Gene References


XDH (xanthyne deydrogenase)

Khan SA, Lee K, Minhas KM et al. Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling. Proc Nat Acad Sci USA 2004; 101:15944-8.

Rytkonen EMK, Halila R, Laan M et al. The human gene for xanthine dehydrogenase (XDH) is localized on chromosome band 2p22. Cytogenet Cell Genet 1995; 68:61-3.

Sakamoto N, Yamamoto T, Moriwaki Y et al. Identification of a new point mutation in the human xanthine dehydrogenase gene responsible for a case of classical type I xanthinuria. Hum Genet 2001; 108:279-83.

Vorbach C, Scriven A, Capecchi MR. The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland. Genes Dev 2002; 16:3233-5.

Yang J, Kamide K, Kokubo Y et al. Associations of hypertension and its complications with variations in the xanthine dehydrogenase gene. Hypertens Res 2008; 31:931-40.

Xu P, Huecksteadt TP, Hoidal JR. Molecular cloning and characterization of the human xanthine dehydrogenase gene (XDH). Genomics 1996; 34:173-80.

Xu P, Zhu XL, Huecksteadt TP, Brothman AR, Hoidal JR. Assignment of human xanthine dehydrogenase gene to chromosome 2p22. Genomics 1994; 23:289-91.

XPA (xeroderma pigmentosum, complementation group A)

Boyle J, Kill IR, Parris CN. Heterogeneity of dimer excision in young and senescent human dermal fibroblasts. Aging Cell 2005; 4:247-55.

Butkiewicz D, Krześniak M, Vaitiekunaite R et al. A functional analysis of G23A polymorphism and the alternative splicing in the expression of the XPA gene. Cell Mol Biol Lett 2010; 15:611-29.

Crew KD, Gammon MD, Terry MB et al. Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2007; 16:2033-41.

Dong Z, Guo W, Zhou R et al. Polymorphisms of the DNA repair gene XPA and XPC and its correlation with gastric cardiac adenocarcinoma in a high incidence population in North China. J Clin Gastroenterol 2008; 42:910-5.

Feng J, Sun X, Sun N et al. XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer. Acta Biochim Biophys Sin 2009; 41:429-35.

Gu A, Ji G, Zhou Y et al. Polymorphisms of nucleotide-excision repair genes may contribute to sperm DNA fragmentation and male infertility. Reprod Biomed Online 2010; 21:602-9.

Gu A, Ji G, Zhu P et al. Nucleotide excision repair polymorphisms, polycyclic aromatic hydrocarbon exposure, and their effects on sperm deoxyribonucleic acid damage and male factor infertility. Fertil Steril 2010; 94:2620-5.

Langie SA, Wilms LC, Hämäläinen S, Kleinjans JC, Godschalk RW, van Schooten FJ. Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors. Br J Nutr 2010; 103:490-501.

Messaoud O, Ben Rekaya M, Cherif W et al. Genetic homogeneity of mutational spectrum of group-A xeroderma pigmentosum in Tunisian patients. Int J Dermatol 2010; 49:544-8.

Monzo M, Moreno I, Navarro A et al. Single nucleotide polymorphisms in nucleotide excision repair genes XPA, XPD, XPG and ERCC1 in advanced colorectal cancer patients treated with first-line oxaliplatin/fluoropyrimidine. Oncology 2007; 72:364-70.

Palli D, Polidoro S, D’Errico M et al. Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer. Mutagenesis 2010; 25:569-75.

Saldivar JS, Lu KH, Liang D et al. Moving toward individualized therapy based on NER polymorphisms that predict platinum sensitivity in ovarian cancer patients. Gynecol Oncol 2007; 107:223-9.

Takahashi Y, Endo Y, Sugiyama Y et al. XPA gene mutations resulting in subtle truncation of protein in xeroderma pigmentosum group A patients with mild skin symptoms. J Invest Dermatol 2010; 130:2481-8.

Vogel U, Overvad K, Wallin H et al. Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer. Cancer Lett 2005; 222:67-74.

Wang F, He Y, Guo H et al. Genetic variants of nucleotide excision repair genes are associated with DNA damage in coke oven workers. Cancer Epidemiol Biomarkers Prev 2010; 19:211-8.

XRCC1 (X-ray repair complementing defective repair in Chinese hamster cells 1)

Batar B, Güven M, Bariş S, Celkan T, Yildiz I. DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia. Leuk Res 2009; 33:759-63.

Chen PL, Yeh KT, Tsai YY et al. XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium. Mol Vis 2010; 16:991-6.

Cheng XD, Lu WG, Ye F, Wan XY, Xie X. The association of XRCC1 gene single nucleotide polymorphisms with response to neoadjuvant chemotherapy in locally advanced cervical carcinoma. J Exp Clin Cancer Res 2009; 28:91.

Coppedè F, Migheli F, Lo Gerfo A et al. Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2010; 11:122-4.

Grimminger PP, Brabender J, Warnecke-Eberz U et al. XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer. J Surg Res 2010; 164:61-6.

Harth V, Schafer M, Abel J et al. Head and neck squamous-cell cancer and its association with polymorphic enzymes of xenobiotic metabolism and repair. J Toxicol Environ Health A 2008; 71:887-97.

Henriette Tanja L, Guchelaar HJ, Gelderblom H. Pharmacogenetics in chemotherapy of colorectal cancer. Best Pract Res Clin Gastroenterol 2009; 23:257-73.

