Diseases and Medical Terms

5-alpha-Reductase deficiency 2426
5-Fluorouracil/oxaliplatin combined therapy 2030
6-Mercaptopurine sensitivity 1049
11β-Hydroxysteroid dehydrogenase type 2 deficiency 1124
22q13.2 deletion syndrome 1438
46,XX/SRY-negative true hermaphrodite 1946
46,XY Disordered sex development and androgenization at adrenarche 1947
A
ABCA1 and ACAT2 mutant phenotypes 815
ABCG2 demethylation 1000
ABCG2 inhibitors 1000
ABCG2-ABCB1 synergism 1000
Abdominal and urinary tract infections 341
Abdominal aortic aneurysm 1125, 1224, 1947, 2152, 2277, 2297, 2336
Abdominal surgery 263
Abetalipoproteinemia 1119, 2292
Abnormal uterine bleeding 456, 535, 621
Abscess 255
Absence (petit mal) seizures 286
Acatalasia 1213
Acceleration of transit of barium through small bowel 687
Acetaldehyde-derived DNA adducts 1593
Acetaminophen toxicity 9
Achlorhydria 78
Acid indigestion 160, 296
Acidosis 691
Acne 248, 255, 412, 672, 731
Acne rosacea 74
Acne vulgaris 61, 74, 276, 707, 718, 2197
Acquired idiopathic sideroblastic anemia (AISA) 2281
Acquired immunodeficiency syndrome 769, 770, 780, 2212, 2215
Acromegaly 94, 415, 539, 572, 2088, 2428
ACTH-dependent Cushing’s syndrome 185
ACTH-independent macronodular adrenal hyperplasia 2090
Actinic keratosis 31, 223, 379
Activated polyamine catabolism 1913
Activating mutations in the GNAS gene 2090
Activating transcription factor-4 1594
Active benign ulcer 645
Activins and Inhibins 1947
Acute agitation 805
Acute and chronic respiratory tract infections 700
Acute asthma 673, 804, 1075, 1267
Acute bacterial otitis media 129, 137
Acute bacterial sinusitis 63, 426
Acute bronchitis 745
Acute bronchospasm 673, 745
Acute cardiac ischemic events 3
Acute coronary syndrome 176, 739, 746, 1035, 1268, 1407, 2016, 2206, 2368
Acute eosinophilic leukemia (AEL) 1046
Acute exacerbation of chronic bronchitis 128, 129, 130, 162, 435, 503, 664, 731, 768
Acute exacerbation of multiple sclerosis 186
Acute gout 5, 724
Acute gouty arthritis 291, 617, 709, 764
Acute graft vs host disease 2215, 2444
Acute heart failure 227, 636, 637, 1071
Acute hepatic porphyria 1100
Acute herpes zoster 779, 810
Acute hypoxia 556, 1643
Acute intermittent porphyria 152, 356
Acute intestinal amebiasis 743
Acute iritis 773
Acute iron intoxication 206
Acute ischemic events 87
Acute ischemic stroke 25, 611, 1079
Acute leukemia 373, 836, 1594
Acute lymphoblastic leukemia (ALL) 465, 836, 932, 966, 1025, 1280, 1643, 2063, 2084, 2108, 2137, 2182, 2248, 2255, 2286, 2297, 2316, 2368, 2405, 2477, 2480, 2527
Acute lymphocytic (lymphoblastic) leukemia 190
Acute lymphocytic leukemia 52, 195, 569, 723, 792
Acute manic episodes 49, 635, 805
Acute maxillary sinusitis 129
Acute mountain sickness 8, 2299
Acute myeloblastic leukemia 1439, 2435
Acute myelocytic leukemia 190
Acute myelogenous (nonlymphocytic) leukemia 734
Acute myelogenous leukemia 340, 675, 795, 1046, 2331
Acute myeloid leukemia 195, 305, 373, 836, 966, 1000, 1440, 1643, 1987, 2021, 2063, 2119, 2237, 2279, 2393
Acute myocardial failure 643
Acute myocardial infarction 25, 482, 611, 626, 651, 703, 1072, 1250, 2518
Acute organ rejection 197
Acute otitis media 63, 134, 167, 709, 768, 769
Acute pain 139, 409, 502, 717
Acute painful musculoskeletal conditions 189
Acute painful shoulder 709
Acute pancreatitis 624, 2368
Acute promyelocytic leukemia 50, 763
Acute psychotic episodes 49
Acute pulmonary edema 333
Acute pulmonary embolism 25, 744, 777, 797
Acute pyelonephritis 426
Acute rejection of renal transplant 504
Acute renal allograft rejection 45, 504, 505
Acute renal failure 450
Acute respiratory depression 107
Acute respiratory syndrome 2055
Acute rhinitis 556
Acute sinusitis 162
Acute temporomandibular joint pain 472
Acute tenosynovitis 764
Acute upper gastrointestinal bleeding 1381
Acute/subacute bursitis 764
Acute-phase reaction 812
ADA deficiency 1048
Addictive disorders 1351
Addictive behavior 1989
Adenocarcinoma 308, 1113, 1280, 2027, 2375
Adenocarcinoma of breast or ovary 736
Adenocarcinoma of stomach or pancreas 494
Adenoid cystic carcinoma 2238
Adenoma or hyperplastic polyp risk 2366
Adenomatous polyposis coli 1113
Adenosine deaminase deficiency 569
Adenoviral vectors 1644
Adiponectin 815, 1060
Adiposity 2036, 2206
Adjunct anesthetic in ophthalmic surgery 624
Adolescent idiopathic scoliosis 2206, 2290
Adrenal adenomas 1934
Adrenal steroidogenesis 1934
Adrenocortical carcinoma 495
Adrenocortical insufficiency 186, 187, 312, 363, 764
Adrenogenital syndrome 312
Adriamycin-induced glomerulosclerosis 1125
Adult-onset hypogonadotropic hypogonadism 1947
Advanced macular degeneration 2250
Adverse drug effects 2491
AEBP1 (Adipocyte enhancer-binding protein 1) 1125
Aerodigestive tract cancer 1594
Aflatoxin-related hepatocarcinogenesis 2108
African trypanosomiasis 712
Age- and sex-related effects 1481
AGER/NOTCH4 1126
Age-related changes 836, 988, 1001, 1359, 1440, 1594, 1645, 1913, 1947
Age-related differences 1381
Age-related eye disorders 2102
Age-related hearing impairment 2119
Age-related macular degeneration 1125, 1245, 2133, 2136, 2143, 2452
Age-related macular degeneration type 5 2033
Age-related macular dystrophy 2450
Aggression-related traits 988
Aggressive behavior 1947, 2160
Aggressive fibromatosis 2238
Aging 932, 1126, 1487, 1489
Agitated states 810
Agitation 37
Agranulocytosis 1457
AICA-ribosiduria 1191
AIDS 967, 2126, 2130, 2133, 2136, 2206, 2182
AIDS-related Kaposi’s sarcoma 387, 559, 791
Airway diseases 673
Airway obstruction 381, 726, 732
Albright hereditary osteodystrophy 2090
Alcohol (Ethyl) biodisposition 1056
Alcohol abstinence 4
Alcohol abuse 1054, 2079
Alcohol consumption 2305
Alcohol dependence 1052, 1054, 1055, 1104, 1250, 1255, 1266, 1997, 2160, 2419
Alcohol dependence, susceptibility to 1250, 1255, 1997, 2079
Alcohol metabolism and alcoholism 1055, 1101, 1467
Alcohol use disorders 147, 1595
Alcohol-associated cancer 1055
Alcoholic cardiomyopathy 1595
Alcoholic fatty liver 2343
Alcoholic liver cirrhosis 1595
Alcoholic liver disease 1054, 1105, 1467, 2215
Alcoholic steatohepatitis 1595
Alcohol-induced liver injury 1595
Alcoholism 166, 733, 1054, 1055, 1065, 1101, 1105, 1647, 1999, 2322, 2394, 2398
Alcoholism, susceptibility to 1065, 1999
Alcohol-related breast cancer 1056
Alcohol-related cancer 1054
Alcohol-related colorectal cancer 1056
Alcohol-related pathology 1105
Aldosterone synthase (CYP11B2) 1935
Aldosterone synthase (CYP11B2) inhibitors 1935
Aldosterone synthase deficiency type I 1935
Aldosterone-producing adenomas 1934
Alert classifications in product labeling 1647
Allergic asthma 544, 673, 804
Allergic conditions 622
Allergic conjunctivitis 62, 75, 266, 771
Allergic dermatosis 232, 610, 613
Allergic disorders 187, 613
Allergic rhinitis 54, 62, 95, 211, 232, 254, 322, 425, 499, 551, 764, 771, 1648, 2438
Allergic skin manifestations 771
Allergic states 613, 764
Allergy 214, 232, 613
Allogenic bone marrow transplantation 675
Alloimmune thrombocytopenia 2226
Alloimmunity 837
Alopecia areata 764
Alpers’ syndrome 2334
Alpers-Huttenlocher
syndrome
2334
alpha-1-Antitrypsin deficiency 23
Altitude illness 1935
Alveolar echinococcosis 1650
Alzheimer’s disease 1, APP-related 1165
Alzheimer’s disease, susceptibility to 812, 1195, 1220, 1249, 1263, 2071
Alzheimer’s disease 166, 240, 272, 335, 360, 460, 713, 750, 805, 812, 816, 837, 988, 991, 1001, 1029, 1094, 1109, 1115, 1126, 1165, 1195, 1202, 1211, 1213, 1220, 1224, 1230, 1249, 1258, 1263, 1441, 1948, 1980, 2036, 2071, 2100, 2112, 2113, 2127, 2130, 2146, 2158, 2169, 2192, 2206, 2211, 2215, 2242, 2258, 2263, 2281, 2299, 2303, 2307, 2319, 2332, 2336, 2349, 2358, 2369, 2419, 2422, 2444, 2455, 2470, 2518
Ambient particulate matter 1280
Amblyopia 166
Amebiasis 229
Amebic liver abscess 743
Amebic meningoencephalitis 39
Amenorrhea 535, 2036
Aminoglycoside-induced and nonsyndromic hearing loss 2281, 2282
Aminoglycoside-induced deafness 2284
AMME complex 1044
Amnestic dementia 1128
Amyloid A3 1948
Amyloid polyneuropathy-nephropathy Iowa type 1116
Amyotrophic lateral sclerosis 656, 839, 1111, 1129, 2360
Anaerobic bacterial and protozoal infections 483
Anaerobic infections 377
Analgesic response 2267
Anaphylactic reactions 266, 622
Androgen deficiency 728
Androgen insensitivity syndrome 1184
Androgenetic alopecia 492
Anemia 202, 268, 269, 366, 511, 556, 2227
Aneurysm 1129
Angina 355, 399, 525, 742, 2060
Angina pectoris 41, 56, 227, 399, 403, 482, 507, 533, 626, 742, 788, 2060
Angioedema 121, 184, 771
Angiofibroma 2268
Angiogenesis 1129, 1615
Angiotensin-converting enzyme inhibitor (ACEi)-induced cough 2361
Angle-closure glaucoma 222, 256, 590
Anhaptoglobinemia 2152
Ankylosing spondylitis 5, 11, 139, 223, 284, 291, 348, 383, 384, 512, 709, 724, 1273, 1444, 2133, 2136, 2192, 2429, 2465
Anogenital pruritus 78, 212, 226, 253, 610
Anorectal surgical wounds 798
Anorexia 249, 458, 2036, 2161, 2398, 2476
Antagonistic pleiotropy 1129
Anterior cruciate ligament (ACL) ruptures 1261
Anterior uveitis 657
Anthropometric parameters 1949
Antibiotic-associated pseudomembranous colitis produced by Clostridiuim difficile 783
Antibody-induced pure red cell aplasia 190
Anticholinesterase inhibitor poisoning 59
Anticonvulsant hypersensitivity syndrome 2021
Antidepressant exposure in breastfed infants 1557
Antidepressants in late pregnancy 1555
Antihypertensive therapy 2023, 2304
Anti-inflammatory phenotype 1130
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) 1273
Antiphospholipid syndrome 1381, 2056
Antipsychotic-induced extrapyramidal side-effects 1523
Antipsychotic-induced obesity 2005, 2165
Antipsychotic-induced parkisonism 2380
Antipsychotic-induced side-effects 1063
Antipsychotic-induced tardive dyskinesia 2002, 2004, 2289
Antiretroviral therapy 1224
Antiretroviral therapy-associated lipid disorders 1130
Antisocial behavior 2259
Antithrombotic therapy 1407
Anti-tuberculosis drug-induced hepatic injury 2496
Anti-tuberculosis drug-induced hepatitis 1407
Anti-tuberculosis drug-induced maculopapular eruption 1381
Antitumor prodrug development 1658
Anti-VEGF therapy 1130
Antley-Bixler craniosynostosis syndrome (cytochrome P450 oxidoreductase deficiency) 1949, 1957
Anthracycline-induced extravasation 217
Anuria 450
Anxiety disorder 23, 35, 37, 93, 102, 103, 144, 147, 177, 220, 245, 251, 368, 439, 450, 464, 552, 620, 702, 1061, 2079, 2476
Anxious depression 450, 2305
Aortic aneurysm 2290
Aortic coarctation 1935
Aphthous ulcers 119, 449
Aplastic anemia 45, 1659, 2182, 2441, 2444
Apnea 244, 1130, 1195
Apnea of prematurity 107, 732
ApoA-I mimetic peptide 4F 1130
ApoB-100 1130
APOE and lipid metabolism 1128
APOE haplotype 1131
APOE in Alzheimer’s disease 1126, 1128
ApoE receptor 2 1131
ApoE-/- PGC-1α-/- mice 1131
ApoE-1 mimetic peptide D4-F 816
APOE-related phenotypic profiles in Alzheimer’s disease 1128
Apolipoprotein B peptide vaccine 1131
Apolipoprotein E 72-166 peptides 1131
Apoptosis 989
Apoptosis signal-regulating kinase 1 1131
APP and presenilins in Alzheimer’s disease 1166
APP-related cerebral amyloid angiopathy 1169
Argininemia 1189
Ariboflavinosis 653
Aromatase (CYP19A1) 1949
Aromatase and dual aromatase-steroid sulfatase inhibitors 1950
Aromatase deficiency 1949
Aromatase excess syndrome 1949
Aromatase inhibitor-induced arthralgia in breast cancer 1950
Aromatase inhibitors vs Tamoxifen in advanced breast cancer 1951
Aromatic L-amino acid decarboxylase deficiency (AADC) 1448, 1989
Arrhythmia 565, 2389
Arsenic metabolism 1190
Arsenic poisoning 2112, 2113
Arsenic toxicity 2119
Arsenic-induced disease 1190, 1220
Arterial hypertension 612, 626, 636, 643, 650, 701, 720, 725, 742, 757, 758, 765, 782, 788, 1063, 1068, 1071, 1077, 1081, 1197, 1202, 2014
Arterial properties 1051
Arteriosclerosis 182, 1914, 2521
Arteriosclerosis obliterans 401
Arteriovenous fistula stenosis 2277
Arthralgia 234
Arthritis 144, 155, 284, 455, 673, 772
Arthrosis 724
Aryl hydrocarbon receptor 841, 1002, 1132, 1280, 1337
Aryl hydrocarbon receptor-interacting protein (AIP) 1306
ASA-intolerant myocardial infarct 2439
Asbestosis 2114
Ascites 15, 285
Aseptic prophylaxis of burns 685
Aspergillosis 402
Aspergillus infection 39, 126, 2452
Aspirin hypersensitivity 2202
Aspirin intolerance 1382
Aspirin-induced asthma 2311, 2439
Aspirin-induced peptic ulcer 1381, 2439
Aspirin-intolerant asthma (AIA) 2360, 2361, 2362, 2363, 2366
Assisted Reproductive Technology 621, 777
Association of APOE with beta-amyloid and tau proteins in AD pathology 1127
Association of APOE-4 with an anticipation of the age-at-onset and fast cognitive decline 1127
Association of CYP2D6 variants with Alzheimer’s disease-related genes 1442
Asthma 69, 97, 187, 211, 253, 322, 328, 467, 499, 500, 673, 801, 804, 933, 1044, 1048, 1050, 1075, 1109, 1116, 1214, 1225, 1267, 1271, 1273, 1337, 1408, 1615, 1980, 2055, 2105, 2112, 2115, 2182, 2202, 2219, 2224, 2256, 2349, 2361, 2369, 2417, 2437, 2439, 2444, 2452, 2514
Asthma, susceptibility to 1075
Astrocyte elevated gene-1 (AEG1) 841
Astrocytes 1132
Astrocytic and oligodendroglial brain tumors 1002
Astrocytoma 124, 721, 1002, 2115
Asystole 59, 266, 785
Ath29 1132
Atherosclerosis 57, 323, 611, 667, 816, 989, 1089, 1109, 1116, 1132, 1225, 1244, 1269, 1663, 1935, 1980, 2056, 2060, 2092, 2222, 2248, 2325, 2327, 2339, 2341, 2343, 2362, 2384, 2444, 2465
Atherosclerosis, susceptibility to 1269, 2092
Athlete’s foot 681, 692, 707, 725, 753, 763, 776
Atopic dermatitis 42, 78, 314, 322, 590, 714, 2202, 2219
ATP-binding cassette transporter G1 deficiency 989
Atrial fibrillation 6, 238, 250, 279, 372, 618, 623, 626, 637, 699, 788, 789, 797, 1030, 1085, 1935, 2304
Atrial flutter 250, 279, 372, 618, 626, 699, 788
Atrioventricular nodal block 265
Attention-deficit hyperactivity disorder (ADHD) 38, 56, 216, 218, 255, 432, 470, 478, 787, 1063, 1065, 1068, 1351, 1997, 2005, 2007, 2090, 2160, 2161, 2162, 2259, 2260, 2394, 2396, 2398, 2418, 2476
Attention-deficit hyperactivity disorder, susceptibility to 1063, 1065, 1068, 1997, 2005, 2007, 2090
Atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung 1951
Atypical depression 2259
Autism 1048, 1061, 1951, 2095, 2108, 2162, 2166, 2226, 2258, 2270, 2289, 2318
Autism spectrum disorder 658, 1061, 2095, 2289, 2318
Autistic disorder 658, 2318
Autoimmune Addison’s disease 1273
Autoimmune disorders 1273, 2401
Autoimmune hemolytic anemia 190
Autoimmune hepatitis 1449, 1540, 2143
Autoimmune hypothyroidism 2203
Autologous hCD40L/IL-2 tumor vaccine 1002
Autonomic nervous system dysfunction 2005
Autosomal dominant dopa-responsive dystonia 2081
Autosomal dominant periodic fever syndrome 2465
Autosomal dominant retinitis pigmentosa 2223
Autosomal dominant thrombophilia 2353
Autosomal dominant type III hyperlipoproteinemia 1132
Autosomal recessive dopa-responsive dystonia with or without hyperphenylalaninemia 2081
Autosomal recessive juvenile Parkinson’s disease 2 2326
Autosomal recessive mental retardation 6 2095
Autosomal recessive spastic paraplegia 7 2425
Autosomal recessive thrombophilia 2353
AV nodal block 59, 398
AV nodal re-entrant tachycardias 626
AWP1 Protein characterization 2529
Axenfeld-Rieger syndrome 1337
Axillary node tumor 267
Azoospermia, oligospermia 1233, 1665, 2119
B
B-cell chronic lymphocytic leukemia 18, 380
Babesia microti infection 638
Bacillus Calmette-Guérin and Salmonella infection 2219
Bacillus Calmette-Guérin-refractory carcinoma in situ of the urinary bladder 781
Bacterial conjunctivitis 63, 426, 503, 613, 707
Bacterial Eikenella corrodens infections 133
Bacterial infections 39, 137, 178, 208, 255, 276, 341, 380, 430, 483, 492, 558, 575, 576, 594, 598, 769
Bacterial infections of the eye 316
Bacterial meningitis 465
Bacterial sepsis 2466
Bacterial septicemia 137, 377
Bacterial sinusitis 503
Bacterial vaginosis 169, 412, 483, 743
Baldness 1185
Balkan endemic nephropathy 1666
Bariatric surgery 990
Bariatric surgery-induced weight loss 1596
Barrett’s metaplasia 1666
Bartter- and Gitelman-like syndromes 1936
Basal cell carcinoma 316, 379
Basal cell nevus syndrome 1281, 1450, 2109
B-cell lymphoma 843
Beckwith-Wiedemann syndrome 2190
Bee stings 73, 255
Behavioral symptoms 1133
Behcet’s disease 732, 1274, 2176, 2206, 2212, 2224, 2401, 2455
Beneficial body composition 2316
Benign essential
blepharospasm
2007
Benign facial lentigines 718
Benign familial tremor 617
Benign gastric ulcer 296, 415, 534, 545, 645
Benign metastasizing leiomyoma 1951
Benign prostate hyperplasia 19, 252, 612, 685, 716, 725, 1063, 1098, 1666, 1951
Benzene toxicity 1596, 2021, 2109, 2307
Benzodiazepine intoxication 312
Benzodiazepine-induced sedation 312
Berardinelli-Seip congenital generalized lipodystrophy (type 1) 1083
Beryllium disease 2138
beta-Amyloid 817
beta-Hemolytic streptococci 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 140, 178, 540, 549
