et al. Synergistic interaction of T-786→C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasm. Pharmacogenetics 2003; 13:683-8.

Nakayama S, Torikoshi Y, Takahashi T et al. Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells. Breast Cancer Res 2009; 11:12.

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Nakhoul FM, Miller-Lotan R, Awaad H, Asleh R, Levy AP. Hypothesis-haptoglobin genotype and diabetic nephropathy. Nat Clin Pract Nephrol 2007; 3:339-44.

Nalda-Molina R, Valenzuela B, Ramon-Lopez A, Miguel-Lillo B, Soto-Matos A, Perez-Ruixo JJ. Population pharmacokinetics meta-analysis of plitidepsin (Aplidin) in cancer subjects. Cancer Chemother Pharmacol 2009; 64:97-108.

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Nam DT, Arseneault M, Murthy V, Ramassamy C. Potential role of acrolein in neurodegeneration and in Alzheimer’s disease. Curr Mol Pharmacol 2010; 3:66-78.

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Nam RK, Zhang WW, Trachtenberg J et al. Comprehensive assessment of candidate genes and serological markers for the detection of prostate cancer. Cancer Epidemiol Biomarkers Prev 2003; 12:1429-37.

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Nambu T, Hamada A, Nakashima R et al. Association of SLCO1B3 polymorphism with intracellular accumulation of imatinib in leukocytes in patients with chronic myeloid leukemia. Biol Pharm Bull 2011; 34:114-9.

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