Hoskins JM, Marcuello E, Altes A et al. Irinotecan pharmacogenetics: influence of pharmacodynamic genes. Clin Cancer Res 2008; 14:1788-96.

Jaremko M, Justenhoven C, Schroth W et al. Polymorphism of the DNA repair enzyme XRCC1 is associated with treatment prediction in anthracycline and cyclophosphamide/methotrexate/5-fluorouracil-based chemotherapy of patients with primary invasive breast cancer. Pharmacogenet Genomics 2007; 17:529-38.

Ji G, Gu A, Zhou Y et al. Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm. PLoS One 2010. doi:10. 1371/journal. pone. 0013145.

Ji G, Gu A, Zhu P et al. Joint effects of XRCC1 polymorphisms and polycyclic aromatic hydrocarbons exposure on sperm DNA damage and male infertility. Toxicol Sci 2010; 116:92-8.

Jiang J, Liang X, Zhou X et al. DNA repair gene X-ray repair cross complementing group 1 Arg194Trp polymorphism on the risk of lung cancer: a meta-analysis on 22 studies. J Thorac Oncol 2010; 5:1741-7.

Jiang Z, Li C, Xu Y, Cai S. A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk. Int J Colorectal Dis 2010; 25:169-80.

Jorgensen TJ, Helzlsouer KJ, Clipp SC, Bolton JH, Crum RM, Visvanathan K. DNA repair gene variants associated with benign breast disease in high cancer risk women. Cancer Epidemiol Biomarkers Prev 2009; 18:346-50.

Kalikaki A, Kanaki M, Vassalou H et al. DNA repair gene polymorphisms predict favorable clinical outcome in advanced non-small-cell lung cancer. Clin Lung Cancer 2009; 10:118-23.

Kim IS, Kim DC, Kim HG et al. DNA repair gene XRCC1 polymorphisms and haplotypes in diffuse large B-cell lymphoma in a Korean population. Cancer Genet Cytogenet 2010; 196:31-7.

Lao T, Gu W, Huang Q. A meta-analysis on XRCC1 R399Q and R194W polymorphisms, smoking and bladder cancer risk. Mutagenesis 2008; 23:523-32.

Mandal RK, Gangwar R, Mandhani A, Mittal RD. DNA repair gene X-ray repair cross-complementing group 1 and xeroderma pigmentosum group D polymorphisms and risk of prostate cancer: a study from North India. DNA Cell Biol 2010; 29:183-90.

Marsh S, Hoskins JM. Irinotecan pharmacogenomics. Pharmacogenomics 2010; 11:1003-10.

Marsh S, Paul J, King CR, Gifford G, McLeod HL, Brown R. Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer. J Clin Oncol 2007; 25:4528-35.

Paré L, Marcuello E, Altés A et al. Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin/5-fluorouracil as first-line chemotherapy. Br J Cancer 2008; 99:1050-5.

Rajaraman P, Hutchinson A, Wichner S et al. DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Neuro Oncol 2010; 12:37-48.

Saadat M. Haplotype analysis of XRCC1 (at codons 194 and 399) and susceptibility to breast cancer, a meta-analysis of the literatures. Breast Cancer Res Treat 2010; 124:785-91.

Sun Z, Chen J, Aakre J et al. Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients. Ann Oncol 2010; 21:2011-6.

Tahara T, Shibata T, Nakamura M et al. Association between polymorphisms in the XRCC1 and GST genes, and CpG island methylation status in colonic mucosa in ulcerative colitis. Virchows Arch 2011; 458:205-11.

Tumer TB, Yilmaz D, Tanrikut C, Sahin G, Ulusoy G, Arinç E. DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia. Leuk Res 2010; 34:1275-81.

Wang J, Zhao Y, Jiang J et al. Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: a case-control study in an Indian population. J Cancer Res Clin Oncol 2010; 136:1517-25.

Wang M, Qin C, Zhu J et al. Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer. DNA Cell Biol 2010; 29:303-11.

Wang P, Tang JT, Peng YS, Chen XY, Zhang YJ, Fang JY. XRCC1 downregulated through promoter hypermethylation is involved in human gastric carcinogenesis. J Dig Dis 2010; 11:343-51.

Wang Q, Ji F, Sun Y et al. Genetic polymorphisms of XRCC1, HOGG1 and MGMT and micronucleus occurrence in Chinese vinyl chloride-exposed workers. Carcinogenesis 2010; 31:1068-73.

Wang Z, Xu B, Lin D et al. XRCC1 polymorphisms and severe toxicity in lung cancer patients treated with cisplatin-based chemotherapy in Chinese population. Lung Cancer 2008; 62:99-104.

Xie J, Yang S, Xu Y, Zhang Z. XRCC1 Arg194Trp polymorphism and risk of chronic obstructive pulmonary disease. J Huazhong Univ Sci Technolog Med Sci 2009; 29:551-6.

Yang Y, Zhai XD, Gao LB, Li SL, Wang Z, Chen GD. Genetic polymorphisms of DNA repair gene XRCC1 and risk of uterine leiomyoma. Mol Cell Biochem 2010; 338:143-7.

Zipprich J, Terry MB, Brandt-Rauf P et al. XRCC1 polymorphisms and breast cancer risk from the New York Site of the Breast Cancer Family Registry: A family-based case-control study. J Carcinog 2010; 9:4.

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