beta-Thalassemia 977, 2125
Bilateral adrenal incidentalomas 2316
Bilateral striatal necrosis 2280, 2283
Bile acid homeostasis 1914
Bile acid metabolism 1668
Bile acid-activated vitamin D receptor signaling 1914
Bile salt deficiency 456
Biliary and renal colic 368
Biliary atresia 2518
Biliary cholesterol excretion 844
Biliary epithelium 1669
Biliary tract cancer 1408
Biliary tract infections 129
BIN1 1133
Bioartificial liver systems 1669
Biotin deficiency 84
Biotransformation of antidepressants 1444
Bipolar I disorder 52, 118, 414, 541, 635, 658
Bipolar affective disorder 658, 2396, 2428
Bipolar depression 658
Bipolar disorder 49, 434, 635, 658, 781, 805, 808, 810, 1210, 1258, 1991, 1997, 2003, 2009, 2062, 2096, 2100, 2158, 2162, 2167, 2188, 2398, 2476
Bipolar mania 635, 658, 781
Birdshot chorioretinopathy 2130
Birth weight 2306
Birth weight and metal toxicity 2128
Bisallylic hydroxylation 1669
Bisphosphonate-related osteonecrosis in multiple myeloma 1371
Bladder cancer 68, 164, 247, 494, 791, 844, 1094, 1235, 1240, 1282, 1307, 1338, 1450, 1670, 1903, 2027, 2109, 2203, 2239, 2251, 2294, 2297, 2470, 2498, 2507, 2518, 2527
Bladder outlet obstruction 1952
Bladder overactivity 202
Bladder tumors 791, 1240, 1903, 2251, 2290
Blastocystis hominis infections 391
Blastomyces dermatitidis 39, 514
Blastomycosis 310, 402, 407
Bleeding disorder 2325, 2439
Blepharitis 514
Blepharospasm 90
Blood 1670
Blood lead levels 1100
Blood lipids 1915, 2226
Blood pressure 1670, 1936, 2395
Blood pressure regulation 1225
Blood-brain barrier 844, 934, 1003, 1133, 1282, 1338, 1670
Blood-testis barrier 845
Body bone mineral density 2343
Body mass index 1080, 2154
Body weight loss 1082, 1468
Bone and joint infections 128, 129, 132, 133, 137, 138, 140, 162, 377, 740
Bone development 2071
Bone fracture risk 1261
Bone infections 140, 341, 377, 740
Bone loss 1952
Bone marrow transplantation 305, 845
Bone metabolism 1671
Bone metastases of
malignancy
171
Bone metastases of
solid tumors
806
Bone mineral density 18, 1044, 2036, 2043, 2206
Bone morphogenetic protein-2 (BMP-2) 1952
Bone structural traits 1133
Bowel disease 224, 592
Brachytic2/ZmABCB1 846
Bradyarrhythmias 398
Bradycardia 265, 1450
Bradycardia-induced long QT syndrome 2231
Brain 846, 934, 1003, 1468, 1615, 1936, 1980
Brain apolipoproteins 1133
Brain aromatase 1952
Brain arteriovenous malformations 1047
Brain cancer 2294
Brain CYP2B 1359
Brain CYP2D6 1451
Brain CYP2E1 1597
Brain CYP3A4 1672
Brain injury 1953
Brain metabolism 1496
Brain microvessels 1338
Brain penetration 846
Brain serotonin receptor binding 1447
Brain steroidogenesis 1953
Brain tumors 124, 436, 619, 845, 1672, 2527
Brain white matter lesions 1134
Brain-derived neurotrophic factor 1134
Brainstem glioma 124
BRCA1/BARD1 complex 1954
Breast and endometrial carcinoma 458
Breast and other epithelial carcinomas 1271
Breast cancer 42, 81, 146, 190, 237, 247, 267, 274, 281, 293, 316, 318, 349, 373, 404, 421, 473, 494, 511, 559, 562, 641, 715, 728, 756, 791, 792, 793, 846, 934, 981, 1003, 1027, 1054, 1089, 1094, 1107, 1113, 1194, 1206, 1208, 1214, 1221, 1230, 1233, 1235, 1237, 1249, 1261, 1263, 1282, 1307, 1338, 1371, 1382, 1402, 1408, 1452, 1597, 1672, 1954, 1999, 2016, 2024, 2027, 2036, 2043, 2105, 2109, 2115, 2119, 2151, 2156, 2188, 2213, 2222, 2239, 2247, 2261, 2271, 2286, 2294, 2299, 2307, 2333, 2336, 2411, 2416, 2432, 2436, 2441, 2444, 2448, 2470, 2480, 2487, 2496, 2504, 2507, 2510, 2526, 2527
Breast cancer chemoprevention 1955, 1954
Breast cancer, invasive 641, 715
Breast cancer, susceptibility to 1249, 1261, 1263, 1999, 2336
Breast, head and neck, and lung carcinomas 473, 792
Breast-ovarian cancer 1053
Bronchial airway hyperactivity 469
Bronchial asthma 157, 265, 266, 516, 726, 764
Bronchial epithelial and alveolar macrophage cells 1673
Bronchial hyperresponsiveness 2037
Bronchitis 136, 393, 745
Bronchoconstriction 328
Bronchodilator 664, 726, 750
Bronchopulmonary dysplasia 652, 750
Bronchospasm 265, 266, 313, 328, 393, 673, 745
Brucellosis 704
Brugada syndrome 2386, 2389
Brunner syndrome 2259
Buccal mucosa carcinogenesis 1903
Budd-Chiari syndrome 2049
Bulimia nervosa 317, 2475
Burkitt’s lymphoma variant/acute lymphoblastic leukemia with translocations t(2;8)(p12;q24);t(8;22)(q24;q11) 1025
Burkitt’s lymphoma 190, 967
Burns 15, 255, 287, 608, 610, 685, 699, 724
Bursitis 383, 764, 709, 724
Buruli ulcer 2401
C
Cachexia 458, 699
CADASIL 2302
Caffey disease 1261
CAG repeat polymorphisms 1185
Calcineurin inhibitor-induced chronic kidney disease 1615
Calcium deficiency 110, 111, 113
Calcium depletion 110, 112
Calcium oxalate calculi 21
Calcium supplementation 112
Camurati-Engelmann disease 2444
Cancer 848, 1105, 1110, 1134, 1193, 1214, 1453, 1597, 1678, 1992, 2027, 2101, 2102, 2112, 2113, 2286, 2290, 2491, 2526
Cancer chemotherapy 977
Cancer chemotherapy-induced nausea and vomiting 506, 561, 620, 773
Cancer metastasis 1615
Cancer pain 301, 848, 2081
Cancer risk 2510
Cancer susceptibility 2369
Candida infection 39, 310, 725, 795
Candidal cystitis 39
Candidemia 43, 126, 310, 795
Candidiasis 407, 538, 603, 725, 726
Candiduria 407
Cannabinoid receptor GPR55 934
Capillary infantile hemangioma 2236
Carbamazepine hypersensitivity 2157
Carbonic anhydrase II 1956
Carbuncles 287, 309
Carcinogenesis 1468
Carcinoid syndrome 703, 2268
Carcinoid tumor 703
Carcinoid tumors, intestinal 539
Carcinoma 849, 1615, 2090
Carcinoma cells 2328
Carcinoma of the colon or rectum 395
Cardiac arrest 266, 772, 1597
Cardiac arrest and therapeutic hypothermia 1597
Cardiac arrhythmias 449, 2229, 2386
Cardiac bypass surgery 772
Cardiac CYP450s 1283, 1615
Cardiac decompensation 206, 236
Cardiac ischemic complications 271
Cardiac potassium channel KCNA5 849
Cardiac resuscitation 112
Cardiac valve disease 1134
Cardiac valve replacement 797
Cardiofaciocutaneous syndrome 1204, 2239
Cardiomyopathy 217, 2284, 2395, 2482
Cardiomyopathy and deafness 2284
Cardiomyopathy with or without skeletal myopathy 2285
Cardiopulmonary bypass 15, 218
Cardiopulmonary bypass and coronary artery bypass grafting 1134
Cardiotoxicity 1549, 1568
Cardiovascular adverse events 1454
Cardiovascular disease 57, 78, 1051, 1057, 1070, 1076, 1080, 1085, 1089, 1095, 1105, 1117, 1120, 1197, 1269, 1371, 1597, 1615, 1936, 1956, 2044, 2051, 2128, 2146, 2152, 2211, 2286, 2299, 2366, 2422, 2452
Cardiovascular function 1067, 1076, 2081
Cardiovascular risk 1447, 2053, 2366
Cardiovascular status 2316
Carminative 780
Carotid atherosclerosis 611, 2306
Carotid endarterectomy 1245
Castration 1683
Cataplexy 693
Cataract surgery 9, 409, 520, 624, 774
Cauterization of wounds and sluggish ulcers 684
Caveolin-1-deficiency 1936
CCR5-tropic HIV-1 infection 451
CD34/M-cadherin bone marrow progenitor cells 1134
CD36 1134
CD44 849
CD147/basigin 849
CD 437 1235, 2062, 2137, 2238, 2347, 2472
CD 4528 2516
CDX2 (caudal-related homeobox transcription factor) 849
Celiac disease 1274, 1684, 1907, 2139, 2199
Cellulites 309
Central core disease 2383
Central hypoventilation syndrome 2379
Central nervous system infections 39
Central nervous system injury 1257
Central nervous system lymphoma 1004
Central obesity 2316
Centronuclear myopathy 2383
Cerebellar ataxia 2334
Cerebral amyloid angiopathy 1134, 1169, 1936
Cerebral contusion 141
Cerebral edema 214, 450
Cerebral infarction 1907, 2060, 2365
Cerebral malaria 2455
Cerebral microhemorrhage and vascular amyloid deposition 1135
Cerebral palsy 65, 85, 90, 123, 200
Cerebral vascular disease 166, 342, 794
Cerebral venous thrombosis 797, 2048
Cerebrooculofacioskeletal syndrome 2031
Cerebrooculofacioskeletal syndrome (type 1) 2033
Cerebrooculofacioskeletal syndrome 4 2029
Cerebrotendinous xanthomatosis 1684, 1915, 1981
Cerebrovascular accident 2513
Cerebrovascular atherosclerosis 611, 1135
Cerebrovascular disorders 523, 611, 1135, 1160, 1408
Cerebrovascular insufficiency 272
Cervical cancer 359, 755, 793, 1225, 2025, 2057, 2192, 2307, 2444, 2471
Cervical dystonia 91, 2007
Cervical neoplasia 755, 793, 2438
Cervical/urethral gonorrhea 131, 162, 540, 700, 731
Cervicitis 63, 540
Cervicocerebral artery atherosclerosis 1135
Chagas’ disease 2197
Channelopathy-associated insensitivity to pain 2390
Chaperone 1685
Charcoal-broiled meat 1685
Chemical inhibitors of CYPs 1455
Chemically-induced carcinogenesis 1598
Chemokine (C-C motif) receptor 5-2459 genotype 1360
Chemokine receptor CCR6 1135
Chemotherapeutics 2307
Chemotherapy-induced anemia 202
Chemotherapy-induced leukemia 2115
Chemotherapy-induced nausea and vomiting 620, 773
Chickenpox 779
Childhood acute lymphoblastic leukemia 1283, 1598
Childhood asthma 672, 804
Childhood leukemia 2128
Chitosan micellar system 850
Chlamydial infection 147, 167, 168, 248, 276, 340, 700, 709, 731
Chlamydophila pneumoniae 719
Chloroquine-resistant Plasmodium falciparum malaria 616, 633, 638
Cholangiocarcinoma 850, 2092
Cholera 761
Cholestasis 749, 967, 1687, 1916, 2491
Cholestatic liver disease 2400
Cholesterol 823, 929, 996, 1116, 1120, 1161, 1169, 1182, 1187, 1215, 1242, 1687, 1932, 2188, 2245, 2250, 2253, 2300, 2312, 2314, 2337, 2385, 2446, 2465, 2516, 2519
Cholesterol 25-hydroxylation activity of CYP3A 1982
Cholesterol efflux pathways 990
Cholesterol gallstone disease 1916
Cholesterol homeostasis in laboratory opossums (Monodelphis domestica) 1981
Cholesterol levels 1058, 2088
Cholesterol metabolism 817
Cholesterol-free mouse 1916
Cholesteryl ester transfer protein (CETP) 990
Cholesteryl oleyl ether 2385
Cholestenoic acid 1981
Cholic acid 823, 929, 962, 964, 1215, 1687, 1916, 1932, 2019, 2150, 2183, 2194, 2198, 2208, 2217, 2253, 2337, 2446, 2458
Cholic and chenodeoxycholic acid 1233, 1687
Choline acetyltransferase 1135
Choline-related organ dysfunction 2332
Chondrogenesis 850
Chorea 729
Choreiform syndrome 1477
Choriocarcinoma 146, 791, 1004
Chorionic gonadotropin 990
Christmas disease 295
Chromomycosis 407
Chromosomal damage 2498
Chromosomal damage and cancer risk 2527
Chromosome 5q deletion syndrome 1271
Chromosome fusion 1956
Chronic alcoholism 235, 2405
Chronic allograft nephropathy 2455
Chronic anal fissure 90
Chronic angina 645
Chronic anterior uveitis 657
Chronic asthma 732, 801, 804, 1075
Chronic bacterial prostatitis 162
Chronic bronchitis 47, 168, 253, 340, 426, 540, 664, 745, 768
Chronic bronchopulmonary disease 9
Chronic constipation 413, 629, 631
Chronic consumptive coagulopathy 356
Chronic diarrhea 437
Chronic eczematous external otitis 314
Chronic granulomatous disease 390
Chronic hepatitis 1469
Chronic hepatitis B virus infection 12, 413, 718, 723, 2321
Chronic hepatitis C 570, 571, 652, 1598
Chronic high-cholesterol diet 1916
Chronic idiopathic constipation 443, 718
Chronic idiopathic pancreatitis 624
Chronic idiopathic urticaria 54, 142, 211, 425, 438
Chronic immune thrombocytopenia 2197
Chronic iron overload 206
Chronic kidney disease 109, 161, 206, 246, 292, 303, 566, 682, 817, 851, 2247, 2299, 2377
Chronic kidney failure 1031
Chronic liver disease 1489, 1982
Chronic lung diseases 732
Chronic lymphocytic leukemia 18, 71, 146, 167, 190, 311, 380, 540, 578, 661, 851, 2055
Chronic mucocutaneous candidiasis 407
Chronic myelocytic leukemia 190, 195, 367
Chronic myelogenous leukemia 103, 167, 204, 205, 373, 386, 387, 526, 734, 792, 1025
Chronic myeloid leukemia 172, 204, 525, 851, 935, 1004, 1026, 1196,1283, 2429
Chronic myeloproliferative disorders 2331
Chronic nonspherocytic hemolytic anemia 2078
Chronic obstructive pulmonary disease (COPD) 15, 31, 47, 58, 63, 77, 381, 393, 467, 664, 673, 745, 1254, 1266, 1274, 1283, 1309, 1338, 1351, 1598, 2021, 2207, 2247, 2297, 2343, 2527
Chronic open-angle glaucoma 79, 125, 233, 256, 423, 480
Chronic pain 301, 364
Chronic pancreatitis 1056
Chronic periodontitis 2203
Chronic plaque psoriasis 17, 108, 258, 284, 718
Chronic Pseudomonas aeruginosa infection in cystic fibrosis 748, 2056
Chronic renal failure 202, 211, 268, 269, 396
Chronic rheumatoid arthritis 226, 724, 738, 749, 752, 764, 812
Chronic rhinitis 556
Chronic rhinosinusitis 2270
Chronic solid organ rejection 613
Chronic stable angina 5, 34, 86, 229, 403, 523, 788
Chronic suppurative otitis media 540
Chronic swelling 214
Chronic synovitis 2133
Chronic thromboembolic pulmonary hypertension 797, 2138
Chronic uremia 1135
Chronic urticaria 551, 584
Circadian regulation 1916
Circadian rhythm sleep disorders 2289
Circulating thymic factor 2208
Cirrhosis 701, 754, 1688, 2128, 2444
Cisplatin-induced renal toxicity 28
Citrobacter rodentium infection 1598
Classic subfoveal choroidal neovascularization 790
Claudin-7-deficiency 1936
Cleft lip/palate 1220, 2287, 2291
Clopidogrel and proton pump inhibitors 1410
Cloning 1693
Clonorchiasis 612
Clubfoot 1283, 1310
Cluster headache 711, 755
Clusterin 1135
c-Myc 852
CNS drugs 1532
CNS-active drugs 1598
CNS infections 483, 549
CNS leukemia/lymphoma 737
CNS metastases 736
CNS pathology-associated risk factors 1128
Coarctation of aorta 24
Cocaine abuse 2000
Cocaine-related disorders 1258
Coccidioides immitis 39
Coccidioidomycosis 310, 407
Cochlea and organ of Corti 1004
Cockayne syndrome (type B) 2033
Cockayne syndrome, photosensitive trichothiodystrophy, and xeroderma pigmentosum/cockayne syndrome complex 2031
Codeine dependence 1459
Coelenterazine- and D-luciferin-based bioluminescence 852, 935
COG112 ApoE-mimetic peptide 1136
Cognition 1050, 2167, 2170
Cognition and prefrontal cortex function 2099
Cognition disorders 794
Cognitive deterioration 794, 1957
Cognitive dysfunction 794
Cognitive function 675, 1136, 1459, 2009
Colchicine resistance 853
Cold stress 1917
Cold-induced CYP1A activation 1283, 1310
Colitis 1283
Collagen diseases 42, 613
Colon adenoma 1696
Colon cancer 316, 421, 436, 549, 631, 935, 1110, 1211, 1230, 1917, 2192, 2281, 2287, 2361, 2393, 2487, 2518
Colon cancer, advanced 549, 642
Colonic evacuation 680, 694
Colonic neoplasms 964, 1209, 2365, 2483
Colorectal adenocarcinoma 2251
Colorectal adenoma 1383, 1917, 2207
Colorectal cancer 115, 494, 549, 642, 704, 817, 853, 1005, 1054, 1058, 1105, 1113, 1203, 1204, 1211, 1221, 1269, 1283, 1310, 1339, 1459, 1598, 1696, 1957, 1982, 2021, 2029, 2031, 2044, 2084, 2109, 2115, 2119, 2128, 2176, 2188, 2190, 2219, 2225, 2240, 2247, 2271, 2277, 2291, 2294, 2297, 2333, 2341, 2343, 2360, 2369, 2380, 2412, 2415, 2438, 2444, 2448, 2452, 2471, 2480, 2498, 2501, 2515, 2527
Colorectal cancer, susceptibility to 1058, 1269, 2291
Colorectal liver metastases 1696
Colorectal polyps 1095, 2369
Colorectal tumor 642, 1058, 1269, 2291
Combined deficiency of vitamin K-dependent clotting factors 2083
Comedications 1957
Common cold 144, 630, 771
Common variable immunodeficiency 380, 2203
Community-acquired pneumonia 129, 130, 134, 135, 167, 168, 275, 426, 430, 503, 540, 719
Comparative studies 1477, 1481, 1487, 1496, 1502, 1510, 1522, 1523, 1525, 1531, 1550, 1557, 1568, 1578, 1696
Complement 1599
Complement C5a inhibitors 1137
Complement receptor 1 (CR1) 1137
Complex absence seizures 781
Complex partial seizures 781
Compulsive craving during alcohol withdrawal 1957
Concurrent primary aldosteronism and subclinical cortisol hypersecretion 1936
Condylomata acuminata 387, 388
Connective tissue-activating peptide 2323
Conformational changes and ligand promiscuity 1699
Congenital adrenal hyperplasia (P450 oxidoreductase deficiency) 1383, 1459, 1957
Congenital afibrinogenemia 2060
Congenital agammaglobulinemia 380
Congenital bilateral absence of the vas deferens 1247
Congenital cardiac disease 2287
Congenital corneal opacification infantile glaucoma and von Hippel’s ulcer 1339
Congenital disorders of glycosylation type I 2426
Congenital glaucoma 1339
Congenital heart disease 24, 652, 2297
Congenital hyperinsulinism 981, 2233
Congenital hypoaldosteronism and sensorineural hearing loss 1937
Congenital myasthenic syndrome associated with episodic apnea 1249
Congenital mysathenic syndromes 1252
Congenital pancreatic hypoplasia and pancreatic agenesis 982
Congenital sucrase-isomaltase deficiency 671
Congestive heart failure 8, 227, 331, 355, 361, 362, 380, 476, 520, 533, 651, 757, 1068, 1218
Congestive heart failure, susceptibility to 1068
Conjunctival congestion 731
Conjunctivitis 121, 162, 214, 337, 410, 514, 613, 707
Constipation 85, 447, 631, 680
Constitutive androstane receptor (CAR) 854, 1699
Contraception 710
Conventional phenotyping 1506
Conversion of cholesterol into bile acids 1917
Convulsive disorders 220
Convulsive states 332, 734
Co-prescription of CYP2D6/3A4 inhibitor-substrate pairs 1700
Corneal edema 691
Corneal epithelium 1005
Corneal injury 214, 316, 613, 1107
Corneal ulcer 162, 426, 613, 707
Coronary arteriosclerosis 610, 611, 2253
Coronary artery aneurysms 380
Coronary artery bypass graft surgery 610, 611, 739
Coronary artery disease (CAD) 442, 610, 611, 817, 977, 991, 1031, 1048, 1058, 1076, 1110, 1119, 1137, 1371, 1383, 1410, 1599, 1616, 1917, 1925, 2036, 2092, 2109, 2192, 2245, 2256, 2287, 2299, 2325, 2336, 2441
Coronary artery disease in familial hypercholesterolemia, protection against 442, 610, 611, 686
Coronary artery disease, autosomal dominant, 1 610, 611
Coronary artery disease, autosomal dominant, 2 610, 611
Coronary artery disease, modifier of 610, 611
Coronary artery disease, resistance to 610, 611
Coronary artery disease, susceptibility to 610, 611, 1076, 2092, 2336
Coronary artery stenting 271, 610
Coronary atherosclerosis 610, 611, 2152, 2225, 2277, 2336
Coronary disease 79, 610, 611, 1117, 1244, 1269, 2049, 2336
Coronary heart disease 339, 610, 611, 686, 1056, 1085, 1090, 1269, 1616, 2176, 2215, 2277, 2287, 2304
Coronary heart disease, susceptibility to, 2 610, 611
Coronary heart disease, susceptibility to, 3 610, 611
Coronary heart disease, susceptibility to, 4 610, 611
Coronary heart disease, susceptibility to, 6 610, 611
Coronary heart disease, susceptibility to, 7 610, 611
Coronary heart disease, susceptibility to, 8 610, 611
Coronary heart disease, susceptibility to, 9 610, 611
Coronary occlusion 6, 610
Coronary restenosis 610
Coronary revascularization 610
Coronary spasm 610, 611, 2299
Coronary spasms, susceptibility to 610, 611
Coronary stenosis 610, 1137
Coronary stent implantation 610, 740, 1700
Coronary thrombosis 610, 611, 722
Coronary vasospasm (coronary spastic angina) 610, 611, 1137
Corpus luteum 1616
Corticobasal degeneration 1137
Corticosteroid-responsive dermatosis 16, 170, 226, 353, 354, 363, 613
Corticosterone methyloxidase deficiency 1937
Corynebacterium infections 337
Cough 219, 249, 351, 362, 393
Coumarin 7-hydroxylation 1351
Coumarin resistance 2521
Courtship behavior 1957
CpG methylation 1311
CpG ODN 2006 2184, 2208, 2217, 2446, 2458
CPG-oligonucleotide 2371
C-Reactive protein 1937
Cramps 60, 780
Craniocerebral trauma 141
Creutzfeldt-Jakob disease 1137, 2349
Cri-du-chat syndrome 2441
Crigler-Najjar’s syndrome 2487, 2496
CRIM1 855
Crohn’s disease 11, 97, 141, 384, 514, 732, 855, 1085, 1225, 1258, 1271, 1274, 1701, 1907, 2058, 2207, 2215, 2219, 2311, 2362, 2452, 2466
Crohn’s disease-associated growth failure 2207
Cryopreserved human hepatocytes 1701
Cryopyrin-associated periodic syndromes 113, 656
Cryptococcal meningitis 310
Cryptococcus neoformans 39
Cryptorchidism 1185
CUGBP2 1137
Cushing’s syndrome 30, 214, 1702
Cutaneous and mucosal leishmaniasis 2212
Cutaneous candidiasis 158, 177, 256, 407, 538
Cutaneous dermatophytoses 407, 610, 613
Cutaneous drug-metabolizing enzymes 1402
Cutaneous larva migrans 733
Cutaneous leishmaniasis 2452
Cutaneous malignant melanoma 1204, 1235
Cutaneous melanoma 2515
Cutaneous T-cell lymphoma 208, 608, 664, 796
Cutaneous/gastrointestinal/oropharyngeal anthrax 426
CXCL16 1138
CXCRs 1005
Cyanide poisoning 41, 366, 477, 695
Cyclic AMP 1247, 1259, 2150, 2154, 2155, 2194, 2220, 2346
Cyclic GMP 967, 971, 1088, 1106, 2300, 2305, 2371, 2458
Cyclin D1 1957
Cyclin-dependent kinase 2 1702
Cyclin-dependent kinase inhibitors 855, 1702
Cyclooxygenase-2 856, 1005
Cyclooxygenases (COX-1, COX-2) 968
Cyclophosphamide in breast cancer 1360
Cyclophosphamide in lupus nephritis 1361
Cycloplegia 59, 190
CYP induction 1361
CYP inhibitors 1412, 1460, 1599, 1712
CYP phosphorylation 1712
CYP17 inhibitors 1712
CYP1A1 expression 1284
Cyp1a1-Ren-2 transgenic rats 1284
CYP1A2 induction 1311
CYP1A2 metabolism screening 1311
Cyp2a5-null mouse 1351
CYP2A6 variants 1351
CYP2A13 and lung cancer 1352
CYP2C induction 1403
CYP2C P450 enzymes in human hepatocytes 1705
CYP2C18-19 humanized mice 1402
CYP2D6 and antidepressant switching 1445
CYP2D6 in Alzheimer’s disease 1442
CYP2D6-CYPOR 1460
CYP2D6-NADPH cytochrome P450 reductase fusion protein 1705
CYP2D6-related biochemical and hemodynamic phenotypes in Alzheimer’s disease 1442
CYP2D6-related therapeutic response to a multifactorial treatment 1442
CYP2J2 inhibitors 1616
CYP2J2 substrates 1617
CYP3A cluster (CYP3A4, CYP3A5, CYP3A7, CYP3A43) 1705
CYP3A isozyme ligands 1708
CYP3A4 5′ promoter variants 1709
CYP3A4 5′ regulatory region 1707
CYP3A4 catalytic specificity 1705
CYP3A4 degradation 1706
CYP3A4 induction 1708
CYP3A4 inhibitors 1708
CYP3A4 multiple substrate binding 1709
CYP3A4 oxidation 1709
CYP3A4 transactivation 1710
CYP3A4 vs CYP3A5 1706
CYP3A4*20 (CYP3A4 allele without functional activity) 1706
CYP3A4/5/7 gene expression 1707
CYP3A4/5/7 gene expression in cancer 1707
CYP3A4-ABCB1 (MDR1) interactions 1708
CYP3A4-CYP2C8 interactions 1706
CYP3A4-CYP2D6 interactions in psychiatric patients 1706
CYP3A4-PXR relationship 2311
CYP3A4-UDP-glucuronosyltransferase activity 1710
Cys11-Cys15-endothelin-1 (11-21) 2013
Cystic fibrosis 9, 242, 748, 935, 1247, 1460, 1712, 2192, 2444
Cystic fibrosis lung transplant 1412
Cystic fibrosis pulmonary disease 2014
Cystic hydatid disease 14
Cystic tumors 764
Cysticercosis 612
Cystine-based glutathion precursor (F1 antioxidant) 1138
Cystinuria 574
Cystitis 162, 307
Cytochrome b5 1460, 1713
Cytochrome C oxidase deficiency 2281
Cytochrome P450 1A1 gene transcription 2109
Cytochrome P450 oxidoreductase 1312, 1460, 1957
Cytochrome P450 oxidoreductase deficiency 1957
Cytochrome P450 oxidoreductase deficiency and Antley-Bixler craniosynostosis syndrome 1957
Cytochrome P450 reductase 1713
Cytochrome P450 time-dependent inhibition assays 1713
Cytokine-induced killer (CIK) cell 856
Cytomegalovirus 818
Cytomegalovirus disease 195, 780
Cytomegalovirus infections 336, 780
Cytomegalovirus retinitis 158, 330, 336, 780
Cytokines 936, 1403, 1713
Cytotoxic ribonuclease PE5 857
D
Dandruff 179, 407, 672, 679
Dap1/PGRMC1 1624, 1714
de novo Acute leukemia 1006
De Sanctis-Cacchione syndrome 2033
Death 1524
Decreased viability among fetuses 2287
Deep venous thrombosis 199, 327, 703, 744, 797, 1384, 2048, 2299
Defective control of prolactin secretion 628
Defective CYP3A4 and CYP3A5 SNPs 1715
Deficiencies of carbamoylphosphate synthetase, ornithine transcarbamylase, or argininosuccinic acid synthetase 693
Deficiency of the prothrombin complex coagulation factors II, VII, IX, and X 628
Degenerative disc disorder 2081
Degree of CYP450 enzyme inhibition of antidepressant drugs at their usual therapeutic dose 1444
Dehydration 220
Delayed male puberty 728
Delayed puberty 349
Delayed sleep phase syndrome 1273
Delirium 301, 589, 1138
Delta-storage pool deficiencies 968
Dementia 277, 662, 713, 750, 1170
Dementia of the Alzheimer’s type 662, 713, 750, 1170
Dementia syndromes 342
Demyelinating diseases 380
Dengue disease 2130, 2438
Dengue hemorrhagic fever 2444
Dental caries 315
Dental expression 1006
Dental pain 321
Depression 33, 37, 165, 210, 245, 378, 396, 450, 485, 493, 497, 516, 537, 583, 609, 629, 702, 710, 762, 770, 791, 857, 1138, 1263, 1265, 1266, 1412, 1461, 2062, 2092, 2162, 2163, 2287, 2369, 2395, 2396, 2417, 2520
Depressive disorder 609, 648, 1266, 2165
Depressive emotional conditions 342
Dermatitis 314, 672
Dermatitis herpetiformis 201
Dermatologic diseases 613, 764
Dermatophytes 725, 776
Dermatophytoses 35, 177, 256
Dermatosis 212, 217, 322, 350, 407, 499
Des-Arg9-Bradykinin 2459
Desmoid disease 1113
Desmoid tumor 791
Dexmedetomidine anesthesia 959, 1066, 1930
Developmental changes 1461
Developmental delay, epilepsy and neonatal diabetes syndrome 2233
Deviant anti-social sexual behavior 71
Diabetes 631, 936, 1372, 1958, 1983, 2197, 2261, 2339
Diabetes and food intake 1477
Diabetes and insulin resistance syndrome 2343
Diabetes insipidus 211, 785
Diabetes mellitus 79, 610, 818, 982, 991, 1076, 1081, 1117, 1138, 1214, 1240, 1269, 1384, 1462, 1617, 1718, 2037, 2211, 2235, 2281, 2415, 2483, 2501
Diabetes mellitus (type 1 and type 2) 1226
Diabetes mellitus (type 1) 385, 610, 1049, 1058, 1233, 2130, 2134, 2138, 2140, 2143, 2180, 2219, 2299, 2445
Diabetes mellitus (type 2) 293, 344, 345, 346, 394, 610, 649, 667, 676, 689, 1066, 1076, 1081, 1086, 1235, 1269, 2053, 2088, 2093, 2101, 2248, 2290, 2478, 2529
Diabetes mellitus, insulin-dependent 610
Diabetes mellitus, noninsulin-dependent 4, 610, 649, 667, 676, 689, 750, 751
Diabetes, susceptibility to 2290
Diabetic gastric stasis 481
Diabetic gastroparesis 240
Diabetic ketoacidosis 385
Diabetic macrovascular disease (type 1) 1983
Diabetic nephropathy 117, 252, 394, 441, 636, 1086, 1138, 1983, 2109, 2192, 2235, 2346, 2422
Diabetic nephropathy (type 2) 636, 2215
Diabetic neuralgia 118
Diabetic neuropathic ulcers 68
Diabetic neuropathy 116, 615
Diabetic retinopathy 2336, 2346
Diabetic vascular disease 2153
Diagnostic procedures 773
Diagnostic test 775, 785
Diaper rash 144, 805
Diarrhea 60, 86, 144, 155, 412, 480, 519, 529, 565, 601, 671
Diarrhea-predominant irritable bowel syndrome 22, 1066
Diazoxide-responsive hyperinsulinemic hypoglycemia 982, 2149
Dicer-related liver zonation 1599
Diet 1720
Dietary factors 1720
Dietary fiber supplement 631
Dietary rice protein 1139
Dietary sodium intake 1937
Dietary supplement 111, 112, 113, 145, 154, 446, 447, 750, 795, 1139
Diffuse large B-cell CD20-positive NHL 661, 757
Diffuse large B-cell lymphoma 2528
Diffuse panbronchiolitis 1720
Dihydropyrimidinase deficiency 1996
Dihydropyrimidine dehydrogenase deficiency 1995
Dihydrotestosterone (DHT) 1027, 1098, 1099, 1102, 1103, 1161, 1182, 1187, 1194, 1220, 1222, 1233, 1978, 2040, 2072, 2177, 2188, 2253, 2312, 2345, 2352, 2376, 2446, 2453, 2459, 2519
Dilated cardiomyopathy 1068, 1071, 1073, 2354, 2358
Diphtheria 255, 276
Discoid lupus erythematosus 732, 764
Disinfection of utensils and equipment 692
Disseminated candidiasis 310
Distal hereditary motor neuropathy 1193
Distal interphalangeal joint osteoarthritis 2192
Distal myopathy 2334
Diuretic non-responders with non-azotemic cirrhosis and ascites 1937
Diverticulitis 677
Dizziness 255
DNA hypomethylation 983
DNA methylation and Epigenetic phenomena 859
DNA microarray technology 1723
DNA repair 1600
Dominant beta-thalassemia inclusion body type 2125
Dopa-responsive dystonia 2081
Double-transduced MDCKII Cells 861
Down’s syndrome 991, 1170, 2287, 2291
Doxorubicin and cyclophosphamide in breast cancer 1361
Doxycycline-inducible, tissue-specific aromatase-expressing transgenic mouse 1958
Dracunculiasis 733
Drinking behavior 1600
Drug addictions 166
Drug biotransformation 1725
Drug disposition 1007
Drug oxidation 1464
Drug transporters and phase I and II metabolism 1725
Drug-associated torsades de pointes, LQTS and arrhythmia 2229, 2231
Drug-induced extrapyramidal symptoms 26, 621, 767
Drug-induced liver injury 1385, 1725
Drug-induced methemoglobinemia 477
Drug-induced osteoporosis 1958
Drug-induced torsade de pointes 2231
Drug-resistant tuberculosis 286
Drugs of abuse 1007
Drug-virus interaction 1725
Dry eye syndrome 367
Ductal carcinoma 715
Ductus arteriosus 24, 383
Duodenal ulcer 160, 279, 296, 415, 534, 545, 640, 645, 706, 710
Dutch familial combined hyperlipidemia 2466
Dynamic equines foot deformity 90
Dysfunctional uterine bleeding 349
Dyskeratosis congenita 2441
Dyslipidemia 57, 299, 522, 597, 675, 1726, 1918, 2052, 2054, 2292
Dysmenorrhea 5, 265, 371, 455, 780
Dysphagia 399
Dysprothrombinemia 2048
Dysuria 307
E
E. coli infection 39, 119, 128, 594
Early-onset diabetes (type 2) 1251
Eating disorders 1465, 2167
Eclampsia 449
Ecto-5′-nucleotidase and thiopurine 968
Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) 1139
Ectopic calcification 287
Eczema 255
Edema 8, 98, 150, 153, 285, 333, 362, 381, 476, 613, 701, 2377
Edematous states 29, 613
Efferocytosis 818
Ehlers-Danlos syndrome 1261
Ehrlichiosis 1727
Elderly 1535, 1558
Electrolyte replacement 448
Electrolytes 1248
Embolism 356, 797
Embryonic carcinoma 1007
Emergency contraception 427
Emetogenic cancer chemotherapy 46
Emphysema 47, 253, 393, 745, 1904, 2021
Empiric antifungal therapy 795
Endobronchial non-small cell lung cancer 1968
Endocarditis 309, 310, 341, 377, 704
Endocrine disorders 613, 764
Endoglin 1139
Endometrial cancer 190, 456, 1285, 1314, 1335, 1728, 1958, 2023, 2044, 2432
Endometrial hyperplasia 456, 621
Endometrioid adenocarcinomas 1045
Endometriosis 101, 200, 349, 422, 508, 535, 864, 1095, 1412, 1958, 1965, 1983, 2156, 2176, 2518
Endometriosis-associated pain 456
Endoscopic retrograde cholangiopancreatography visualization 678
Endothelial nitric oxide synthase 1340
Endothelin-1 991
Endothelin-1 receptor antagonists 864
Endotracheal intubation 58, 164, 646, 663, 705
End-stage renal disease 416, 1937, 2037
Engraftment syndrome 1007
Enteric fever 1247
Enteric rods 162
Enteritis 769
Enterobacter infection 39, 119
Enterocutaneous and rectovaginal fistulas 384
Enuresis 211, 265
Enzyme kinetics 1729
Ependymoma 124, 864, 1007
Epicondylitis 764
Epidermal growth factor receptor 2-positive metastatic breast cancer 760, 1959
Epidermal nevus 2240, 2333
Epidermis 1959
Epidermophyton infections 725
Epigenetics 1340, 1729, 1959
Epilepsy 170, 220, 333, 463, 808, 864, 1140, 1253, 1285, 1385, 1413, 1465, 1729, 2349, 2385, 2386, 2387, 2467
Epilepsy with generalized tonic-clonic seizures 220, 584, 588
Epilepsy with grand mal seizures on awakening 617
Epilepsy, generalized idiopathic 1253
Epilepsy, juvenile myoclonic 1253
Epileptic seizures 118
Episcleritis 457
Episiotomies 798
Epithelial keratitis 767
Epithelial ovarian cancer, somatic 460
Erectile dysfunction 24, 684, 715, 783, 1730, 2092, 2299
ERK1 and ERK2 MAPKs 1314
Erosive esophagitis 279, 415, 545, 645, 1413, 1420
Erythema multiforme 732
Erythema nodosum leprous 732
Erythrasma 276
Erythromycin breath test 1731
Erythropoietic protoporphyria 77
Escherichia coli infection 39, 119, 128, 594
Esophageal achalasia 90
Esophageal adenocarcinoma 1959
Esophageal cancer 603, 866, 1007, 1054, 1105, 1240, 1386, 1600, 2115, 2130, 2134, 2369, 2471, 2518
Esophageal candidiasis 310, 486, 795
Esophageal mucosa and nitrosamine metabolism 1732
Esophageal spasms 399
Esophageal squamous cell carcinoma 1352, 1732
Esophageal varices 696, 785
Esophagitis 215, 296
Essential fatty acid deficiency 699, 1919
Essential hypertension 114, 229, 612, 626, 636, 643, 650, 701, 720, 725, 742, 757, 758, 765, 782, 788, 1035, 1063, 1066, 1068, 1071, 1077, 1081, 1197, 1937, 2007, 2023, 2093, 2143, 2380, 2415
Essential tremor 617, 626, 2003
Estradiol deficiency 1959
Estrogen receptor alpha 1413
Estrogen receptor beta modulator 8β-VE2 1140
Estrogen receptor beta signaling 1007
Estrogen receptor mutant (temperature-sensitive) 2037
Estrogen receptor mutations 1960
Estrogen receptor-positive breast cancer 756, 1960
Estrogen replacement therapy 1140
Estrogen resistance 2037
Estrogen-related receptor gamma (ERRG) 1960
Estrous cycle 1600
Ethanol dependence 510
Ethanol metabolism 1107
Ethanol withdrawal 220, 552
Ethnic differences 866, 936, 968, 978, 1008, 1140, 1286, 1314, 1352, 1362, 1373, 1386, 1403, 1413, 1471, 1601, 1618, 1734, 1960
Euvolemic and hypervolemic hyponatremia 184, 754
Evacuation of bowel 680, 694
Evolution of CYP3A4 expression variability 1739
Ewing’s sarcoma 190, 198, 867, 1008
Ex3α ERKO male infertility 1960
Excitability 359, 702, 780
Exercise-induced asthma 2257
Exercise-induced bronchospasm 187, 673
Exercise training 2346
Exfoliation glaucoma 2251
Exogenous obesity 74, 225, 470
Experimental autoimmune neuritis 1142
Experimental colitis 1919
Experimental venous thrombosis 1938
Extensive metabolizers (EMs) 1506
External genital and perianal warts secondary to Condylomata acuminate 687
Extra-adrenal 21-hydroxylation 1739
Extraintestinal amebiasis 149
Extrapyramidal side-effects 1549
Extrapyramidal symptoms 1488
Eye irritations 276
F
Fabry disease 13
Facial dermatoses 613
Facial lipoatrophy 601
Facial mottled hyper-/hypopigmentation 718
Facial skin wrinkling 718
Factor V deficiency 2049
Factor VII deficiency 295, 2051
Factor IX deficiency 295
Fallot’s tetralogy 24
Familial adenomatous polyposis 139, 1113, 2068
Familial Alzheimer’s disease 1165, 2263, 2355, 2358
Familial atrial fibrillation 2235
Familial atrial fibrillation 3 2235
Familial atrial fibrillation 4 2230
Familial atrial fibrillation 6 2305
Familial cold autoinflammatory syndrome 113, 656
Familial combined hyperlipidemia 2054
Familial dysbetalipoproteinemia 611, 1132
Familial febrile convulsions, 3 2385
Familial hemiplegic migraine-3 2386
Familial hyperaldosteronism 1938
Familial hyperaldosteronism type 1 1938
Familial hypercholesterolemia 611, 686, 818, 991, 1119, 2245
Familial hyperinsulinemic hypoglycemia 1 983
Familial hyperinsulinemic hypoglycemia 2 2233
Familial hyperinsulinism 983
Familial hyperproreninemia 2377
Familial hypertriglyceridemia 611
Familial hypobetalipoproteinemia 1119
Familial hypocalciuric hypercalcemia 1212
Familial juvenile glaucoma 1341
Familial male-limited precocious puberty (testotoxicosis) 1961
Familial Mediterranean fever 181
Familial medullary thyroid carcinoma 2379
Familial melanoma 619
Familial mild hyperglycemia 983
Familial partial lipodystrophy (type 3) 2343
Familial/Primary hyperaldosteronism type I 1938
Fanconi’s anemia 1209
Fas receptor 1739
Fatal familial insomnia 2349
Fatigue 343
Fatty acid metabolism and metabolic diseases 1908
Fatty liver (Hepatic steatosis) 1120, 1489, 2292, 2311
Favism 2077
Febrile granulocytopenic patients 135
Febrile neutropenia 126, 131, 162
Febrile seizures 2385
Female genital neoplasm 2432
Female infertility 326, 462
Fertility 1140
Fertility status in endometriosis 1961
Fetal alcohol syndrome 1054
Fetal and newborn complications 1535
Fetal drug exposure 868
Fetal hydantoin syndrome 2021
Fetal tissues 1618
Feto-placental unit 1741
Fetoprotection 1008
Fever 7, 53, 234, 371, 673
Fibrillation 372
Fibrinogen plasma levels 2060
Fibrinolysis 30
Fibroblast growth factor 15/19 1919
Fibroblast growth factor receptor 4 1920
Fibrocystic breast disease 200
Fibroids 600
Fibrolamellar hepatocellular carcinoma 1961
Fibromyalgia 251, 490, 615, 1141, 1263
Fibrosarcoma 196
Fibrositis 702
Fibrotic and inflammatory lung diseases 1601
Fibrous dysplasia 2071
First-pass hepatic and intestinal biotransformation 1742
FK506-binding protein 1742
Flinders sensitive line rat model of depression 1315
FLT3-Internal tandem duplication 2063
Flucloxacillin-induced liver injury 2126
Fluorouracil resistance 1114
Flutter 618, 626, 637
Focal segmental glomerulosclerosis 1938
Folate homeostasis 1745
Follicular carcinoma of the thyroid gland 1993
Follicular non-Hodgkin lymphoma 370, 387, 757
Folliculitis 309
Food consumption 2396
Food intake 1141
Food-drug interactions 1745
Forensic toxicology 1746
Forkhead box transcription factor O1 1920
Fragile X syndrome 2069
Fragile X-associated tremor/ataxia syndrome 2069
Fredrickson type IIa, IIb, and IV hyperlipidemias 182, 667
Fredrickson type III hyperlipidemia 667
Freezing human liver microsomes 1746
Friedreich’s ataxia 373
Frontotemporal dementia 2349, 2356
Frontotemporal dementia with parkinsonism linked to chromosome 17 2264
Frontotemporal lobar degeneration 1141
Fuchs uveitis 2176
Functional bowel disorders 70
Functional disorders of the biliary tract 592
Functional dyspepsia 2478
Functional indigestion 562
Fungal infection 39, 126, 177, 310, 402, 514, 707, 763, 795
Fungal peritonitis 39
Furuncles 287
G
Galactorrhea 434
Gallbladder bile sampling 687
Gallbladder cancer 1009, 1226, 1286, 1920, 2369
Gallbladder stone disease 145, 1920
Gallbladder stone dissolution 778
Gallstone disease 2487
Gallstone formation 1920
Gardner’s syndrome 1114
Gardnerella vaginalis 743
Gastric adenocarcinoma 237
Gastric antacids 1469
Gastric cancer 247, 870, 937, 968, 1009, 1095, 1114, 1240, 1316, 1341, 1484, 1602, 2025, 2090, 2105, 2109, 2219, 2270, 2275, 2287, 2297, 2307, 2369, 2412, 2422, 2480, 2518, 2526, 2528
Gastric cancer and Helicobacter pylori 2192, 2197
Gastric cardiac adenocarcinoma 2445, 2526
Gastric expression 1484
Gastric hyperacidity 691
Gastric hypersecretory states 160, 640
Gastric tumors 1747
Gastric ulcer 160, 279, 494, 534, 545, 645
Gastrinoma 539, 678
Gastroenteritis 276
Gastroesophageal reflux diseases 160, 163, 215, 279, 296, 415, 481, 534, 545, 564, 640, 645, 1414, 2197
Gastrointestinal cancer 1602
Gastrointestinal complications 160
Gastrointestinal diseases 613, 763
Gastrointestinal hypersecretory disorders 640
Gastrointestinal infections 140
Gastrointestinal prokinetics 1748
Gastrointestinal side-effects 1483
Gastrointestinal stromal tumor 376, 712, 2238, 2331
Gastrointestinal tract 66
Gastroparesis 163
Gastroschisis 2434
GATA4 deficiency 1962
Gaucher’s disease 1032
Gaucher’s disease (type 1) 20, 377, 490
Gender 872, 1469, 1921
Gender-related differences 1316, 1485, 1962
Gene interactions 1141
Gene silencing 1142
General anesthesia 397, 472, 487, 496, 563, 593, 622, 624, 646, 648, 663, 682, 705, 706, 734, 786
Generalized aggressive periodontitis 2197
Generalized anxiety disorder 567, 787, 1447
Generalized epilepsy with febrile seizures plus 2 2386
Generalized epilepsy with febrile seizures plus, type 7 2390
Generalized tonic-clonic seizures (grand mal) 118, 617
Generalized tonic-clonic (grand mal), complex partial seizures 617
Genetic markers for antidepressant medication intolerance 1535
Genetic predictors of inter-individual variability 1748
Genetic variation in the human AS3MT gene 1191
Genital and perianal warts 379, 687
Genital herpes 10, 779
Genital infections 129
Genital warts 359, 388, 600
Genitourinary irrigant 698
Genitourinary tract infections 140, 536
Genomic index of sensitivity to endocrine therapy 1962
Genomic instability 1010
Germ cell tumor 88, 2238
Germline genetic variation 1485
Gerstmann-Sträussler disease 2349
Gestational diabetes mellitus 1962, 2149, 2190, 2235
Gestational hypertension 1938
Gestational trophoblastic neoplasm 198
GGN repeat polymorphisms 1185
GH stimulation 680
Ghosal hematodiaphyseal dysplasia syndrome 2440
GI hemorrhage 785
Giardiasis 743
Gilbert’s syndrome 2487, 2494, 2496, 2499
Gingival hyperplasia 1749
Gingivitis 119, 255
Gitelman syndrome 2402
Glanzmann thrombasthenia 2226
Glaucoma 8, 117, 166, 590, 742, 1077, 1090, 1142, 2287
Glaucoma surgery 624
Glioblastoma 937, 1010, 1235, 1240, 1750, 2025, 2115, 2120, 2203, 2270, 2271, 2333, 2471
Glioblastoma multiforme 124, 721, 1002, 2343
Glioma 872, 978, 1002, 1010, 1045, 1231, 1962, 2441
Glucocorticoid receptor 1750
Glucocorticoid resistance 2316
Glucocorticoid-induced hypertension 2249
Glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia 1750
Glucocorticoid-induced osteoporosis 18, 657
Glucocorticoid-remediable aldosteronism 1938
Glucose homeostasis 2343
Glucose metabolism 2052
Glucose-6-phosphate dehydrogenase deficiency 2077
Glucosylceramide synthase 872
Glucuronic acid epimerase 1142
Glucuronidation 1750
Glutathione synthetase deficiency 2103
Glutathione synthetase deficiency of erythrocytes 2103
Glutathione transferases (GSTs) superfamily 2107
Gonadal ontogeny 1962
Gonorrhea 134, 137, 138, 536, 540, 574, 700, 731
Goose fatty liver 1921
Gout 53, 572, 2259, 2445
Gouty arthritis 21, 617, 709, 764
GP88 (PC-Cell derived growth factor, Progranulin) 1962
gp120 binding B40 aptamer 1751
Graft vs host disease 732, 795, 2143
Gram-negative bacterial infection 29, 63, 183, 377, 731, 740, 747, 748, 2452
Gram-negative organisms 731, 747
Gram-positive organisms 65, 377, 731
Grand mal 617
Granulocytic leukemia 734
Granuloma annulare lesions 764
Graves disease, susceptibility to 1077, 2090
Graves’ disease 1077, 1274, 1991, 2090, 2130, 2176, 2203, 2207, 2224, 2287
Graves’ ophthalmopathy 991
Graves-Basedow disease 873
GRF test 680
Group X secretory phospholipase A2 818, 992
Growth failure 697
Growth hormone 1486
Growth hormone deficiency 175, 697
Growth hormone secreting pituitary tumors 2090
Guanosine triphosphate 1010, 2154
Guillain-Barré syndrome 1142, 2058
Guillain-Barré syndrome and experimental autoimmune neuritis 1142
Gut microbes 874
Gynecologic cancers 1983
Gynecologic infections 132, 133, 137, 377, 740
H
Haemophilus influenzae type b infection 39, 63, 134, 337, 353, 654, 2215
Hair and skin pigmentation 2267
Hair growth 1963
Hairy cell leukemia 167, 386, 387,578
Haloperidol pyridinium neurotoxicity 1488
Hand dermatoses 613
Hand-foot syndrome 1243
HAP1 (Huntingtin-associated protein 1)(17q21.2-q21.3) 2173
HAPIP (Huntingtin-associated protein-interacting protein) 2173
Haptoglobin 1142
Hashimoto’s thyroiditis 1274, 2439
Hay fever 304
HBV infection 1755
HDL (reconsitituted) 1142
HDL-Cholesterol 818, 824, 1161, 1244, 2037, 2044, 2338, 2385, 2460
HDL cholesteryl ester 2385
Head and neck cancer 28, 316, 792, 1010, 1056, 1286, 1415, 1619, 2294, 2471, 2488, 2499
Head and neck squamous cell carcinoma 1317, 1341, 1389, 1602, 2291, 2307, 2380, 2412, 2442, 2445
Head lice 449
Headache 144, 228, 342, 1755
Hearing disorders 791
Heart 1010
Heart CYP expression 1619
Heart failure 79, 86, 114, 117, 125, 153, 158, 261, 355, 433, 491, 636, 754, 758, 782, 1071,1939, 2098, 2228
Heart transplant 714, 780, 874
Heart, kidney, or liver transplant recipients 713
Heartburn 296
Heat shock proteins (HSP60, HSP72, HSP90, and HSC70) 1010
Heavy metal detoxification 937
Hedgehog signaling 874
Heinz body anemias 2125
Helicobacter pylori infection 38, 86, 415, 545, 640, 645, 731, 1415, 1416, 1756, 2199, 2343
Helicobacter pylori-related chronic gastritis/gastric ulcer 415, 874
Helminthic infections 733
Hematologic diseases 613, 764
Hematologic malignant diseases 1619
Hematopoietic stem cell proliferation 819
Hematopoietic stem cell transplantation 2287
Heme 1010, 1182, 2054, 2446
Heme oxygenase-1 1317, 1603
Hemiballismus 729
Hemodialysis 682, 1756
Hemoglobinopathies 2125
Hemolytic anemia due to glutathione synthetase deficiency 2103
Hemolytic-uremic syndrome 1245
Hemophilia 295, 759
Hemophilia A 43, 44, 211, 295
Hemophilia B 43, 295
Hemorrhage 266
Hemorrhagic shock 1389, 1489
Hemorrhoids 73, 221, 255, 610, 798
Hemostasis 183, 737
Heparin overdosage 627
Heparin-induced thrombocytopenia 48
Hepatic cirrhosis 29, 285, 333
Hepatic coma 566
Hepatic drug transport 2409
Hepatic encephalopathy 519
Hepatic ischemia-reperfusion injury 1603
Hepatic lipase deficiency 2250
Hepatic steatosis 675, 1756, 1787
Hepatic steatosis and acetaminophen hepatotoxicity 1469
Hepatic venocclusive disease 2105
Hepatitis 1603, 1756
Hepatitis A 357, 379
Hepatitis B 387, 1142, 1226, 2138, 2143
Hepatitis B and hepatocellular carcinoma 2215
Hepatitis B infection 2037
Hepatitis C 386, 387, 388, 1142, 1226, 1489, 2143, 2179, 2182
Hepatitis C virus protease inhibitor S5 874
Hepatoblastoma 874, 937, 1114
Hepatocarcinoma 874
Hepatocellular carcinoma 929, 1011, 1114, 1218, 1267, 1317, 1603, 1908, 1921, 2037, 2115, 2144, 2369, 2471, 2499
Hepatocellular carcinoma (childhood type) 2270
Hepatocellular tumors 1756, 2240
Hepatocyte growth factor 1363, 1756
Hepatocyte nuclear factor 1 alpha 1922
Hepatocyte nuclear factor 3 gamma 1403
Hepatocyte nuclear factor 4 alpha 1373, 1757
Hepatocyte transplantation 875, 1603
Hepato-intestinal metabolic activity 1489
Hepatoma cell line H4IIE 1287
Hepatoma cells 1757
Hepatoma multidrug resistant cell line SK-Hep-1 937
Hepatotoxicity 1489, 1569, 2294
Hepatotrophic factor 1757
Herbal bioactivation 1287
Hereditary angioedema 200, 254
Hereditary antithrombin III deficiency 44
Hereditary hemochromatosis 2128
Hereditary hemorrhagic telangiectasia 2 1047
Hereditary hypertriglyceridemia 1922
Hereditary nonpolyposis colorectal cancer, type 2 2273
Hereditary nonpolyposis colorectal neoplasms 2279
Hereditary sensory and autonomic neuropathy (type II) 2522
Hereditary spastic paraplegia type 5 1922
Hereditary spastic paresis 1922, 1984
Hereditary tyrosinemia type 1 530
Hermansky-Pudlak syndrome 7 2009
Herpes genitalis 10, 296, 779
Herpes simplex encephalitis 10
Herpes simplex infection 10, 237, 296, 411
Herpes simplex labialis 10, 255, 296, 411, 573, 779
Herpes simplex virus types 1 and 2 767
Herpes zoster 10, 296, 779, 810
Hertwig’s epithelial root sheath/Epithelial rests of Malassez cells 1011
Heterotopic ossification 287
Heterozygous familial hypercholesterolemia 299, 611, 686
Hiccups 152
High blood pressure 791
High density lipoprotein cholesterol 992, 1143, 1363, 2012, 2249
High density lipoprotein deficiency type 1 813, 1115, 1116
High density lipoprotein deficiency type 2 813, 1115, 1116
High-fat diet 1317, 1603
High-grade malignant glioma 124
High-mobility group box protein 1 1143
High-throughput analysis of drug-drug interactions 1760
High-throughput genotyping method 1493
High-throughput single nucleotide polymorphism screening 1317
HIP1 (Huntingtin-interacting protein 1) 2173
HIP2 (Huntingtin-interacting protein 2) 2173
HIP12 (Huntingtin-interacting protein 12) 2173
HIP14 (Huntingtin-interacting protein 14) 2173
Hippocampal neurogenesis 1963
Hippocampal sclerosis 1143
Hippocampal volume 1143
Hirschsprung’s disease 2379
Hirsutism 259, 701
Histamine 1143
Histamine pharmacogenetics 2155
Histiocytosis 791
Histone demethylase LSD1 deficiency 1939
Histone methylation 1760
Histone methyltransferase G9a 1922
Histoplasma capsulatum 39
Histoplasmosis 310, 402, 407, 1760
HIV infection 1, 2, 40, 55, 58, 224, 328, 382, 413, 451, 518, 653, 659, 660, 674, 702, 723, 801, 804, 813, 819, 875, 965, 1121, 1143, 1223, 1226, 1318, 1760, 1984, 1992, 1993, 2055, 2056, 2126, 2131, 2135, 2152, 2181, 2199, 2214, 2315, 2451
HIV-1 infection 203, 207, 258, 261, 262, 291, 328, 642, 745, 2452
HIV-1 mother-to-child transmission 1227
Hodgkin Reed-Sternberg cells 938
Hodgkin’s and non-Hodgkin lymphoma 146, 190, 195, 619, 791, 792
Hodgkin’s disease 124, 196, 436, 454, 619, 703, 791
Hodgkin’s lymphoma 88, 619, 792, 1761
Homocysteine 1040, 1171, 1182, 1196, 1216, 2013, 2086, 2288, 2291, 2300, 2425, 2513, 2519
Homocystinuria 78, 1220, 2287
Homology modeling 876
Homophily and heterophily 1353
Homotropic/Heterotropic cooperativity 1759, 1761
Homozygous cystinuria 745
Homozygous familial hypercholesterolemia 294, 686
Homozygous sitosterolemia 294
Hookworms 453
Hormonal imbalance 281
Hormone refractory prostate cancer 106, 1963
Hormone replacement therapy 819, 876, 1318, 1762, 2250
Hormone-dependent advanced prostate cancer 101
Hot flushes 273, 787, 2042
Human influenza 2214
Human kinetic adjustment factor 1318
Humectant 698
Humerospinal dysostosis 1257
Huntingtin (HTT) 2172
Huntingtin-associated proteins 2173
Huntington’s chorea 729
Huntington’s disease 710, 1061, 2096, 2173
Huntington’s disease-like 1 2350
Hurler and Hurler-Scheie forms 417
Hyaline membrane disease 76
Hydronephrosis 1287
Hydroxycholesterols 1932
Hyperacidity 26, 447
Hyperactive children 152
Hyperalphalipoproteinemia 1244
Hyperammonemia 123
Hyperandrogenic states in pregnancy 1963
Hyperandrogenism 2207, 2466
Hyperapobetalipoproteinemia 2052, 2339
Hyperbilirrubinemia 1922, 2416, 2488
Hypercalcemia 108, 171, 335, 562, 806
Hypercholanemia 2021
Hypercholesterolemia 155, 294, 299, 323, 442, 522, 611, 618, 667, 686, 1923, 2146, 2253, 2306
Hypercholesterolemia, familial 686
Hypercoagulability disorder 2521
Hyperemia 1049
Hyperglycemia 514, 1993
Hyperglycemia-induced liver injury 1603
Hyperhidrosis 368
Hyperhomocysteinemia 78, 1220, 1619, 2287, 2291, 2297
Hyperinsulinemia 1027
Hyperkalemia 111, 112, 691, 695
Hyperkalemic periodic paralysis 2388
Hyperkinetic movement disorders 729
Hyperlipidemia 82, 597, 611, 667, 686, 819, 1120, 1144, 2253
Hyperlipidemia type IIB 992
Hyperlipoproteinemia 611
Hyperlipoproteinemia (type I) 611
Hyperlipoproteinemia (type Ib) 611
Hyperlipoproteinemia (type II) 611
Hyperlipoproteinemia (type IIA) 611
Hyperlipoproteinemia (type III) 611
Hyperlipoproteinemia (type V) 611, 1117
Hypermagnesemia 111
Hyperosmotic laxative 698
Hyperoxic lung injury 1287
Hyperparathyroidism 2268
Hyperparathyroidism (secondary) 246
Hyperphosphatemia 26, 110, 111
Hyperpigmentation 365
Hyperprolactinemia 94, 106, 635, 1549
Hyperprothrombinemia 2048
Hypersensitivity 2154
Hypersensitivity pneumonitis 2438
Hypertension 5, 21, 29, 34, 56, 70, 86, 98, 117, 125, 150, 153, 158, 175, 221, 244, 261, 268, 270, 298, 300, 331, 351, 352, 355, 361, 362, 381, 394, 401, 411, 412, 433, 441, 453, 476, 481, 482, 492, 498, 507, 515, 523, 525, 528, 542, 553, 581, 586, 612, 626, 636, 643, 650, 701, 720, 725, 742, 757, 758, 765, 782, 788, 992, 1032, 1051, 1063, 1066, 1068, 1071, 1077, 1081, 1086, 1090, 1095, 1105, 1144, 1197, 1214, 1318, 1341, 1373, 1415, 1469, 1496, 1619, 1762, 1908, 1923, 1936, 1939, 2044, 2060, 2105, 2226, 2287, 2292, 2346, 2365, 2391, 2403, 2410, 2424, 2522, 2525
Hypertension resistant to conventional therapy 2299
Hypertension secondary to pre-eclampsia/eclampsia 361
Hypertension, essential 114, 229, 1035, 1933, 2006, 2023, 2093, 2143, 2380, 2415
Hypertensive crisis 279
Hyperthyroidism 471, 627, 692
Hypertriglyceridemia 82, 299, 339, 522, 544, 782, 1044, 1116, 1117, 1144, 2052, 2253, 2306
Hypertrophic cardiomyopathy 1036, 1939, 2281, 2346
Hypertrophic obstructive cardiomyopathy 626
Hypertrophic subaortic stenosis 626
Hyperuricemia 21, 297, 617
Hypervitaminosis D 1984
Hypnosedatives 780, 1495
Hypoaldosteronism 29
Hypocalcemia 109, 111, 112
Hypocalcemic tetany 111, 229
Hypochloremia 691
Hypochloremic states 35
Hypochlorhydria 78
Hypocitraturia 606
Hypodermoclysis 360
Hypoestrogenism 281
Hypoglycemia 346, 1993
Hypogonadal osteoporosis 727
Hypogonadism 479
Hypogonadotropic hypogonadism 156, 326
Hypokalemia 605, 606, 701
Hypokalemic periodic paralysis 222, 2388
Hypomagnesemia 445, 446, 449
Hyponatremia 690, 691, 754
Hypoparathyroidism 109, 110, 111, 272
Hypophosphatemia 272, 607, 694
Hypoplastic left ventricle 24
Hypoprothrombinemia 589
Hyposalivation 672
Hypospadias 1287
Hypotension 265, 355, 587
Hypothalamic amenorrhea 349
Hypothalamic-pituitary ACTH function 484
Hypothermia 1763
Hypothyroidism 428, 431, 737, 1923, 1991
Hypoxemia 556
Hypoxia 1495, 1763
Hypoxia-induced extracellular acidosis 877
Hypoxia-inducible factor 1 1341
Hypoxia-inducible factor-1alpha (HIF1A) 877, 1011
Hypoxic respiratory failure 531
I
IC50-based approaches for assessment of time-dependent inhibition of CYP3A4 1763
Ichthyosis 1909
Idiopathic arthritis 284
Idiopathic chronic urticaria 254
Idiopathic dilated cardiomyopathy 2445
Idiopathic edema 285
Idiopathic hirsutism 1963
Idiopathic hypereosinophilic syndrome 2329, 2331
Idiopathic male infertility 1341, 2287, 2299
Idiopathic Parkinson’s disease 120, 609, 647, 665, 668, 751
Idiopathic pulmonary arterial hypertension 269, 375, 762, 1047
Idiopathic pulmonary fibrosis 2442
Idiopathic pulmonary hemosiderosis 190
Idiopathic recurrent miscarriages 2430
Idiopathic short stature 697
Idiopathic thrombocytopenia 665, 2226
Idiopathic thrombocytopenia purpura 190, 260, 380, 651, 665
Idiopathic uveitis 146, 764
Ifosfamide-induced hemorrhagic cystitis 467
IgA deficiency 2144
IgA nephropathy 1032, 1087, 1939, 2193, 2328, 2343
IL1B monoclonal antibodies 1145
Ileal resection 1923
Illicit growth promoters in cattle 1963
Immortalized non-tumorigenic human liver epithelial cells 1766
Immune function 938
Immunization against typhoid fever caused by Salmonella typh 776
Immunization against vaccinia virus 690
Immunization against varicella 785
Immunization with aldehyde-modified fibronectin 1144
Immunoglobulin deficiency 379
Immunosuppressant 78, 614
Immunotherapy 2350
Immunotherapy in elderly transplant recipients 1766
Impaired glucose tolerance 2249
Impetigo 309, 504, 650
Impotence 479, 800
Impulsivity 2259
In vitro fertilization 1964
In vitro interaction cocktail assays 1771
In vitro systems for assessment of CYP3A4 induction 1771
Inactivating mutations in the GNAS gene 2090
Inactive chloasma 365
Inclusion body myositis 1144
Increased frequency of APOE-4 in AD and protective effect of APOE-2 1127
Indigestion 144
Individual variation 1603
Inducers 938
Inducers and inhibitors 1341
Induction of labor at term 558
Induction of ovulation 462
Industrial carcinogens 2109
Infant birth size 1095
Infant botulism 92
Infant colic 368
Infantile hypertrophic cardiomyopathy 2280
Infantile parkinsonism-dystonia syndrome 2396
Infantile spasms 186, 755, 790
Infected dermatoses 532
Infected or noninfected wounds 409
Infection respiratory tract 700
Infections 147, 248, 608, 1144
Infections by gram-positive bacilli 65
Infections of the skin 63
Infections of the upper and lower respiratory tract 138
Infectious diarrhea 162
Infectious mononucleosis 2130
Infective endocarditis 38, 39, 169, 201
Infertility 337, 2038, 2075
Infertility in Etv5-/- female mice 1963
Inflammasome 1144
Inflammation 16, 53, 76, 94, 119, 170, 171, 192, 214, 223, 226, 227, 255, 291, 307, 322, 363, 365, 409, 413, 416, 440, 441, 448, 520, 524, 570, 657, 812, 992, 2167
Inflammatory bowel disease 437, 631, 878, 1767, 1909, 1923, 2176, 2193, 2197, 2200, 2227, 2311, 2343, 2370, 2403, 2430, 2456, 2477
Inflammatory bowel disease 5 2408
Inflammatory conditions 316, 359, 441, 448, 764, 2359, 2360, 2362
Inflammatory dermatosis 78, 314, 613, 764
Inflammatory disease 5, 63, 137, 169, 540, 371, 709, 938
Inflammatory myopathy 2058
Inflammatory phase of xerosis 78
Influence of APOE-CYP2D6 interactions on Alzheimer’s disease therapeutics 1128
Influence of CYP2D6 genotypes on liver transaminase activity 1442
Influenza 255, 385, 548, 656, 803, 2144
Influenza vaccination 1144
Insect bites and stings 73, 287
Insomnia 35, 96, 144, 249, 273, 280, 284, 320, 359, 437, 439, 530, 634, 643, 677, 720, 765, 780, 802, 808, 809
Insufficient blood flow 791
Insulin resistance 1058, 1081, 2054, 2384, 2427
Insulin resistance, susceptibility to 1081
Insulin secretion 878
Insulin sensitivity 2093, 2247, 2344, 2346
Insulin-dependent diabetes mellitus 610, 1274, 2207
Insulin-like growth factor-1 1145, 1768, 1963
Insulin-like growth factor-1 deficiency 454, 2188
Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors 1768
Insulinoma and pancreatic cancer 2297
Intensive care 624
Interactions of anti-cancer drugs 879
Interleukin 1 receptor antagonist deficiency 2197
Intermediate metabolizers 1506
Intermittent claudication 159, 342, 579
Interruption of aortic arch 24
Interstitial cystitis 231, 578
Intestinal amebiasis 248, 391, 566, 743
Intestinal CYP3A and regulation of detoxifying systems in the liver 1768
Intestinal CYPs 1619
Intestinal expression 938
Intestinal metabolism 1768
Intestinal metabolizing enzymes 1363, 1984
Intestinal metaplasia 2307
Intestinal tract 820
Intestinal transporters 879
Intimal hyperplasia 2364
Intra-abdominal and urinary tract infections 137
Intra-abdominal infections 132, 133, 162, 242, 275, 377, 465, 483, 741
Intracerebral hemorrhage 1145
Intracranial hemorrhage in brain arteriovenous malformations 1047, 2207
Intracranial hypertension 734
Intracranial pressure 450, 734
Intracranial volume and white matter lesions 1145
Intractable chronic pain 803
Intrahepatic cholestasis 1923
Intrahepatic cholestasis of pregnancy 929
Intraocular hypertension 125, 418, 423, 612, 742, 761
Intraocular pressure 46, 423, 450
Intratumoral aromatase deficiency 1963
Intrauterine growth 2088
Intrauterine growth retardation associated with precocious puberty and sertoli cell hyperplasia (Russell-Silver syndrome-like phenotype) 1963
Intronic polymorphisms 1498
Invasive aspergillosis 795, 2452
Invasive cervical cancer 2136
Invasive fungal infections 795, 1416
Invasive pneumococcal disease 2197
Ionizing radiation 1923
IQ 1145
Iridectomy 9
Iridocyclitis 677, 773
Iron deficiency anemia, susceptibility to 396
Iron deprivation 879
Iron-deficiency anemia 302, 303, 396, 602
Irrigating solution 66
Irritable bowel syndrome 22, 70, 224, 368, 443, 592, 624, 718, 768, 1066, 2093, 2456, 2475
Irritations 805
Ischemia 2112
Ischemia-reperfusion injury 879, 1374, 1469
Ischemic and hemorrhagic stroke 1051
Ischemic cerebrovascular disease 1119, 1269, 1477
Ischemic heart disease 1269, 2292, 2299, 2424
Ischemic stroke 611, 1059, 1079, 2056, 2060, 2203, 2225, 2287, 2306, 2353, 2370, 2445
Islet cell carcinoma 196
Isolated growth hormone deficiency 2086
Isolated growth hormone deficiency (type IA) 2086
Isolated growth hormone deficiency (type IB) 2086
Isolated growth hormone deficiency (type II) 2086
Ispinesib/docetaxel combination-induced myelosuppression 1773
Itching eyes 75, 771
Ivermectin-sensitive Border Collie 880
J
Japanese encephalitis 405
Jervell and Lange-Nielsen syndrome 1 2235
Jervell and Lange-Nielsen syndrome 2 2228
Joint osteoarthritis 2197
Juvenile idiopathic arthritis 3, 11, 288, 2200, 2215
Juvenile onset cholestasis 1923
Juvenile rheumatoid arthritis 73, 139, 223, 288, 371, 459, 512, 550, 752
K
KATP channels 983
Kaposi’s sarcoma 198, 791, 2207
Kawasaki disease 380, 1227, 2134, 2215, 2476
Kearns-Sayre syndrome 2285
Keloid 764
Keratinocytes 1288
Keratitis 514, 773
Keratoconjunctivitis sicca-associated ocular inflammation 192
Keratoplasty 9
Kidney angiomyolipoma 2182
Kidney diseases 1091, 2048
Kidney failure 1087
Kidney proximal tubular cells 1776
Kidney transplant rejection 1274
Kidney transplantation 61, 714, 780, 881
Klebsiella 39, 128
Klinefelter’s syndrome 1185, 1964
Kohonen maps 1776
Korsakoff’s syndrome 733
Kowarski syndrome 2086
Kuru 2350
L
Lacrimation 771
Lactase deficiency 2243
Lactation 1924
Lactose intolerance 412
Lacunar infarcts 1105
Lambert-Eaton myasthenic syndrome 28
Lamellar ichthyosis type 3 1909
Langerhans cell differentiation 1013
LAPTM4B 882
Large-joint osteoarthritis 1964
Laron syndrome 2088
Larsen’s syndrome 1257
Laryngeal carcinoma 1013
Laryngeal squamous cell carcinoma 882, 1288, 1778
Laryngospasm 2388
Larynx 1904
Larynx cancer 1221
Late-onset Alzheimer’s disease 812, 1220, 2300
LDL-cholesterol 611, 2245, 2338
Lead encephalopathy 257
Lead poisoning 231, 257, 705, 1100
Lead poisoning, susceptibility to 257
Leber’s hereditary optic neuropathy 2280, 2281, 2282, 2283
Lecithin cholesterol acyltransferase deficiency 992
Left ventricular dysfunction 261
Left ventricular dysfunction postmyocardial infarction 117, 125, 758, 782
Left ventricular failure 502
Left ventricular hypertrophy 441, 1036, 1939, 2306
Left ventricular hypervoltage 1940
Left ventricular mass 2093
Left ventricular systolic dysfunction 2339
Legionella pneumonia 654
Leigh’s syndrome 2280, 2283
Lennox-Gastaut syndrome 297, 414, 669, 755
Lentigo 365
Lepidoptera 882
Leprosy 201, 2183, 2216, 2219, 2255, 2326
Leptin receptor 1146
Leptospirosis 1146, 2130
Letrozole and Norethisterone acetate vs Letrozole and Triptorelin in endometriosis 1965
Letrozole, Misoprostol and Mifepristone in therapeutic abortion 1965
Letterer-Siwe disease 791
Leucine-induced hypoglycemia 983
Leukapheresis 577
Leukemia 473, 791, 882, 964, 969, 978, 1363, 1778, 2307, 2240
Leukemia, acute lymphocytic 190, 195
Leukopenia 2314
Leukotriene B4 receptor-1 1146
Levodopa-induced dyskinesia 1146
Lewis lung carcinoma 1013
Lewy body dementia 713, 2350, 2420
Lichen planus plaques 764
Lichen simplex chronicus plaques 764
Liddle’s syndrome 2391
Life-threatening ventricular arrhythmias 623, 748
Li-Fraumeni syndrome 2471
Ligula intestinalis infection 1965
Lipid A 2184, 2220, 2453
Lipid abnormalities 2207
Lipid peroxides 2106, 2111, 2121
Lipids 820, 883, 1242
Lipid rafts 820, 939
Lipodystrophy 1083, 2247, 2334, 2375
Lipodystrophy induced by antiretroviral therapy in HIV patients 1146
Lipomatosis 675
Lipophilicity 1502
Lipoprotein glomerulopathy 1146
Lipoprotein lipase 1146
Lipoprotein lipase deficiency 2253
Lipoxygenase 993
Liquid chromatography-tandem mass spectrometry analysis 1780
Listeria infections 39
Lithocholic acid-induced liver injury 1984
Liver cancer 883, 1604, 1781, 1940, 2110, 2295, 2297, 2518
Liver cirrhosis 1056, 2499
Liver disease 388, 1013, 1105, 1502, 1781
Liver drug metabolism transcriptome 1781
Liver fatty acid binding protein 1924
Liver fibrosis 883
Liver receptor homolog-1 1924, 1965
Liver regeneration 1924
Liver transplantation 1416, 1503, 1781
Liver X receptor 1013, 1288
Liver X receptor agonists 820, 1781
Liver X receptor alpha (LXRα) 993
Liver X receptor alpha/ NR1H3 1147
Liver X receptor-activating ligands (DMHCA, TO901317) 1146
Local anesthesia 99, 464, 616, 666, 730
Loeys-Dietz syndrome 2448
Long QT syndrome 1072, 2154, 2229, 2230, 2231, 2235, 2390
Long QT syndrome-1 1072
Long QT syndrome 1/2 2231, 2235
Long QT syndrome 2 2231
Long QT syndrome 2/3 2231
Long QT syndrome 2/5 2231
Long QT syndrome 2/9 2231
Longevity 1014, 1049, 1147, 1244, 1374, 1965
Loss of transport function of SLC15A2 2404
Low bone mineral content 2249
Low-density lipoproteins (LDL) 820
Low-density lipoprotein receptor-related protein 1b (LRP1b) 993, 1147
Lower respiratory tract disease 561
Lower respiratory tract infections 63, 128, 137, 162,
Lower urinary tract 1063
Low-grade non-Hodgkin lymphoma 757
Lung adenocarcinoma 2018, 2140, 2236, 2333
Lung cancer 190, 237, 274, 338, 436, 473, 619, 792, 884, 939, 969, 1014, 1056, 1254, 1288, 1320, 1342, 1353, 1504, 1604, 1784, 1904, 1965, 2018, 2021, 2025, 2033, 2110, 2116, 2120, 2130, 2134, 2144, 2240, 2242, 2295, 2297, 2308, 2319, 2337, 2362, 2370, 2379, 2404, 2405, 2442, 2450, 2471, 2515, 2526, 2528
Lung cancer risk 1254, 2055, 2337
Lung cells 1784
Lung diseases 2193
Lung transcriptome 1288
Lupus 2060
Lupus erythematosus 366, 1269, 2060, 2179, 2227
Lupus nephritis 190, 2183
Luteinizing hormone 1965
Luteinizing hormone-releasing hormone agonists 1965
Lyme disease 138
Lymphatic metastasis in gastric carcinoma 2331
Lymphedema 285, 1785
Lymphoblastic leukemia 2227
Lymphocytes 1619, 1785
Lymphocytic leukemia 247, 2471
Lymphoid leucemia 1237
Lymphoma 103, 473, 495, 736, 885, 1240
Lymphoma, non-Hodgkin 619, 757, 791
Lymphoplasmacytic enteritis 885
Lymphoproliferative disorders 2021
Lynch syndrome 1288
LXR-Alpha 954
M
Macrocytic anemia 325
Macroglobulinemia 190
Macrophage stimulatory lipopeptide 2 2372
Macrophage lipid metabolism 993
Macrophages 820, 885
Macular degeneration 790, 2158, 2253
MAD2 885
Madurella mycetomatis-induced mycetoma 1965
Maintenance of normal microflora in the gastrointestinal tract 671
Major depressive disorder 14, 49, 100, 213, 252, 317, 567, 678, 681, 759, 787, 886, 1258, 1483, 2009, 2101, 2159, 2163, 2168, 2170, 2193, 2259, 2316, 2319, 2396, 2398, 2439, 2456, 2475, 2476
Major PRNP variants associated with prion disease 2350
Malabsorption syndrome 562
Malaria 36, 51, 149, 248, 255, 366, 458, 622, 633, 708, 886, 1320, 1786, 1990, 2056, 2078, 2134, 2153, 2176, 2219
Male hypogonadism 728
Male infertility 1096, 1186, 2335, 2526, 2528
Malignant ascites 127
Malignant gliomas 2329
Malignant hypertension 221
Malignant hyperthermia 200, 2382
Malignant lymphomas 247
Malignant melanoma 196, 387
Malignant mesothelioma 993, 1966
Malignant murine skin tumors 1966
Malignant osteopetrosis 390
Malignant pleural effusion 715
Malignant pleural mesothelioma 573
Mammary tissue 820
Mandibular height 2088
Manganese deficiency 449
Manganese intoxication 1504
Mania 152, 434
Mantle cell lymphoma 89, 1233
Maroteaux-Lamy syndrome 336
Masculinization 1966
Mast cell leukemia 2238
Mastitis 309
Mastocytosis 2238
Maternal behavior 1966
Maternal depression effects on fetal neurodevelopment 2398
Maternal fine particulate matter exposure 1504
Maternal protein restriction-related epigenetic changes in offspring cholesterol 1925
Maternal tobacco use and risk of adverse pregnancy outcomes 1353
Maternal undernutrition 1940
Maternally transmitted diabetes mellitus-deafness syndrome 2284
Maturity-onset diabetes of the young 1201
Maturity-onset diabetes of the young type 1 (MODY1) 2149
McCune-Albright syndrome 1966, 2090
MDMA and designer drugs of the amphetamine type 1478, 1555
MDMA-induced neurotoxicity 1479
MDR1 RNAi 886
Measles (rubeola) 379, 452, 453
Mechanical ventilation 663
Mediterranean diet 1147
Medullary thyroid carcinoma 196, 2379
Medulloblastoma 124
Megaloblastic anemia 325
Melanoma 17, 198, 367, 436, 619, 886, 939, 1231, 1240, 1984, 2027, 2031, 2211, 2238, 2267, 2331, 2515
MELAS syndrome 2282, 2283, 2285
Melatonin and Silymarin in maneb- and paraquat-induced Parkinson’s disease phenotype 1604
Membranoproliferative glomerulonephritis 1245
Memory 1147, 2163
Memory deficits 342, 791
Memory disorder 596
Menarche 1966
Meniere’s disease 77, 161
Meningeal carcinomatosis 1966
Meningeal leukemia 195
Meningitis 132, 137, 310
Meningococcal disease 39, 461, 2056
Meningoencephalitic stage of Trypanosoma brucei gambiense infection 259
Menkes’ disease 1193
Menopausal neurosis 702
Menopause 255, 281, 283, 1320, 1788, 2038
Menstrual cycle 1788, 2075
Mental development 1342
Mental disorders 1505, 1997, 2007
Mental retardation 1991
Mental retardation X-linked type 63 (MRX63) 1045
MEOS (Microsomal Ethanol-Oxidizing System) 1788
Merkel cell carcinomas 2329
MERRF syndrome 2284, 2285, 2335
Mesothelioma 887
Meta-analysis of association studies investigating genes for PD 1531
Metabolic acidosis 690, 691, 693, 772
Metabolic alkalosis 35
Metabolic bone diseases 2038
Metabolic syndrome 994, 1033, 1043, 1059, 1078, 1081, 1087, 1091, 1117, 1120, 1148, 1269, 1789, 1925, 1940, 1966, 2052, 2165, 2177, 2198, 2211, 2245, 2255, 2292, 2339, 2452
Metabolic traits 1148
Metabolism of neurosteroids 1479
Metabolizing capacity 1505
Metastatic brain tumors 124
Metastatic breast cancer 115, 274, 338, 416, 479, 511, 715, 728, 756
Metastatic colorectal cancer 81, 115, 143, 563, 2058
Metastatic islet cell carcinoma of the pancreas 704
Metastatic ovarian carcinoma 247, 367
Metastatic prostate cancer 83
Metastatic tumors 454
Methanol or Ethylene glycol poisoning 326
Methotrexate toxicity 421, 1049, 1191
Methylation-related Tamoxifen resistance 1508
Methylcobalamin deficiency (cblG type) 2291
Methylenetetrahydrofolate reductase 1925
MGMT promoter methylation 2271
Microangiopathic ischemic stroke 1269
Microchimerism 2456
Microglia 1148
Micropenis 2426
MicroRNAs 821, 994, 1015, 1793, 1925, 1967
Microsporum infection 725
Middle ear infections 556
Migraine 22, 90, 144, 255, 259, 313, 332, 480, 507, 513, 599, 662, 711, 742, 755, 780, 807, 1263, 1511, 1795, 1989, 2014, 2038, 2160, 2161, 2456, 2476
Migraine with aura 259, 313, 332, 662, 807, 1989, 2287
Migraine without aura 662, 807, 1989
Mild cognitive impairment 1148
Mild-to-moderate metabolic acidosis 690, 691, 693
Mild-to-moderate pain 180, 226, 371, 408, 448, 512, 457, 625, 673
Milk cholesterol secretion 994
Milk fatty acids and traits 1015
Mineralocorticoid receptor activation 1940
Minor burns 73, 610
Miosis 321
miR-378 1604
Mismatch repair cancer syndrome 2273, 2279
Mitochondrial CYP2E1 1605
Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome (MELAS) 2282, 2283, 2285
Mitochondrial neurogastrointestinal encephalopathy syndrome 2335
Mitochondrial permeability transition pore 888
Mitogen-activated protein kinases (MAPKs) 1364, 1796
Mixed dyslipidemia 299, 675
Mixed hyperlipidemia 82, 294, 611, 667
Moisturizer for dry, rough skin 777
Molecular interaction fields 889
Monoamine metabolite concentrations 2167
Monocyte locomotion inhibitory factor 2185, 2195, 2201, 2209, 2217
Monocytic leukocytes 1619
Mood disorders 1050, 2001, 2399
Moraxella catarrhalis 63
Morbid obesity 2249, 2344
Morbid obesity with hypogonadism 2247
Morganella morganii 119
Morphea 607
Motion sickness 161, 189, 232, 455, 622, 677
Mountain sickness 1033, 1087, 1119
Moyamoya disease 2278
Muckle-Wells syndrome 113, 656
Mucopolysaccharidosis I 417
Mucopolysaccharidosis VI 336
Mucosal-associated invariant T (MAIT) cells 889
Mucositis 73, 672
Muir-Torre syndrome 2274, 2279
Multidrug resistance gene HA117 889
Multinodular goiter 737
Multiple endocrine adenomas 296
Multiple endocrine neoplasia, type I 2268
Multiple endocrine neoplasia, type II 2379
Multiple myeloma 89, 124, 190, 460, 562, 599, 619, 732, 806, 890, 1342, 1417, 1799, 1990, 2211
Multiple pterygium syndrome 1252
Multiple sclerosis 190, 198, 200, 306, 389, 495, 514, 613, 889, 1149, 1227, 1274, 1984, 2131, 2139, 2144, 2183, 2193, 2198, 2200, 2255, 2267, 2270, 2344, 2361, 2445, 2465
Multiple system atrophy 2420
Multixenobiotic transporters 890
Mumps 452, 453
Muscle paralysis 609
Muscle spasm 123, 154, 189, 472, 677
Muscle spasticity 747
Musculoskeletal pain 154, 468, 772, 2163
Mushroom poisoning 632
Myalgia in statin-treated patients 2168
Myasthenia gravis 27, 186, 190, 257, 360, 519, 609, 632, 890, 1038, 1252
Myasthenia gravis with thymus hyperplasia 609
Myasthenic syndrome 2388
Mycetoma (Madurella mycetomatis) 1342
Mycobacterial diseases 285
Mycobacterial infection 406, 653, 704
Mycobacterium tubercolosis infection 2401
Mycoplasma pneumoniae 719
Mycosis fungoides 190, 454, 791
Mydriasis 59, 190, 773, 800
Myeloblastic and lymphoid cell lines 1799
Myelodysplastic syndrome 60, 205, 419, 795, 1046, 1271, 1799, 2120, 2128, 2285
Myeloid reconstitution 675
Myeloid/lymphoid or mixed lineage leukemia 2101
Myelopoiesis 1149
Myocardial infarction (MI) 53, 176, 327, 433, 502, 611, 626, 643, 703, 742, 1015, 1033, 1056, 1059, 1072, 1091, 1149, 1189, 1227, 1375, 1392, 1417, 1515, 1619, 1799, 1909, 1925, 2038, 2050, 2051, 2060, 2146, 2226, 2250, 2255, 2256, 2282, 2306, 2365, 2370, 2440, 2450, 2452
Myocardial injury 2226
Myocardial ischemia 565, 611, 626, 643, 703, 1087
Myoclonic epilepsy associated with ragged-red fibers 2284, 2285, 2335
Myoclonic seizures 174, 530
Myoclonus 1535
Myofascial pain syndrome 287
Myoma 1967
Myoneural gastrointestinal encephalopathy syndrome 2284
Myophosphorylase deficiency 1033
Myosin regulatory light chain 890
Myositis 234
Myositis ossificans 287
Myxedema coma/precoma 431
N
N-Acetyltransferases 1322
NAD 1216, 2473
NADP 1295, 1346, 1368, 1400, 1423, 1613, 2352
NADPH-CYP450 oxidoreductase 1322, 1799
N-Containing drugs and xenobiotics oxygenated by FMO1 2065
N-Dealkylation 1516
Nano-biotechnology culture system 1800
Nanoparticles 891, 1800
Narcolepsy 38, 49, 218, 478, 497, 693
Narrow complex tachycardia 618
Narrow-angle glaucoma 471
Nasal and nasopharyngeal mucosal congestion 799
Nasal congestion 255, 266, 512, 630, 731, 799
Nasal delivery 891
Nasal mucosa 1904
Nasal polyps 69, 97, 499
Nasopharyngeal carcinoma 940, 1015, 1605, 1620, 1801, 1904, 2131, 2153, 2275, 2471
Nasopharyngeal mucosal congestion 799
Natural killer-cell neoplasms 891
Nausea/vomiting 46, 144, 152, 161, 189, 230, 239, 249, 250, 329, 350, 546, 677, 1535, 2168
Necrobiosis lipoidica diabeticorum 764
NEDD9 1149
Neonatal alloimmune thrombocytopenia 2225
Neonatal diabetes mellitus 2233
Neonatal gastroesophageal reflux disease 1417
Neonatal severe hyperparathyroidism 1212
Neoplasm 234, 613, 764, 1988, 1995, 2179, 2271, 2471, 2526
Neovascular (wet) age-related macular degeneration 644
Nephritic syndrome 362, 701
Nephropathic cystinosis 194
Nephropathy 21
Nephrotic syndrome 153, 190, 333, 381, 476, 764, 812, 892
Nephrotoxicity 1375, 2408
Nephrotoxicity associated with cisplatin therapy 695
Neprilysin 1149
Nerve growth factor-mediated neurite outgrowth 1150
Nervous tension 359
Neural stem cell 1150
Neural tube defects 325, 2288, 2291
Neuralgia 234, 334, 359, 702, 772
Neuritic plaques 1150
Neuroblastoma 164, 190, 196, 198, 247, 290, 400, 460, 755,791, 907, 940, 2190, 2207
Neurocysticercosis 14, 2453
Neurodegenerative disorders 141, 994, 2103, 2295
Neurodermatitis 78
Neurofibrillary tangles 2101
Neurogenic bladder 80, 368, 554
Neurogenic bowel disturbances 70
Neuroinflammation 1968
Neuroleptic malignant syndrome 1457, 1488, 1517, 1549
Neuroleptic-related weight gain in schizophrenia 1064
Neurological toxicities 632
Neuromuscular blockade 368
Neuromyelitis optica 1925
Neuronal excitability and survival 2071
Neuropathic pain 755, 787, 1803
Neuropathy, ataxia, and retinitis pigmentosa 2280
Neuropsychiatric disorder and early-onset cataract 2285
Neurotic disorders 37
Neurotransmitters 1803
Neutralization of heparin during surgery or dialysis 627
Neutropenia 305
Neutropenic allogeneic hematopoietic stem cell recipients 795
Neutropenic fever 795
Neutrophil growth factors 1392
NF-kappaB 894, 1803, 1808
N-glycosylation of ABC transporters 892
NHERF-1 (Na+/H+ exchanger regulatory factor 1) 956
N-in-1 dosing pharmacokinetics 1804
Nicotine addiction 1250, 1356, 1998, 2002, 2003
Nicotine dependence 2007, 2399
Nicotine dependence, susceptibility to 1997
Nicotine replacement therapy 2323
Niemann-Pick C1 protein 1925
Niemann-Pick disease 2304
Niemann-Pick disease, type C 821, 1150
Niemann-Pick disease, type C1 2304
Niemann-Pick disease, type D 2304
Nighttime sleep aid 232
Nitrous oxide sensitivity in MTHFR deficiency 2288
NK-Cell leukemia 892
Nocardiosis 708, 709
Nocturia 307
Nocturnal asthma 328
Nocturnal enuresis 378
Nocturnal frontal lobe epilepsy (type 1) 1253
Nodular acne 400
Noise-induced hearing loss 2229
Non-alcoholic fatty liver disease 994, 1323, 1605, 1807, 2332, 2489
Non-alcoholic steatohepatitis 1605
Non-articular rheumatism 5
Non-atopic asthma 2203
Non-coding vault RNAs 1807
Non-erosive reflux disease 279
Non-familial idiopathic cardiomyopathy 2145, 2422
Non-familial structural atrial fibrillation 1940
Non-familiar atrial fibrillation 2231
Non-fatal myocardial infarction and stroke 2225
Non-gonococcal urethritis 276
Non-growth hormone-deficient short stature 697
Non-Hodgkin lymphoma 88, 124, 370, 436, 454, 599, 619, 757, 791, 792, 893, 1096, 1605, 2056, 2058, 2255, 2279, 2288
Non-hypertrophic AK on face or scalp 379
Non-insulin-dependent diabetes mellitus 344, 610, 649, 667, 689, 750, 751, 984, 2120, 2150, 2207, 2233, 2250
Non-lymphocytic leukemias 495
Non-metastatic gestational trophoblastic disease 231
Non-myeloid malignancies 269
Non-obstructive urinary retention 80
Non-productive cough 73
Non-Q-wave myocardial infarction 199, 271
Non-small cell lung cancer 338, 559, 573, 603, 723, 793, 893, 940, 964, 1016, 1240, 1342, 1375, 1807, 1968, 2018, 2029, 2031, 2193, 2224, 2528
Non-spherocytic hemolytic anemia 2078
Non-squamous non-small cell lung cancer 81
Non-steroidal anti-inflammatory drug-associated gastrointestinal bleeding 1393
Non-ST-segment elevation 176, 262, 263, 271, 531, 610, 637
Non-syndromic sensorineural deafness 2284
Non-toxic goiter 431
Non-ulcer dyspepsia 163
Non-viral hepatitis-related hepatocellular carcinoma 1968
Noonan’s syndrome 697, 1204, 2240, 2430
Normal tension glaucoma 2014
Normal-pressure hydrocephalus 1150
NOS1 promoter repeat 1150
Nosocomial pneumonia 162, 426, 430
Novel substrates 1808
Nox1 NADPH oxidase 1150
Nrf2-dependent gene expression 1151
NSAID-associated gastric ulcer 415
NT5E deficiency (arterial calcification due to deficiency of CD73) 978
Nuclear factor (erythroid-derived 2)-like 2 1016
Nuclear factor-erythroid 2 related factor 2 1354
Nuclear receptors 1808
Nuclear receptors in oncology 1808
Nuclear transcription factors 1809
Nucleotides 2227, 2324
Nutrigenetics (gene-diet interaction) 1151
Nutritional disturbances 699
Nutritional factors 1522
Nutritional supplement 188
O
Obesity 225, 470, 547, 583, 586, 683, 821, 894, 994, 1059, 1059, 1067, 1072, 1078, 1081, 1088, 1151, 1203, 1269, 1323, 1926, 1968, 2001, 2079, 2093, 2107, 2170, 2207, 2243, 2249, 2253, 2292, 2304, 2306, 2337, 2346, 2427, 2483
Obesity (severe) due to leptin deficiency 2247
Obesity and body mass index 2342, 2344
Obesity, hyperphagia, and developmental delay 2320
Obesity, susceptibility to 1067, 1072, 1078, 1081, 1269, 2001
Obesity-related fatty liver 1926
Obsessive-compulsive disorder 173, 317, 324, 567, 681, 787, 1522, 2096, 2160, 2163, 2167, 2399
Obsessive-compulsive disorder, susceptibility to 2096
Obstructive airway disease 422, 673
Obstructive sleep apnea syndrome 49, 2014
Occipital horn syndrome 1193
Occluded arteriovenous cannulas 703
Occult subfoveal choroidal neovascularization 790
Ocular aspergillosis 39
Ocular histoplasmosis 790
Ocular hypertension 79, 84, 92, 93, 242, 418, 742, 761
Ocular infections 162, 768
Ocular inflammation 94, 192, 657, 764
Ocular itching 409, 543
O-Glycosylation 1151
Oil sediment genotoxicity 1940
Oleoyl-Coenzyme A 2106
Oligoarticular juvenile idiopathic arthritis 2140
Oligodendroglioma 1002
Oliguria 450
Omani type spondylo-epiphyseal dysplasia 1257
Omeprazole-Amoxicillin dual therapy for Helicobacter pylori eradication 1417
Onchocerciasis 403, 712, 2140
One-and two-sided undescended testicles 349
Ontogenesis of CYP1A proteins 1497
Ontogeny 1812
Onychomycoses 158, 402, 725, 1567, 1812
Oocytes 894
Open-angle glaucoma 84, 92, 93, 242, 256, 418, 423, 471, 480, 761, 1073, 1077, 2337
Ophthalmic diseases 613
Ophthalmic epinephrine sensitivity reaction 457
Ophthalmic infections 341, 748
Opiate dependence 99, 2323
Opioid-related disorders 510
Opisthorchiasis 14, 612
Opisthorchis viverrini-associated cholangiocarcinoma 1354, 1606
Oral and laryngeal cancer 1054
Oral cancer 1289, 1606, 2190
Oral drug overdose 393
Oral lesions 449, 764
Oral mucositis 253, 560
Oral squamous cell carcinoma 1016, 1342, 1606, 2289
Oral ulcer 449
Organ transplantation 895
Organic anion-transporting polypeptides 1926
Organic solute transporter α deficiency 1926
Organophosphate poisoning, sensitivity to 609
Orofacial infections 223, 700
Orolaryngeal carcinoma 2505
Oronasopharyngeal itching 771
Oropharyngeal candidiasis 177, 310, 603
Oropharyngeal mucositis 75
Orphan nuclear receptors 895
Orthostatic hypotension 265,488
Orthostatic intolerance 2395
Osteitis deformans 742
Osteoarthritis 53, 77, 116, 139, 155, 223, 226, 288, 291, 300, 307, 321, 383, 408, 440, 448, 459, 506, 512, 527, 550, 597, 704, 709, 724, 738, 752, 1186, 1991, 2198
Osteoarthrosis 5
Osteogenesis imperfecta 1261
Osteogenic sarcoma 247, 2375
Osteolytic bone lesions 562
Osteomalacia 110, 111, 1814
Osteomyelitis 76, 223, 309, 508, 549
Osteonecrosis 1375, 1814
Osteopenia 2207
Osteoporosis 18, 67, 108, 110, 111, 112, 113, 209, 281, 287, 370, 417, 550, 562, 641, 657, 727, 806, 1261, 1969, 2064, 2193, 2198, 2207, 2515
Osteoporosis, postmenopausal 209, 417, 641, 657, 727, 806
Osteoporotic fracture risk 2337
Osteosarcoma 473, 895, 1017, 1814, 2337, 2434, 2448, 2471
Otitis externa 214, 309, 465, 532, 540, 602
Otitis media 38, 63, 128, 129, 131, 134, 136, 137, 138, 140, 167, 540, 576, 600, 709, 768, 769
Otosclerosis 1261
Ovarian cancer 25, 81, 122, 146, 164, 190, 237, 247, 338, 386, 489, 549, 559, 755, 791, 793, 895, 940, 1017, 1053, 1083, 1207, 1209, 1233, 1235, 1237, 1240, 1272, 1289, 1375, 1393, 1620, 1814, 2025, 2075, 2113, 2151, 2226, 2240, 2326, 2333, 2370, 2382, 2442, 2471, 2515, 2519, 2526
Ovarian dysgenesis 2075
Ovarian hyperstimulation syndrome 1969, 2075
Ovarian response to FSH 2075
Overactive bladder 304, 696, 753, 774
Overdose of anticholinesterase medications 609
Ovulation induction 156, 325, 777
Ovulatory failure 172
Oxidative stress 1152, 1470, 1606, 1815
Oxidized low-density lipoprotein 1927
Oxysterol 994, 1152
Oxysterol 7α-hydroxylase 1927
Oxysterol 27-hydroxycholesterol 1984
P
P28GANK 896
p53 regulation 2511
P450cam 1816
Paclitaxel resistance 2025
Paclitaxel/Carboplatin-induced myelosuppression 1375
Paget disease of bone 18, 108, 287, 562, 657, 742, 806
Pain 7, 53, 70, 75, 94, 99, 105, 116, 154, 155, 180, 200, 234, 255, 291, 300, 301, 362, 364, 408, 409, 440, 463, 469, 509, 520, 527, 557, 565, 577, 673, 717, 758, 772, 803, 1375, 2167, 2323, 2399, 2478
Painful disorders 5
Palliative treatment of hyperthyroidism in preparation for surgical treatment or radioactive iodine 627
Palmar hyperhidrosis 90
Palpebral and bulbar conjunctivitis 316, 613
Pancreas 1818
Pancreatic cancer 274, 338, 897, 964, 1017, 1207, 1240, 2179, 2180, 2188, 2213, 2240, 2268, 2428, 2471
Pancreatic exocrine dysfunction 678
Pancreatic insufficiency 456
Pancreatitis 368, 624, 1056
Pancreatoduodenectomy 1418
Panic disorder 23, 174, 317, 567, 681, 787, 1062, 1266, 2399
Papillary thyroid carcinoma 1114, 2393
Papillary tumors 68
Paracoccidioidomycosis 407
Paralytic ileus 217, 768
Paramyotonia congenita of von Eulenburg 2388
Paraosteoarthropathy 287
Parathyroid adenoma 2268
Parathyroid carcinoma 161
Parathyroid tumors 1212
Parenteral nutrition 694
Parenteral nutrition solution 220
PARK genes 1531
Parkinson disease 8 2254
Parkinson’s disease 45, 72, 74, 94, 120, 166, 240, 335, 434, 609, 626, 647, 662, 665, 668, 678, 751, 767, 1056, 1062, 1152, 1264, 1264, 1324, 1343, 1529, 1819, 1969, 1989, 2001, 2003, 2005, 2078, 2081, 2098, 2112, 2113, 2116, 2128, 2193, 2254, 2260, 2264, 2283, 2288, 2291, 2295, 2308, 2326, 2337, 2420
Parkinsonian syndrome 70, 85, 94, 106, 232, 264, 580, 621, 1989
Parkinsonism 26, 120, 1981
Parotid and submandibular glands 940
Paroxysmal atrial fibrillation 618, 637
Paroxysmal AV junctional rhythm 637
Paroxysmal extreme pain disorder 2391
Paroxysmal nocturnal hemoglobinuria 256, 2242
Paroxysmal supraventricular tachycardia 12, 229, 618, 637
Paroxysmal ventricular tachycardia 235,637
Partial or secondary generalized seizures 79, 790
Partial seizures 118, 177, 287, 297, 334, 414, 552, 584, 588, 738, 781, 784, 808
Patent ductus arteriosus 383
Pathologic myopia 790
Pathological hypersecretory conditions 640, 645
PCSK9 (Proprotein convertase subtilisin/kexin type 9) 1152
Pediatric acute nephritis 449
Pediatric solid tumors 103
Pediatric tuberculosis 2402
Pediculus humanus infestations 582
Pellagra 522
Pelvic infections 275
Pelvic inflammatory disease 63, 137, 169
Pemphigus 60, 607
Penicillin allergy 2203, 2216
Peptic ulcer 70, 347, 368, 462, 475, 624, 2155
Peptic ulcer (low dose aspirin-induced) 1088
Percutaneous coronary intervention 610, 739
Percutaneous transluminal coronary angioplasty 746
Perennial allergic rhinitis 69, 97, 142, 151, 157, 168, 187, 193, 304, 584, 764, 771
Periarthritis 724
Periarticular ossification 287
Periodontitis 119, 162, 1153, 2213
Perioperative blood loss, prevention 47
Perioperative genomic profiles 1821
Perioperative nausea and vomiting 620
Peripartum cardiomyopathy 2358
Peripheral and cerebral ischemia 565
Peripheral and pulmonary embolism 797
Peripheral arterial disease 356, 2426
Peripheral arterial occlusive disease 2177
Peripheral nervous system 1153
Peripheral neuropathy 1274, 2341, 2422
Peripheral stem cell transplantation 675
Peripheral vascular disease 159, 355, 401, 522
Peripheral vasospastic disorders 751
Peritonitis 15, 310, 699
Permanent neonatal diabetes mellitus 984, 2233
Pernicious anemia 188
Peroxisomal acyl-CoA oxidase deficiency 1042
Peroxisomal disorders 1042
Peroxisome proliferator 2106, 2340
Peroxisome proliferator-activated receptor alpha (PPARA) 1393, 1620
Peroxisome proliferator-activated receptor gamma1 (PPARG1) 995
Peroxisome proliferator activated receptor-gamma (PPARG)-coactivator 1alpha (PGC-1alpha) 1471, 1927
Peroxisome proliferator-activated receptor-gamma (PPARG), Pioglitazone and Rosiglitazone 1941
Peroxisome proliferator-activated receptor δ isosteric selenium agonists 1153
Perpetrators of pharmacokinetic drug-drug interactions 1324
Personality 1537
Personality disorders 2005
Personality traits 2163, 2167
Personality traits and substance dependence 1053
Pertussis 255,276
Peters’ anomaly 1343
Petit mal (absence) seizures 475
Petit mal epilepsy 463
Petit mal variant 174
Peyronie’s disease 607
P-Glycoprotein 897, 898
Pharmacodynamics 1153
Pharmacogenetic testing 1393
Pharmacokinetics in children 1822
Pharmacokinetics in the elderly 1822
Pharmacoresistant temporal lobe epilepsy 899
Pharyngitis/tonsillitis 75, 128, 129, 130, 134, 136, 167
Pharyngitis/tonsillitis due to Streptococcus pyogenes 63
Phase I and Phase II hepatic drug metabolism activities in human liver preparations 1822
Phenolic function 1823
Phenothiazine-induced bladder dysfunction 80
Phenotypic appearance and neuropathology findings from patients with the known PARK mutations 1531
Pheochromocytoma 175, 484, 585, 586, 626, 2379
Philadelphia chromosome-positive chronic myelogenous leukemia 376, 386
Phosphodiesterase type 5 (PDE5) 1969
Phospholipase D 1909
Phospholipids 824, 1116, 1343, 1824, 2101
Photodynamic therapy 1017
Physical activity/exercise 1153
Pick’s disease 2264, 2357
Piebaldism 2238
Pim-1 kinase 1017
Pinworm and roundworm infections 453, 595, 631
Pituitary adenoma 2268
Pituitary function test 48, 628
Pituitary TSH suppression 428
Pituitary-testicular function 1969
Pityriasis (tinea) versicolor 104, 158, 256, 553
Placenta 822, 900, 995, 1018, 1290, 1343, 1826
Placental abruption 2300
Plague 704
Plaque psoriasis 11, 108, 109, 192, 315, 384, 718, 778
Plasma apolipoprotein E 1154
Plasma concentrations 1444
Plasma volume expansion 599
Plasmodium chabaudi malaria 1912, 1927
Plasmodium falciparum malaria 36, 51, 637, 1990
Plasmodium ovale malaria 616
Plasmodium vivax malaria 616
Platelet activating factor 824, 901, 1092, 1111, 1270, 2013, 2195, 2270, 2340, 2345, 2367, 2372, 2381, 2453, 2462
Platelet aggregation 2324, 2325
Platinum-based chemotherapy 2029
Pleural mesothelioma 1018
Pneumococcal disease, invasive, protection against 39
Pneumoconiosis and occupationally related tumors 1343
Pneumocystis carinii pneumonia 58, 576, 768
Pneumocystis jiroveci (Pneumocystis carinii) pneumonia 769, 770
Pneumonia 131, 223, 309, 310, 340, 600
Poisoning 145, 393
Pokemon gene transcription 901
Polarized light irradiation 1910
Poliomyelitis 601
Polycystic ovary syndrome 326, 1059, 1290, 1970, 2022, 2247, 2290, 2344
Polydipsia 211
Polymicrobic infections 377
Polypoidal choroidal vasculopathy 1245
Polyuria 211
Pompe disease 20
Poor metabolizers 1506
Porphyria 1827
Porphyria cutanea tarda 940, 1290, 1326
Porphyria variegate 2129
Porphyrin metabolism 1018
Porphyromonas gingivalis 1154
Portal hypertension 612
Portal venous thrombosis 797
Portal-systemic encephalopathy 413
Postabortion hemorrhage 273, 477, 558
Post-encephalitic parkinsonism 120, 677
Posterolateral lumbar spinal fusion 271
Post-evacuation cholecystography 687
Post-herpetic neuralgia 116, 615
Post-menopausal endometriosis 1970
Post-menopausal hormone therapy 1154
Post-menopausal osteoporosis 67, 110, 111, 112, 641, 657, 727, 806
Post-menopausal urogenital symptoms 281
Post-myocardial infarction 56, 79, 611, 742, 797
Post-operative antiemetic 622, 624
Post-operative delirium 1535
Post-operative nausea and vomiting 620, 768, 773
Post-operative pain 217, 424, 622, 666, 686, 724
Post-operative trauma 141
Post-partum depression 1264, 2259
Post-partum hemorrhage 122
Post-stroke neurogenesis 1970
Post-surgical analgesia 648
Post-surgical and post-traumatic pain 622, 666
Post-surgical pain 116, 622, 666, 686
Post-traumatic epilepsy 1154
Post-traumatic stress disorder 567, 2062
Potassium deficiency 604, 605
Potential health risks of complementary alternative medicines in HIV patients 1828
PPARG agonist-induced edema and fluid retention 2344
Prader-Willi syndrome 697
Preanesthetic agent 677
Precocious puberty 349, 358, 1829
Precursor cell lymphoblastic leukemia-lymphoma 1240, 2405
Prediction of anticancer drug activity 1343
Prediction of oral drug interactions caused by CYP3A4 1829
Pre-eclampsia 449, 1088, 1970, 2012, 2022, 2038, 2050, 2288, 2445, 2453
Pregnancy 289, 1326, 1540, 1620, 1829, 1928
Pregnancy loss 489, 494
Pregnancy-induced hypertension 612, 2300
Pregnane X nuclear receptor 1395
Pregnane X receptor 902, 1154, 1830
Premalignant genital lesions 359
Premature labor 2120
Premature ovarian failure 1928, 1971, 2069
Premature ventricular contractions 618
Premenstrual dysphoric disorder 317, 567, 681
Prenatal stress 1971
Preoperative medication 677
Preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression 1326
Prepubertal cryptorchidism 156
Prepubertal gynecomastia in monozygotic twins with Peutz-Jeghers syndrome 1971
Preterm cardiorespiratory disease 1033
Prevention of cancer-chemotherapy-induced nausea and vomiting 620, 773
Prevention of kidney stone 745
Prevention of postoperative nausea and vomiting 620, 768
Prevention of pregnancy 776
Primary acute leukemia 2179, 2180
Primary aldosteronism 1941
Primary aldosteronism associated with subclinical Cushing’s syndrome 1941
Primary antiphospholipid syndrome 1201
Primary bile acid malabsorption 2400
Primary biliary cirrhosis 778, 1540, 1832, 1928, 2145
Primary brain tumors 619, 903
Primary central nervous system lymphoma 903
Primary congenital glaucoma 1343
Primary cultured human hepatocytes 903
Primary degenerative dementia 342
Primary dysmenorrhea 139, 223, 408, 457, 527, 724
Primary dystonia 1154
Primary erythermalgia 2391
Primary generalized tonic-clonic seizures 423, 755
Primary hyperaldosteronism 701
Primary hyperaldosteronism due to adrenal microadenoma 1941
Primary hypercholesterolemia 182, 442, 618, 667, 686
Primary hyperoxaluria (type I) 1093
Primary immunodeficiency syndromes 380
Primary insomnia 2399
Primary keratoconjunctivitis 767
Primary nephrotic syndrome 2445
Primary open-angle glaucoma 1073, 1154, 1344, 2193
Primary ovarian insufficiency 1971
Primary pulmonary hypertension 361, 533, 612, 684, 1047, 1203, 1620
Primary restless legs syndrome 609, 665
Primary spontaneous intracerebral hemorrhage 1052
Prion disease 1154, 2350, 2351
PRNP Met129Val polymorphism in Alzheimer’s disease and prion disorders 2350
Proatherogenic microbes 1154
Probe substrates for clinical drug interaction studies 1832
Procarcinogen activation 1541
Proctitis 466, 1833
Proctosigmoiditis 466
Progesterone deficiency 621
Progesterone receptor membrane component 1 (PGRMC1) 1375
Progressive external ophthalmoplegia 2335
Progressive external ophthalmoplegia with myoclonus 2284
Progressive external ophthalmoplegia, proximal myopathy, and sudden death 2285
Progressive familial intrahepatic cholestasis PFIC3 903
Progressive osseous heteroplasia 2091
Progressive supranuclear palsy 2264
Prolactin-secreting adenomas 94
Proliferative diabetic retinopathy 2177
Proliferative vitreoretinopathy 2255
Prolonged bleeding time, brachydactyly and mental retardation 2091
Promotion of weight gain 550
Promoters for driving transgene expression 1833
Prophylaxis of acute organ rejection in renal transplant 688
Prostaglandin transporter 1971
Prostate cancer 2, 101, 193, 207, 237, 281, 282, 321, 349, 358, 407, 422, 495, 526, 712, 772, 791, 822, 903, 970, 995, 1018, 1114, 1186, 1209, 1267, 1272, 1291, 1326, 1344, 1835, 1971, 1985, 2018, 2110, 2116, 2120, 2151, 2156, 2177, 2188, 2216, 2241, 2255, 2275, 2331, 2341, 2370, 2416, 2422, 2426, 2442, 2489, 2510, 2515, 2528
Prostatic hyperplasia 306, 1064, 1836
Prostatitis 140, 307, 426
Protease inhibitor-associated hyperlipidemia 1836
Proteasome 1607, 1836
Protection against nicotine dependence 2396
Protein C deficiency 2353
Protein kinase Cβ (PKCβ) 1928
Proteomics of human blood-brain barrier transporters 903
Proteus infection 29, 119, 128
Pruritic dermatosis 73,610,613
Pruritus 73, 155, 182, 188, 245, 368, 610
Pruritus ani 610, 798
Pseudobulbar affect 1545
Pseudoexfoliation syndrome 1142
Pseudoexfoliative glaucoma 2110, 2120
Pseudohermaphroditism 2317
Pseudohypoaldosteronism 1941
Pseudohypoaldosteronism, type 1 2391
Pseudohypoparathyroidism 109
Pseudohypoparathyroidism (type IA) 2091
Pseudohypoparathyroidism (type IB) 2091
Pseudomembranous colitis 155, 783
Pseudomonas aeruginosa infections 29, 119, 131, 135, 594, 822
Pseudopseudohypo-parathyroidism 2091
Pseudosymmetric solute translocation pathways 904
Pseudovaginal perineoscrotal hypospadias 2426
Pseudoxanthoma elasticum 978, 2276
Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency 2083
Psoriasis 10, 42, 78, 179, 314, 473, 474, 672, 778, 940, 1155, 1228, 2126, 2136, 2216, 2220, 2456
Psoriasis vulgaris 255, 2220
Psoriatic arthritis 11, 60, 284, 348, 384, 2136, 2220, 2256, 2344
Psoriatic plaques 764
Psychogeriatric patients 1447
Psychomotor and focal seizures 617
Psychosis 95, 474, 580, 805, 810, 1155, 2399
Psychosis/schizophrenia 474, 620, 635, 658, 710, 735, 736, 766, 805, 810, 1064, 1067, 1250, 1255, 1264, 1998, 2001, 2004, 2006, 2007, 2009, 2079, 2094, 2096, 2097, 2099, 2231, 2323
Psychostimulant abuse 2323
Psychotic depression 37
Psychotic disorders 71, 319, 354, 442, 620, 736, 805, 2006
Pterygium 2528
Puberty 1838
PUFA metabolism (Arachidonic acid, Eicosatrienoic acid, Eicosapentaenoic acid, Docosahexaenoic acid) 1910
Pulmonary alveolar proteinosis 995
Pulmonary arterial hypertension 27, 90, 525, 612, 684, 689, 762, 1047, 1345, 2014, 2302
Pulmonary artery pressure 2328
Pulmonary atresia 24
Pulmonary edema 502
Pulmonary embolism 6, 218, 263, 327, 356, 703, 744, 777, 797, 2325
Pulmonary emphysema 745
Pulmonary function 310
Pulmonary hypertension secondary to connective tissue disease 689
Pulmonary hypertension, familial persistent, of the newborn 683
Pulmonary stenosis 24
Pulmonary thromboembolism 797
Pulmonary tuberculosis 191, 655, 2456
Pulmonary vasoconstriction 751
Pulseless arrest 785
Puromycin aminonucleoside-induced nephrosis 1980
Purpura fulminans 628
Pyelonephritis 131, 162, 275
Pyodermas 532
Pyorrhea 255
Pyridoxine deficiency 1607
Pyridoxine-dependent seizures 632
Q
QT dispersion (QTd) 1033
QT interval 904, 1488, 1839
R
Rabies 640, 641
Radiation 1155
Radiation therapy 1841
Radiation therapy-induced mucositis 672
Radiation-induced apoptotic cell death 905
Radioiodine ablation of thyroid tissue remnants 737
Radiotracers 905, 1019
RANKL antibody 1972
Rasmussen’s encephalitis 2094
Rat strain differences 1607
Raynaud’s disease 401, 612
Reactive arthritis 2402
Receptor for activated C-kinase 1 (RACK1) 1019
Receptor for advanced glycation end products (RAGE) 1155
Recessive ataxia syndrome 2335
Rectal cancer 316, 2528
Recurrent cutaneous T-cell lymphoma 608, 664, 796
Recurrent miscarriage 1291, 2061
Reduce duodenal motility during diagnostic radiologic procedures 624
Reduced triglycerides, susceptibility to 611
Refractory acute lymphoblastic leukemia 172
Refractory acute myeloid leukemia 2347
Refractory constipation 163
Refractory cutaneous T-cell lymphoma 82
Refractory delirium tremens 624
Refractory depression 100
Refractory leukemia 103
Refractory non-Hodgkin lymphoma 311, 608, 757
Refractory rickets 272
Refractory testicular tumors 290
Regional analgesia 464
Regional anesthesia 622
Regulation of UGT1A1 by BRCA1 2489
Relapsing-remitting multiple sclerosis 343
Relaxation of skeletal muscles 646, 663, 705, 786
Removal of granulation tissue and warts 685
Renal adenocarcinoma 1910
Renal agenesis 2379
Renal cancer 17, 88, 292, 436, 456, 568, 698, 712, 722, 791, 941, 1274, 1345, 1420, 1843, 2270, 2297, 2337, 2385
Renal colic 5
Renal CYP3A activity 1843
Renal damage 1155
Renal disease 285, 2052
Renal dysfunction 699
Renal failure in IgA nephropathy 1088
Renal function 906
Renal hypouricemia 970
Renal insufficiency 111, 511
Renal ischemia-reperfusion 1607
Renal transplantation 67, 906, 1843
Renal tubular dysgenesis 1034, 1092, 2377
Resistance to platinating agents 1193
Resistant depression 1844
Respiratory allergies 95
Respiratory depression 244, 257
Respiratory diseases 613, 764
Respiratory distress syndrome 76
Respiratory infections 131, 140, 700
Respiratory syncytial virus 561,652
Respiratory tract diseases 2456
Respiratory tract infections 129, 132, 133, 134, 137, 140, 219, 341, 700
Response to diuretics 1051
REST (RE1-silencing transcription factor) 2174
Resting heart rate 1073
Restless legs syndrome 609, 665
Restoration of water/sodium losses 691
Retinal artery occlusion 2288
Retinoblastoma 190, 198, 906, 941, 1019, 2207, 2291, 2375
Retinopathy 2519
Retinopathy of prematurity 2300
Retrolental fibroplasia 750
Retroviral transfer of human CYP450 genes 1845
REV-ERBalpha 1929
Reversal of nondepolarizing neuromuscular blockers 632
Reversible obstructive airway disease 15, 31, 673
Rhabdomyolysis 906, 1376, 1471, 1561, 1845, 2147, 2415
Rhabdomyosarcoma 190, 196, 198, 791, 907, 2471
Rhabdomyosarcoma and neuroblastoma 907
Rheumatic diseases 613, 764
Rheumatic fever 53, 576
Rheumatic heart disease 2445, 2456
Rheumatism 255, 772
Rheumatoid arthritis 3, 5, 11, 42, 53, 60, 61, 116, 139, 141, 155, 192, 223, 284, 288, 291, 300, 321, 347, 348, 366, 383, 384, 408, 419, 440, 448, 459, 473, 506, 512, 550, 574, 597, 661, 708, 709, 724, 732, 738, 749, 764, 812, 907, 1062, 1155, 1191, 1201, 1228, 1237, 1327, 1918, 2058, 2139, 2140, 2145, 2198, 2200, 2211, 2216, 2278, 2290, 2295, 2337, 2347, 2408, 2439, 2456, 2465, 2471, 2515
Rheumatoid disorders 190, 371
Rhinitis 215, 368, 556
Rhinorrhea 393, 771
Rho guanine nucleotide exchange factors PDZ-RhoGEF and LARG 822
Riboflavin deficiency 653
Ribosome inactivating protein 2186
Rickets 110
Rickettsia 731
Rigidity 368
Risk of coronary stent thrombosis 610, 1420, 2226
Risk of metabolic syndrome, diabetes or vascular disease 2249
Ritonavir-induced hyperlipidemia 1929
RNA interference 908, 1156, 1850, 1972
RNF2 (ring finger protein 2)(1q25.3) 2174
Rosacea 61, 78, 248
Rotavirus gastroenteritis 668
Roundworms 453, 631
Rubella 379, 453, 669
Runx2 1973
S
S100A12 1156
Sacral chordoma 909
Salivary glands 1853
SALL4 1020
Salmonella infection 39
Salmonellosis or shigellosis 769
Salt 1620
Salt sensitivity 1395
Salt-sensitive essential hypertension 612, 1052
Salt-sensitivity variants 1853
Salzmann nodular degeneration 1020
SANDO syndrome 2335
Sarcoidosis 2145, 2157, 2519
Sarcoma botryoides 198
S-Containing drugs and xenobiotics oxygenated by FMO1 2065
Scabies 188, 909
Scalp seborrheic dermatitis 672, 679
Scavenger receptor class B type I (SR-BI) 1156
Scedosporium apiospermum 795
Scheie form of MPS I 417
Schistosoma mansoni infection, susceptibility/resistance to 612
Schistosomiasis 612, 2216
Schizoaffective disorder 1064
Schizophrenia 49, 52, 95, 152, 178, 318, 319, 354, 374, 443, 474, 499, 541, 560, 582, 595, 620, 635, 658, 710, 735, 736, 766, 805, 810, 910, 1046, 1062, 1064, 1067, 1122, 1156, 1250, 1255, 1264, 1554, 1854, 1998, 2001, 2004, 2006, 2007, 2009, 2027, 2079, 2094, 2096, 2097, 2099, 2101, 2110, 2131, 2157, 2159, 2164, 2165, 2167, 2168, 2170, 2193, 2216, 2231, 2260, 2270, 2278, 2282, 2288, 2289, 2318, 2323, 2332, 2359, 2381, 2396, 2399, 2418, 2426, 2456, 2471, 2475, 2476
Schizophrenia, susceptibility to 1064, 1067, 1250, 1254, 1264, 1998, 2001, 2004, 2006, 2007, 2079, 2094, 2096, 2097, 2099, 2231, 2323
Schizophrenia-related weight gain 1064
Sciatica 702
Scleroderma 607
Sclerosing cholangitis 910
Scorpion alcoholic extraction 910
Scott syndrome 822
Scurvy 51
Seasonal affective disorder 702, 2164
Seasonal allergic conjunctivitis 409, 410, 424, 441, 457, 516, 543, 613
Seasonal allergic rhinitis 69, 97, 121, 142, 151, 157, 168, 187, 193, 438, 500, 584, 764, 771
Seasonal changes 1291, 1973
Seborrheic dermatitis 78, 158, 179, 672
Second- and third-degree burns 445, 685
Secondary amenorrhea 456, 621
Secondary hyperparathyroidism 109, 161, 566
Secondary Parkinson’s disease 609
Secondary pulmonary hypertension 612, 684, 689
Sedation 145, 301, 624
Sedative/hypnotic withdrawal 577
Seizure disorders 174, 669, 781
Seizures 278, 334, 584, 669, 781, 1535
Seizures and myoclonus 1483, 1535
Selenium and vitamin E deficiency 1904
Senile chorea 729
Senile cognitive impairment 166
Senile dementia 272, 360, 620, 662, 750
Senile dementia of Alzheimer’s type 141, 166, 620, 662, 713
Sepsis 138, 251, 1291, 2050, 2216, 2256
Sepsis-induced drug metabolizing dysfunction 1608
Septic arthritis 309
Septic shock 214, 785, 2456
Septicemia 129, 132, 133, 137, 309, 310, 341, 549, 740
Serotonergic 5-HT2A receptor signaling 1973
Serotonergic 5HTR6 compounds inducing hypophagia 2170
Serotonin syndrome 1536, 1555
Serotonin transporter 1556
Serratia 29
Serum incubation method 1856
Serum lipid levels and metabolic syndrome 2150
Serum opacity factor 995
Serum thyroglobulin testing 737
Severe acne 169
Severe acute respiratory syndrome 1034
Severe burns 685
Severe combined immune deficiency 2242
Severe combined immunodeficiency due to ADA deficiency 1049
Severe combined immunodeficiency syndromes 380
Severe congenital protein C deficiency 628
Severe congestive heart failure 241
Severe fibrosis 1985
Severe heart failure 701
Severe malaria anemia 2216
Severe myoclonic epilepsy 2386
Severe pain 409, 427, 555, 717, 758, 803
Severe primary axillary hyperhidrosis 90
Severely-restricted mobility 263
Sevoflurane, Isoflurane, Propofol or Dexmedetomidine anesthesia 959, 1930
Sex determination and disorders of sex development 1973
Sex steroids 1857, 1973
Sex-related differences 1523, 1856
Sex-related metabolic profiles 1559
Sexual development 1973
Sexual dysfunction 1536
Sexually-transmitted disease 63
Sézary syndrome 1993
Shigellosis 39, 131
Shock 15, 218, 241, 265, 535, 2157
Short bowel syndrome 456
Short QT syndrome 2236
Short QT syndrome 1 2232
Short QT syndrome 2 2236
Short stature 697, 2088
Short-term treatment of insomnia 677, 720, 765, 802, 809
Shoulder-hand syndrome 724
Sialorrhea 90, 368
Sick building syndrome 1608
Sick sinus syndrome 2390
Sickle cell anemia 2125
Sickle-cell disease 367, 1420
Side chain-oxidized oxysterols 1985
Sigma receptors 910, 1156
Silent myocardial ischemia 1067
Silver-Russell syndrome 2190
Single ventricle 1941
Sinus bradycardia 59
Sinus congestion 771
Sinus tachycardia 279
Sinusitis 38, 512, 556, 630
SIRT1 822
Situational anxiety 620
Sjögren’s syndrome 143
Skeletal metastases 704
Skeletal muscle pain 123, 772
Skeletal muscle relaxant 646, 747
Skeletal myopathy, responsive to riboflavin 2285
Skin 1861
Skin and skin structure infections 129, 130, 131, 132, 133, 134, 135, 137, 140, 168, 430, 465, 483, 503, 540, 740, 741
Skin and soft tissue infections 138, 341,700
Skin cancer 1096, 2031, 2216, 2471
Skin cleanser 148
Skin discoloration 365
Skin disorders 2154
Skin infections 128, 129, 130, 131, 132, 133, 134, 135, 137, 140, 168, 341, 426, 430, 465, 483, 503, 519, 540, 639, 700, 707, 740, 741
Skin lesions 26
Skin resurfacing 764
Sleep disorders 497
Sleep initiation and maintenance disorders 791, 808
Small-cell lung cancer 290, 755, 911, 941, 964, 1020, 1989, 2102, 2103, 2528
Small heterodimer partner (SHP) 1930
Small interfering RNA (siRNA) 911
Smallpox 690, 2288
Smallpox vaccine 690, 2288
Smith-Lemli-Opitz syndrome 823
Smokeless tobacco 1328
Smoking 524, 784, 823, 1291, 1328, 1354, 1366, 1470, 1488, 1524, 1531, 1620, 1862, 2260
Sneezing 771
S-Nitrosylation 1157
Social anxiety disorder 324, 567 ,681, 787, 1061
Social phobia 787
Sodium depletion 1941
Soft tissue infections 700
Soft tissue or skeletal infections 131
Soft tissue sarcoma 88, 196, 198, 247, 791, 1189
Solar keratosis 316
Solid tumor malignancies 647, 712
Solid-organ transplantation 1862
Solute carriers 1863
Soman nerve gas exposure 632
Somatic colon cancer 2344
Somatic gastric cancer 2224
Somatic gastrointestinal stromal tumor 2329
Somatic mutations in pituitary adenomas 2091
Somatic pilocytic astrocytoma 2241
Somatoform disorders 702
Sonic hedgehog 1941
Sore throat pain 585
Sorsby fundus dystrophy 2450
Sour stomach 160, 296
Spasm 677
Spastic colon 768
Spasticity 200, 790
Species differences 1329, 1366, 1396, 1608, 1620
Species differences and evolutionary origins 1973
Sperm 1292
Spermatogenesis 156, 325, 326, 1975
Sperm whale skin biopsies 1292
Sphingomyelins 995, 1157, 1178, 1183
Sphingosine kinase 941
Sphingosine 1-phosphate 2212, 2237
Sphingosine-1-phosphate receptors 1157
Spina bifida 2297, 2337
Spina bifida and neural tube defect 2405
Spinal and bulbar muscular atrophy 1186
Spinal anesthesia 619, 706, 730
Spinal cord injury 65, 200, 984
Spondylolisthesis 271
Spontaneous abortion 1930, 2136
Spontaneous preterm birth 2361
Sporadic amyotrophic lateral sclerosis 656, 1111, 2104, 2528
Sporadic breast cancer 1196
Sporadic colorectal adenocarcinomas 1046
Sporadic solitary aldosterone- and cortisol-co-secreting adenomas 1942
SPRED2 (sprouty-related protein with EVH1 domain 2) 1942
Squamous cell carcinoma 88, 913
Squamous cell carcinoma of the head and neck 143, 237, 367, 2505
Squamous cell carcinoma of the larynx and hypopharynx 1608, 1623, 1590, 1864
Squamous cell lung carcinoma 1292
SSRI-induced sexual dysfunction 800
SSRI-related hyponatremia 1479, 1536
SSRIs, TCAs and neuroleptics 1479
Stable angina 788
Stable monomorphic VT 618
Staining of anterior capsule of the lens 774
Staphylococcal infections 39, 309, 337, 508, 639, 654, 741, 783
Staphylococcus aureus bacteremia 201, 504, 639, 741
STAT3 decoy oligodeoxynucleotides 913
Static magnetic field 913
Stature quantitative trait locus 1237
Status asthmaticus 673
Status epilepticus 439, 781
Stearoyl-Coenzyme A 2106
Steatohepatitis 78
Steatosis 2292
Stem cells 941, 1366, 1609, 1930
Stent thrombosis 610, 914, 1396
Steroid receptor coactivator 2 (SRC-2) 1975
Steroid-induced osteonecrosis 914
Steroidogenic acute regulatory protein 996
Steroidogenic factor-1 (SF-1) 1942
Steroid-resistant asthma 914
Sterol carrier protein-2 1930
Stevens-Johnson syndrome 2131, 2134
Stimulation of pancreatic secretion for analysis 687
Stomach 1869
Stomach cancer 316, 494
Stomatitis 73, 119, 255
Strabismus 90
Strategies for minimizing mechanism-based inhibition of CYP3A4 1869
Streptococcal or enterococcal endocarditis 39, 309, 549, 704
Streptococcal serum opacity factor 1157
Streptococcus pneumoniae 63, 134
Streptozotocin-induced diabetic nephropathy 1621
Stress 343, 2306
Stress/anxiety 144, 620, 702
Stress-related diseases 2062
Stroke 53, 176, 200, 523, 611, 643, 740, 823, 941, 1034, 1079, 1118, 1228, 1270, 1421, 1869, 1907, 1910, 1942, 2038, 2048, 2050, 2198, 2300, 2337
Stroke, susceptibility to 1079, 1270, 2337
Stroke-like-episodes 2284
Strongyloidiasis 403, 733
Structure-activity relationship analysis of CYP450 metabolism 1870
ST-segment elevation myocardial infarction 263, 651, 722, 739
Sturge-Weber syndrome with congenital glaucoma 1345
Subacute sclerosing panencephalitis 2203
Subacute stent thrombosis 610, 740
Subarachnoid hemorrhage 528, 759, 1158
Substance abuse 2007, 2162, 2164
Substrate preferences 1870
Substrate-dependent activity of CYP2D6 isoenzymes 1562
Sucrase deficiency 671
Sudden cardiac arrest 1034
Sudden cardiac death 2390
Sudden death 2236
Sudden infant death syndrome 2159, 2198, 2216, 2282, 2285
Sudden sensorineural hearing loss 1292
Suicidal behavior 2396
Suicidal ideation 914
Suicide 2165
Sulfonylurea-induced hypoglycemia 1396
Sulfonylurea receptor 2A 985
Sulfonylurea receptor 2B 985
Sulfotransferases 1870
Sunburn 73
Superficial eye infections 602, 748, 768
Superficial mycoses 177
Suppression of Rh isoimmunization 651
Suprapubic pain 307
Supraventricular tachyarrhythmias 227, 229, 279, 308, 623, 626, 788
Susceptibility to arsenic-induced diseases 1190, 1220
Susceptibility to atypical hemolytic uremic syndrome 2449
Susceptibility to carcinogens 2120
Susceptibility to cleft lip/palate 2291
Susceptibility to diabetic nephropathy 2129
Susceptibility to different types of cancer 2031
Susceptibility to essential hypertension 612, 1063, 1066, 1068, 1071, 1077, 1081, 1197, 2093
Susceptibility to hip fracture 2227
Susceptibility to obsessive-compulsive disorder 2096
Susceptibility to recurrent viral infections 2059
Susceptibility to UV-induced sun damage 2267
Susceptibility to West Nile virus 1228
Sweetening agent 698
Sympathetic ophthalmia 764
Sympathoadrenal, metabolic, and hormonal balance 2306
Symptomatic parkinsonism 120
Syndrome of inappropriate ADH secretion (SIADH) 754
Synovitis 764
Syphilis 248, 255, 276, 731
Systemic carnitine deficiency 425
Systemic fungal infections 407
Systemic juvenile rheumatoid arthritis 2207
Systemic lupus erythematosus 764, 1201, 1421, 1609, 1975, 1985, 2038, 2056, 2059, 2110, 2145, 2157, 2203, 2208, 2216, 2295, 2439, 2456, 2466
Systemic mastocytosis 187
Systemic sclerosis 1201, 1562, 2139, 2300, 2439
Systolic blood pressure in preterm infants 1562
Systolic hypertension 153, 612
T
Tachycardia 355, 1073
Tachypnea 301
Tamoxifen resistance 2026
Tangier disease 823
Tardive dyskinesia 710, 729, 750, 790, 1258, 1330, 1566, 1875, 2002, 2004, 2422
Tauopathies 1158, 2264
Tau-tubulin kinase-1 1158
T-cell acute lymphoblastic leukemia 517, 966
T-cell leukemia 608
T-cell lymphoblastic lymphoma 517, 608, 1875
T-cell prolymphocytic leukemia, sporadic 608
TGFβ1 1931
Telangiectasia 2471
Telomere shortening 1976
Temporal arteritis 764
Temporomandibular joint pain 123
Tenascin-C 917
Tendinitis 383, 709, 724
Test to evaluate thyroid function 628, 692
Testicular cancer 88, 146, 164, 190, 198, 290, 374, 791, 2272
Testicular germ cell cancer 1329, 1877, 2335
Testicular steroids 1354, 1609
Testicular tumors 198, 290, 790
Testotoxicosis 1961
Tetanus 152, 379, 472, 729
Tetrahydrobiopterin (BH4) responsive phenylketonuria 674
Tetrahydrobiopterin-deficient hyperphenylalaninemia due to GTP cyclohydrolase I deficiency 2082
Thalassemia 206, 1330, 1878
Thalidomide-related neuropathy 823
Therapeutic abortion 1965
Therapy-related acute myeloid leukemia (t-ML) 2274, 2308
Thiamine deficiency 733
Third degree burns 685
Thrombocytopenia 41, 260, 420, 546, 665, 2200, 2227
Thrombocytopenic purpura 380, 2227
Thromboembolic disease 6, 233, 420, 797
Thromboembolic stroke 611, 2203
Thromboembolism 356, 797, 2050, 2353
Thrombophilia 2449
Thrombophilia due to activated protein C resistance 2050
Thrombophilia due to factor V Leiden 2050
Thromboprophylaxis 196
Thrombosis 48, 199, 1158, 2227, 2288
Thrombotic stroke 233, 611, 740
Thymine 1995
Thymocytes 919
Thymocyte and lymphocyte proliferation 996
Thyroid cancer 247, 692, 737, 1021, 2018, 2026, 2297, 2450, 2489, 2511
Thyroid disease 919, 1992, 2434
Thyroid dysfunction 2230
Thyroid dyshormogenesis 2392
Thyroid function 628, 692
Thyroid hormone 1991, 2417
Thyroid nodules 737
Thyroid papillary carcinoma 2270
Thyroidectomy 737
Thyroiditis 737
Thyrotoxic crisis 627
Thyrotoxicosis 737
Ticlopidine-induced hepatotoxicity 2131
Tie1 1158
Time-dependent CYP450 inhibition 1880
Tinea corporis 104, 158
Tinea cruris 104, 158
Tinea pedis 104, 158
TNFα 1610, 1931
Tinnitus 161, 342, 2399
TMCC2 1158
Tobacco 1292, 1610
Tobacco smoking 1067
Tobacco use disorder 1253, 1255, 1610, 1989, 2006, 2259
Tobacco-related cancers 2505
Tocopherol-ω-hydroxylase 1910
Toll-like receptor 2 (TLR2) 1159
Toll-like receptor 4 (TLR4) 1159
TOMM40 poly-T variants 1159
Tonic-clonic (grand mal) seizures 287, 617
Tonsillar disease 2453
Tonsillitis 255
Tooth agenesis 1249
Toothache 234
Topical infections 608
Topoisomerase I 1022
Torg-Winchester syndrome 2276
Torsades de pointes 449, 1882, 2232
Torsades de pointes, drug-associated 2232
Torulopsis glabrata 39
Tourette’s syndrome 354, 591, 729, 805, 2002, 2198
Toxoplasma gondii 633, 708, 768
Toxoplasma gondii encephalitis 58, 2141
Toxoplasma gondii infection 633, 708, 768
Toxoplasmosis 633, 708, 768
Trace metal deficiencies 757
Trachoma 707, 2153, 2216
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) 919
TRAIL death receptor 5 (DR5) 919
Transcription factor 2071
Transcriptional activation of CYP3A4 2150
Transcriptome 1159
Transforming growth factor beta (TGFB) 1610
Transforming growth factor-beta1 (TGFB1) 996, 1610
Transient ischemic attacks 6, 233, 523, 797
Transient neonatal diabetes mellitus 985, 2234
Transitional cell carcinoma 793
Transkingdom RNAi 920
Transplant recipients 1883
Transplant-associated coronary disease 2177
Transplant-free survival for single ventricle patients 2012
Transporter-enzyme interactions 1883
Transurethral prostatic resection 698
Traumatic brain injury 342, 1159
Traumatic spinal cord injury 1159
Travelers’ diarrhea 655, 761, 769
Treatment of acute lymphocytic leukemia 723, 792
Treatment of growth failure associated with chronic renal insufficiency 697
Treatment of short stature or growth failure associated with short stature homeobox gene deficiency 697
Treatment of short-bowel syndrome 697
Treatment of tinea versicolor and acne 553, 679, 695, 707, 725
Treatment-resistant depression 774
Trefoil factor 1 (TTF1) 1976
Tremor 368, 1376
Treponema pallidum 575
Trichinosis 613, 733
Trichomoniasis 743
Tricuspid atresia 24
Trifluoromethylpyrimidine class of tyrosine kinase 2 (PYK2) inhibitors 1885
Trigeminal neuralgia 748
Trigeminal/glossopharyngeal/diabetic neuralgia 118
Triglycerides 2196, 2210, 2301, 2318, 2338, 2463
Triiodothyronine 1046, 1054, 1183, 1223, 1262, 1613, 1885, 1992, 2054, 2074, 2075, 2082, 2086, 2118, 2125, 2159, 2253, 2275, 2276, 2318, 2333, 2376, 2447, 2463
Trilostane (3β-hydroxysteroid dehydrogenase inhibitor) 1977
Trimethylaminuria 2068
Trophoblastic neoplasms 473
Tuberculosis 32, 68, 116, 285, 286, 397, 613, 631, 654, 704, 920, 1887, 2067, 2183, 2220, 2402, 2407, 2466, 2515
Tularemia 704
Tumor necrosis factor-alpha (TNF) 920, 996, 1022, 1145
Tumor proliferation 1621
Tumorigenesis 2072
Tumor-induced angiogenesis 2276
Turner’s syndrome 697
Type 1 Gaucher’s disease 786
Type III hyperlipoproteinemia 1159
Type III hyperlipoproteinemia associated with APOE deficiency 1160
Type III hyperlipoproteinemia due to APOE4-Philadelphia 1160
Typhoid fever 162, 255, 769, 2145
Tyroid carcinoma 2515
U
Ubiquitin-dependent proteasomal degradation 1610
UDP-glucuronosyltransferase 2B7 modulation 1887
UGT1A9 regulation by BRCA1 2502
UHRF1 921
Ulcerative colitis 66, 363, 384, 466, 543, 699, 708, 921, 970, 1258, 1355, 2116, 2120, 2150, 2200, 2217, 2312, 2344, 2456, 2528
Ulcerative gastroesophageal reflux disease 415, 640
Ultra-rapid metabolizers 1507
Ultrasound 921
Ultraviolet-induced dyschromia 365
Unresponsive hyperinsulinemic hypoglycemia 985
Unstable angina 87, 176, 199, 263, 327, 610, 738, 739, 788
Upper airway secretions 347
Upper and lower respiratory tract infections 138, 255, 700
Upper gastrointestinal tract cancer 1096
Upper GI bleeding 240
Upper respiratory allergies 630
Urate/uric acid and gout 617, 1022
Urea cycle disorder 693
Ureteral spasm 624
Urethra gonorrhea 700, 731
Urethritis 63, 307, 540
Urethrocystitis 307
Urethrotrigonitis 307
Uric acid 647
Urinary bladder neoplasms 2480
Urinary bladder spasm 624
Urinary burning 255
Urinary incontinence 265, 304, 1977
Urinary outflow obstruction 244, 306
Urinary retention 306
Urinary tract infection 8, 119, 128, 129, 131, 132, 133, 134, 137, 138, 162, 191, 242, 255, 275, 310, 330, 377, 471, 509, 532, 536, 583, 708, 709, 740, 768, 769, 1905, 2453
Urine alkalinization 604, 606
Urokinase plasminogen activator 1160
Urolithiasis 2516
Urothelial carcinoma 793, 1611, 2112, 2113
Urticaria 121, 142, 151, 168, 193, 215, 773
Uterine atony 273
Uterine leiomyoma 422, 1345, 2528
Uterine sarcomas 198
Uveal melanoma 1241
Uveal tract inflammation 359
Uveitis 59, 314, 316, 764
V
Vaginal irritation 608
Vancomycin-resistant Enterococcus faecium infections 430, 639
Vancomycin-sensitive Enterococcus faecalis 741
Varicella 379,453
Varicella zoster 10
Varicella zoster virus in pregnant women 785
Varicocele-associated male infertility 1977
Varicose veins 502, 695
Varicosis 1621
Vascular calcification 1160
Vascular dementia 342, 523, 1160, 2456
Vascular disorders 523, 2300
Vascular factors 1160
Vascular failure 587
Vascular headaches 273, 479
Vascular injury 1160
Vasoactive intestinal peptide, 4-chloro-Phe6-Leu17- 2447, 2520
Vasodilatory shock 785
Vasomotor rhinitis 62, 95, 121
Vasospastic (Prinzmetal’s) angina 34,788
Vein graft disease 1160
Venoocclusive disease 1889
Venous thromboembolism 199, 628, 797, 1398, 2203, 2325
Venous thrombosis 6, 218, 356, 797, 2050, 2364
Ventricular arrhythmias/tachycardia 5, 398, 429, 485, 501, 698, 699
Ventricular asystole 59
Ventricular fibrillation 32, 785
Ventricular premature complexes 235
Ventricular tachycardia 32, 308, 501, 618, 626, 785, 1073, 2390
Vernal conjunctivitis 187, 435, 457
Vernal keratitis 187, 435
Vernal keratoconjunctivitis 187, 435
Vertebral fractures 1977
Vertigo 161, 189, 230, 342, 454, 710, 791
Vestibular disorders 161
Vestibular vertigo 313, 791
Vincent’s infection 119
Viral croup 266
Viral infection 2180
Visceral pain syndromes 234, 287
Visual disorders 342
Vitamin A deficiency 651
Vitamin B6 deficiency 632
Vitamin B12 deficiency 188, 366
Vitamin C deficiency 1611
Vitamin D deficiency 154
Vitamin D3 hydroxylase 1986
Vitamin D3 25-hydroxylases 1621
Vitamin D-dependent rickets (type II) 2516
Vitamin deficiencies 795
Vitamin E deficiency 750
Vitamin K1 oxidase 1911
Vitiligo 474, 500, 1215
Vitreal kinetics 924
Vomiting 161, 230,239
von Hippel-Lindau disease 1221
von Willebrand disease 44, 211
Vulvar and vaginal atrophy 281, 283
Vulvitis 798
Vulvovaginal candidiasis 104, 177, 310, 486, 681, 725, 744
W
Waldenström’s macroglobulinemia 732
Warts 115, 672, 766
Water channel 1895
WAVE1 924
Wegener’s granulomatosis 190
Weight gain 1064, 1524, 1549
Weight loss 78, 800, 1046, 1082
Wernicke’s encephalopathy 733
Whipworms 453
White matter changes 1161
Whole blood serotonin 2227
Wilms’ tumor 198, 247, 791, 925
Wilson’s disease 574, 766, 2198
Wiskott-Aldrich syndrome 380
Wolff-Parkinson-White syndrome 623
Wound cleansing, irrigation, and flushing 691
Wound irrigation 691, 692
Wounds and injuries 449, 701, 805
X
Xanthelasma 675
Xanthinuria 2525
Xenobiotics 925, 961, 1096, 1471, 2105, 2314
Xenobiotic and endobiotic metabolism 1905
Xeroderma pigmentosum 2032
Xeroderma pigmentosum, complementation group A 2526
Xerostomia 590, 672
X-linked adrenoleukodystrophy 1911
X-linked cutis laxa 1193
X-linked immunodeficiency 380
X-linked mental retardation 2094
X-linked mental retardation type 94 (MRX94) 2094
Z
Zinc and Paraquat co-exposure 1611
Zinc supplement 805
ZFAND6 function 2529
Zollinger-Ellison syndrome 279, 296, 415, 564, 640